syphylis

1. Presented by
Simi joju k
First year M.Pharm.,
Dept. of Pharmacy Practice,
Grace College of Pharmacy.

2. Syphilis….
is a contagious bacterial infection that
is transmitted through contact with an
chancre on an infected person, usually
during intimate sexual contact
chancre

3. SYPHILIS
Syphilis is a venereal (sexually-transmitted) bacterial
disease caused by Treponema pallidum usually spread by
sexual contact.
The disease starts as a painless sore (typically on
genitals, rectum or mouth).

4. EPIDEMIOLOGY

5. INCUBATION PERIOD:
10 days- 3 weeks (may be upto 3 months)
MODE OF TRANSMISSION
Sexual intercourse
Intimate person-to-person contact
Transfusion of infected blood
Materno-foetal transmission

6. CLINICAL
PRESENTATIONS
Primary syphilis
Secondary syphilis
Latent syphilis
Tertiary (late) syphilis
- Syphilitic Gumma
- Diffuse lesions
(cardiovascular syphilis,
neurosyphilis)
Congenital syphilis

7. DIAGNOSIS
1. Dark field microscopic examination:
Direct fluorescent antibody (test) for T. pallidum
(DFA-TP)
2. Serological tests:
•Nontreponemal tests
Venereal Disease Research Laboratory (VDRL)
slide test
rapid plasma reagin (RPR) card test
unheated serum reagin (USR) test
toluidine red unheated serum test (TRUST).

9. •Treponemal tests
 Fluorescent treponemal antibody absorption
(FTA-ABS)
•Other serologic tests
 T. pallidum hemagglutination assay (TPHA)
 Microhemagglutination assay for antibodies to
T. pallidum (MHA-TP)
 T. pallidum particle agglutination assay (TPPA)

10. TREATMENT
Primary/
secondary/
latent
syphilis
Benzathine penicillin
G
Neurosyphilis
Aqueous crystalline
penicillin G OR
Aqueous procaine
penicillin G
Congenital
syphilis
Aqueous crystalline
penicillin G OR
Procaine penicillin
G

11. Penicillin-allergic patients
Primary/
secondary/
early latent
Doxycycline
Tetracycline
Doxycycline
Tetracycline
Ceftriaxone
Late latent
syphilis

12. PREVENTION
Avoid recreational drugs
Abstain or be monogamous
Use a latex condom

13. THANK YOU!!!!