Major changes are coming to space transportation that will require upgrades to spaceport and range infrastructure. The current system is vehicle-centric rather than transportation-centric, with launch sites that are isolated, outdated, and user-specific. Future challenges include supporting more complex missions such as operationally responsive space, NASA exploration initiatives, and hypersonic vehicles. A vision is presented for seamlessly integrated, nationally interoperable ranges with high flight rates, global coverage, and standardization to reduce costs. A spiral development approach is proposed utilizing technology demonstrations and investments to transform the current system to one with more airport-like operations through 2050.