Harnessing Microbes for Good Health
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Presentation by Susan Erdman, DVM
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Harnessing Microbes for Good Health
- 1. You are what you eat (sort of) : targeting microbes for good health SE Erdman, MIT DCM
- 3. sick healthy
- 4. sick healthy
- 5. TEFF TREG Healthful longevity Th-2Th-1 Th-17 sick
- 6. TREGTEFF
- 9. brain microbes Testing Microbes in Good Health ? epithelia
- 10. Why use animal models?
- 11. Gut microbially-triggered systemic events (modified from Coombs, et al 2005; Fiona Powrie lab) Neutrophil recruitment Macrophages Inflammatory cytokines Migration and maturation Dendritic Cells TR IL10 IL10 IL10 TE TE CD40-CD40L TR TGFb IL10 TGFb IL10
- 13. Adoptive Transfer Models of Inflammation TREG cellsTEFF cells No IBD IBD No IBD No cells (modified from Powrie 1995)
- 14. Fatter Thinner
- 16. Yassin IbrahimBernard Varian Tatiana Levkovich
- 17. brain microbes Testing Microbes in Good Health ? epithelia
- 18. Oral dosing with L. reuteri in water Lactobacillus reuteri human breast milk Bacteria fed to mice in drinking water gut brain gut bacteria immunity
- 23. frequent = at least once a week up to daily Humans Eating at Fast Food Restaurants * P<0.05
- 24. MuscleFibersBodyMorphology Humanmicrobesovertime ‘Fast Food’ Control Muscle weight/body weight Muscle fiber size ‘Fast Food’ Microbe treated Control Microbe treated Control Microbe treated DAYS Control Thymus weight/body weight Growth hormone Microbe Control Microbe Control MicrobeControl Microbe ‘Fast Food’ + microbeControl chow Control chow + microbe Microbes help reduce body fat and increase muscle fiber size Human microbiome changes are on daily timescales and according to diet. ThymusGland ratio ratio Wounds at 5 days after shaving and biopsy Microbes facilitate wound healing throughout the body, and rapidly enlarge thymus gland size and consequently change the immune system and restore health
- 28. Hair follicles (HF) in subcutis
- 29. Hair follicles (HF) in subcutis
- 32. + Probiotics (elderly Swiss male)
- 34. Oral dosing with L. reuteri in water Lactobacillus reuteri human breast milk Bacteria fed to mice in drinking water gut brain gut bacteria immunity
- 35. TREGTH17TH17 TREG “Fast food” Beneficial Bacteria Sexy!Shiny!Skinny! Disease Health
- 37. Wound healing is 2X faster ControlL.reuteri WoundHealing Phases neutrophils collagen Inflammatory cell infiltrates Wounding neutrophils collagen lymphocytes Inflammatory cell infiltrates lymphocytes Day6 Day 0 Day 6 Day 12
- 39. Control Microbe Brain (PVN) oxytocin positive cells using immunohistochemistry Plasma corticosterone Dietary microbes bias stress responses in mouse models Plasma oxytocin Untreated Microbes Untreated Microbes Corticosterone,ng/ml Oxytocin,pg/ml
- 40. You are invited to participate in a research project. Our research aims to investigate the connection of healthful bacteria to skin health and wound healing. Previous studies show a link between probiotic bacteria, radiant skin and shiny hair. We are looking for female volunteers, ages 19-40, who are healthy and not taking any medication. The study involves taking a probiotic supplement daily and undergoing a small skin biopsy. The total involvement is 5 weeks. Help us discover the key to “glow of health” If you are interested in receiving more information, please contact Eliška Didyk at eliska@mit.edu. Pilot Study in Human Subjects Division of Comparative Medicine Contact: serdman@mit.edu
- 41. MuscleFibersBodyMorphology Humanmicrobesovertime ‘Fast Food’ Control Muscle weight/body weight Muscle fiber size ‘Fast Food’ Microbe treated Control Microbe treated Control Microbe treated DAYS Control Thymus weight/body weight Growth hormone Microbe Control Microbe Control MicrobeControl Microbe ‘Fast Food’ + microbeControl chow Control chow + microbe Microbes help reduce body fat and increase muscle fiber size Human microbiome changes are on daily timescales and according to diet. ThymusGland ratio ratio Wounds at 5 days after shaving and biopsy Microbes facilitate wound healing throughout the body, and rapidly enlarge thymus gland size and consequently change the immune system and restore health
- 44. Thank you! NIH R01-CA108854 (Erdman) NIH P30-ES002109 (Erdman & Alm) • Comparative Medicine (MIT) • Eric Alm and lab (MIT-Broad) • David Hafler and lab (Yale-Broad)