The document discusses cholinergic drugs, which include both direct-acting cholinoceptor stimulants and indirect-acting cholinesterase inhibitors. Direct-acting drugs bind to and activate muscarinic or nicotinic receptors, while indirect-acting drugs inhibit the acetylcholinesterase enzyme, increasing endogenous acetylcholine levels. Examples of these drug classes are discussed along with their mechanisms of action, pharmacokinetic properties, therapeutic uses, and toxicity profiles. The major sites of action for cholinergic drugs are the autonomic nervous system, neuromuscular junction, central nervous system, and blood vessels.
Pharmacology of Cholinergic Drugs. It contains a detailed elaboration of Cholinergic Agents, Cholinomimmetics, Cholinergic Antagonists, Synthesis of Ach, Receptors, Classification, Mechanism of Action, Pharmacokinetics and Dynamics, Dosage and Adverse effects
2 Pharmacology I, intro ANS cholinergic drugs.pptxAhmad Kharousheh
The document provides an overview of the autonomic nervous system, describing the two divisions of the sympathetic and parasympathetic nervous systems. It explains the neurotransmitters involved, including acetylcholine and norepinephrine, and the receptors they act on. The document also discusses the classes of drugs that act on the autonomic nervous system, including direct-acting cholinergic agonists, indirect-acting cholinergic agonists that inhibit acetylcholinesterase, and antimuscarinic drugs that block muscarinic receptors.
Cholinergic agonists mimic acetylcholine by directly binding to cholinergic receptors or indirectly by inhibiting acetylcholinesterase. Direct-acting agonists include acetylcholine, bethanechol, carbachol, methacholine, nicotine, and pilocarpine. Indirect-acting agonists reversibly or irreversibly inhibit acetylcholinesterase, prolonging the actions of endogenous acetylcholine. Common indirect agonists are neostigmine, physostigmine, and organophosphates. Cholinergic agonists have widespread effects throughout the body and can be used to treat various conditions like glaucoma, urinary retention, and myasthenia gravis
The document discusses the autonomic nervous system (ANS) and drugs that act on it. It begins by describing the organization of the nervous system into the central and peripheral divisions. It then focuses on the ANS, which controls involuntary functions and has two divisions - the sympathetic ("fight or flight") and parasympathetic ("rest and digest"). The document goes on to describe the anatomy and functions of the sympathetic and parasympathetic systems, as well as their neurotransmitters (epinephrine/norepinephrine and acetylcholine). It then discusses different types of drugs that act on the cholinergic and adrenergic systems, including direct-acting cholinergic drugs, anticholinesterases, antimuscar
Unit 3 Drugs Affecting PNS (As per PCI syllabus)Mirza Anwar Baig
This document provides an overview of a lecture on drugs acting on the autonomic nervous system. It discusses the autonomic neurotransmission and classification of drugs into parasympathomimetics, parasympatholytics, sympathomimetics, and sympatholytics. Specific drugs discussed in detail include direct-acting cholinergic agonists like acetylcholine and indirect-acting cholinergic agonists like anticholinesterase agents. Anticholinergic drugs like atropine are also summarized in terms of their mechanisms and therapeutic uses.
This document discusses cholinergic and anticholinergic drugs. It begins by listing the objectives of understanding the characteristics, indications, adverse effects, nursing considerations, and client responses to these drug classes. It then covers the cholinergic system and neurotransmitter acetylcholine. It describes the different cholinergic receptors and actions of acetylcholine at each receptor type. The document outlines the mechanisms and effects of direct-acting and indirect-acting cholinergic drugs. It also discusses anticholinergic drugs, focusing on their mechanisms of action and classifications. Adverse effects are provided for both drug classes.
This document discusses drugs that act on the autonomic nervous system. It explains that there are two main types of cholinergic drugs: direct-acting cholinergic agonists that bind directly to cholinergic receptors, and indirect-acting cholinergic agonists that inhibit the enzyme acetylcholinesterase to prevent the breakdown of acetylcholine. Examples of each type are provided, including direct agonists like acetylcholine and indirect agonists like physostigmine. The document aims to help students understand neurotransmitter release and the differences between the sympathetic and parasympathetic nervous systems.
Para-sympathomimetics can directly activate cholinergic receptors as agonists or indirectly increase acetylcholine levels by inhibiting acetylcholinesterase. Direct agonists include natural alkaloids like muscarine and synthetic ones like carbachol. Indirect anticholinesterases prevent acetylcholine degradation, either reversibly like neostigmine or irreversibly like organophosphates. Their effects are mediated through muscarinic and nicotinic receptors in the autonomic ganglia, neuromuscular junction and central nervous system. They have therapeutic uses for conditions like glaucoma and myasthenia gravis but overdose can cause toxic effects that require atropine and oxime
Pharmacology of Cholinergic Drugs. It contains a detailed elaboration of Cholinergic Agents, Cholinomimmetics, Cholinergic Antagonists, Synthesis of Ach, Receptors, Classification, Mechanism of Action, Pharmacokinetics and Dynamics, Dosage and Adverse effects
2 Pharmacology I, intro ANS cholinergic drugs.pptxAhmad Kharousheh
The document provides an overview of the autonomic nervous system, describing the two divisions of the sympathetic and parasympathetic nervous systems. It explains the neurotransmitters involved, including acetylcholine and norepinephrine, and the receptors they act on. The document also discusses the classes of drugs that act on the autonomic nervous system, including direct-acting cholinergic agonists, indirect-acting cholinergic agonists that inhibit acetylcholinesterase, and antimuscarinic drugs that block muscarinic receptors.
Cholinergic agonists mimic acetylcholine by directly binding to cholinergic receptors or indirectly by inhibiting acetylcholinesterase. Direct-acting agonists include acetylcholine, bethanechol, carbachol, methacholine, nicotine, and pilocarpine. Indirect-acting agonists reversibly or irreversibly inhibit acetylcholinesterase, prolonging the actions of endogenous acetylcholine. Common indirect agonists are neostigmine, physostigmine, and organophosphates. Cholinergic agonists have widespread effects throughout the body and can be used to treat various conditions like glaucoma, urinary retention, and myasthenia gravis
The document discusses the autonomic nervous system (ANS) and drugs that act on it. It begins by describing the organization of the nervous system into the central and peripheral divisions. It then focuses on the ANS, which controls involuntary functions and has two divisions - the sympathetic ("fight or flight") and parasympathetic ("rest and digest"). The document goes on to describe the anatomy and functions of the sympathetic and parasympathetic systems, as well as their neurotransmitters (epinephrine/norepinephrine and acetylcholine). It then discusses different types of drugs that act on the cholinergic and adrenergic systems, including direct-acting cholinergic drugs, anticholinesterases, antimuscar
Unit 3 Drugs Affecting PNS (As per PCI syllabus)Mirza Anwar Baig
This document provides an overview of a lecture on drugs acting on the autonomic nervous system. It discusses the autonomic neurotransmission and classification of drugs into parasympathomimetics, parasympatholytics, sympathomimetics, and sympatholytics. Specific drugs discussed in detail include direct-acting cholinergic agonists like acetylcholine and indirect-acting cholinergic agonists like anticholinesterase agents. Anticholinergic drugs like atropine are also summarized in terms of their mechanisms and therapeutic uses.
This document discusses cholinergic and anticholinergic drugs. It begins by listing the objectives of understanding the characteristics, indications, adverse effects, nursing considerations, and client responses to these drug classes. It then covers the cholinergic system and neurotransmitter acetylcholine. It describes the different cholinergic receptors and actions of acetylcholine at each receptor type. The document outlines the mechanisms and effects of direct-acting and indirect-acting cholinergic drugs. It also discusses anticholinergic drugs, focusing on their mechanisms of action and classifications. Adverse effects are provided for both drug classes.
This document discusses drugs that act on the autonomic nervous system. It explains that there are two main types of cholinergic drugs: direct-acting cholinergic agonists that bind directly to cholinergic receptors, and indirect-acting cholinergic agonists that inhibit the enzyme acetylcholinesterase to prevent the breakdown of acetylcholine. Examples of each type are provided, including direct agonists like acetylcholine and indirect agonists like physostigmine. The document aims to help students understand neurotransmitter release and the differences between the sympathetic and parasympathetic nervous systems.
Para-sympathomimetics can directly activate cholinergic receptors as agonists or indirectly increase acetylcholine levels by inhibiting acetylcholinesterase. Direct agonists include natural alkaloids like muscarine and synthetic ones like carbachol. Indirect anticholinesterases prevent acetylcholine degradation, either reversibly like neostigmine or irreversibly like organophosphates. Their effects are mediated through muscarinic and nicotinic receptors in the autonomic ganglia, neuromuscular junction and central nervous system. They have therapeutic uses for conditions like glaucoma and myasthenia gravis but overdose can cause toxic effects that require atropine and oxime
Parasympathomimetic Agents Direct Acting with SAR & Cholinesters Reactivation TejasSuruse
This document discusses parasympathomimetic agents, which are medications that activate the parasympathetic nervous system by mimicking or modifying the effects of acetylcholine. These include direct-acting muscarinic receptor agonists and indirect-acting acetylcholinesterase inhibitors. The document discusses the structure-activity relationship of these agents and how their chemical structure affects biological activity. It classifies parasympathomimetic agents and describes several direct-acting agents, including acetylcholine, carbachol, bethanechol, methacholine, and pilocarpine. It also discusses cholinesterase reactivators like pralidoxime that are used to treat organophosphate poisoning.
This document discusses drugs that act on the autonomic nervous system. It covers acetylcholine and choline esters, which are the prototypical cholinergic agents. It then discusses synthetic derivatives like carbachol and betanechol, which have longer durations of action. Anticholinesterase drugs and cholinomimetic alkaloids are also covered. The document then discusses adrenergic drugs like adrenaline and noradrenaline, and their effects on different organ systems. It provides details on the pharmacokinetics, pharmacodynamics, indications, and side effects of various cholinergic and adrenergic drugs.
015 cholinesterase inhibitors and anticholinergic drugs bothyshiri
Acetylcholine is a major neurotransmitter in both the central and peripheral nervous systems. It acts on nicotinic and muscarinic receptors. Acetylcholinesterase inhibitors such as neostigmine prolong the action of acetylcholine by inhibiting its breakdown, allowing rebinding to nicotinic receptors and reversal of neuromuscular blockade. The choice of inhibitor, dosage, muscle relaxant being antagonized, and depth of blockade all impact the speed and completeness of reversal. Anticholinergics are given to prevent muscarinic side effects from excess acetylcholine.
cholingeric and Anticholinesterase drug in detail .this ppt contains introduction ,mechanism of action ,pharmacological action ,uses and adverse effect of the drug
This document discusses the autonomic nervous system and drugs that affect it. It begins by describing the organization of the nervous system and autonomic nervous system. It then discusses exceptions in the sympathetic nervous system related to sweat glands, kidneys, and adrenal glands. The document goes on to classify drugs that can mimic or block neurotransmitters in the autonomic nervous system like acetylcholine and adrenaline. It also discusses indirect-acting drugs and different receptor types like muscarinic, nicotinic, alpha, and beta receptors. The locations and functions of these receptors are explained. Finally, examples of drugs are provided that can act as agonists or antagonists at these different receptor types.
ANS pharmacology.pptxhealth doc about autonomic nerve system of pharmacology ...SamuelDebele1
health doc about autonomic nerve system of pharmacology power point which is very useful for health students in university hggggggggggggggggggggggggggggg
This document summarizes parasympathomimetics (cholinergic agonists). It discusses how the parasympathetic nervous system uses acetylcholine as a neurotransmitter and how cholinergic agonists mimic acetylcholine's actions. It classifies cholinergic agonists into direct-acting and indirect-acting types. Direct agonists bind receptors, while indirect agonists inhibit acetylcholinesterase to increase acetylcholine levels. Examples of both types are provided along with their structures, mechanisms of action, and uses. The document also covers acetylcholine synthesis and catabolism as well as structure-activity relationships of parasympathomimetics.
This document discusses anticholinesterases, which are drugs that inhibit acetylcholinesterase and thereby increase acetylcholine levels at neuromuscular junctions. It describes the mechanisms of both reversible and irreversible anticholinesterases. Reversible anticholinesterases include neostigmine, pyridostigmine, and edrophonium. Irreversible anticholinesterases include organophosphorus compounds. The document also discusses the mechanism of action and effects of the selective relaxant binding agent sugammadex, which is able to rapidly reverse the effects of the neuromuscular blocking drug rocuronium.
Skeletal muscle relaxants consist of both antispasticity and antispasmodic agents, a distinction prescribers often overlook. The antispasticity agents-baclofen, tizanidine, dantrolene, and diazepam-aid in improving muscle hypertonicity and involuntary jerks.
1. Parasympathomimetics are drugs that mimic the effects of acetylcholine. They are classified as direct-acting cholinergic agonists or indirect-acting anticholinesterases.
2. Direct agonists like carbachol and methacholine directly activate cholinergic receptors. Indirect anticholinesterases like neostigmine, pyridostigmine and edrophonium inhibit acetylcholinesterase and prolong the effects of endogenous acetylcholine.
3. These drugs have therapeutic uses for various conditions like myasthenia gravis, glaucoma, urinary retention and postoperative ileus by strengthening muscle weakness or increasing parasympathetic effects. Their effects are
3 ANS PHARMACOLOGY FOR PHARMACY 01 Midwife 2015(1).pptxwakogeleta
This document discusses autonomic drugs and their classification. It begins by outlining the objectives of understanding different classes of autonomic drugs and their effects. It then provides details on the autonomic nervous system, including its divisions and neurotransmitters. The main classes of autonomic drugs discussed are cholinergic agents, anticholinergic agents, adrenergic agents, and ganglionic blockers. Specific drugs within each class are defined along with their mechanisms of action, therapeutic uses, side effects, and contraindications. Neuromuscular blocking agents are also briefly covered.
This document discusses cholinergic agonists, which are drugs that act on receptors activated by acetylcholine in the autonomic nervous system. It describes the synthesis and mechanisms of acetylcholine as a neurotransmitter. It then discusses various direct-acting cholinergic agonists like bethanechol, carbachol, and pilocarpine and their actions and uses. Pilocarpine is used topically to treat glaucoma by contracting the iris and ciliary muscles. The document also covers indirect agonists known as anticholinesterases, which inhibit the enzyme acetylcholinesterase and thereby increase acetylcholine levels. Physostigmine is an example of a reversible anticholinesterase
This document provides information about cholinergic antagonists (also known as anticholinergic or parasympatholytic drugs). It discusses two main classes - muscarinic receptor antagonists and nicotinic receptor antagonists. Muscarinic receptor antagonists like atropine block muscarinic receptors and have various therapeutic effects. Nicotinic receptor antagonists are further divided into neuromuscular junction blocking agents and ganglionic blocking agents. Neuromuscular junction blocking agents are used as muscle relaxants during anesthesia while ganglionic blockers inhibit transmission in both parasympathetic and sympathetic ganglia. The document outlines the mechanisms, sites of action, uses and adverse effects of various cholinergic antagonists.
This document discusses cholinergic agonists, which are classified as either direct-acting muscarinic and nicotinic agonists like acetylcholine and bethanechol, or indirect-acting anticholinesterases that inhibit the hydrolysis of acetylcholine like neostigmine and physostigmine. Direct-acting agonists act on both muscarinic and nicotinic receptors, while indirect agents protect acetylcholine from breakdown. Organophosphate inhibitors like echothiophate are irreversible while carbamates like neostigmine are reversible. Cholinergic agonists have therapeutic uses for conditions like glaucoma, gastrointestinal and urinary disorders, and myasthenia gra
This document provides an overview of adrenergic agents, including:
1) It defines adrenergic drugs as those that enhance or reduce activity of the sympathetic nervous system and discusses the sympathetic neurotransmitters epinephrine and norepinephrine.
2) It describes the types of adrenergic receptors (alpha and beta), their locations, and effects of stimulating each receptor type.
3) It discusses sympatholytic and sympathomimetic drugs, including examples of each type and their therapeutic uses.
This document provides information about the parasympathetic nervous system and cholinergic agents. It begins by outlining learning objectives about defining the biochemistry of the parasympathetic system, classifying agonists and antagonists, and explaining the structure-activity relationship of acetylcholine. It then discusses the anatomy and functions of the motor nerves, including the roles of acetylcholine. The document outlines the SAR of acetylcholine and binding interactions. It describes cholinergic agonists and antagonists, including clinical uses. Muscarinic and nicotinic receptors and their subtypes are defined. The actions and uses of cholinergic drugs like atropine and tubocurarine are summarized.
The document discusses parasympathomimetic drugs, which mimic the action of acetylcholine in the parasympathetic nervous system. It describes how acetylcholine is synthesized, stored, and released as a neurotransmitter. It then discusses the two main types of acetylcholine receptors - muscarinic and nicotinic receptors. Parasympathomimetic drugs are classified as either direct-acting agonists that bind acetylcholine receptors or indirect-acting inhibitors of the acetylcholinesterase enzyme. Examples of different classes of parasympathomimetic drugs are provided along with their properties, mechanisms of action, and clinical uses.
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
Parasympathomimetic Agents Direct Acting with SAR & Cholinesters Reactivation TejasSuruse
This document discusses parasympathomimetic agents, which are medications that activate the parasympathetic nervous system by mimicking or modifying the effects of acetylcholine. These include direct-acting muscarinic receptor agonists and indirect-acting acetylcholinesterase inhibitors. The document discusses the structure-activity relationship of these agents and how their chemical structure affects biological activity. It classifies parasympathomimetic agents and describes several direct-acting agents, including acetylcholine, carbachol, bethanechol, methacholine, and pilocarpine. It also discusses cholinesterase reactivators like pralidoxime that are used to treat organophosphate poisoning.
This document discusses drugs that act on the autonomic nervous system. It covers acetylcholine and choline esters, which are the prototypical cholinergic agents. It then discusses synthetic derivatives like carbachol and betanechol, which have longer durations of action. Anticholinesterase drugs and cholinomimetic alkaloids are also covered. The document then discusses adrenergic drugs like adrenaline and noradrenaline, and their effects on different organ systems. It provides details on the pharmacokinetics, pharmacodynamics, indications, and side effects of various cholinergic and adrenergic drugs.
015 cholinesterase inhibitors and anticholinergic drugs bothyshiri
Acetylcholine is a major neurotransmitter in both the central and peripheral nervous systems. It acts on nicotinic and muscarinic receptors. Acetylcholinesterase inhibitors such as neostigmine prolong the action of acetylcholine by inhibiting its breakdown, allowing rebinding to nicotinic receptors and reversal of neuromuscular blockade. The choice of inhibitor, dosage, muscle relaxant being antagonized, and depth of blockade all impact the speed and completeness of reversal. Anticholinergics are given to prevent muscarinic side effects from excess acetylcholine.
cholingeric and Anticholinesterase drug in detail .this ppt contains introduction ,mechanism of action ,pharmacological action ,uses and adverse effect of the drug
This document discusses the autonomic nervous system and drugs that affect it. It begins by describing the organization of the nervous system and autonomic nervous system. It then discusses exceptions in the sympathetic nervous system related to sweat glands, kidneys, and adrenal glands. The document goes on to classify drugs that can mimic or block neurotransmitters in the autonomic nervous system like acetylcholine and adrenaline. It also discusses indirect-acting drugs and different receptor types like muscarinic, nicotinic, alpha, and beta receptors. The locations and functions of these receptors are explained. Finally, examples of drugs are provided that can act as agonists or antagonists at these different receptor types.
ANS pharmacology.pptxhealth doc about autonomic nerve system of pharmacology ...SamuelDebele1
health doc about autonomic nerve system of pharmacology power point which is very useful for health students in university hggggggggggggggggggggggggggggg
This document summarizes parasympathomimetics (cholinergic agonists). It discusses how the parasympathetic nervous system uses acetylcholine as a neurotransmitter and how cholinergic agonists mimic acetylcholine's actions. It classifies cholinergic agonists into direct-acting and indirect-acting types. Direct agonists bind receptors, while indirect agonists inhibit acetylcholinesterase to increase acetylcholine levels. Examples of both types are provided along with their structures, mechanisms of action, and uses. The document also covers acetylcholine synthesis and catabolism as well as structure-activity relationships of parasympathomimetics.
This document discusses anticholinesterases, which are drugs that inhibit acetylcholinesterase and thereby increase acetylcholine levels at neuromuscular junctions. It describes the mechanisms of both reversible and irreversible anticholinesterases. Reversible anticholinesterases include neostigmine, pyridostigmine, and edrophonium. Irreversible anticholinesterases include organophosphorus compounds. The document also discusses the mechanism of action and effects of the selective relaxant binding agent sugammadex, which is able to rapidly reverse the effects of the neuromuscular blocking drug rocuronium.
Skeletal muscle relaxants consist of both antispasticity and antispasmodic agents, a distinction prescribers often overlook. The antispasticity agents-baclofen, tizanidine, dantrolene, and diazepam-aid in improving muscle hypertonicity and involuntary jerks.
1. Parasympathomimetics are drugs that mimic the effects of acetylcholine. They are classified as direct-acting cholinergic agonists or indirect-acting anticholinesterases.
2. Direct agonists like carbachol and methacholine directly activate cholinergic receptors. Indirect anticholinesterases like neostigmine, pyridostigmine and edrophonium inhibit acetylcholinesterase and prolong the effects of endogenous acetylcholine.
3. These drugs have therapeutic uses for various conditions like myasthenia gravis, glaucoma, urinary retention and postoperative ileus by strengthening muscle weakness or increasing parasympathetic effects. Their effects are
3 ANS PHARMACOLOGY FOR PHARMACY 01 Midwife 2015(1).pptxwakogeleta
This document discusses autonomic drugs and their classification. It begins by outlining the objectives of understanding different classes of autonomic drugs and their effects. It then provides details on the autonomic nervous system, including its divisions and neurotransmitters. The main classes of autonomic drugs discussed are cholinergic agents, anticholinergic agents, adrenergic agents, and ganglionic blockers. Specific drugs within each class are defined along with their mechanisms of action, therapeutic uses, side effects, and contraindications. Neuromuscular blocking agents are also briefly covered.
This document discusses cholinergic agonists, which are drugs that act on receptors activated by acetylcholine in the autonomic nervous system. It describes the synthesis and mechanisms of acetylcholine as a neurotransmitter. It then discusses various direct-acting cholinergic agonists like bethanechol, carbachol, and pilocarpine and their actions and uses. Pilocarpine is used topically to treat glaucoma by contracting the iris and ciliary muscles. The document also covers indirect agonists known as anticholinesterases, which inhibit the enzyme acetylcholinesterase and thereby increase acetylcholine levels. Physostigmine is an example of a reversible anticholinesterase
This document provides information about cholinergic antagonists (also known as anticholinergic or parasympatholytic drugs). It discusses two main classes - muscarinic receptor antagonists and nicotinic receptor antagonists. Muscarinic receptor antagonists like atropine block muscarinic receptors and have various therapeutic effects. Nicotinic receptor antagonists are further divided into neuromuscular junction blocking agents and ganglionic blocking agents. Neuromuscular junction blocking agents are used as muscle relaxants during anesthesia while ganglionic blockers inhibit transmission in both parasympathetic and sympathetic ganglia. The document outlines the mechanisms, sites of action, uses and adverse effects of various cholinergic antagonists.
This document discusses cholinergic agonists, which are classified as either direct-acting muscarinic and nicotinic agonists like acetylcholine and bethanechol, or indirect-acting anticholinesterases that inhibit the hydrolysis of acetylcholine like neostigmine and physostigmine. Direct-acting agonists act on both muscarinic and nicotinic receptors, while indirect agents protect acetylcholine from breakdown. Organophosphate inhibitors like echothiophate are irreversible while carbamates like neostigmine are reversible. Cholinergic agonists have therapeutic uses for conditions like glaucoma, gastrointestinal and urinary disorders, and myasthenia gra
This document provides an overview of adrenergic agents, including:
1) It defines adrenergic drugs as those that enhance or reduce activity of the sympathetic nervous system and discusses the sympathetic neurotransmitters epinephrine and norepinephrine.
2) It describes the types of adrenergic receptors (alpha and beta), their locations, and effects of stimulating each receptor type.
3) It discusses sympatholytic and sympathomimetic drugs, including examples of each type and their therapeutic uses.
This document provides information about the parasympathetic nervous system and cholinergic agents. It begins by outlining learning objectives about defining the biochemistry of the parasympathetic system, classifying agonists and antagonists, and explaining the structure-activity relationship of acetylcholine. It then discusses the anatomy and functions of the motor nerves, including the roles of acetylcholine. The document outlines the SAR of acetylcholine and binding interactions. It describes cholinergic agonists and antagonists, including clinical uses. Muscarinic and nicotinic receptors and their subtypes are defined. The actions and uses of cholinergic drugs like atropine and tubocurarine are summarized.
The document discusses parasympathomimetic drugs, which mimic the action of acetylcholine in the parasympathetic nervous system. It describes how acetylcholine is synthesized, stored, and released as a neurotransmitter. It then discusses the two main types of acetylcholine receptors - muscarinic and nicotinic receptors. Parasympathomimetic drugs are classified as either direct-acting agonists that bind acetylcholine receptors or indirect-acting inhibitors of the acetylcholinesterase enzyme. Examples of different classes of parasympathomimetic drugs are provided along with their properties, mechanisms of action, and clinical uses.
हिंदी वर्णमाला पीपीटी, hindi alphabet PPT presentation, hindi varnamala PPT, Hindi Varnamala pdf, हिंदी स्वर, हिंदी व्यंजन, sikhiye hindi varnmala, dr. mulla adam ali, hindi language and literature, hindi alphabet with drawing, hindi alphabet pdf, hindi varnamala for childrens, hindi language, hindi varnamala practice for kids, https://www.drmullaadamali.com
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
LAND USE LAND COVER AND NDVI OF MIRZAPUR DISTRICT, UPRAHUL
This Dissertation explores the particular circumstances of Mirzapur, a region located in the
core of India. Mirzapur, with its varied terrains and abundant biodiversity, offers an optimal
environment for investigating the changes in vegetation cover dynamics. Our study utilizes
advanced technologies such as GIS (Geographic Information Systems) and Remote sensing to
analyze the transformations that have taken place over the course of a decade.
The complex relationship between human activities and the environment has been the focus
of extensive research and worry. As the global community grapples with swift urbanization,
population expansion, and economic progress, the effects on natural ecosystems are becoming
more evident. A crucial element of this impact is the alteration of vegetation cover, which plays a
significant role in maintaining the ecological equilibrium of our planet.Land serves as the foundation for all human activities and provides the necessary materials for
these activities. As the most crucial natural resource, its utilization by humans results in different
'Land uses,' which are determined by both human activities and the physical characteristics of the
land.
The utilization of land is impacted by human needs and environmental factors. In countries
like India, rapid population growth and the emphasis on extensive resource exploitation can lead
to significant land degradation, adversely affecting the region's land cover.
Therefore, human intervention has significantly influenced land use patterns over many
centuries, evolving its structure over time and space. In the present era, these changes have
accelerated due to factors such as agriculture and urbanization. Information regarding land use and
cover is essential for various planning and management tasks related to the Earth's surface,
providing crucial environmental data for scientific, resource management, policy purposes, and
diverse human activities.
Accurate understanding of land use and cover is imperative for the development planning
of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
Executive Directors Chat Leveraging AI for Diversity, Equity, and InclusionTechSoup
Let’s explore the intersection of technology and equity in the final session of our DEI series. Discover how AI tools, like ChatGPT, can be used to support and enhance your nonprofit's DEI initiatives. Participants will gain insights into practical AI applications and get tips for leveraging technology to advance their DEI goals.
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.
The simplified electron and muon model, Oscillating Spacetime: The Foundation...RitikBhardwaj56
Discover the Simplified Electron and Muon Model: A New Wave-Based Approach to Understanding Particles delves into a groundbreaking theory that presents electrons and muons as rotating soliton waves within oscillating spacetime. Geared towards students, researchers, and science buffs, this book breaks down complex ideas into simple explanations. It covers topics such as electron waves, temporal dynamics, and the implications of this model on particle physics. With clear illustrations and easy-to-follow explanations, readers will gain a new outlook on the universe's fundamental nature.
Walmart Business+ and Spark Good for Nonprofits.pdfTechSoup
"Learn about all the ways Walmart supports nonprofit organizations.
You will hear from Liz Willett, the Head of Nonprofits, and hear about what Walmart is doing to help nonprofits, including Walmart Business and Spark Good. Walmart Business+ is a new offer for nonprofits that offers discounts and also streamlines nonprofits order and expense tracking, saving time and money.
The webinar may also give some examples on how nonprofits can best leverage Walmart Business+.
The event will cover the following::
Walmart Business + (https://business.walmart.com/plus) is a new shopping experience for nonprofits, schools, and local business customers that connects an exclusive online shopping experience to stores. Benefits include free delivery and shipping, a 'Spend Analytics” feature, special discounts, deals and tax-exempt shopping.
Special TechSoup offer for a free 180 days membership, and up to $150 in discounts on eligible orders.
Spark Good (walmart.com/sparkgood) is a charitable platform that enables nonprofits to receive donations directly from customers and associates.
Answers about how you can do more with Walmart!"
How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
How to Setup Warehouse & Location in Odoo 17 InventoryCeline George
In this slide, we'll explore how to set up warehouses and locations in Odoo 17 Inventory. This will help us manage our stock effectively, track inventory levels, and streamline warehouse operations.
2. Learning Outcomes
▪ The student should be able to:
▪ Know what cholinergic drugs are; the specific drug
examples for the different groups.
▪ Briefly describe their mechanisms of action and
adverse effects associated with their uses;
▪ Attain knowledge on the important pharmacokinetic
features;
▪ and the therapeutic uses of these drugs.
3. Cholinergic (cholinomimetic) Drugs
▪ Drugs that act on receptors @ all sites in the body
where ACh is transmitter of the nerve impulse.
▪ They act directly on peripheral blood vessels to dilate
them.
▪ Cholinergics include ACh receptor stimulants plus
cholinesterase inhibitors cholinomimetic agents
(mimic ACh).
▪ Cholinoceptor stimulants are classified by:
1. type of receptor that is activated
muscarinic or nicotinic agents
2. MOA
– drugs that bind directly to (& activate) cholinoceptors &
– drugs that act indirectly by inhibiting hydrolysis of
endogenous ACh.
4. Cont…
▪ Cholinergic drugs include:
(a) choline esters, e.g. carbachol, bethanecol
(b) alkaloids, e.g. pilocarpine, muscarine
(c) cholinesterase inhibitors, e.g. physostigmine, neostigmine
▪ Sites of action include:
(1) Autonomic nervous system
(a) Parasympathetic division
▪ Ganglia
▪ Post-ganglionic endings (all)
(b) Sympathetic division
▪ Ganglia
▪ A minority of post-ganglionic endings (e. g. sweat glands)
(2) Neuromuscular junction
(3) Central nervous system
(4) Blood vessels, mainly arterioles
6. Mode of action of cholinergics
▪ Direct-acting cholinergic agents bind to & activate
muscarinic or nicotinic receptors.
▪ Indirect-acting agents elicit primary effects through
inhibition of acetylcholinesterase (AChE), which
hydrolyzes ACh to choline & acetic acid.
▪ Inhibition of AChE →↑endog ACh conc in synaptic clefts &
neuroeffector junctions. Xs ACh then stimulates
cholinoceptors to induce ↑ed responses.
▪ These drugs act primarily where ACh is physiologically
released & are thus amplifiers of endog ACh.
7. MOA:-Direct stimulants of muscarinic
receptors
▪ Activate parasympathetic nervous system &
modify organ function through muscarinic
receptors by two major mechanisms:
1. ACh released from parasympathetic nerves
activates muscarinic receptors on effector cells
to alter organ function directly.
2. ACh released from parasympathetic nerves
interacts with muscarinic receptors on nerve
terminals to inhibit release of their
neurotransmitter.
8. MOA:- Direct stimulants of nicotinic receptors
▪ Nicotinic agonist occupies nicotinic receptor → ion
(Na-K) channels open; allowing Na+ & K+ to diffuse
rapidly down their concentration gradients.
▪ Receptor activation → depolarization of nerve cell or
neuromuscular end plate membrane.
▪ Prolonged agonist occupancy of nicotinic receptor:
• impedes effector response, i.e. postganglionic neuron
stops firing (ganglionic effect) & skeletal muscle cell relaxes
(neuromuscular end plate effect).
• prevents electrical recovery of postjunctional membrane
→ induction of a state of "depolarizing blockade“.
• (further discussions in future lectures in this series)
9. Chemistry of choline
esters
▪ Have a permanently
charged quaternary
NH4
+ group →
relatively insoluble in
lipids.
▪ ACh & methacholine
are acetic acid esters
of choline and b-
methylcholine,
respectively.
▪ Carbachol &
bethanechol are
carbamic acid esters of
the same alcohols.
Source: Fig 7.2, chpt 7; Katzung 10th ed.,
10. Choline esters
Pharmacokinetics
▪ Poorly absorbed & poorly distributed into CNS
(hydrophilic).
▪ All are hydrolyzed in GIT ( less active by oral
route) BUT
▪ They have marked differences in susceptibility to
hydrolysis by cholinesterase.
▪ Acetylcholine is very rapidly hydrolyzed;
▪ large amounts req’d through IVI to produce detectable
effects.
▪ large IV bolus injection has brief effect ( 5-20 secs),
▪ IM & SC inj produce only local effects.
11. Cont…
▪ Methacholine is more resistant to AChE
hydrolysis.
▪ Carbamic acid esters, carbachol &
bethanechol are even more resistant to
hydrolysis by cholinesterase.
❖ have correspondingly longer durations of action.
▪ The b-methyl gp (methacholine, bethanechol)
↓ potency of these drugs at nicotinic
receptors.
12. Alkaloids (Source: Fig 7.3, chpt 7; Katzung 10th ed.,)
•Pilocarpine, nicotine &
lobeline: tertiary natural
cholinergic alkaloids; well
absorbed from most sites of
admin.
• Nicotine (liquid), lipid-
soluble - absorbed across the
skin.
•Lobeline similar to nicotine.
•Muscarine, a quaternary
amine, oral absorption less
than tertiary amines; toxic
when ingested, e.g., via
mushrooms & can enter BBB.
•Excreted mainly by kidneys
13. Indirect-acting cholinomimetics
▪ These drugs are also known as anti-
cholinesterase (anti-CHE) agents / cholinesterase
inhibitors.
▪ Commonly used agents fall into three chemical
gps:
1. Simple alcohols (ROHs) bearing a quaternary NH4+
gp e.g. edrophonium
2. Carbamic acid esters of ROHs bearing a quaternary
or tertiary NH4+ gps (carbamates, e.g. neostigmine)
3. Organic derivatives of phosphoric acid
(organophosphates, e.g. isoflurophate)
14. Variation in MOA of anti-CHE agents based on
chemical subgroup
▪ Quartenary ROHs (edrophonium)
▪ reversibly bind electrostatically by hydrogen bonds to active
site preventing access of ACh.
▪ Carbamate esters (neostigmine & physostigmine)
▪ undergo a two-step hydrolysis sequence similar to ACh BUT
covalent bond of the carbamoylated enzyme is > resistant to
the 2nd step, hence the process is prolonged .
▪ Organophosphates
▪ undergo initial binding & hydrolysis by AChE → a
phosphorylated active site; the covalent phosphorus-enzyme
bond is very stable & hydrolyzes in water @ v slow rate
(hundreds of hours).
▪ after initial binding-hydrolysis step, phosphorylated enzyme
complex undergoes a process called aging.
15. Chemistry of cholinesterase
inhibitors
▪ Neostigmine - a typical
comp’d that is an ester of
carbamic acid (1) & a
phenol with a quaternary
NH4+ gp (2).
▪ Physostigmine – a
naturally occurring
carbamate & a tertiary
amine.
▪ Edrophonium – not an
ester but binds to active
site of the enzyme.
▪ Carbaryl – example of a
large gp of carbamate
insecticides; v ↑ lipid
solubility so v rapid
absorptn into insect &
distribution to CNS .
Source: Fig 7-5, p97 of Katzung 7th ed.
16. Quartenary carbamates
PHARMACOKINETICS
• Absorption of quaternary carbamates from conjunctiva,
skin & lungs is poor (permanent charge on molec → lipid
insoluble).
• Oral doses higher than parenteral.
• Distribution into CNS is negligible.
• Physostigmine, well absorbed from all sites & hence used
topically in the eye;
• distributed into CNS & is > toxic than more polar
quaternary carbamates.
17. Cont…
▪ Neostigmine & pyridostigmine, poor oral
absorption thus larger doses needed.
▪ Carbamates, relatively stable in aq. solution;
metabolized by non-specific esterases in the
body plus cholinesterase.
▪ Duration of action dependent on stability of
inhibitor-enzyme complex (not metabolism/
excretion).
18. Organophosphate cholinesterase inhibitors
Pharmacokinetics
• Very lipid-soluble liquids, highest risk of toxicity & ↑ vapor
pressures.
• Less volatile agents & common agents such as insecticides
(e.g., diazinon, malathion in agric); dispersed as aerosols/ as
dusts adsorbed to an inert, finely particulate material.
• Rapidly absorbed from skin, lung, gut & conjunctiva (toxic to
humans).
• Aq solutions relatively < stable than carbamates & thus have
limited t1/2 in environment (compared w other major class of
insecticides, halogenated hydrocarbons like DDT).
19. Cont..
• Echothiophate highly polar & more stable than
other organophosphates;
• Aq preparation for ophthalmic use has long
activity (weeks).
• All (except echothiophate)distributed to all parts
of body + CNS.
• Poisoning may include CNS toxicity.
20. Therapeutic uses
▪ Major uses of cholinomimetics include diseases of the:
1. Eye (glaucoma, accommodative esotropia),
2. GI & urinary tracts (postoperative atony, neurogenic
bladder),
3. Neuromuscular junction (myasthenia gravis, curare-
induced neuromuscular paralysis) &
4. Very rarely heart (certain atrial arrhythmias).
▪ Anti-CHE agents used in treatment of atropine
overdose.
▪ Newer cholinesterase inhibitors used in Alzheimer's
disease.
21. Specific uses & duration of action of
cholinesterase inhibitors (Source: Tbl 7-4, p98 of Katzung 7th ed.)
Drug group Uses Approx duration of action
Alcohols, e.g.
edrophonium
Myasthenia gravis, ileus,
arrhythmias
5 – 15 mins
Carbamates & related,
neostigmine
Myasthenia gravis, ileus 0.5 – 2 hrs
pyridostigmine Myasthenia gravis, ileus 3 – 6 hrs
physostigmine Glaucoma 0.5 – 2hrs
ambenonium Myasthenia gravis 4 – 8 hrs
demecarium Glaucoma 4 – 6 hrs
Organophosphates, e.g.
ecothiophate
Glaucoma 100 hrs
22. Toxicity
▪ Toxic effects of cholinoceptor stimulants is
influenced by their:
▪ absorption,
▪ access to CNS,
▪ & metabolism
▪ Direct-acting muscarinic stimulants (e.g.,
pilocarpine & choline esters) cause predictable
signs of muscarinic excess in over-dosage.
▪ Effects include nausea, vomiting, diarrhea, urinary
urgency, salivation, sweating, cutaneous vasodilation &
bronchial constriction.
▪ They are all blocked competitively by atropine & its
congeners.
23. Direct-acting nicotinic stimulants (e.g. nicotine)
Acute toxicity
▪ Fatal dose, approx 40 mg ( 1 drop of pure liquid = amount
in 2 regular cigarettes).
▪ Ingestion of nicotine insecticides/ tobacco by infants &
children causes vomiting
▪ Large doses:
– CNS stimulation → convulsions → coma & respiratory arrest
– muscle end plate depolarization, which may lead to
depolarization blockade and respiratory paralysis
– hypertension & cardiac arrhythmias
Chronic nicotine toxicity
▪ Addiction to cigarettes (directly related to nicotine content).
▪ Increased risk of vascular disease & sudden coronary death
(associated with smoking).
▪ Contributes to ↑ incidence of ulcer recurrences in smokers with
peptic ulcer.
24. Cholinesterase inhibitors
▪ Dominant initial signs of acute effects:
▪ miosis, salivation, sweating, bronchial
constriction, vomiting & diarrhoea
▪ then CNS effects soon after, accompanied by
peripheral nicotinic effects, esp. depolarizing
neuromuscular blockade.
▪ Parenteral atropine given in large doses to
control signs of muscarinic excess.
25. Summary
▪ Cholinergic drugs act on receptors at all sites in
the body where ACh is transmitter of the nerve
impulse.
▪ These drugs can directly activate cholinoceptors
(nicotinic & muscarinic receptors) ultimately
causing increased effector response;
▪ Or they can indirectly increase levels of
endogenous acetylcholine by inhibiting
acetylcholinesterase, enzyme responsible for
breakdown of ACh.