High Burden of VENO-OCCLUSIVE DISEASE: A Pilot Real World Evidence study by NOVEL Health Strategies

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Veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT) conditioning or high-dose non-transplant chemotherapy. VOD/SOS with multi-organ dysfunction (MOD) is associated with a mortality rate of > 80% (Richardson, Aggarwal et al). The VOD Health Economics and Outcomes Research (HEOR) team at NOVEL Health Strategies recently conducted an exploratory analysis of all-payer national database to develop hypothesis on burden of VOD in Medicaid patients

Healthcare

Burden of Veno-Occlusive Disease in US Medicaid Patients
Pilot RWE Analysis by NOVEL Health Strategies
February 2022
NOVEL Leads
Saurabh (Rob) Aggarwal, PhD
Ozlem Topaloglu, MPH, PhD
NOVEL Health Strategies
sa@novelhealthstrategies.com
www.NOVELHealthStrategies.com
NOVEL Health Strategies, Washington DC, +1-646-717-4789, www.NOVELHealthStrategies.com

Mean LOS for Medicaid VOD patients is 53.5 days (more than
double of Medicare patients)

Mean Hospital charges for Medicaid VOD patients are $1.5 Millon

Mortality in Medicaid VOD patients is ~16% (for Medicare it was 33%)

Medicaid VOD patients have significantly higher co-morbidities

While 33% of Medicare patients came to hospital via ED, most
Medicaid patients were directly admitted to the hospital

Co-diagnosis trend shows 100% of Medicaid patients had liver disease

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Running head: CHRONIC KIDNEY DISEASE 1 Chronic Kidney Disease: Problems, Perceptions, and Strategies for Intervention David Brown Walden University HLTH 4900, Section 2, Capstone November 16, 2013 Instructor: Dr. Jody Early CHRONIC KIDNEY DISEASE: PROBLEMS, PERCEPTIONS, AND STRATEGIES FOR INTERVENTION 2 Abstract Chronic kidney disease is considered one of the most significant health issues affecting morbidity and mortality and contributes heavily to the state of global health. Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are chronic illnesses that have a dramatic impact on the cost of health care delivery in the United States. Early detection and intervention are critical to the long-term prognosis of this patient population; however, a health disparity exists because not everyone who is at risk for CKD has access to resources for screening and treatment. One of the goals of community-level and national programs is to create parity of care by focusing attention on marginalized communities that are at a statistically higher risk for CKD. The global impact of CKD and ESRD is significant because long-term survival depends on expensive technology and many regions of the world lack the resources needed to treat this disease. Health behavior and culture are known contributors to the long-term survivability of the disease. Since early detection is the key, creating screening programs that target populations at greatest risk will have the highest impact, and be the most cost-effective solution to combating this chronic illness. CHRONIC KIDNEY DISEASE: PROBLEMS, PERCEPTIONS, AND STRATEGIES FOR INTERVENTION 3 Chronic Kidney Disease: Problems, Perceptions, and Strategies for Intervention Chronic kidney disease (CKD) is considered one of the primary global health issues and contributes significantly to the social burden of care. CKD, along with cardiovascular disease, diabetes, chronic respiratory disease, and cancer, is a chronic illness that is classified as a non- communicable disease (Healthy People 2020, 2013). Non-communicable diseases have a significant societal impact to domestic growth, productivity, and health care costs and are the most common cause of morbidity and premature death in the United States (Couser, Remuzzi, Mendis, & Tonelli, 2011). Chronic illnesses are also characterized by physical and emotional stressors that can become overwhelming when simultaneously coping with multiple comorbidities (Moulton, 2008). Although the World Health Assembly has determined that non- communicable diseases contribute heavily to the state of global health, they concede that public health policy can dramatically affect patient morbidity and mortality (Couser et al., 2011). CKD is a public health threat that is on the rise and will likely not slow without deliberate intervention. This literature review will describe the impact that chronic kid.

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