The 12 Factor App methodology provides guidelines for building software-as-a-service applications in the cloud. It advocates for codebases that are tracked in revision control, explicit declaration of dependencies, separation of configuration from code, treating backing services as attached resources, and strict separation between build, release, and run stages. The methodology also includes guidelines for processes, port binding, concurrency, disposability, keeping development and production environments similar, and treating logs as event streams. Following the 12 factors can help applications maximize portability, be more robust and agile, and scale smoothly by avoiding reliance on implicit tools or behaviors.