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You are what you eat (sort of) :
targeting microbes for
good health
SE Erdman, MIT DCM
sick healthy
sick healthy
TEFF TREG
Healthful longevity
Th-2Th-1 Th-17
sick
TREGTEFF
brain
microbes
Testing Microbes in Good Health
?
epithelia
Why use animal models?
Gut microbially-triggered systemic events
(modified from Coombs, et al 2005; Fiona Powrie lab)
Neutrophil recruitment
Macr...
TREGTH17
sick
healthy
TH17
TREG
Immune Balance
Immune Dysregulation
Adoptive Transfer Models of Inflammation
TREG cellsTEFF cells
No IBD IBD No IBD
No cells
(modified from Powrie 1995)
Fatter Thinner
Probiotics? Yummy.
Yassin IbrahimBernard Varian Tatiana Levkovich
brain
microbes
Testing Microbes in Good Health
?
epithelia
Oral dosing with L. reuteri in water
Lactobacillus reuteri
human breast milk
Bacteria fed to mice in drinking water
gut br...
controlprobiotic‘Fastfood’
‘Fastfood’
+probiotic
sick healthy
TREGTH17
TH17
TREG
frequent = at least once a week up to daily
Humans Eating at Fast Food Restaurants
* P<0.05
MuscleFibersBodyMorphology
Humanmicrobesovertime
‘Fast Food’
Control
Muscle weight/body weight Muscle fiber size
‘Fast Foo...
Hair follicles (HF) in subcutis
Hair follicles (HF) in subcutis
Paired testis weight
+ Probiotics (elderly Swiss male)
Oral dosing with L. reuteri in water
Lactobacillus reuteri
human breast milk
Bacteria fed to mice in drinking water
gut br...
TREGTH17TH17
TREG
“Fast food” Beneficial Bacteria
Sexy!Shiny!Skinny!
Disease Health
Wound healing is 2X faster
ControlL.reuteri
WoundHealing
Phases
neutrophils
collagen
Inflammatory cell infiltrates
Woundin...
Control Microbe
Brain (PVN) oxytocin positive cells using immunohistochemistry
Plasma corticosterone
Dietary microbes bias...
You are invited to participate in a research project.
Our research aims to investigate the connection of healthful bacteri...
MuscleFibersBodyMorphology
Humanmicrobesovertime
‘Fast Food’
Control
Muscle weight/body weight Muscle fiber size
‘Fast Foo...
gut inflammation
brain
thymus
HYPOTHESIS
FoxN1
bacteria neutrophils
oxytocin
oxytocin
public health impact!
Sexy!Shiny!Skinny!
Thank you!
NIH R01-CA108854 (Erdman)
NIH P30-ES002109 (Erdman & Alm)
• Comparative Medicine (MIT)
• Eric Alm and lab (MIT-...
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
Harnessing Microbes for Good Health
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Harnessing Microbes for Good Health

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Presentation by Susan Erdman, DVM

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Harnessing Microbes for Good Health

  1. 1. You are what you eat (sort of) : targeting microbes for good health SE Erdman, MIT DCM
  2. 2. sick healthy
  3. 3. sick healthy
  4. 4. TEFF TREG Healthful longevity Th-2Th-1 Th-17 sick
  5. 5. TREGTEFF
  6. 6. brain microbes Testing Microbes in Good Health ? epithelia
  7. 7. Why use animal models?
  8. 8. Gut microbially-triggered systemic events (modified from Coombs, et al 2005; Fiona Powrie lab) Neutrophil recruitment Macrophages Inflammatory cytokines Migration and maturation Dendritic Cells TR IL10 IL10 IL10 TE TE CD40-CD40L TR TGFb IL10 TGFb IL10
  9. 9. TREGTH17 sick healthy TH17 TREG Immune Balance Immune Dysregulation
  10. 10. Adoptive Transfer Models of Inflammation TREG cellsTEFF cells No IBD IBD No IBD No cells (modified from Powrie 1995)
  11. 11. Fatter Thinner
  12. 12. Probiotics? Yummy.
  13. 13. Yassin IbrahimBernard Varian Tatiana Levkovich
  14. 14. brain microbes Testing Microbes in Good Health ? epithelia
  15. 15. Oral dosing with L. reuteri in water Lactobacillus reuteri human breast milk Bacteria fed to mice in drinking water gut brain gut bacteria immunity
  16. 16. controlprobiotic‘Fastfood’ ‘Fastfood’ +probiotic
  17. 17. sick healthy TREGTH17 TH17 TREG
  18. 18. frequent = at least once a week up to daily Humans Eating at Fast Food Restaurants * P<0.05
  19. 19. MuscleFibersBodyMorphology Humanmicrobesovertime ‘Fast Food’ Control Muscle weight/body weight Muscle fiber size ‘Fast Food’ Microbe treated Control Microbe treated Control Microbe treated DAYS Control Thymus weight/body weight Growth hormone Microbe Control Microbe Control MicrobeControl Microbe ‘Fast Food’ + microbeControl chow Control chow + microbe Microbes help reduce body fat and increase muscle fiber size Human microbiome changes are on daily timescales and according to diet. ThymusGland ratio ratio Wounds at 5 days after shaving and biopsy Microbes facilitate wound healing throughout the body, and rapidly enlarge thymus gland size and consequently change the immune system and restore health
  20. 20. Hair follicles (HF) in subcutis
  21. 21. Hair follicles (HF) in subcutis
  22. 22. Paired testis weight
  23. 23. + Probiotics (elderly Swiss male)
  24. 24. Oral dosing with L. reuteri in water Lactobacillus reuteri human breast milk Bacteria fed to mice in drinking water gut brain gut bacteria immunity
  25. 25. TREGTH17TH17 TREG “Fast food” Beneficial Bacteria Sexy!Shiny!Skinny! Disease Health
  26. 26. Wound healing is 2X faster ControlL.reuteri WoundHealing Phases neutrophils collagen Inflammatory cell infiltrates Wounding neutrophils collagen lymphocytes Inflammatory cell infiltrates lymphocytes Day6 Day 0 Day 6 Day 12
  27. 27. Control Microbe Brain (PVN) oxytocin positive cells using immunohistochemistry Plasma corticosterone Dietary microbes bias stress responses in mouse models Plasma oxytocin Untreated Microbes Untreated Microbes Corticosterone,ng/ml Oxytocin,pg/ml
  28. 28. You are invited to participate in a research project. Our research aims to investigate the connection of healthful bacteria to skin health and wound healing. Previous studies show a link between probiotic bacteria, radiant skin and shiny hair. We are looking for female volunteers, ages 19-40, who are healthy and not taking any medication. The study involves taking a probiotic supplement daily and undergoing a small skin biopsy. The total involvement is 5 weeks. Help us discover the key to “glow of health” If you are interested in receiving more information, please contact Eliška Didyk at eliska@mit.edu. Pilot Study in Human Subjects Division of Comparative Medicine Contact: serdman@mit.edu
  29. 29. MuscleFibersBodyMorphology Humanmicrobesovertime ‘Fast Food’ Control Muscle weight/body weight Muscle fiber size ‘Fast Food’ Microbe treated Control Microbe treated Control Microbe treated DAYS Control Thymus weight/body weight Growth hormone Microbe Control Microbe Control MicrobeControl Microbe ‘Fast Food’ + microbeControl chow Control chow + microbe Microbes help reduce body fat and increase muscle fiber size Human microbiome changes are on daily timescales and according to diet. ThymusGland ratio ratio Wounds at 5 days after shaving and biopsy Microbes facilitate wound healing throughout the body, and rapidly enlarge thymus gland size and consequently change the immune system and restore health
  30. 30. gut inflammation brain thymus HYPOTHESIS FoxN1 bacteria neutrophils oxytocin oxytocin
  31. 31. public health impact! Sexy!Shiny!Skinny!
  32. 32. Thank you! NIH R01-CA108854 (Erdman) NIH P30-ES002109 (Erdman & Alm) • Comparative Medicine (MIT) • Eric Alm and lab (MIT-Broad) • David Hafler and lab (Yale-Broad)

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