This document provides an overview of the M2 Musculoskeletal Sequence curriculum at the University of Michigan Medical School in Fall 2009. The goals are to learn the musculoskeletal exam, common musculoskeletal disorders and treatments, forms of arthritis, autoimmune disorders, and metabolic bone diseases. The curriculum includes lectures, pathology labs, physical exam sessions, case discussions and is graded based on exams, participation and practice sessions. The overall aim is to improve musculoskeletal education and prepare students for managing related conditions.