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2001 Proceedings of the 23rd Annual EMBS InternationalConference, October 25-28, Istanbul, Turkey


                              A ROBOT FOR WRIST REHABILITATIOlN
                              Dustin J. Williamsā€™, Hermano Igo Krebsā€™, Neville Hoganā€™
                  I   Mechanical Engineering Dept., Massachusetts Institute of Technology, Cambridge, USA


 Abstract -In 1991, a novel robot named MIT-MANUS was                   The results of the initial studies, as measured by standard
 introduced as a test bed to study the potential of using robots   clinical instruments, showed statistically significant
 to assist in and quantify the neuro-rehabilitation of motor       difference between the experimental and control group for
 function. It proved an excellent fit for the rehabilitation of    shoulder and elbow (the focus of the exercise routines), but
 shoulder and elbow of stroke patients with results in clinical
                                                                   no differences for wrist and fingers (which were not
 trials showing a reduction of impairment in these joints. The
 greater reduction in impairment was limited to the group of       exercised). This result suggests a local effect with limited
 muscles exercised. This suggests a need for additional robots     generalization of the benefits to the unexercised limb or
 to rehabilitate other degrees of freedom. This paper outlines     muscle groups. If this is the case, we must extend our robot-
 the mechanical design of a robot for wrist rehabilitation.        aids to exercise different groups of muscles and limb
 Keywords - neurological, rehabilitation, stroke, robot, wrist.    segments. We are presently developing robots to work with
                                                                   different muscles and limb segments, e.g., spatial motion,
                         I. INTRODUCTION                           wrist, fingers, legs [3, 4, 71. [n this paper, we describe the
                                                                   design of a device for wrist rehabilitation.
 Rather than using robotics as an assistive technology, our
 research focuses on the development of robotics as a tool to               I . SPECIFICATION NEWWRIST
                                                                             I            FOR A      DEVICE
 enhance the productivity of clinicians in their efforts to
 facilitate a disabled individualā€™s recovery. To that end, we      It is of paramount importance that the wrist device be easy
 deployed and commenced extensive clinical trials of our first     for the therapist and the patient to use. To prevent daily use
 robot, MIT-MANUS (see figure l ) , at the Burke                   from becoming a chore for thc patient and the therapist only
 Rehabilitation Hospital, White Plains, NY in 1994 [5]. MIT-       a minimum amount of time and effort must be required to
 MANUS has been in daily operation for over 6 years,               attach and remove the patierit from the wrist device. The
 delivering therapy to over 100 stroke patients. Copies have       setup target time was estimated at 2 minutes maximum.
 been recently deployed at the Spaulding (Boston), Helen                 Another key aspect is low endpoint impedance. That is,
 Hayes (NY), Baltimore & Cleveland VA Hospitals.                   when a patient attempts to backdrive the robot,the effective
      Our results suggest that goal oriented exercise of a         friction, inertia and stiffness should ideally be low enough
 hemiparetic limb appears to harness and promote the               such that it feels as if no robot is connected to the user. In
 neuromotor recovery following a stroke [ 1,5,6, 10, 1I].          this case, the robot hardware i s termed ā€œbackdrivableā€. The
      Seventy-six stroke patients exhibiting a unilateral lesion   maximum reflected inertia for backdriveability for each wrist
 were enrolled in the initial clinical trials. Patients were       degree of freedom was estimated to be 30 to 45.104 kg-m2.
 randomly assigned to an experimental and a control group.         The maximum reflected friction for backdriveability was
 The experimental group received an hour per day of robot-         estimated to be 0.2 N-m. The wrist device should also have
 aided therapy exercising the shoulder and elbow. The control      ranges of motion of a normal wrist in everyday tasks, i.e.,
 group received an hour per week of ā€œshamā€ robot-aided             flexiontextension 70ā€/65ā€, aibductionladduction 15ā€/30ā€,
 therapy with the same video games.                                pronatiodsupination 90ā€190ā€ The torque output from the
                                                                   device must be capable of lifting the patientā€™s hand against
                                                                   gravity, accelerating the inertia, and overcoming any tone.
                                                                   The estimated value for flexiontextension and abduction/
                                                                   adduction was 1.2 N-m and for pronationlsupination
                                                                    1.69 N-m [8, 121.

                                                                                      A. Kinemaric Selection

                                                                        A curved slider was found to suffice for the robotā€™s
                                                                   pronationlsupination axis. A curved rail sits between four
                                                                   guide wheels, which allow it tlo rotate (see Figure 2). Several
                                                                   different options were coinsidered for the remaining
 Fig. 1. A recovering stroke patient receiving upper extremity
                                                                   kinematics. These options must allow the patient to move in
 robotic therapy with MIT-MANUS.
                                                                   flexiontextension and abductionladduction and also must

0-7803-7211-5/01/$17.00 0 2001 IEEE                            1336
allow the robot to apply torques to the patient's hand. After
reviewing each of these kinematic options, a cardan joint
was found to be the most appropriate (see Figure 3). A
mockup is shown in figure 4.

    B. Actuator Placement and Transmission Selection

     Three major sub-categoriesemerged from the various
actuatorltransmission packages considered.The first option
placed all actuators on the ground frame (see link 1 in figure
                                                                                       Fig.2. Curved Slider
3). The second option placed an actuator on the ground and
two actuators on link 2 (differential configuration).The last
option placed an actuator on the ground frame, an actuator
on link 2, and an actuatoron link 3 (serial configuration)[9].
     In comparing these options, the differential
configuration clearly held the advantage. For the same
actuators, the range of output torque was up to twice that of
the serial configration. Another advantage over the serial
configuration is that the actuators can more effectively
counterbalance each other. This is because both actuators
are placed on a single link ( i k2). By symmetricallylocating
                             ln
the actuators about the robot's pronatiodsupination axis, the
torque due to the weight of the motors is canceled.

                    C. Actuator Selection
                                                                                  Fig.3. Cardan Joint Kinematics
     We limited our search to ultimag rotary actuators, servo-
disc, DC-brushed and brushless motors. Of these, we selected
the brushless motors, which deliver high torque and runs
smoothly at low speeds, a requirement in this application
[2]. The brushless motors also allow for better heat
dissipation because the windings are on the stator.
     In order to select from the many available brushless
motors, the reflected output impedances for each axis of
rotation were compared. The following brushless motors
were deemed acceptable (< 0.5 kg): Parker series SMlBOA
and SM161A, Pittman series 34x1,2 and 44x1,2,3, and the
Kollmorgen series 512,513,711-714 actuators.
     Figure 5 shows a sample of how the actuators were
compared. In this case, we are comparing the added inertia
in abductiodadduction and flexiodextension due to the
motor. The abscissa shows the reduction ratio required for
each motor to achieve the specified maximum output torque
of 1.2 N-m. The ordinate shows the added inertia in both
flexiodextensionand abductiodadduction.This number was
found by taking 2.1 .R2,where I is the inertia of the given
motor armature, R l"s the reductizn ratio and the factor of 2
is due to the fact that both motors on link 2 will be backdriven.
In a similar fashion, we estimated the added friction in
abductionladduction and flexiodextension. A similar
approach yielded estimates.for pronatiodsupination.
     We opted for the Kollmorgen's RBE 71 1 motors for              Fig.4. Mockup in FlexionExtension, Abduction/
the abductionfadduction and flexiodextension actuators              Adduction, and PronationfSupination
and the RBE 712 motors for pronatiodsupination.
Because the flexiodextension and abductionladduction



                                                                1337
The total reduction in one train from the actuator pinion to
                                                                   the differential endgear is 8:1.




Fig. 5. Added Inertial Impedance in FlexiodExtension
and AbductiodAdduction

motors will be in close proximity to the patient, a finite
element analysis was performed to ensure that motor
temperature would not rise to uncomfortable levels.

                 D.SENSOR SELECTION

      The determining factor in selecting the type of position
feedback device was its size, servo-amplifiercompatibility,
and insensitivity to noise. The smallest system found was an
incremental encoder from Gurley Precision, the RI 19. It is
a high-resolution mini-encoder with 10,240 cycles per rev.                         Fig. 6. Comp:lete Wrist Device
Its size was well suited for the wrist device allowing for its
placement inside of the transmission housing.

                  111. HARDWARE
                             OVERVIEW

To illustrate the proposed device, we will use Pro/J3ngineerm
solid models. Figure 6 shows the solid model and the
complete device. Figure 7 illustrates how the patient's hand,
wrist and upper forearm will be held on the device via a
series of Velcro straps: two straps over the back of the palm,
a single strap over the proximal or middle phalanges, two
straps to the wrist connection piece, and a strap over the
forearm. Also shown is a protrusion, which prevents the hand
from slipping around the handle. Figure 8 shows the
transmission from the abduction/adduction and flexion/
extension actuators to the a m To increase visibility, a section
                            r.
of the transmission housing has been removed in the close
up view. The gears are also darkened to distinguish them
from other components. Two spur gear trains are used to
transmit torque from the actuators to the differential. The
three bevel gears of the differential, the spider gear and the
two end bevel gears, are represented by their pitch cones.
     The two spur gear trains consist of four gears. These                        Fig. 7. Connection to the Patient
gears include the motor pinion gear (gear A), two
intermediate gears which are rigidly attached and rotate
together (gears B and C), and the endgear of the differential
(gear D). The intermediate gears were added to keep the
differential endgears and the rest of the transmission small.
improvements by extending treatment with robot-aids at
                                                                   patientsā€™ homes.
                                                                         From the realm of science fiction to the substance of
                                                                   humbling reality, the novel module for wrist rehabilitation
                                                                   is another marker along the trail. It follows the same design
                                                                   guidelines of MIT-MANUS,      which includes back-drivability.
                                                                   O r experience has shown that it is an important feature of
                                                                     u
                                                                   any successfulinteractive robot-aid. On final note, while very
                                                                   little technology presently exists to support the recovery
                                                                   phase of rehabilitation, we believe the landscape will change
                                                                   quickly in the near future.

                                                                                         V. ACKNOWLEDGMENT
Fig 8. Transmission System for AbductiodAdduction &                This work was supported in part by The Burke Medical
FlexiodExtension.                                                  Research Institute, the Langeloth Foundation, and NIH Grant
                                                                      RO1-HD37397-01 & and #1 R01-HD36827-02.
     The two stops shown in figure 8 prevent over rotation
of the patient in abduction and adduction. These stops also                                  VI. REFERENCES
prevent the robot arm and handle components from
contacting other components. They limit the range of motion             Aisen, M.L., Krebs, H.I., McDowell, E, Hogan, N., Volpe, N., The
to 30ā€ in adduction and 20ā€ in abduction. Although not                  effect of robot assisted therapy and rehabilitative training on motor
shown, similar stops restrict rotation in flexion and extension.        recovery following stroke, Arch o Neurol, 54(1997):443-446.
                                                                                                           f
These stops limit rotation in flexiodextension to 60ā€ in each           Asada H., Direct Drive Robots. MIT Press, Cambridge, MA
                                                                        Buerger, S.P., Krebs, H.I., Hogan, N., Characterization and Control
direction.The final design is below specification by 10ā€ in             of a Screw-Driven Robot Neurorehabilitation, IEEE-CCMSK2001.
flexion and 5ā€ in extension.                                            Jugenheimer, K.A., Hogan, N., Krebs, H.I., ā€œA Robot for Hand
     The axis for pronation and supination makes use of two             Rehabilitation: A Continuation of the MIT-MANUS Neuro-
geared 180O-sliderings. Each slide ring has opposing ā€œVā€                Rehabilitation Workstation, ASME IDETC/CIE, 2001 (accepted).
                                                                        Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T., Robot-aided neuro-
shaped edges, which roll between four guide wheels with                 rehabilitation, IEEE Trans. Rehab. Eng, 6:1(1998):75-87.
ā€œVā€ shaped grooves. The lower two guide wheels are                      Krebs, H.I., Volpe, B.T., Aisen, M.L., Hogan, N.; ā€œIncreasing
eccentric allowing adjustment in the preload of the wheels              Productivity and Quality of Care: Robot-Aided Neurorehabilitationā€,
against the slide rings. The upper guide wheels are concentric          VA J. Rehab Res and Development 37:6(2OOO):639-652.
                                                                        Krebs, H.I., Buerger, S.P., Jugenheimer, K.A., Williams, D., Hogan,
and cannot be adjusted. Two stops limit the rotation of the             N., 3-D Extension for MIT-MANUS: a Robot-Aided Neuro-
wrist to 76ā€ in pronation and 76ā€ in supination, which is               Rehabilitation,A~~E~D~C/ClE,        (Sept2OOO)DETC/MECH-14151.
slightly below our target requirementsof 90ā€.                           Palastanga Nigel, Anatomy and Human Movement: Structure and
                                                                        Function, Butterworth Heinemann, Jordan Hill, Oxford, Britain.
                                                                        Slocum, Alex H., Precision Machine Design, Society of
                       N.CONCLUSION                                     Manufacturing Engineers, Dearborn, Michigan
                                                                   [IO] Volpe, B.T., fiebsIH.I., Hogan, N., Edelstein, L., Diels C., Aisen,
Clinical results to date suggest that robot-aided neuro-                M.L., Robot Training Enhanced Motor Outcome in Patients With
rehabilitation can have a positive influence on neuro-                  Stroke Maintained over Three Years, Neurol, 53(1999):1874-1876.
                                                                   [11] Volpe,B.T., Krebs,H.l.,Hogan,N.,Edelstein,L.,Diels,C.M.,       Aisen,
recovery following a stroke. Our pioneering clinical results            M.; ā€œA Novel Approach to Stroke Rehabilitation: Robot Aided
are consistent with a prominent theme of current                        Sensorymotor Stimulationā€, Neurol., 54(2000):1938-1944.
neuroscience research into the sequelae of brain injury, which     [I21 Webb Associates, Anthropometric Source Book Volume I:
posits that activity-dependent plasticity underlies neuro-              Antliropometv for Designers, Scientific and Technical Information
                                                                        Office, Yellow Springs, Ohio, 1978
recovery. Furthermore, our results with more than 100 stroke
patients open up a number of opportunities. We envision the
rehabilitation clinic of the future as gyms of ā€œrehabilitatorsā€
working with different limb segments, muscle groups, and
functional tasks. At this gym, the therapist tailors an exercise
routine to the particular patientā€™s needs to optimize recovery,
increasing the clinicā€™s productivity by overseeing several
patients at the same time. The productivity of the overall
rehabilitation system may further be improved by the
objective and precise measurements afforded by robotics,
with the potential to automate the assessment and
documentation of recovery. We also envision further


                                                               1339

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01020443 (robotic hand)

  • 1. 2001 Proceedings of the 23rd Annual EMBS InternationalConference, October 25-28, Istanbul, Turkey A ROBOT FOR WRIST REHABILITATIOlN Dustin J. Williamsā€™, Hermano Igo Krebsā€™, Neville Hoganā€™ I Mechanical Engineering Dept., Massachusetts Institute of Technology, Cambridge, USA Abstract -In 1991, a novel robot named MIT-MANUS was The results of the initial studies, as measured by standard introduced as a test bed to study the potential of using robots clinical instruments, showed statistically significant to assist in and quantify the neuro-rehabilitation of motor difference between the experimental and control group for function. It proved an excellent fit for the rehabilitation of shoulder and elbow (the focus of the exercise routines), but shoulder and elbow of stroke patients with results in clinical no differences for wrist and fingers (which were not trials showing a reduction of impairment in these joints. The greater reduction in impairment was limited to the group of exercised). This result suggests a local effect with limited muscles exercised. This suggests a need for additional robots generalization of the benefits to the unexercised limb or to rehabilitate other degrees of freedom. This paper outlines muscle groups. If this is the case, we must extend our robot- the mechanical design of a robot for wrist rehabilitation. aids to exercise different groups of muscles and limb Keywords - neurological, rehabilitation, stroke, robot, wrist. segments. We are presently developing robots to work with different muscles and limb segments, e.g., spatial motion, I. INTRODUCTION wrist, fingers, legs [3, 4, 71. [n this paper, we describe the design of a device for wrist rehabilitation. Rather than using robotics as an assistive technology, our research focuses on the development of robotics as a tool to I . SPECIFICATION NEWWRIST I FOR A DEVICE enhance the productivity of clinicians in their efforts to facilitate a disabled individualā€™s recovery. To that end, we It is of paramount importance that the wrist device be easy deployed and commenced extensive clinical trials of our first for the therapist and the patient to use. To prevent daily use robot, MIT-MANUS (see figure l ) , at the Burke from becoming a chore for thc patient and the therapist only Rehabilitation Hospital, White Plains, NY in 1994 [5]. MIT- a minimum amount of time and effort must be required to MANUS has been in daily operation for over 6 years, attach and remove the patierit from the wrist device. The delivering therapy to over 100 stroke patients. Copies have setup target time was estimated at 2 minutes maximum. been recently deployed at the Spaulding (Boston), Helen Another key aspect is low endpoint impedance. That is, Hayes (NY), Baltimore & Cleveland VA Hospitals. when a patient attempts to backdrive the robot,the effective Our results suggest that goal oriented exercise of a friction, inertia and stiffness should ideally be low enough hemiparetic limb appears to harness and promote the such that it feels as if no robot is connected to the user. In neuromotor recovery following a stroke [ 1,5,6, 10, 1I]. this case, the robot hardware i s termed ā€œbackdrivableā€. The Seventy-six stroke patients exhibiting a unilateral lesion maximum reflected inertia for backdriveability for each wrist were enrolled in the initial clinical trials. Patients were degree of freedom was estimated to be 30 to 45.104 kg-m2. randomly assigned to an experimental and a control group. The maximum reflected friction for backdriveability was The experimental group received an hour per day of robot- estimated to be 0.2 N-m. The wrist device should also have aided therapy exercising the shoulder and elbow. The control ranges of motion of a normal wrist in everyday tasks, i.e., group received an hour per week of ā€œshamā€ robot-aided flexiontextension 70ā€/65ā€, aibductionladduction 15ā€/30ā€, therapy with the same video games. pronatiodsupination 90ā€190ā€ The torque output from the device must be capable of lifting the patientā€™s hand against gravity, accelerating the inertia, and overcoming any tone. The estimated value for flexiontextension and abduction/ adduction was 1.2 N-m and for pronationlsupination 1.69 N-m [8, 121. A. Kinemaric Selection A curved slider was found to suffice for the robotā€™s pronationlsupination axis. A curved rail sits between four guide wheels, which allow it tlo rotate (see Figure 2). Several different options were coinsidered for the remaining Fig. 1. A recovering stroke patient receiving upper extremity kinematics. These options must allow the patient to move in robotic therapy with MIT-MANUS. flexiontextension and abductionladduction and also must 0-7803-7211-5/01/$17.00 0 2001 IEEE 1336
  • 2. allow the robot to apply torques to the patient's hand. After reviewing each of these kinematic options, a cardan joint was found to be the most appropriate (see Figure 3). A mockup is shown in figure 4. B. Actuator Placement and Transmission Selection Three major sub-categoriesemerged from the various actuatorltransmission packages considered.The first option placed all actuators on the ground frame (see link 1 in figure Fig.2. Curved Slider 3). The second option placed an actuator on the ground and two actuators on link 2 (differential configuration).The last option placed an actuator on the ground frame, an actuator on link 2, and an actuatoron link 3 (serial configuration)[9]. In comparing these options, the differential configuration clearly held the advantage. For the same actuators, the range of output torque was up to twice that of the serial configration. Another advantage over the serial configuration is that the actuators can more effectively counterbalance each other. This is because both actuators are placed on a single link ( i k2). By symmetricallylocating ln the actuators about the robot's pronatiodsupination axis, the torque due to the weight of the motors is canceled. C. Actuator Selection Fig.3. Cardan Joint Kinematics We limited our search to ultimag rotary actuators, servo- disc, DC-brushed and brushless motors. Of these, we selected the brushless motors, which deliver high torque and runs smoothly at low speeds, a requirement in this application [2]. The brushless motors also allow for better heat dissipation because the windings are on the stator. In order to select from the many available brushless motors, the reflected output impedances for each axis of rotation were compared. The following brushless motors were deemed acceptable (< 0.5 kg): Parker series SMlBOA and SM161A, Pittman series 34x1,2 and 44x1,2,3, and the Kollmorgen series 512,513,711-714 actuators. Figure 5 shows a sample of how the actuators were compared. In this case, we are comparing the added inertia in abductiodadduction and flexiodextension due to the motor. The abscissa shows the reduction ratio required for each motor to achieve the specified maximum output torque of 1.2 N-m. The ordinate shows the added inertia in both flexiodextensionand abductiodadduction.This number was found by taking 2.1 .R2,where I is the inertia of the given motor armature, R l"s the reductizn ratio and the factor of 2 is due to the fact that both motors on link 2 will be backdriven. In a similar fashion, we estimated the added friction in abductionladduction and flexiodextension. A similar approach yielded estimates.for pronatiodsupination. We opted for the Kollmorgen's RBE 71 1 motors for Fig.4. Mockup in FlexionExtension, Abduction/ the abductionfadduction and flexiodextension actuators Adduction, and PronationfSupination and the RBE 712 motors for pronatiodsupination. Because the flexiodextension and abductionladduction 1337
  • 3. The total reduction in one train from the actuator pinion to the differential endgear is 8:1. Fig. 5. Added Inertial Impedance in FlexiodExtension and AbductiodAdduction motors will be in close proximity to the patient, a finite element analysis was performed to ensure that motor temperature would not rise to uncomfortable levels. D.SENSOR SELECTION The determining factor in selecting the type of position feedback device was its size, servo-amplifiercompatibility, and insensitivity to noise. The smallest system found was an incremental encoder from Gurley Precision, the RI 19. It is a high-resolution mini-encoder with 10,240 cycles per rev. Fig. 6. Comp:lete Wrist Device Its size was well suited for the wrist device allowing for its placement inside of the transmission housing. 111. HARDWARE OVERVIEW To illustrate the proposed device, we will use Pro/J3ngineerm solid models. Figure 6 shows the solid model and the complete device. Figure 7 illustrates how the patient's hand, wrist and upper forearm will be held on the device via a series of Velcro straps: two straps over the back of the palm, a single strap over the proximal or middle phalanges, two straps to the wrist connection piece, and a strap over the forearm. Also shown is a protrusion, which prevents the hand from slipping around the handle. Figure 8 shows the transmission from the abduction/adduction and flexion/ extension actuators to the a m To increase visibility, a section r. of the transmission housing has been removed in the close up view. The gears are also darkened to distinguish them from other components. Two spur gear trains are used to transmit torque from the actuators to the differential. The three bevel gears of the differential, the spider gear and the two end bevel gears, are represented by their pitch cones. The two spur gear trains consist of four gears. These Fig. 7. Connection to the Patient gears include the motor pinion gear (gear A), two intermediate gears which are rigidly attached and rotate together (gears B and C), and the endgear of the differential (gear D). The intermediate gears were added to keep the differential endgears and the rest of the transmission small.
  • 4. improvements by extending treatment with robot-aids at patientsā€™ homes. From the realm of science fiction to the substance of humbling reality, the novel module for wrist rehabilitation is another marker along the trail. It follows the same design guidelines of MIT-MANUS, which includes back-drivability. O r experience has shown that it is an important feature of u any successfulinteractive robot-aid. On final note, while very little technology presently exists to support the recovery phase of rehabilitation, we believe the landscape will change quickly in the near future. V. ACKNOWLEDGMENT Fig 8. Transmission System for AbductiodAdduction & This work was supported in part by The Burke Medical FlexiodExtension. Research Institute, the Langeloth Foundation, and NIH Grant RO1-HD37397-01 & and #1 R01-HD36827-02. The two stops shown in figure 8 prevent over rotation of the patient in abduction and adduction. These stops also VI. REFERENCES prevent the robot arm and handle components from contacting other components. They limit the range of motion Aisen, M.L., Krebs, H.I., McDowell, E, Hogan, N., Volpe, N., The to 30ā€ in adduction and 20ā€ in abduction. Although not effect of robot assisted therapy and rehabilitative training on motor shown, similar stops restrict rotation in flexion and extension. recovery following stroke, Arch o Neurol, 54(1997):443-446. f These stops limit rotation in flexiodextension to 60ā€ in each Asada H., Direct Drive Robots. MIT Press, Cambridge, MA Buerger, S.P., Krebs, H.I., Hogan, N., Characterization and Control direction.The final design is below specification by 10ā€ in of a Screw-Driven Robot Neurorehabilitation, IEEE-CCMSK2001. flexion and 5ā€ in extension. Jugenheimer, K.A., Hogan, N., Krebs, H.I., ā€œA Robot for Hand The axis for pronation and supination makes use of two Rehabilitation: A Continuation of the MIT-MANUS Neuro- geared 180O-sliderings. Each slide ring has opposing ā€œVā€ Rehabilitation Workstation, ASME IDETC/CIE, 2001 (accepted). Krebs, H.I., Hogan, N., Aisen, M.L., Volpe, B.T., Robot-aided neuro- shaped edges, which roll between four guide wheels with rehabilitation, IEEE Trans. Rehab. Eng, 6:1(1998):75-87. ā€œVā€ shaped grooves. The lower two guide wheels are Krebs, H.I., Volpe, B.T., Aisen, M.L., Hogan, N.; ā€œIncreasing eccentric allowing adjustment in the preload of the wheels Productivity and Quality of Care: Robot-Aided Neurorehabilitationā€, against the slide rings. The upper guide wheels are concentric VA J. Rehab Res and Development 37:6(2OOO):639-652. Krebs, H.I., Buerger, S.P., Jugenheimer, K.A., Williams, D., Hogan, and cannot be adjusted. Two stops limit the rotation of the N., 3-D Extension for MIT-MANUS: a Robot-Aided Neuro- wrist to 76ā€ in pronation and 76ā€ in supination, which is Rehabilitation,A~~E~D~C/ClE, (Sept2OOO)DETC/MECH-14151. slightly below our target requirementsof 90ā€. Palastanga Nigel, Anatomy and Human Movement: Structure and Function, Butterworth Heinemann, Jordan Hill, Oxford, Britain. Slocum, Alex H., Precision Machine Design, Society of N.CONCLUSION Manufacturing Engineers, Dearborn, Michigan [IO] Volpe, B.T., fiebsIH.I., Hogan, N., Edelstein, L., Diels C., Aisen, Clinical results to date suggest that robot-aided neuro- M.L., Robot Training Enhanced Motor Outcome in Patients With rehabilitation can have a positive influence on neuro- Stroke Maintained over Three Years, Neurol, 53(1999):1874-1876. [11] Volpe,B.T., Krebs,H.l.,Hogan,N.,Edelstein,L.,Diels,C.M., Aisen, recovery following a stroke. Our pioneering clinical results M.; ā€œA Novel Approach to Stroke Rehabilitation: Robot Aided are consistent with a prominent theme of current Sensorymotor Stimulationā€, Neurol., 54(2000):1938-1944. neuroscience research into the sequelae of brain injury, which [I21 Webb Associates, Anthropometric Source Book Volume I: posits that activity-dependent plasticity underlies neuro- Antliropometv for Designers, Scientific and Technical Information Office, Yellow Springs, Ohio, 1978 recovery. Furthermore, our results with more than 100 stroke patients open up a number of opportunities. We envision the rehabilitation clinic of the future as gyms of ā€œrehabilitatorsā€ working with different limb segments, muscle groups, and functional tasks. At this gym, the therapist tailors an exercise routine to the particular patientā€™s needs to optimize recovery, increasing the clinicā€™s productivity by overseeing several patients at the same time. The productivity of the overall rehabilitation system may further be improved by the objective and precise measurements afforded by robotics, with the potential to automate the assessment and documentation of recovery. We also envision further 1339