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Project Statement In order to contribute to the discovery of antimalarial drugs, extracts from Tanzanian marine organisms ...
Goal Discovery of antimalarial compounds from marine invertebrates as an initial step for the  development of antimalarial...
Objectives <ul><li>Collection and taxonomic identification of 200-250 marine invertebrates (Sponges and Tunicates) from Ta...
Indicators: Objective 1: Collection and taxonomic identification of 200-250 marine invertebrates (Sponges and tunicates) f...
Indicators Objective 2: Mapping of the identified marine invertebrates using GPS Identified marine invertebrates geographi...
Indicators Objective 3: In vitro screening of identified invertebrates for potential antimalarial activity At least 50 ide...
Indicators Objective 4: Isolation and characterization of active antimalarial compounds from these organisms <ul><li>At le...
Indicators Objective 5: Developing human resources and infrastructure to enhance antimalarial drug discovery in Tanzania <...
Objective 6: Collaborating with national, regional and international  networks in the field of antimalarial drug discovery...
<ul><li>Collection and identification of samples </li></ul><ul><li>Bioassay of extracts </li></ul><ul><li>Identification o...
Main steps <ul><li>Grant approval  </li></ul><ul><li>Study preparation </li></ul><ul><li>Seeking permits </li></ul><ul><li...
<ul><li>Field Work </li></ul><ul><ul><li>sample collection and labeling, transport in ice boxes and preservation for furth...
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Marine Drugs

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Marine Drugs

  1. 1. Project Statement In order to contribute to the discovery of antimalarial drugs, extracts from Tanzanian marine organisms will be screened to identify potential compounds by the year 2007
  2. 2. Goal Discovery of antimalarial compounds from marine invertebrates as an initial step for the development of antimalarial drugs
  3. 3. Objectives <ul><li>Collection and taxonomic identification of 200-250 marine invertebrates (Sponges and Tunicates) from Tanzanian sea </li></ul><ul><li>Mapping of the identified marine invertebrates using GPS </li></ul><ul><li>In vitro screening of identified invertebrates for potential antimalarial activity </li></ul><ul><li>Isolation and characterization of active antimalarial compounds from these organisms </li></ul><ul><li>Developing human resources and infrastructure to enhance antimalarial drug discovery in Tanzania </li></ul><ul><li>Collaborating/participating in national, regional and international networks in the field of antimalarial drug discovery </li></ul>
  4. 4. Indicators: Objective 1: Collection and taxonomic identification of 200-250 marine invertebrates (Sponges and tunicates) from Tanzanian seas <ul><li>200-250 samples collected by August 2004 </li></ul><ul><li>at least 50 of the collected marine invertebrates taxonomically identified by mid 2007 </li></ul>
  5. 5. Indicators Objective 2: Mapping of the identified marine invertebrates using GPS Identified marine invertebrates geographically located in Tanzanian seas
  6. 6. Indicators Objective 3: In vitro screening of identified invertebrates for potential antimalarial activity At least 50 identified marine invertebrates screened for potential antimalarial activity (by …..KEMRI)
  7. 7. Indicators Objective 4: Isolation and characterization of active antimalarial compounds from these organisms <ul><li>At least 10 Number of active antimalarial compounds isolated from the identified marine organisms </li></ul><ul><li>Number of active antimalarial compounds characterized from the identified marine organisms </li></ul>
  8. 8. Indicators Objective 5: Developing human resources and infrastructure to enhance antimalarial drug discovery in Tanzania <ul><li>One PhD and one MSc trained in chemistry of marine natural products and screening for antimalarial drugs by--- </li></ul><ul><li>One Postdoc.scientist trained in chemistry of marine microorganisms natural products by--- </li></ul><ul><li>Two technicians trained in screening for antimalarial drugs by--- </li></ul><ul><li>Laboratory equipped in phytochemistry and screening for antimalarial drugs by--- </li></ul><ul><li>Technology transfer in </li></ul><ul><li>The field of marine microbial natural products from SIO, USA </li></ul><ul><li>Screening for antimalarial compounds from KEMRI/LSTH </li></ul>
  9. 9. Objective 6: Collaborating with national, regional and international networks in the field of antimalarial drug discovery Indicators local (IMS/ITM), regional (KEMRI) and international (LSTH, University of Botswana) institutes with which links have been established:
  10. 10. <ul><li>Collection and identification of samples </li></ul><ul><li>Bioassay of extracts </li></ul><ul><li>Identification of active compounds </li></ul><ul><li>Reporting </li></ul>Main steps Note: Capacity building is part of all these steps
  11. 11. Main steps <ul><li>Grant approval </li></ul><ul><li>Study preparation </li></ul><ul><li>Seeking permits </li></ul><ul><li>Training of the research team on the available SOPs adopted from Department of Biodiversity of Queensland Museum </li></ul><ul><li>preparation of sampling materials (UWC, collection bags, knives diving gears, GPS, preservatives, ice boxes) </li></ul><ul><li>Coordinating activities and defining roles of the field workers according to the SOPs </li></ul><ul><li>Creating the database for all collected data </li></ul>
  12. 12. <ul><li>Field Work </li></ul><ul><ul><li>sample collection and labeling, transport in ice boxes and preservation for further taxonomic identification </li></ul></ul><ul><ul><li>Storage of samples in deep freezers in the lab for future studies </li></ul></ul><ul><ul><li>Recording of the coordinates of collection points </li></ul></ul>Main steps

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