4. Fundamental components of
nucleid acids:
•Acid component: Phosphates
Neutral component: Sugar
•Basic component: Nitrgenous
bases
Structural levels:
Pramary:leneal polymer
Secondary: association of
two poli-nucleotide chains
throught the nitrogenous
bases
Superor order: all three-
dimensional structures
5. Monday, January 28, 2013 -
10:30 in Biology & Nature
At the Max Planck
Institute of
Biochemistry in
Martinsried near
Munich scientists have
now elucidated the
structure of a ring-
shaped protein
complex (SMC-kleisin),
which ensures order in
this packaging process.
6.
7.
8.
9. I think it is very important for
science discovery of complex
proteins that act SMC-kleisin
embaleje DNA in the cell division
process because thanks to these
proteins is possible to get a better
understanding of the organization of
chromosomes and i like the article
because it links the protein complex
with disorders such as cancer and
genetic defects as the example of
trisomy 21
10. January 24th in the journal Cell
Cancer is thought to
arise from DNA damage
at fragile sites in the
genome. A new class of
fragile sites that
contributes to DNA
alterations in a type of
blood cancer called B
cell lymphoma
11. DNA damage can Because immune system
occur at fragile sites cells called B cell
when DNA is lymphocytes are among
replicated prior to the most rapidly dividing
cell division, and cells, they are at great
regions that are hard risk for replication-
to copy are induced DNA damage
especially prone to
double-strand breaks
B lymphocytes can
acquire double-
strand breaks
which causes a lot of through the action of
collateral damage in the an enzyme that helps
genome, storing up build antibody genes
problems that get called activation-
exacerbated during induced cytidine
replication deaminase (AID)
12.
13. Cancer is an evolving disease, and DNA damage
associated with replication is one of the
processes occurring in malignant cells to help
them adapt and survive when a tumor
metastasizes
14. I think this article has a great
clinical importance, the
discovery of these fragile sites
in replication could mean the
beginning to design effective
treatments for lymphoma cells
and subsequently by other
types of cancer,
understanding how replication
can induce DNA damage is
very useful to know how
cancer arises
15. The SMC-kleisin protein complex are related
packaging of DNA and therefore play an
important role in maintaining the structure of
nucleic acids.
16. Damage to this structure lead to diseases such as
cancer and genetic defects as the example of
trisomy 21, therefore to ensure a secure
complimentary DNA during division the fibers
must be correctly packed.
17. The discovery of regions prone to DNA damage
can mean the beginning of new treatments for
cancer management.
18. The study is based mainly on the study of B-cell
lymphoma because the fragile sites were found
in B lymphocytes through its division rate but the
study of these could lead to the treatment of
other types of cancer.
19. Martínez Sánchez, Lina María. Biologia molecular. 7ª
edition .Upb medical faculty.
What Holds Chromosomes Together? Structure of DNA-
Packaging Proteins Described. Biology & Nature. January
28, 2013
Discovery of New Class of Damage-Prone DNA Regions
Could Lead to Better Cancer Treatments. Journal Cell.
January 24, 2013
