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Puerperium and
Lactation
Puerperium
• The puerperium is the period from after 3rd stage of
labor to 6 weeks after delivery
• During the puerperium the pelvic organs return to the
non - gravid state, the metabolic changes of pregnancy
are reversed and lactation is established
• the early puerperium is especially dangerous and most
maternal deaths occur during this time
• It carries the highest risk of developing VTE
The uterus
• By 6 weeks after birth the uterus has returned to its
normal size (100 g )
• cells diminish in size &no effect on the number of
muscle cells
• Immediately after labor the uterus is 12 cm above the
symphysis pubis (4 cm below umbilicus)
• no longer palpable abdominally by 2 weeks after
delivery
• by the end of the second week the internal os
should be closed
2 weeks cant be felt , 6 weeks prepregnancy size
Time Uterus size
Day 1 post partum 18 weeks size
Day 7 14 weeks
Day 14 12 weeks
After day 14 Not palpable
• Hemostasis immediately by arterial smooth muscle
contraction and compression of vessels by the uterine
muscle.
• Lochia:
red (rubra )
yellow (serosa)(3rd-4th day)
white mucopurulent(alba)
mean duration of 22 – 27 days.
• A new endometrium will grow from the
basal layers of the decidua but this is
influenced by the method of infant
feeding
• new endometrium within 3 – 4 weeks if
non lactating and few months if lactating
Ovarian function
• Lactating women:
- Ovulation – after 6 months
- Prolactin levels decrease back to normal levels after 6 weeks
- Amenorrhea
• Non-lactating women:
- Ovulation – 70 days
- Menstruation resumes after 7 weeks.
- Prolactin levels decrease back to normal levels after 3 weeks
Hematological & CVS changes
COP , SV , HR will be normal in 2 days
Blood pressure and plasma volume will increased
initially for few days then return to normal
Coagulation factors and platelets will return to
normal in 3-6 weeks
Initial rise in platelets then back to normal
Initial rise in WBc then return to normal
Thyroid function
• Size will be normal by 12 weeks
and level of hormones will be
normal in 4 weeks
Weight loss
• There is an immediate loss of 5 kg following
birth due to the baby, the placenta, amniotic
fluid and blood loss that occurs at delivery
• Most will return to pre pregnancy weight by 6
months but some will gain a net weight of 5
kgs
• Breast feeding is not related to weight loss if
less than 6 months
Hair loss
• May occur … needs 6 months to 1 year to
return to normal
Changes in lab parameters
Urinary tract
• The hydrouretur and pelvic dilation in
the kidneys are almost eliminated by 2-
3 weeks and completely return to
normal by 6-8 weeks after birth
• Catheterization and manipulation may
lead to UTI (Ecoli )
• Urine retention is common
(PG, epidural and instrumental )
(48 hours catheterization )
To minimize the risk women with spinal
anesthesia , leave catheter for 12 hrs
Anal incontinence
• Especially those with 3rd and 4th degree tears
and forceps delivery
• Symptoms occur in 6-10 %
• Sonographic evidence in 1/3 of PG and 70 % in
patients delivered using(asymptomatic)
• Most of them will be asymptomatic by 12
months
• Pelvic floor exercise
Secondary postpartum
hemorrhage
Defined as : bleeding from the genital tract between 24
hours and 6 weeks after delivery
Rule out endometritis and retained POC
Antibiotic , uterotonic , evacuation ?
Secondary PPH , fever , abdominal pain and offensive discharge is
suggestive for endometritis and needs admission with IV
antibiotics
Nerve injury
• Meralgia (lateral cutaneous femoral nerve)
• Foot drop (common peroneal nerve)
• Nerve injuries in CS: ilioinguinal, iliohypogastic
• Femoral nerve palsy : medial anterior thigh
numbness and unable to flex knee
Perineal pain
• 80 % in the first 3 days (maybe up to 10 days)
• Spontaneous opening of repaired perineal
tears and episiotomies is usually the result of
secondary infection , leave for secondary
intention
VTE & PE
• Pulmonary embolism is the most serious cause
of death in the puerperium
• VTE is the most common cause of direct
maternal death
• Assess the risk and manage accordingly but
hydration and early manipulation is essential
+-LMWH
Postpartum fever
• It is the presence of fever > 38c, >2 occasions, >6 hours
apart excluding the first 24 hours
• UTI ( E Coli )
• Endometritis (polymicrobial and 50% GAS ) 5%
• wound infection(staph aureus )
• septic thrombophlebitis
• Mastitis (staph aureus )
• Sepsis (GAS )
Important causes of puerperal
sepsis
Sepsis
• Present with 2ry PPH , abdominal pain , uterine
tenderness , foul smelling discharge , signs of sepsis
• Polymicrobial
• Cs , PPROM , PTL , GBS and chlamydia positive are at
higher risk
• Treated as inpaitnet with IV amp, Genta +-
metronidazole , or by piperacillin azopactam
(other regimens are used )
Endometritis
Management
Regimen for chorioamnionitis
and endometritis
Mastitis
• Stasis of milk and engorgement of breast with
infection
• Most commonly by staph aureus
• Treated with antibiotic (flucloxacillin, clindamycin)
• Abscess needs breast ultrasound and drainage with
antibiotic cover
Psychological disorders
The ‘pinks’:
for the first 24–48 hours following
delivery elevation of mood, a feeling
of excitement, overactivity and
difficulty sleeping.
• 80%
• the first 2 weeks after delivery.
• Fatigue, short temper, difficulty sleeping, depressed mood
and tearfulness
• Resolves spontaneously in the majority of cases
• Reassurance & support
• (no need for admission or medications)
BLUES
Depression
• 10-15 %
• Occur around 6 weeks postnatal
• Screened by Edinburgh Postnatal Depression Scale
Risk factors for postnatal depressive illness
• Past history of psychiatric illness.
• Depression during pregnancy.
• Obstetric factors (e.g. caesarean section/fetal or
neonatal loss).
• Social isolation and deprivation.
• Poor relationships.
• Recent adverse life events (bereavement/illness).
• Severe postnatal ‘blues’.
• Symptoms :
Lack of interest
Impaired concentration.
Tearfulness.
Feelings of guilt and failure.
Anxiety
Treatment :
• Cognitive–behavioral therapy (1st line )
• Drug therapy (second line or history of depression) SSRI
Postpartum psychosis
• 0.1-0.2 %
• Occur after 4 weeks postnatally
• Usually there is a history of psychological
illness (personal or family )
• refer urgently to a psychiatrist
• Admit to a mother-and-baby unit
Lactation
Prolactin and return of
menstrual cycle
• Prolactin level return to normal in 3 weeks if
not lactating and remain elevated if lactating
• In lactating women average period for
menstruation is 7 months (28 weeks ) and
ovulation needs further 2 months (9 months )
• Lactational method as contraception has 98 %
success rate if * exclusively breastfeeding ,
less than 6 months , amenorrhea .
Lactation & breast milk
•Protection against infections:
(IgA ,lysosome, lactoferrin , enhance flora )
Breast-feeding largley protects against
gastrointestinal tract infections and to a lesser
extent against respiratory tract infections.
reduced incidence of diarrhea and vomitting
compared to thoses who are bottle-fed
Advantage of breast milk
• improved childhood cognitive functions
• decreases the incidence of atopic illness such as eczema
and asthma
• decreased risk of juvenile DM and neoplastic disease
- protects preterm infants from developing necrotizing
enterocolitis
- Artificially fed children have twice the risk of developing
childhood obesity and high blood pressure than breast-fed
children
- There is a decreased risk of breast cancer among women
who breastfeed their babies
• -
Advantage of breast milk…..
Physiology of lactation
• At puberty, estrogen , growth hormone promotes
ducts growth
• Progesterone promotes growth of milk-producing
alveolar cells
• After delivery, progesterone levels fall allowing the
positive effect of prolactin on milk production
• During pregnancy progesterone , estrogen , growth
hormone , HPL , prolactin helps in breast tissue
prperation and milk production
Milk production and ejection
• Milk production is stimulated by prolactin which acts on
glandular cells of the breast to stimulate milk secretion
• Milk ejection is stimulated by oxytocin which acts on
myoepithelial cells that contract causing milk ejection
• Prolactin and oxytocin secretion is stimulated by
suckling, and oxytocin secretion is also stimulated by
seeing the infant or hearing its cry
Medications while breastfeeding
Medications while breastfeeding
Lactation as a contraceptive
method
• Lactation can be 98% effective as
contraception if:
- The infant is exclusively breastfed,
- Lactation is done regularly at intervals of 4
hours during the day and 6 hours during the
night
- Before 6 months
- Amenorrhea
Mechanism of lactational amenorrhea:
- Suckling alters hypothalamic sensitivity to estrogen,
making it more sensitive to negative feedback than
positive feedback.
- The pituitary produces enough FSH and LH to start
follicle development but the consequent estrogen
secretion will inhibit gonadotropins production thus
failure of ovulation occurs .
Postpartum contraception
COC : 6 months if breast feeding
3 weeks if not breast feeding
POP :
after 3 weeks if breast feeding and immediately if not breast
feeding
IUCD : not less than 28 days or within 48 hrs*
Cap : 6 weeks
Injectable : 6 weeks (can be earlier )

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Lecture 2 Puerperium and Lactation

  • 2. Puerperium • The puerperium is the period from after 3rd stage of labor to 6 weeks after delivery • During the puerperium the pelvic organs return to the non - gravid state, the metabolic changes of pregnancy are reversed and lactation is established • the early puerperium is especially dangerous and most maternal deaths occur during this time • It carries the highest risk of developing VTE
  • 3. The uterus • By 6 weeks after birth the uterus has returned to its normal size (100 g ) • cells diminish in size &no effect on the number of muscle cells • Immediately after labor the uterus is 12 cm above the symphysis pubis (4 cm below umbilicus) • no longer palpable abdominally by 2 weeks after delivery • by the end of the second week the internal os should be closed 2 weeks cant be felt , 6 weeks prepregnancy size
  • 4. Time Uterus size Day 1 post partum 18 weeks size Day 7 14 weeks Day 14 12 weeks After day 14 Not palpable
  • 5. • Hemostasis immediately by arterial smooth muscle contraction and compression of vessels by the uterine muscle. • Lochia: red (rubra ) yellow (serosa)(3rd-4th day) white mucopurulent(alba) mean duration of 22 – 27 days.
  • 6. • A new endometrium will grow from the basal layers of the decidua but this is influenced by the method of infant feeding • new endometrium within 3 – 4 weeks if non lactating and few months if lactating
  • 7. Ovarian function • Lactating women: - Ovulation – after 6 months - Prolactin levels decrease back to normal levels after 6 weeks - Amenorrhea • Non-lactating women: - Ovulation – 70 days - Menstruation resumes after 7 weeks. - Prolactin levels decrease back to normal levels after 3 weeks
  • 8. Hematological & CVS changes COP , SV , HR will be normal in 2 days Blood pressure and plasma volume will increased initially for few days then return to normal Coagulation factors and platelets will return to normal in 3-6 weeks Initial rise in platelets then back to normal Initial rise in WBc then return to normal
  • 9. Thyroid function • Size will be normal by 12 weeks and level of hormones will be normal in 4 weeks
  • 10. Weight loss • There is an immediate loss of 5 kg following birth due to the baby, the placenta, amniotic fluid and blood loss that occurs at delivery • Most will return to pre pregnancy weight by 6 months but some will gain a net weight of 5 kgs • Breast feeding is not related to weight loss if less than 6 months
  • 11. Hair loss • May occur … needs 6 months to 1 year to return to normal
  • 12. Changes in lab parameters
  • 13. Urinary tract • The hydrouretur and pelvic dilation in the kidneys are almost eliminated by 2- 3 weeks and completely return to normal by 6-8 weeks after birth • Catheterization and manipulation may lead to UTI (Ecoli ) • Urine retention is common (PG, epidural and instrumental ) (48 hours catheterization ) To minimize the risk women with spinal anesthesia , leave catheter for 12 hrs
  • 14. Anal incontinence • Especially those with 3rd and 4th degree tears and forceps delivery • Symptoms occur in 6-10 % • Sonographic evidence in 1/3 of PG and 70 % in patients delivered using(asymptomatic) • Most of them will be asymptomatic by 12 months • Pelvic floor exercise
  • 15. Secondary postpartum hemorrhage Defined as : bleeding from the genital tract between 24 hours and 6 weeks after delivery Rule out endometritis and retained POC Antibiotic , uterotonic , evacuation ? Secondary PPH , fever , abdominal pain and offensive discharge is suggestive for endometritis and needs admission with IV antibiotics
  • 16. Nerve injury • Meralgia (lateral cutaneous femoral nerve) • Foot drop (common peroneal nerve) • Nerve injuries in CS: ilioinguinal, iliohypogastic • Femoral nerve palsy : medial anterior thigh numbness and unable to flex knee
  • 17. Perineal pain • 80 % in the first 3 days (maybe up to 10 days) • Spontaneous opening of repaired perineal tears and episiotomies is usually the result of secondary infection , leave for secondary intention
  • 18. VTE & PE • Pulmonary embolism is the most serious cause of death in the puerperium • VTE is the most common cause of direct maternal death • Assess the risk and manage accordingly but hydration and early manipulation is essential +-LMWH
  • 19. Postpartum fever • It is the presence of fever > 38c, >2 occasions, >6 hours apart excluding the first 24 hours • UTI ( E Coli ) • Endometritis (polymicrobial and 50% GAS ) 5% • wound infection(staph aureus ) • septic thrombophlebitis • Mastitis (staph aureus ) • Sepsis (GAS )
  • 20. Important causes of puerperal sepsis
  • 22. • Present with 2ry PPH , abdominal pain , uterine tenderness , foul smelling discharge , signs of sepsis • Polymicrobial • Cs , PPROM , PTL , GBS and chlamydia positive are at higher risk • Treated as inpaitnet with IV amp, Genta +- metronidazole , or by piperacillin azopactam (other regimens are used ) Endometritis
  • 25. Mastitis • Stasis of milk and engorgement of breast with infection • Most commonly by staph aureus • Treated with antibiotic (flucloxacillin, clindamycin) • Abscess needs breast ultrasound and drainage with antibiotic cover
  • 26.
  • 27.
  • 28.
  • 29. Psychological disorders The ‘pinks’: for the first 24–48 hours following delivery elevation of mood, a feeling of excitement, overactivity and difficulty sleeping.
  • 30. • 80% • the first 2 weeks after delivery. • Fatigue, short temper, difficulty sleeping, depressed mood and tearfulness • Resolves spontaneously in the majority of cases • Reassurance & support • (no need for admission or medications) BLUES
  • 31. Depression • 10-15 % • Occur around 6 weeks postnatal • Screened by Edinburgh Postnatal Depression Scale Risk factors for postnatal depressive illness • Past history of psychiatric illness. • Depression during pregnancy. • Obstetric factors (e.g. caesarean section/fetal or neonatal loss). • Social isolation and deprivation. • Poor relationships. • Recent adverse life events (bereavement/illness). • Severe postnatal ‘blues’.
  • 32. • Symptoms : Lack of interest Impaired concentration. Tearfulness. Feelings of guilt and failure. Anxiety Treatment : • Cognitive–behavioral therapy (1st line ) • Drug therapy (second line or history of depression) SSRI
  • 33. Postpartum psychosis • 0.1-0.2 % • Occur after 4 weeks postnatally • Usually there is a history of psychological illness (personal or family ) • refer urgently to a psychiatrist • Admit to a mother-and-baby unit
  • 34.
  • 36. Prolactin and return of menstrual cycle • Prolactin level return to normal in 3 weeks if not lactating and remain elevated if lactating • In lactating women average period for menstruation is 7 months (28 weeks ) and ovulation needs further 2 months (9 months ) • Lactational method as contraception has 98 % success rate if * exclusively breastfeeding , less than 6 months , amenorrhea .
  • 38. •Protection against infections: (IgA ,lysosome, lactoferrin , enhance flora ) Breast-feeding largley protects against gastrointestinal tract infections and to a lesser extent against respiratory tract infections. reduced incidence of diarrhea and vomitting compared to thoses who are bottle-fed Advantage of breast milk
  • 39. • improved childhood cognitive functions • decreases the incidence of atopic illness such as eczema and asthma • decreased risk of juvenile DM and neoplastic disease - protects preterm infants from developing necrotizing enterocolitis - Artificially fed children have twice the risk of developing childhood obesity and high blood pressure than breast-fed children - There is a decreased risk of breast cancer among women who breastfeed their babies • - Advantage of breast milk…..
  • 40. Physiology of lactation • At puberty, estrogen , growth hormone promotes ducts growth • Progesterone promotes growth of milk-producing alveolar cells • After delivery, progesterone levels fall allowing the positive effect of prolactin on milk production • During pregnancy progesterone , estrogen , growth hormone , HPL , prolactin helps in breast tissue prperation and milk production
  • 41. Milk production and ejection • Milk production is stimulated by prolactin which acts on glandular cells of the breast to stimulate milk secretion • Milk ejection is stimulated by oxytocin which acts on myoepithelial cells that contract causing milk ejection • Prolactin and oxytocin secretion is stimulated by suckling, and oxytocin secretion is also stimulated by seeing the infant or hearing its cry
  • 44. Lactation as a contraceptive method • Lactation can be 98% effective as contraception if: - The infant is exclusively breastfed, - Lactation is done regularly at intervals of 4 hours during the day and 6 hours during the night - Before 6 months - Amenorrhea
  • 45. Mechanism of lactational amenorrhea: - Suckling alters hypothalamic sensitivity to estrogen, making it more sensitive to negative feedback than positive feedback. - The pituitary produces enough FSH and LH to start follicle development but the consequent estrogen secretion will inhibit gonadotropins production thus failure of ovulation occurs .
  • 46. Postpartum contraception COC : 6 months if breast feeding 3 weeks if not breast feeding POP : after 3 weeks if breast feeding and immediately if not breast feeding IUCD : not less than 28 days or within 48 hrs* Cap : 6 weeks Injectable : 6 weeks (can be earlier )