El documento presenta conferencias sobre el sistema dopaminérgico y su relación con la ingesta calórica y el comportamiento alimentario. Se describe cómo la dopamina juega un papel crucial en la regulación de la conducta alimentaria y los efectos de la obesidad en esta respuesta. Además, se examina la posibilidad de regular la ingesta calórica incluso en ausencia de señales gustativas.

1. !"#$%&'"()#*&%#+,-"#+.(/&(01*%-,-2#(3(4+.1/(
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Luis Téllez
&
Universidad de Yale
5"6-#$"7(89(/&(",*1:%&7(8;<=(

2. Congreso
Internacional
de
Nutrición
Dr.
José
María
Bengoa
Caracas,
Venezuela
¿Cómo
elegimos
lo
que
comemos?
El
sistema
dopaminérgico
como
un
sensor
calórico.

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8. Tellez L A et al. J Physiol 2013

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10. El Sistema Dopaminérgico Nigrostriatal…
• Juega un papel crítico en la conducta (e.g. atención, motivación,
recompensa, la conducta dirigida por objetivos, y la adquisición de
“hábitos” , incluyendo la auto-administración de drogas);
• Los ratones deficientes en DA mueren de hambre, un efecto que puede
ser revertido mediante la restauración farmacológica de DA en el estriado
dorsal;
• Los niveles extracelulares de DA se incrementan durante la ingestión
de alimentos.

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Tellez L A et al. J Physiol 2013

13. ¿Es
posible
regular
la
ingesta
calórica
en
ausencia
de
esFmulación
gustaFva?

15. 1000
3.5
900
800
3
600
500
400
2.5
kcal
Licks
700
2
300
200
1.5
100
0
1
Tellez
LA
et
al.
Biological
Psychiatry
2013

16. Los
niveles
extracelulares
de
dopamina
en
el
estriado
reflejan
la
ingesta
calórica,
incluso
en
la
ausencia
de
señales
gusta=vas.

17. En
ausencia
de
señales
gustaFvas,
bloquear
el
receptor
de
dopamina
interrumpe
la
detección
de
calorías.
©2012 by The Physiological Society
Ferreira J G et al. J Physiol 2012

18. ¿Cómo
afecta
el
estado
metabólico
a
este
sensor
calórico?

19. La
respuesta
dopaminérgica
se
encuentra
alterada
en
organismos
obesos.
(Wang
et
al,
2001)
Se
ha
propuesto
que
la
disminución
en
la
función
dopaminérgica
conlleva
a
la
sobrealimentación
como
un
mecanismo
compensatorio.
(Johnson
&
Kenny,
2010)

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25. Daniele
Piomelli
Trends
in
Endocrinology
&amp;
Metabolism
Volume
24,
Issue
7
2013
332
-­‐
341

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29. ¿Cuáles
son
las
consecuencias
conductuales
derivadas
del
incremento
en
los
niveles
de
DA
inducidos
por
la
OEA?

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34. Gracias
Fundación Bengoa para la
Yale University
Alimentación y Nutrición
Ivan E. de Araujo
Sara Medina
Jozelia Ferreira
Wenfei Han
Xueying Ren
Dana Small
Tukiet Lam
Funding
National Institute on Deafness and Other
Communication Disorders (NIDCD)
National Institute on Diabetes, Digestion and
Kidney (NIDDK)
Ajinomoto, Inc.
Albert Einstein College of Medicine
Gary J Schwartz

35. (J1*7(I think this is the beginning of a beautiful friendship!

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39. n.s.
8
30
25
pmol/g
6
4
2
20
15
10
5
0
0
Serum
n.s.
140
120
100
pmol/g
pmol/mL
n.s.
80
60
40
20
0
Brain
Liver

40. Dopaminergic
effects
of
OEA
are
mediated
by
the
nuclear
receptor
PPAR-­‐α
and
by
the
vagus
PPAR-­‐α
KO
capsaicin
treatment

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