This document summarizes a study that examined the relationship between salted fish consumption and nasopharyngeal carcinoma (NPC) incidence and mortality rates in 8 regions over several decades. The study found decreasing NPC rates in Hong Kong correlated with decreasing salted fish consumption. However, these correlations were no longer significant after adjusting for changes in tobacco use and vegetable consumption. Additionally, no consistent relationships were observed between NPC rates and salted fish intake in the 7 other regions studied. The results do not strongly support the role of salted fish in explaining global NPC rate trends.
Risk factors of chronic liver disease amongst patients receiving care in a Ga...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This document provides an introduction to network medicine and discusses its application to chronic obstructive pulmonary disease (COPD). It defines network medicine as studying cellular, disease, and social networks to quantify factors contributing to individual diseases. For COPD, network approaches are being used to build disease networks, define molecular pathways, identify optimal disease phenotypes, develop new classifications, and integrate multi-omics data. Genome-wide association studies have identified risk loci for COPD, which are now being functionally validated in cellular and animal models. Network medicine aims to take a holistic rather than reductionist approach to complex diseases like COPD.
BRN Seminar 12/06/14 Introduction to Network Medicine brnmomentum
This document provides an introduction to network medicine and discusses its application to chronic obstructive pulmonary disease (COPD). It defines network medicine as studying cellular, disease, and social networks to quantify factors contributing to individual diseases. For COPD, network approaches are being used to build disease networks, define molecular pathways, identify optimal disease phenotypes, develop new classifications, and integrate multi-omics data. Genome-wide association studies have identified risk loci for COPD, which are now being functionally validated in cellular and animal models. Network medicine aims to take a holistic rather than reductionist approach to complex diseases like COPD.
This document summarizes results from a study of 148 patients initiating quadruple antiretroviral therapy during primary HIV-1 infection. By week 48 of treatment, 36% of patients had stopped treatment or were lost to follow-up. Among the 115 patients still in follow-up, viral loads decreased by a median of 5.4 log copies/mL and CD4 counts increased by a median of 147 cells/mm3. 84.2% of patients had viral loads ≤50 copies/mL and lower baseline CD8+/CD38++ T cell counts and cell-associated DNA levels predicted achieving viral loads ≤3 copies/mL. 83 patients experienced serious adverse events. The study demonstrates significant antiviral activity and immune reconstit
This document summarizes a study on the prevalence of type 2 diabetes among hepatitis C virus seropositive subjects in Dutse, Nigeria. The study found that 16.1% of male and 19.4% of female HCV-infected subjects had fasting blood sugar levels above 7 mmol/L, indicating a higher risk of diabetes compared to the control group. Liver enzymes were significantly higher in the HCV group. While some metabolic syndrome parameters differed between groups, the differences were not statistically significant. The study concludes that there is a high prevalence of type 2 diabetes among HCV-infected individuals in Dutse, and factors like age, BMI, triglycerides, and HDL may contribute to the development of diabetes.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Comparison of Infection Episodes in CKD Patients with or without Hemodialysis...ijtsrd
This study compared infection episodes in chronic kidney disease (CKD) patients with and without hemodialysis. A cross-sectional study of 56 CKD patients found that those undergoing hemodialysis had higher rates of chills, increased white blood cell count, and elevated erythrocyte sedimentation rate compared to non-hemodialysis patients. The study concluded that CKD patients on long-term hemodialysis were more prone to developing infections than those not on hemodialysis, likely due to factors such as catheter insertion for hemodialysis. Better infection prevention strategies are needed for CKD patients undergoing hemodialysis.
Risk factors of chronic liver disease amongst patients receiving care in a Ga...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This document provides an introduction to network medicine and discusses its application to chronic obstructive pulmonary disease (COPD). It defines network medicine as studying cellular, disease, and social networks to quantify factors contributing to individual diseases. For COPD, network approaches are being used to build disease networks, define molecular pathways, identify optimal disease phenotypes, develop new classifications, and integrate multi-omics data. Genome-wide association studies have identified risk loci for COPD, which are now being functionally validated in cellular and animal models. Network medicine aims to take a holistic rather than reductionist approach to complex diseases like COPD.
BRN Seminar 12/06/14 Introduction to Network Medicine brnmomentum
This document provides an introduction to network medicine and discusses its application to chronic obstructive pulmonary disease (COPD). It defines network medicine as studying cellular, disease, and social networks to quantify factors contributing to individual diseases. For COPD, network approaches are being used to build disease networks, define molecular pathways, identify optimal disease phenotypes, develop new classifications, and integrate multi-omics data. Genome-wide association studies have identified risk loci for COPD, which are now being functionally validated in cellular and animal models. Network medicine aims to take a holistic rather than reductionist approach to complex diseases like COPD.
This document summarizes results from a study of 148 patients initiating quadruple antiretroviral therapy during primary HIV-1 infection. By week 48 of treatment, 36% of patients had stopped treatment or were lost to follow-up. Among the 115 patients still in follow-up, viral loads decreased by a median of 5.4 log copies/mL and CD4 counts increased by a median of 147 cells/mm3. 84.2% of patients had viral loads ≤50 copies/mL and lower baseline CD8+/CD38++ T cell counts and cell-associated DNA levels predicted achieving viral loads ≤3 copies/mL. 83 patients experienced serious adverse events. The study demonstrates significant antiviral activity and immune reconstit
This document summarizes a study on the prevalence of type 2 diabetes among hepatitis C virus seropositive subjects in Dutse, Nigeria. The study found that 16.1% of male and 19.4% of female HCV-infected subjects had fasting blood sugar levels above 7 mmol/L, indicating a higher risk of diabetes compared to the control group. Liver enzymes were significantly higher in the HCV group. While some metabolic syndrome parameters differed between groups, the differences were not statistically significant. The study concludes that there is a high prevalence of type 2 diabetes among HCV-infected individuals in Dutse, and factors like age, BMI, triglycerides, and HDL may contribute to the development of diabetes.
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Comparison of Infection Episodes in CKD Patients with or without Hemodialysis...ijtsrd
This study compared infection episodes in chronic kidney disease (CKD) patients with and without hemodialysis. A cross-sectional study of 56 CKD patients found that those undergoing hemodialysis had higher rates of chills, increased white blood cell count, and elevated erythrocyte sedimentation rate compared to non-hemodialysis patients. The study concluded that CKD patients on long-term hemodialysis were more prone to developing infections than those not on hemodialysis, likely due to factors such as catheter insertion for hemodialysis. Better infection prevention strategies are needed for CKD patients undergoing hemodialysis.
"Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury, Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD"
Seroprevalence among blood donors is a major public health problem, both in
developed and developing countries, in its magnitude. The aim of this study
was to determine the seroprevalence of hepatitis B in blood donors. This is a
descriptive study carried out in the city of Mbuji-Mayi at the General Hospital
of Dipumba in blood donors (family, volunteer and remunerated) recorded
from 01/to31/December 2016; the data were collected in a transverse fashion.
The following observations were made: During the study period, 1584 blood
donors were registered. After analyzing the data, the seroprevalence of hepatitis
B in blood donors was 2.2%, 77.8% were male (sex ratio M/F 3.5 and voluntary
donors were 50.4%.
This document summarizes key factors related to drug rechallenge following drug-induced liver injury (DILI). It finds that nearly 50 drugs are associated with positive rechallenge, defined as ALT levels 3-5x upper limits of normal. Drugs that cause mitochondrial impairment or immunoallergic injury in vitro have higher positive rechallenge rates, as do those with a daily dose over 50mg. Personal factors like genetics and environment also influence outcomes. Drugs associated with DILI in clinical trials tend to have higher ALT elevations than placebos. While rechallenge carries risks, it may be considered for critical medications if alternatives are unavailable and patients can be closely monitored. More data is still needed to better understand outcomes and identify re
Hepatitis b virus (hbv) infection among alcoholic consumers at a local commun...Alexander Decker
This study investigated the prevalence of hepatitis B virus (HBV) infection among 138 alcoholic consumers in North-East Nigeria. 10 subjects screened positive for HBsAg, indicating a prevalence of 5.3% among alcoholic consumers. The prevalence was higher in males (3.7%) than females (2.1%), and in subjects aged 21-30 years (2.1%). Most positive subjects (4.3%) also had elevated liver enzymes. The study highlights the need for measures to curb HBV transmission and immunization in this community given the virus' effects on the liver.
Fluoroquinolone resistant rectal colonization predicts risk of infectious com...TC İÜ İTF Üroloji AD
This study analyzed data from 2,673 men who underwent rectal culture before transrectal prostate biopsy at six institutions between 2007-2013. The study found that 20.5% of rectal cultures showed fluoroquinolone resistant (FQR) bacteria. Men with positive FQR cultures had higher rates of post-biopsy infection (6.6% vs 1.6%) and hospitalization (4.4% vs 0.9%) compared to men with negative cultures. Logistic regression showed that positive FQR culture was associated with significantly increased risk of both post-biopsy infection and hospitalization. The findings suggest that rectal culture can help identify men at high risk for infectious complications following prostate biopsy.
This randomized clinical trial compared two post-exposure prophylaxis (PEP) regimens for preventing HIV infection: tenofovir/emtricitabine plus ritonavir-boosted lopinavir versus tenofovir/emtricitabine plus raltegravir. The trial found that while overall PEP non-completion at 28 days was similar between the two regimens, the raltegravir-containing regimen had significantly fewer adverse events and better adherence. Specifically, the ritonavir-boosted lopinavir regimen was associated with higher rates of PEP non-completion, loss to follow up, and low adherence, as well as more reported adverse events.
This article summarizes a study of 785 Tanzanian children living in an area with intense malaria transmission. The study found that iron deficiency (ID), as measured by ferritin levels in blood samples taken at routine visits, significantly decreased the odds of subsequent malaria parasitemia, severe malaria, and all-cause mortality in children. When samples from sick visits were also included, ID was associated with significantly lower prevalence of parasitemia, hyperparasitemia (very high parasite levels), and severe malaria at the time of sample collection. The results suggest that naturally occurring ID protects against severe malaria and death in young children, and that iron supplementation may increase malaria risk even in children with ID. Future studies are needed to determine
Prevalence of Hepatitis B Surface Antigen among Undergraduate Students of Gom...IOSR Journals
Incidence of Hepatitis B virus among healthy asymptomatic students in Gombe State University was determined, this was in an effort of providing baseline data on the diseases burden, and the possible risk factors associated with the infection in the study population. A total of 100 serum samples were collected from volunteers and screened using rapid immune chromatographic test kits for Hepatitis B surface antigen (HBsAg). The study revealed that 14% were HBsAg positive. The highest incidence rate of 18.2% (12) was recorded among the age group of 16-25 years, and males recorded the highest incidence rate of 20% (12), indicating that gender but not age might have greater influence on the infection (P= 0.05).
This document summarizes updates to the 2009 American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for the management of chronic hepatitis B. Key changes include:
1) Tenofovir is now recommended as a first-line oral antiviral treatment based on its superior efficacy compared to adefovir in clinical trials. Adefovir is now recommended as a second-line treatment.
2) Entecavir is no longer recommended for patients co-infected with HBV and HIV due to data on its anti-HIV activity.
3) Screening recommendations were expanded to include persons born in intermediate endemic areas and those receiving cancer chemotherapy or long-term immunosuppression based on
Hematological and biochemical alterations in malaria and their correlation wi...iosrphr_editor
Malaria is a major health problem in India with 1.04 million cases reported in 2012 leading to 504 deaths. The clinical spectrum depends on the infecting species, level of parasitemia and the immune status of the host. Malaria pathogenesis is based on extensive changes in hematological and biochemical parameters. The objective of this study was to study the clinical features, hematological and biochemical parameters in malaria patients and correlate them with the parasitic index (PI). Material and methods: We conducted a study on 300 malaria patients. The frequency of various symptoms and signs of malaria caused by various plasmodium species were determined. The degree of anemia, WBC count, platelet count serum bilirubin, liver enzymes and serum creatinine levels were studied and their variation depending on the parasitic index was documented. Results: 197 patients had vivax malaria, 76 patients had falciparum malaria and 27 patients had mixed infection. 171 patients had a PI of less than 2%, 100 patients had PI between 2 to 5%, 23 patients had PI between 5 to 10% and only 6 patients had PI of more than 10%. 72.3% of patients had thrombocytopenia, 46.66% had anaemia, 25% had increased bilirubin 29.66% showed increased liver enzymes and 7.66% had increased creatinine levels. Conclusion: There was a correlation between degree of parasitemia and severity of malaria in majority of cases. Derangements in hematological and biochemical parameters were more frequently seen in patients with higher PI. Hence PI can be used as an indicator by the clinician to know the severity of infection and plan appropriate treatment.
The Natural History of Liver Fibrosis Progression Rate in Hepatitis C Infecti...aranush
The study examined factors associated with the rate of liver fibrosis progression in 72 patients with hepatitis C virus (HCV) infection who had more than one liver biopsy. Approximately one-third of patients showed fibrosis progression over a mean of 4 years between biopsies. Demographic factors did not predict progression rate. A history of failed interferon therapy was associated with a trend towards a lower progression rate, although this was not statistically significant. Co-morbid illnesses, social factors, and lab values did not correlate with progression rate. The overall mean fibrosis progression rate was low.
This document discusses HIV and its effects on the kidney. It begins by outlining how HIV medications and the virus itself can impact renal function. It then discusses how monitoring renal function in HIV patients requires looking beyond creatinine and eGFR, as proximal tubule damage is common. Studies mentioned show increasing rates of chronic kidney disease in HIV populations and risk factors like tenofovir use and older age. Biopsy results from local patients demonstrate frequent tenofovir toxicity and the value of the urine APR test. Ongoing research aims to better estimate glomerular filtration rate and understand discrepancies with estimated values.
Ascaris lumbricoides and other Gastrointestinal Helminthic Parasites among Qe...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This document reviews the association between diabetes mellitus, alcohol abuse, and various cancers. It discusses the mechanisms by which hyperglycemia and hyperinsulinemia associated with diabetes can promote cancer growth. Alcohol metabolism produces acetaldehyde, which is carcinogenic and may initiate or promote cancer development in several tissues. The review summarizes studies showing diabetes and alcohol abuse are risk factors for cancers like breast, colorectal, liver and others. It explores the molecular pathways like IGF-1, MAPK and cytokines through which diabetes and alcohol abuse can increase cancer incidence and mortality.
Context—Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide, and have been linked to acute interstitial nephritis. Less is known about the relationship between PPI use and chronic kidney disease (CKD).
Objective—To quantify the association between PPI use and incident CKD in a population based cohort.
In total, 144,032 participants in Communities study with an estimated glomerular filtration rate of at least 60 mL/min/1.73 m2 were followed from a baseline visit between February 1, 1996, and January 30, 1999, to December 31, 2011. The data was analysed from May 2015 to October 2015.
Convalescent Plasma and COVID-19: Ancient Therapy Re-emergedasclepiuspdfs
Convalescent plasma has been used as a treatment for infectious diseases for over a century. It involves transfusing plasma from patients who have recovered from an infection into patients who are currently ill with that same infection. Clinical trials are now investigating its use for COVID-19. While some early studies showed promising results, larger randomized controlled trials found no significant benefit of convalescent plasma for severe COVID-19. Further research is still needed to determine whether certain patient populations or plasma dosages may be more effective.
The UC San Diego AntiViral Research Center sponsors weekly presentations on infectious diseases research and clinical practices. A presentation on whether widespread HIV treatment can end transmission discussed recent trends showing HIV declining among adolescents and young adults in the US. The presentation reviewed research showing that early HIV treatment dramatically reduces heterosexual transmission but some transmission may still occur through anal sex among men who have sex with men on antiretroviral therapy. Future interventions could focus on optimizing HIV treatment, comparing antiretroviral regimens, and suppressing coinfections like CMV to further reduce HIV transmission.
Epigenetic regulation and role of metastasis suppressor genes in pancreatic d...Enrique Moreno Gonzalez
Pancreatic ductal adenocarcinoma (PDAC) is distinguished by rapid dissemination. Thus, genetic and/or epigenetic deregulation of metastasis suppressor genes (MSG) is a likely event during early pancreatic carcinogenesis and a potential diagnostic marker for the disease. We investigated 9 known MSGs for their role in the dissemination of PDAC and examined their promoters for methylation and its use in PDAC detection.
Low expression of N-myc downstream-regulated gene 2 in oesophageal squamous c...Enrique Moreno Gonzalez
It is currently unclear whether a correlation exists between N-myc downstream-regulated gene 2 (NDRG2) expression and oesophageal squamous cell carcinoma (ESCC). The aim of this study was to examine the underlying clinical significance of NDRG2 expression in ESCC patients and to investigate the effects of NDRG2 up-regulation on ESCC cell growth in vitro and in vivo.
Connexin-43 can delay early recurrence and metastasis in patients with hepati...Enrique Moreno Gonzalez
We studied the relationships among Cx43, CD105, and VEGF in specimens of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) with different serum AFP levels with respect to recurrence and metastasis.
"Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury, Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD"
Seroprevalence among blood donors is a major public health problem, both in
developed and developing countries, in its magnitude. The aim of this study
was to determine the seroprevalence of hepatitis B in blood donors. This is a
descriptive study carried out in the city of Mbuji-Mayi at the General Hospital
of Dipumba in blood donors (family, volunteer and remunerated) recorded
from 01/to31/December 2016; the data were collected in a transverse fashion.
The following observations were made: During the study period, 1584 blood
donors were registered. After analyzing the data, the seroprevalence of hepatitis
B in blood donors was 2.2%, 77.8% were male (sex ratio M/F 3.5 and voluntary
donors were 50.4%.
This document summarizes key factors related to drug rechallenge following drug-induced liver injury (DILI). It finds that nearly 50 drugs are associated with positive rechallenge, defined as ALT levels 3-5x upper limits of normal. Drugs that cause mitochondrial impairment or immunoallergic injury in vitro have higher positive rechallenge rates, as do those with a daily dose over 50mg. Personal factors like genetics and environment also influence outcomes. Drugs associated with DILI in clinical trials tend to have higher ALT elevations than placebos. While rechallenge carries risks, it may be considered for critical medications if alternatives are unavailable and patients can be closely monitored. More data is still needed to better understand outcomes and identify re
Hepatitis b virus (hbv) infection among alcoholic consumers at a local commun...Alexander Decker
This study investigated the prevalence of hepatitis B virus (HBV) infection among 138 alcoholic consumers in North-East Nigeria. 10 subjects screened positive for HBsAg, indicating a prevalence of 5.3% among alcoholic consumers. The prevalence was higher in males (3.7%) than females (2.1%), and in subjects aged 21-30 years (2.1%). Most positive subjects (4.3%) also had elevated liver enzymes. The study highlights the need for measures to curb HBV transmission and immunization in this community given the virus' effects on the liver.
Fluoroquinolone resistant rectal colonization predicts risk of infectious com...TC İÜ İTF Üroloji AD
This study analyzed data from 2,673 men who underwent rectal culture before transrectal prostate biopsy at six institutions between 2007-2013. The study found that 20.5% of rectal cultures showed fluoroquinolone resistant (FQR) bacteria. Men with positive FQR cultures had higher rates of post-biopsy infection (6.6% vs 1.6%) and hospitalization (4.4% vs 0.9%) compared to men with negative cultures. Logistic regression showed that positive FQR culture was associated with significantly increased risk of both post-biopsy infection and hospitalization. The findings suggest that rectal culture can help identify men at high risk for infectious complications following prostate biopsy.
This randomized clinical trial compared two post-exposure prophylaxis (PEP) regimens for preventing HIV infection: tenofovir/emtricitabine plus ritonavir-boosted lopinavir versus tenofovir/emtricitabine plus raltegravir. The trial found that while overall PEP non-completion at 28 days was similar between the two regimens, the raltegravir-containing regimen had significantly fewer adverse events and better adherence. Specifically, the ritonavir-boosted lopinavir regimen was associated with higher rates of PEP non-completion, loss to follow up, and low adherence, as well as more reported adverse events.
This article summarizes a study of 785 Tanzanian children living in an area with intense malaria transmission. The study found that iron deficiency (ID), as measured by ferritin levels in blood samples taken at routine visits, significantly decreased the odds of subsequent malaria parasitemia, severe malaria, and all-cause mortality in children. When samples from sick visits were also included, ID was associated with significantly lower prevalence of parasitemia, hyperparasitemia (very high parasite levels), and severe malaria at the time of sample collection. The results suggest that naturally occurring ID protects against severe malaria and death in young children, and that iron supplementation may increase malaria risk even in children with ID. Future studies are needed to determine
Prevalence of Hepatitis B Surface Antigen among Undergraduate Students of Gom...IOSR Journals
Incidence of Hepatitis B virus among healthy asymptomatic students in Gombe State University was determined, this was in an effort of providing baseline data on the diseases burden, and the possible risk factors associated with the infection in the study population. A total of 100 serum samples were collected from volunteers and screened using rapid immune chromatographic test kits for Hepatitis B surface antigen (HBsAg). The study revealed that 14% were HBsAg positive. The highest incidence rate of 18.2% (12) was recorded among the age group of 16-25 years, and males recorded the highest incidence rate of 20% (12), indicating that gender but not age might have greater influence on the infection (P= 0.05).
This document summarizes updates to the 2009 American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for the management of chronic hepatitis B. Key changes include:
1) Tenofovir is now recommended as a first-line oral antiviral treatment based on its superior efficacy compared to adefovir in clinical trials. Adefovir is now recommended as a second-line treatment.
2) Entecavir is no longer recommended for patients co-infected with HBV and HIV due to data on its anti-HIV activity.
3) Screening recommendations were expanded to include persons born in intermediate endemic areas and those receiving cancer chemotherapy or long-term immunosuppression based on
Hematological and biochemical alterations in malaria and their correlation wi...iosrphr_editor
Malaria is a major health problem in India with 1.04 million cases reported in 2012 leading to 504 deaths. The clinical spectrum depends on the infecting species, level of parasitemia and the immune status of the host. Malaria pathogenesis is based on extensive changes in hematological and biochemical parameters. The objective of this study was to study the clinical features, hematological and biochemical parameters in malaria patients and correlate them with the parasitic index (PI). Material and methods: We conducted a study on 300 malaria patients. The frequency of various symptoms and signs of malaria caused by various plasmodium species were determined. The degree of anemia, WBC count, platelet count serum bilirubin, liver enzymes and serum creatinine levels were studied and their variation depending on the parasitic index was documented. Results: 197 patients had vivax malaria, 76 patients had falciparum malaria and 27 patients had mixed infection. 171 patients had a PI of less than 2%, 100 patients had PI between 2 to 5%, 23 patients had PI between 5 to 10% and only 6 patients had PI of more than 10%. 72.3% of patients had thrombocytopenia, 46.66% had anaemia, 25% had increased bilirubin 29.66% showed increased liver enzymes and 7.66% had increased creatinine levels. Conclusion: There was a correlation between degree of parasitemia and severity of malaria in majority of cases. Derangements in hematological and biochemical parameters were more frequently seen in patients with higher PI. Hence PI can be used as an indicator by the clinician to know the severity of infection and plan appropriate treatment.
The Natural History of Liver Fibrosis Progression Rate in Hepatitis C Infecti...aranush
The study examined factors associated with the rate of liver fibrosis progression in 72 patients with hepatitis C virus (HCV) infection who had more than one liver biopsy. Approximately one-third of patients showed fibrosis progression over a mean of 4 years between biopsies. Demographic factors did not predict progression rate. A history of failed interferon therapy was associated with a trend towards a lower progression rate, although this was not statistically significant. Co-morbid illnesses, social factors, and lab values did not correlate with progression rate. The overall mean fibrosis progression rate was low.
This document discusses HIV and its effects on the kidney. It begins by outlining how HIV medications and the virus itself can impact renal function. It then discusses how monitoring renal function in HIV patients requires looking beyond creatinine and eGFR, as proximal tubule damage is common. Studies mentioned show increasing rates of chronic kidney disease in HIV populations and risk factors like tenofovir use and older age. Biopsy results from local patients demonstrate frequent tenofovir toxicity and the value of the urine APR test. Ongoing research aims to better estimate glomerular filtration rate and understand discrepancies with estimated values.
Ascaris lumbricoides and other Gastrointestinal Helminthic Parasites among Qe...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
This document reviews the association between diabetes mellitus, alcohol abuse, and various cancers. It discusses the mechanisms by which hyperglycemia and hyperinsulinemia associated with diabetes can promote cancer growth. Alcohol metabolism produces acetaldehyde, which is carcinogenic and may initiate or promote cancer development in several tissues. The review summarizes studies showing diabetes and alcohol abuse are risk factors for cancers like breast, colorectal, liver and others. It explores the molecular pathways like IGF-1, MAPK and cytokines through which diabetes and alcohol abuse can increase cancer incidence and mortality.
Context—Proton pump inhibitors (PPIs) are among the most commonly used drugs worldwide, and have been linked to acute interstitial nephritis. Less is known about the relationship between PPI use and chronic kidney disease (CKD).
Objective—To quantify the association between PPI use and incident CKD in a population based cohort.
In total, 144,032 participants in Communities study with an estimated glomerular filtration rate of at least 60 mL/min/1.73 m2 were followed from a baseline visit between February 1, 1996, and January 30, 1999, to December 31, 2011. The data was analysed from May 2015 to October 2015.
Convalescent Plasma and COVID-19: Ancient Therapy Re-emergedasclepiuspdfs
Convalescent plasma has been used as a treatment for infectious diseases for over a century. It involves transfusing plasma from patients who have recovered from an infection into patients who are currently ill with that same infection. Clinical trials are now investigating its use for COVID-19. While some early studies showed promising results, larger randomized controlled trials found no significant benefit of convalescent plasma for severe COVID-19. Further research is still needed to determine whether certain patient populations or plasma dosages may be more effective.
The UC San Diego AntiViral Research Center sponsors weekly presentations on infectious diseases research and clinical practices. A presentation on whether widespread HIV treatment can end transmission discussed recent trends showing HIV declining among adolescents and young adults in the US. The presentation reviewed research showing that early HIV treatment dramatically reduces heterosexual transmission but some transmission may still occur through anal sex among men who have sex with men on antiretroviral therapy. Future interventions could focus on optimizing HIV treatment, comparing antiretroviral regimens, and suppressing coinfections like CMV to further reduce HIV transmission.
Epigenetic regulation and role of metastasis suppressor genes in pancreatic d...Enrique Moreno Gonzalez
Pancreatic ductal adenocarcinoma (PDAC) is distinguished by rapid dissemination. Thus, genetic and/or epigenetic deregulation of metastasis suppressor genes (MSG) is a likely event during early pancreatic carcinogenesis and a potential diagnostic marker for the disease. We investigated 9 known MSGs for their role in the dissemination of PDAC and examined their promoters for methylation and its use in PDAC detection.
Low expression of N-myc downstream-regulated gene 2 in oesophageal squamous c...Enrique Moreno Gonzalez
It is currently unclear whether a correlation exists between N-myc downstream-regulated gene 2 (NDRG2) expression and oesophageal squamous cell carcinoma (ESCC). The aim of this study was to examine the underlying clinical significance of NDRG2 expression in ESCC patients and to investigate the effects of NDRG2 up-regulation on ESCC cell growth in vitro and in vivo.
Connexin-43 can delay early recurrence and metastasis in patients with hepati...Enrique Moreno Gonzalez
We studied the relationships among Cx43, CD105, and VEGF in specimens of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) with different serum AFP levels with respect to recurrence and metastasis.
Differences in microRNA expression during tumor development in the transition...Enrique Moreno Gonzalez
The prostate is divided into three glandular zones, the peripheral zone (PZ), the transition zone (TZ), and the central zone. Most prostate tumors arise in the peripheral zone (70-75%) and in the transition zone (20-25%) while only 10% arise in the central zone. The aim of this study was to investigate if differences in miRNA expression could be a possible explanation for the difference in propensity of tumors in the zones of the prostate.
Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous ...Enrique Moreno Gonzalez
Tumor dissemination to cervical lymph nodes via lymphatics represents the first step in the metastasis of head and neck squamous cell carcinoma (HNSCC) and is the most significant predictor of tumor recurrence decreasing survival by 50%. The lymphatic suppressing properties of mTOR inhibitors are not yet well understood.
The life in sight application study (LISA): design of a randomized controlled...Enrique Moreno Gonzalez
It is widely recognized that spiritual care plays an important role in physical and psychosocial well-being of cancer patients, but there is little evidence based research on the effects of spiritual care. We will conduct a randomized controlled trial on spiritual care using a brief structured interview scheme supported by an e-application. The aim is to examine whether an assisted reflection on life events and ultimate life goals can improve quality of life of cancer patients.
Clinical and experimental studies regarding the expression and diagnostic val...Enrique Moreno Gonzalez
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression. However, the serum CEACAM1 expression in nonsmall-cell lung carcinomas (NSCLC) is unclear. The different expression ratio of CEACAM1-S and CEACAM1-L isoform has seldom been investigated in NSCLC. This research is intended to study the serum CEACAM1 and the ratio of CEACAM1-S/L isoforms in NSCLC.
Clinical and experimental studies regarding the expression and diagnostic val...
Similar to Secular trends of salted fish consumption and nasopharyngeal carcinoma: a multi-jurisdiction ecological study in 8 regions from 3 continents
Inorganic phosphate and the risk of cancer in the Swedish AMORIS studyEnrique Moreno Gonzalez
This document summarizes a study that examined the association between serum inorganic phosphate (Pi) levels and cancer risk in over 397,000 Swedish adults. The study found:
1) Higher Pi levels were associated with increased cancer risk in men, but decreased risk in women.
2) Higher Pi levels were linked to increased risk of specific cancers like pancreas, lung, and bone cancer in men, and esophagus, lung, and skin cancer in women.
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2. Secular trends of salted fish consumption and
nasopharyngeal carcinoma: a multi-jurisdiction
ecological study in 8 regions from 3 continents
Hiu-Ying Lau1,4
Email: adahylau@hku.hk
Chit-Ming Leung1,4
Email: irisl@graduate.hku.hk
Yap-Hang Chan1,4,5,*
Email: chanwill@hku.hk
Anne Wing-Mui Lee3,4
Email: awmlee@ha.org.hk
Dora Lai-Wan Kwong2,4
Email: dlwkwong@hkucc.hku.hk
Maria Li Lung2,4
Email: mlilung@hku.hk
Tai-Hing Lam1,4
Email: hrmrlth@hkucc.hku.hk
1
School of Public Health, University of Hong Kong, Hong Kong, China
2
Department of Clinical Oncology, Queen Mary Hospital, University of Hong
Kong, Hong Kong, China
3
Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital,
Chai Wan, Hong Kong
4
Epidemiology Group, Center for Nasopharyngeal Carcinoma Research, Hong
Kong RGC Area of Excellence Scheme, Hong Kong, China
5
School of Public Health, The University of Hong Kong, 21 Sassoon Road, Hong
Kong, China
*
Corresponding author. School of Public Health, The University of Hong Kong,
21 Sassoon Road, Hong Kong, China
3. Abstract
Background
Despite salted fish being a classical risk factor of Nasopharyngeal Carcinoma (NPC), whether
secular trends in salted fish consumption worldwide accounted for changes in NPC rates were
unknown. The relationship between vegetable and cigarette consumption to NPC risk
worldwide were also largely uncertain. We investigated the longitudinal trends in
standardised NPC incidence/mortality rates across 8 regions and their associations with
secular trends in salted fish, vegetable and tobacco consumptions.
Methods
Age standardised mortality rate (ASMR) and age standardised incidence rate (ASIR) of NPC
were obtained from the WHO cancer mortality database and Hong Kong Cancer Registry. Per
capita consumption of salted fish, tobacco and vegetables in Hong Kong and 7 countries
(China, Finland, Japan, Portugal, Singapore, United Kingdom and United States) were
obtained from the Food and Agriculture Organization of the United Nation (FAO) and Hong
Kong Trade and Census Statistics. Pearson correlation and multivariate analysis were
performed to examine both crude and adjusted associations.
Results
There were markedly decreasing trends of NPC ASIR and ASMR in Hong Kong over the
past three decades, which were correlated with corresponding secular changes in salted fish
consumption per capita (Pearson r for 10 cumulative years : ASIR = 0.729 (male), 0.674
(female); ASMR = 0.943 (male), 0.622 (female), all p < 0.05 except for female ASMR).
However such associations no longer correlated with adjustments for decreasing tobacco and
increasing vegetable consumption per capita (Pearson r for 10 cumulative years: ASIR =
2.007 (male), 0.339 (female), ASMR = 0.289 (male), 1.992 (female), all p > 0.05). However,
there were no clear or consistent patterns in relations between NPC ASIR and ASMR with
salted fish consumption across 7 regions in 3 continents.
Conclusions
Our results do not support the notion that changes in salted fish consumption had played an
important role in explaining secular trends of NPC rates in Hong Kong and worldwide.
Further studies should explore other lifestyle and genetic factors. However, our findings do
support the potentially protective effects of vegetable consumption against NPC.
Keywords
Nasopharyngeal carcinoma, Salted fish consumption, Tobacco, Secular trend, Ecological
study
4. Background
The distribution of nasopharyngeal carcinoma (NPC) has a distinctive geographic variation.
Being a rare malignancy worldwide, it has particularly high rates in Southern China [1].
Residual risk remained high among migrants of Chinese descent [2] to non-endemic areas,
with intergenerational decline [3], suggesting that the aetiology of NPC is a complex
interplay between genetic influences and environmental exposures distinct in these
populations.
Among known environmental exposures relevant to the aetiology of NPC; dietary
consumption of salted fish is the most well recognised risk factor. First suggested by Ho and
colleagues [4] to have a link with the high incidence of NPC in Southern China Guangdong
Province in the early 1970s, subsequent studies quite consistently reported positive
associations between salted fish consumption and risk of NPC in Chinese [5] and other
ethnicities [6] such as Thai and Tunisian [7], and that early exposures during the weaning
period in childhood may play a critical role [1,8]. What makes salted fish an intriguing item
to look at is that nitrosamine in Cantonese style salted fish is carcinogenic to humans and this
food item is rated as a group 1 carcinogen by the International Agency for Research on
Cancer (IARC)[9], whereas other salted fish are only classified as group 3 carcinogen [9].
This can be explained by the different levels of nitrosamines in various types of salted fish,
depending on the method of preservation [10]. However, the low disease rates of NPC even
in endemic regions render case-control studies to be the only feasible epidemiological
method, of which limitations and deficiencies are well-recognised. The extent to which
notorious effects of recall bias [11], lack of adjustment of caloric intake [12] and other
confounders may affect the validity of the study findings remains unknown. Whether any
publication bias may exist due to active reporting of salted fish consumptions as a classical
risk factor of NPC is also uncertain. Although Cantonese-style salted fish has been classified
by IARC as a group 1 carcinogen [9], the putative main biological active component N-
nitrosodimethylamine, is only classified as a group 2A carcinogen [13]. Such incoherence
makes the aetiological role of salted fish especially worthwhile for more thorough re-
exploration.
In the past 30 to 40 years, the incidence and mortality rates of NPC have dropped noticeably
in several Asia regions particularly among some Chinese subpopulations [14,15]. Given the
wide range of the relative risk of high salted fish consumption ranging from 2.5–17.2[16],
which translates into population attributable risk (PAR) of 39%–78%, adopting exposure
prevalence of salted fish consumption in the population, it would be of interest to investigate
whether the secular trend of NPC disease rates is explained by a corresponding change in
salted fish consumption in relevant jurisdictions. To our best knowledge, reports of such
studies were not available.
We, therefore, carried out this Hong Kong and multi-site ecological study to investigate the
relationship between secular trends of salted fish consumption and standardised NPC
incidence and mortality rates over 30 years. We also included an analysis in Hong Kong
taking into account other key lifestyle related factors, including tobacco smoking [17] and
vegetable [18] consumption, which were reported to be a risk and protective factor of NPC
respectively.
5. Methods
Study sites
In this ecological study, we focused on Hong Kong, an endemic area of NPC, and 7 countries
in 3 continents including: China, Finland, Japan, Portugal, Singapore, United Kingdom and
United States. Hong Kong was chosen due to its high prevalence of NPC, with the advantage
of a comprehensive cancer statistics database and the availability of relevant risk/protective
factor profiles. China was also selected for investigation, since there is a substantial variation
in NPC risk of Chinese who lived in different parts of China. For example those who live in
the Northern parts of China have a lower incidence rate than people who live in Southern
China [15]. Another area with a relatively high NPC mortality rate is Singapore, which
attracted much attention in previous NPC case control studies [19,20]. For low risk areas,
Japan, Finland, Portugal, United Kingdom and United States were selected because of their
rather complete cancer statistics.
NPC incidence and mortality statistics
NPC age-standardised mortality rates (ASMR) and age-standardised incidence rates (ASIR)
were obtained from various sources. NPC age-standardised incidence and mortality rates in
Hong Kong during 1978 to 2008 were derived from Hong Kong Cancer Registry [21]with the
world 1966 standard population as reference. NPC mortality statistics of other jurisdictions
were collected from the WHO cancer mortality database [22-24], and age-standardised rates
were also adjusted to the world standard population 1966. The code of cancer site followed
the International Classification of Disease (ICD) coding system, with NPC coded as 147
(ICD-8, WHO 1967; ICD-9, WHO 1977) and C11 (ICD-10, WHO 1992).
Salted fish consumption per capita
Hong Kong SAR trade statistics and census
Salted fish consumption in Hong Kong was estimated from import, export and re-export
volumes of dried fish, and whether or not salted but not smoked provided by the Service
Centre on Trade Statistics, Census and Statistics Department, Hong Kong SAR Government.
The database contains monthly and annual tallies of quantity, value and import by country of
origin (of the product), import by country of consignment (origin of shipment), country of
export, and country of re-export according to Harmonized Commodity Description and
Coding System of the World Customs Organization. Domestic consumption was calculated
from the difference between exports, re-exports and imports. All these data were acquired
from the archive database of Census and Statistics Department. Salted fish consumption per
capita for each year was then estimated according to the formula: (imports − exports − re-
exports) ÷ mid-year population in Hong Kong retrieved from Population Census and By-
census, Demographic Statistics Section, Census and Statistics Department, 1978–2008[25] .
Food and Agriculture Organisation (FAO), United Nations
Worldwide salted fish consumptions were compiled by productions, imports, exports and re-
exports on fish, dried, salted or smoked from Fishery and Aquaculture Statistics Database,
FAO [26], United Nations. This database contains statistics on the annual production,
6. imports, exports and re-exports of fishery commodities by country and commodities in terms
of volume and value from 1976. For every country, per capita consumption was calculated
from the difference between exports, re-exports, imports and production, i.e. [(import +
production) – export– re-export] ÷ total population of the defined jurisdiction in each year.
Total population is estimated from FAOSTAT Population module [27] [26].
Tobacco consumption per capita
Per capita cigarette consumption in Hong Kong was estimated by Hong Kong Council on
Smoking and Health (COSH) via General Household Survey and Thematic Household
Survey 2008[28] in reporting average daily cigarette consumption among smokers(sticks),
number of smokers and percentage of smokers in Hong Kong from 1982–2008. Per capita
consumption was calculated by: Daily average consumption × No. of daily smokers (aged 15
and over) ÷ Population (all age) × 365 days = Per capita consumption (stick/capita/year).
Statistic on tobacco tax was also collected from COSH. Data on percentage increase in
tobacco tax was plotted with per capita consumption of tobacco.
Vegetable consumption per capita
Per capita fresh vegetable consumption data in Hong Kong from 1991 to 2009 were obtained
from the Department Annual Report by Agriculture, Fisheries and Conservation Department
HKSAR [29]. All per capita calculations in Hong Kong were divided by mid-year population
obtained from Population Census and By-census 1991–2009, Demographic Statistics Section,
Census and Statistics Department [25].
Statistical analysis
NPC incidence and mortality rates were estimated from 1978–2008, as cases or deaths per
100,000 persons. The rates were age-standardised to the world 1966 standard population for
all localities using 18 age groups (<1, 1–4, 5–9,…, 80–84, 85+). Age-standardised
mortality/incidence and male/female ratio in age-standardised incidence and mortality rates
were also calculated.
Non-linear regression of least square method was used for fitting any incomplete data point
from 1978–2008. Pearson correlation analysis was used to examine the relations between
cumulative consumption of salted fish, vegetable and tobacco in relation to ASIR and ASMR
from 1991–2008 in Hong Kong. Multivariable linear regression analysis was performed to
adjust for potential confounding effects of tobacco and vegetable consumption during the
period of 1991–2008. Repeated analysis using various duration of cumulative salted fish
intake prior to the NPC disease rate outcomes was performed to test the robustness of
estimates based on differential assumptions in the latency period of cancer development
subsequent to relevant exposures (range: 0, 5, 10 years). A p value smaller than 0.05 (two-
sided) was considered statistically significant. All the data was analysed by SPSS Statistics
17.0.
7. Results
Age-standardised incidence and mortality rates in Hong Kong from 1978–
2008
As shown in Figure 1a and b, both ASIR and ASMR for males and females showed
decreasing trends over the last 30 years, with males having consistently higher rates than
females. By 2008, ASIR and ASMR for males had decreased by 66.1% and 61.7%,
respectively, compared to the late 1970s. Similarly, ASIR and ASMR for females had also
decreased by 73.7% and 70.9%, respectively.
Figure 1 Cancer statistics for NPC in Hong Kong from 1978 to 2008. (a) Age-
standardized incidence rate; (b) Age-standardized mortality rate; (c) Age-standardized
mortality/incidence ratio; (d) Male/Female ratio in age-standardized incidence and mortality
rates.
The age standardised mortality/incidence ratio (Figure 1c) for both genders, albeit with
notable fluctuations, followed an overall slowly declining trend over the past 30 years with
estimates for males being consistently higher than females. The male/female ratios for ASIR
and ASMR, as presented in Figure 1d, maintained a value of around 3 over the past 30 years
with a slowly rising trend. The ASMR male/female ratio was higher than that for ASIR
throughout the whole period.
Secular trend of salted fish consumption estimates in Hong Kong from 1978–
2008
The salted fish consumption based on the FAO and Hong Kong Trade Statistics is presented
in Figure 2a-e. The import data (Figure 2a) from separate databases gave distinct trends. FAO
statistics showed more markedly increased imports over 30 years, while Hong Kong Trade
Statistics increased steadily from 1978 to 2008. Only FAO data was available for production
of salted fish (Figure 2b) which decreased sharply from the 1980s to the mid-1990s such that
by 1999 onwards it had declined to around zero. Apart from the disparities at the beginning
of the curves, both sources produced similar trends in terms of export quantity (Figure 2c).
Annual export was reduced from the peak of 374 and 559 ton in the 1980s for FAO and Hong
Kong Trade Statistics, respectively, to 46 and 21 tons in late 2000s. Consistent with the
higher estimates of salted fish imports from the FAO statistics than the Hong Kong Trade
Statistics, the former also showed a corresponding significant increase in re-exports of salted
fish from Hong Kong (Figure 2d). Based on these raw data and the formula defined a priori,
per capita consumption was derived (Figure 2e). Despite notable differences in some of the
raw parameter estimates, the overall salted fish consumption per capita derived from the FAO
and the Hong Kong Trade Statistics was strongly correlated (Pearson correlation r = 0.780, p
< 0.05) and showed a consistently progressive decline.
Figure 2 FAO commodity statistics of fish, dried, salted or smoked (solid line), and
Hong Kong trade statistics on dried fish, whether or not salted but not smoked (dotted
line), 1978–2008. (a) Import; (b) Production; (c) Export; (d) Re-export; (e) Per capita
consumption. Production data are not available at Hong Kong trade statistics. Pearson
correlation on per capita consumption estimated by FAO commodity statistics and Hong
Kong trade statistics is 0.780 (p < 0.01).
8. Relation between salted fish consumption and NPC in Hong Kong
Table 1 shows that Pearson correlation coefficient (r) was consistently strong between salted
fish consumption per capita and both ASIR (Male: Range 0.700 to 0.729, all p < 0.05;
Female: Range 0.668 to 0.704, all P < 0.05) and ASMR of NPC (Male: Range 0.627 to
0.943, all p < 0.05; Female: cumulative consumption of 5 years = 0.611, p < 0.05). Repeated
analyses using the Hong Kong Trade Statistics data (Table 1b) yielded similar results
compared to the FAO statistics (Table 1a). No clear relationship for the number of
cumulative years and Pearson’s r was observed.
Table 1 Correlation coefficient (r) from Pearson correlation analysis between
cumulative salted fish consumption per capita (per kg) and age-standardized incidence
and mortality rates in Hong Kong, 1991–2008
(a) FAO commodity statistics
Year of cumulative salted fish
consumption per capita
Age-standardized
incidence rate
Age-standardized
mortality rates
Male Female Male Female
0 0.700* 0.668* 0.627* 0.430
5 0.710* 0.704* 0.789* 0.611*
10 0.729* 0.674* 0.943* 0.622
(b) Hong Kong trade statistics
Year of cumulative salted fish
consumption per capita
Age-standardized
incidence rate
Age-standardized
mortality rates
Male Female Male Female
0 0.709* 0.762* 0.652* 0.502*
5 0.792* 0.830* 0.882* 0.729*
10 0.471 0.477 0.893* 0.395
* Significant at 0.05 level.
The cumulative salted fish consumption up to the specified time point was estimated by
aggregating annual salted fish consumption per capita estimates in all years prior to that year
up to 1991. (a) Cumulative salted fish consumption per capita was estimated from FAO
commodity statistics on fish, dried, salted or smoked. (b) Cumulative salted fish consumption
per capita was estimated from Hong Kong trade statistics on dried fish, whether or not salted
but not smoked.
Tobacco consumption and relations with NPC in Hong Kong
Figure 3 showed annual tobacco consumption had an overall decreasing trend over the past 3
decades, from 986 sticks per capita in 1982 to 497 sticks per capita in 2009 (about 50%
decrease), attributable to successful and comprehensive tobacco control measures, including
taxation which might account for the observed marked drop of tobacco consumption in 1983
and the early 1990s (respectively 300% in 1982 and 100% increase in 1991 in tobacco tax).
Table 2 shows correlation between cumulative cigarette consumption per capita and both
ASIR (Male: Range 0.646 to 0.694, all p < 0.05; Female: Range 0.685 to 0.735, all p < 0.05)
and ASMR of NPC (Male: Range 0.598 to 0.941, all p < 0.05; Female: cumulative 5 years =
0.592, p < 0.05).
Figure 3 Per capita cigarette consumption (line + symbol) versus tobacco tax increase
(column) in Hong Kong, 1982–2009.
9. Table 2 Correlation coefficient (r) from Pearson correlation analysis between
cumulative cigarette consumption per capita (per stick) and age-standardized incidence
and mortality rates in Hong Kong, 1991–2008
Year of cumulative cigarette
consumption per capita
Age-standardized
incidence rate
Age-standardized
mortality rates
Male Female Male Female
0 0.694* 0.735* 0.598* 0.446
5 0.646* 0.685* 0.768* 0.592*
10 0.635 0.625 0.941* 0.563
* Significant at 0.05 level.
Vegetable consumption and relations with NPC in Hong Kong
With an overall increasing trend over the past 2 decades, the annual per capita consumption
of vegetables increased from 85 kg per capita in 1991 to 94 kg per capita in 2009 (Figure 4).
Pearson r increased with increasing number of cumulative years (Table 3). A negative
correlation suggested vegetable consumption is a strong protective factor for NPC. Pearson
correlation for ASIR ranged from −0.721 to −0.771 in males and −0.528 to −0.766 in
females, whereas ASMR in males ranged from −0.657 to −0.940 and in females cumulative
consumption of 5 years was −0.661. Pearson’s r stayed similar as the cumulative years
increased.
Figure 4 Fresh vegetable consumption trend in Hong Kong, 1991–2009.
Table 3 Correlation coefficient (r) from Pearson correlation analysis between
cumulative fresh vegetable consumption per capita (per kg) and age-standardized
incidence and mortality rates in Hong Kong,1991–2008
Year of cumulative fresh vegetable
consumption per capita
Age-standardized
incidence rate
Age-standardized
mortality rates
Male Female Male Female
0 −0.466 −0.528* −0.364 −0.294
5 −0.721* −0.752* −0.657* −0.661*
10 −0.771* −0.766* −0.940* −0.599
* Significant at 0.05 level.
Multivariate model
Table 4 shows that in the multivariable model, associations between per capita consumption
of salted fish and ASIR/ASMR of NPC were no longer statistically significant except ASIR
in males at 5 cumulative year level (ASIR: β = 2.744, p < 0.05). Tobacco consumption
showed significant associations with male ASIR at 5 (β = −2.694, p < 0.05) and 10
cumulative years (β = −3.142, p < 0.05). ASIR in males and females both showed significant
association for vegetable consumption (ASIR in 5 cumulative years: β: −0.917 in males;
−0.794 in females; cumulative 10 years: β: −1.793 in males; −2.408 in females; all p < 0.05).
Repeated analysis using data from Hong Kong Trade Statistic for salted fish consumption
gave similar results (data not shown).
10. Table 4 Beta (β) regression coefficient from multivariate regression analysis of NPC
age-standardized incidence and mortality rates on cumulative salted fish (per kg),
cigarette (per stick) and fresh vegetable consumption (per kg) in Hong Kong, 1991–2008
Cumulative window
(Years)
Independent
variable
Age-standardized
incidence rate
Age-standardized
mortality rates
Male Female Male Female
0 Salted fish 0.473 0.345 0.463 0.238
Smoking 0.195 0.321 0.145 0.189
Fresh-vegetables −0.213 −0.249 −0.140 −0.119
5 Salted fish 2.744* 1.740 1.324 1.607
Smoking −2.694* −1.589 −0.814 −1.501
Fresh-vegetables −0.917* −0.794* −0.402 −0.725
10 Salted fish 2.077 0.339 0.289 1.992
Smoking −3.142* −2.038 0.306 −1.571
Fresh-vegetables −1.793* −2.408* −0.363 −0.252
* Significant at 0.05 level.
Cumulative salted fish consumption per capita was estimated from FAO commodity statistics on fish, dried,
salted or smoked.
Multi-jurisdiction ecological analysis
Marked reduction in NPC ASMR for both genders was observed in Hong Kong (Figure 5a)
over the past three decades, with a corresponding drop in salted fish consumption. However
the link between salted fish consumption and NPC ASMR was not observed in other
jurisdictions. In China (Figure 5b), salted fish consumption increased from the early 1990s up
to 2000. Both ASMR for males and females stayed rather stable over the years, with a higher
ASMR in males which fluctuated at around 2.5 per 100,000 person years while ASMR in
females was around 1.1 per 100,000 person years. Figure 5c shows the ASMR trend in
Finland from 1976 to 2008. Males had a slightly higher mortality rate than females and the
ASMR range was narrow. Japan (Figure 5d) had stable ASMRs for both males and females
over the past three decades. In Portugal, (Figure 5e) no clear trend was seen, although a slight
drop in male NPC death rates was observed. ASMR in males in Singapore (Figure 5f)
showed a large reduction through the whole period while the ASMR in females only dropped
slightly. Consumption of salted fish had not changed much during this period. In the United
Kingdom (Figure 5g), there was an overall 20% decrease in ASMR among males from early
1980s to late 2000s. In females the drop was smaller and salted fish intake did not change.
The United States (Figure 5h) had a very similar trend to UK, but a significant trend was seen
only for ASMR in males.
Figure 5 NPC Age-standardized mortality rates in males (solid line) and females (dotted
line) versus salted fish consumption per capita (dash-dotted line) in multiple
jurisdictions. (a) Hong Kong; (b) China (c) Finland; (d) Japan; (e) Portugal; (f) Singapore;
(g) United Kingdom and (h) United States.
Discussion
This is the first multi-jurisdiction ecological study that examined the associations between
secular trends of NPC risk and salted fish consumption per capita. We also adjusted for the
potentially confounding effects of two most important lifestyle factors, namely tobacco and
vegetable consumption, using per capita estimates. We included 7 regions in 3 continents to
11. include both endemic and low-risk areas, to analyse the pattern with a more global
perspective.
We observed a decline in both ASIR and ASMR of NPC in Hong Kong over the past three
decades. Higher NPC ASMR was observed in males than females in most of the jurisdictions
included, consistent with previous studies [11,30,31], which may be due to a combination of
differential risk factor exposures such as greater tobacco consumption in males and genetic
factors. The rather consistent; more than 3-fold risk in males compared with females needs
further investigation. Our results showed markedly decreasing trends in salted fish intake and
tobacco consumption, but an increasing trend in vegetable consumption in Hong Kong over
the past several decades. All of these environmental risk factors were individually highly
correlated with ASMR and ASIR. The decrease in salted fish consumption may represent a
change in dietary culture with westernisation of dietary patterns among Hong Kong citizens
from a traditional Cantonese diet and from increased awareness of the carcinogenicity of
salted fish. Decrease in intake of salted fish should lower the risk of an individual getting
NPC if the relationship is causal [5].
There were no substantial changes in the proportion of Cantonese residing in Hong Kong,
thus any changes noted should not be confounded by migration effect. Additional file 1:
Table S1-S3 show the population structure in Hong Kong from 1961–2006. Nevertheless, in
the multivariable model, the relations between salted fish consumption and NPC ASIR and
ASMR were attenuated and became mostly insignificant. In contrast, the negative association
between vegetable consumption and NPC ASIR remained statistically significant after
adjustment and was robust across varying estimates of cumulative exposure windows prior to
NPC outcomes. Consistent with findings from previous case-control studies [18,32], dietary
intake of fruits and vegetables may have a protective effect against NPC due to its antioxidant
contents, potentially interfering with the actions of nitrosamines [33]. World Cancer Research
Fund (WCRF) panel suggested fruit and vegetable consumption have limited to suggestive
levels of evidence for protection against NPC [34], which is consistent with the result found
in this study. Although positive association was observed for cigarette consumption and NPC
ASIR in males, previous literature suggested that for lung cancer, of which smoking is known
as one of the major risk factor, the lag year for the disease from exposure to cancer onset was
25–30 years [35], it is expected that the lag for NPC should not be shorter if not similar to
lung cancer. As our study is ecological, further analytical studies, such as case control studies
with genetic, viral and other biomarkers are warranted to examine the link between salted fish
and NPC in Hong Kong, taking into account smoking, vegetable consumption and other
potential confounders.
Despite the parallel secular trends of salted fish consumption and NPC rates in Hong Kong,
the same pattern was not observed in all other jurisdictions. For instance, in China, salted fish
consumption increased over the years and there was no sign in apparent increase of ASMR in
both males and females. Similarly, there are jurisdictions where NPC ASIR/ASMR had
markedly decreased, but with no accompanying drop in salted fish consumption. Caution
needs to be taken in interpretation, since the salted fish consumed in other countries might not
be the Cantonese-styled salted fish, which is categorised as a group I carcinogen by IARC.
The effect of salted fish on NPC development might only have a notable impact among Hong
Kong Chinese but not in other populations, due to the higher underlying disease rates of NPC
in Hong Kong, or could be due to genetic differences e.g. nitrosamine metabolism [36].
Indeed, the vast majority of previous case-control studies on salted fish consumption and
NPC were only conducted in Chinese [1,4,5,37]. It remains uncertain whether the same
12. carcinogenesis mechanism could apply to different Chinese sub-group or non-Chinese
populations.
Our findings highlight the importance of examining the relations between key risk factor
exposures and NPC on multiple jurisdictions rather than focusing on a single locality and a
single exposure in an ecological study. Furthermore, since NPC includes a spectrum of
squamous, and keratinising versus non-keratinising subtypes which are linked to differential
risk factors, this may also be an important reason underlying the varying patterns of
ecological associations found across different jurisdictions. Thus an ecological study
investigates the links between risk and protective factors and different subtypes would be of
interest, especially when the pathogenesis processes for various NPC subtypes appear to be
distinct. Therefore it is important to first elucidate the secular trend of salted fish
consumption and NPC incidence/mortality rates between multiple areas. The findings from
this study have encouraged us to further examine the time trend of different NPC subtypes
across regions, and so far our literature review has shown that a more thorough review and
deeper understanding is needed of different NPC histological classification between China
and the West, but such data are often scarce. Also, the differences between Chinese and
WHO classifications need to be further examined and resolved. We believe this would
warrant a separate paper for a detailed discussion.
There are several limitations in our study. First of all we could not be certain that the capture
of NPC incidence and mortality was 100% complete and accurate in each jurisdiction, but
most data were derived from cancer registries where completeness of data; especially that of
mortality, is good with high accuracy. Variations of diagnostic criteria could exist but this
effect is minimised by using International Classification of Disease (ICD 8–10) since NPC is
a rare and uncommon cancer. Secondly, per capita consumption was calculated by taking the
difference between export, import, production and re-export of salted fish. Consequently,
there was a possibility of over or underestimating the actual amount of salted fish being
consumed. Nevertheless, data obtained from Hong Kong Trade and Statistics and from the
FAO were largely consistent. Even though we tried to obtain all the salted fish related data as
precisely as possible, the data we used might include other dried fish products rather than just
Cantonese style salted fish, details of which could not be obtained from other jurisdictions.
Moreover, the uncertainty of latency period between the consumption patterns and
ASIR/ASMR is well acknowledged, for that we included the sensitivity analysis by using
year of cumulative consumption for regression and result were shown to be robust.
Furthermore, vegetable consumption in Hong Kong was not available from Agriculture,
Fisheries and Conservation Department HKSAR prior to 1991, thus multivariable analysis
was done only between 1991–2008 but not from 1978–2008.
Finally, the limitations of ecological studies due to the ecological fallacy are well recognised,
and unknown, unmeasured or immeasurable confounding factors may be present. We tried to
take account of important and known factors by accounting for tobacco consumption,
vegetable consumption and migration effects, which is the first example of its kind in NPC
epidemiological studies. In future studies, age-specific rather than age-standardised mortality
and incidence rates could be more informative to investigate disease risk across different ages
and in different populations. Because NPC is endemic mainly in Southern China, ecological
analysis focusing on the endemic regions of China would yield more important information
than a national study. Data specifically in Southern China on salted fish, vegetable and
cigarette consumptions, together with NPC incidence and mortality rates (with subtypes)
13. would be highly valuable if such data are available in the near future and more in depth
analysis is warranted.
Conclusions
In this study, we found markedly decreasing trends of NPC ASIR and ASMR in Hong Kong
over the past 3 decades, which was correlated with corresponding secular changes in salted
fish consumption per capita. However, this association no longer held after adjustment for
tobacco and vegetable consumption per capita. Our result showed vegetable had a protective
role in NPC ASIR. There was no clear or consistent pattern in the relations between NPC
ASIR and ASMR with salted fish consumption across 7 regions in 3 continents. Whether the
pathogenic role of salted fish consumption is specific to NPC among Hong Kong Chinese
requires further studies.
Competing interest
The authors have no conflict of interest.
Authors’ contributions
HYL and CML conducted data analysis. YHC and CML participated in data collection. YHC
helped in sequence alignment. HYL drafted the manuscript. AWML, DLWK, MLL and THL
helped to draft the manuscript. All authors read and approved the final manuscript.
Acknowledgement
This study was supported by Hongkong RGC Area of Excellence Scheme (Grant Number
AoE/M-06/08), and World Cancer Research Fund (UK, Netherlands, and International; Grant
Number 2011/460.
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Additional file
Additional_file_1 as PPT
Additional file 1 Table S1. Population in Hong Kong aged 5 and over by usual language,
1991, 1996, 2001 and 2006. Table S2 Population by nationality in Hong Kong 1991, 1996,
2001 and 2006. Table S3 Population by place of birth in Hong Kong 1961-2006.