This document discusses opportunities and challenges in the natural products industry. It describes natural products as substances produced by organisms found in nature, with diverse sources and bioactive properties. Major opportunities include new drug discovery from botanicals and other sources, as well as applications in agriculture, food science, bioenergy, and industry. Challenges include providing meaningful data to diverse clients, managing expectations, and overcoming stereotypes to establish credibility in an expanding field. The document promotes natural products research as having a positive impact and standing at the intersection of past knowledge and future potential.

1. Opportunities and challenges in an
expanding industry

2. What are “Natural Products”?
 “Substances produced by
organisms found in nature”
 Diverse sources, structures,
and activities
 Most of economic interest
are bioactive

3. Diverse Sources and Activities
 Bioactive Natural products
found in all Kingdoms
 Animals
 Insects
 Microbes
 Bacteria
 Fungi
 Yeast
 Algae
 Cyanobacteria
 Plants

4. Botanicals
 Remains primary source of
Natural Product discovery
 Traditional and modern source
of medicines
 Huge biological diversity
 Highly efficient producers

5. Opportunities
 New drug discovery
 “Lead Principles” found
through bio-prospecting
 Extracted
 Synthesized
 Analogs
 Derivatives
 Marketed as pharmaceuticals

6. Drug Discovery
Amrubicin Cefditoren Fumagillin Retapamulin
Anidulafungin Cilazapril Galantamine Rifamycin
Codinaeopsin Ixabepilone Romidepsin
Apomorphine
Colchicine Lisdexamfetamine Rosuvastatin
Artemotil Cyclosporine Mescaline Spiruchostatins
Aztreonam Daptomycin Methylnaltrexone Telavancin
Biapenem Dimethyltryptamine Micafungin Telithromycin
Blaxin Docetaxel Miglustat Temsirolimus
Doripenem Morphine Tetracycline
Bivalirudin
Dronabinol Mycophenolate Tigecycline
Bleomycin Erythomycin Nitisinone Tiotropium
Calcineurin Ergotamine Orlistat Trabectedin
Capsaicin Ertapenem Paclitaxel Ziconotide
Captopril Everolimus Penicillin Zithromax
Exenatide Phenethylamine Zotarolimus
Caspofungin
Pimecrolimus

7. Opportunities
Agriculture
 Bio-pesticides
 Herbicides
 Insecticides
 Fungicides
 Bactericides
 Fertilizers

8. Opportunities
Food Science
 Flavoring agents
 Preservatives
 Binding agents
 Nutraceuticals

9. Opportunities
Bio-Energy
 Biofuels
 Bio-alcohols
 Bio-diesels
 Algal Hydrocarbons
 Bio-gasses

10. Opportunities
Industry
 Catalysts
 Bio-plastics
 Cryo-protectants
 Pigments

11. The Natural Products Lab
 Specialize in
Botanicals
 Focus on dietary supplements
 Analysis for GMP labeling
 Quality assurance
 New product development
 Research
 Other botanical commodities
 Hops
 Other food products
 Oils

12. Challenges
 Providing meaningful data
 Client-driven method
development
 Diverse sample matrices
 Little available literature
287.956 µg/ml
 Business vs. Science oriented
clients 97.54 mgVCE/g
 Offering context without 7.59% w/w α-acids
conclusions

13. Challenges
 Managing Client
Expectations
 “CSI” Effect
 “Test This”
 Is it Good?
 Synergistic effects
 “Out of the box” clientele

14. Challenges
 Overcoming stereotypes
 Establishing and
maintaining credibility
 KEEPING UP!

15. The Good News
 Never a dull moment
 Positive impact for a
growing industry in NC
 One foot in the past…
One foot in the future

16. Thank you for your Time.
 I’ll try to answer any questions I can.