Chiral ligands are used with metal catalysts to transfer chirality and create new chiral centers in molecules undergoing asymmetric synthesis. Chiral induction refers to the formation of an excess of one enantiomer over the other from an achiral or racemic substrate using a chiral catalyst or reagent. Examples of drugs synthesized through homogeneous catalysis using chiral ligands include L-DOPA, (R)-naproxen, S-ibuprofen, and (R)-citronellal.

1. Chiral ligand and chiral induction
Presented by-
Sandeep Bindra

2. Chiral ligand-
• Chiral ligand are used in asymmetric synthesis.
• Most of the chiral ligand combine with metals to form chiral catalyst.
• Chiral catalyst engages in chemical reaction in which chirality is
transfer to the reaction product.
• If we want to create a new chiral center in a molecule, our starting
material must have prochirality(the ability to become chiral in one
simple transformation).
• The most common prochiral units that give rise to new chiral centers
are the trigonal carbon atom of alkenes and carbonyl groups, which
become tetrahedral by addition reaction.
• One of the simplest transformations you could imagine of a prochiral
unit in to a chiral one is the reduction of ketone.

4. • FIRST CATALYTIC SYMMETRIC SYNTHESIS- SYNTHESIS OF L-DOPA

6. CHIRAL INDUCTION-
It describe the formation of an excess of an enantiomer over the other
from an achiral or racemic substrate using a chiral catalyst or chiral
reagent is called chiral induction.

7. EXAMPLES OF HOMOGENOUS CATALYSIS USED IN SYNTHESIS OF
DRUGS-
• Synthesis of L-DOPA-

8. • Synthesis of (R) Naproxen-
• Synthesis of S Ibuprofen-

9. • Synthesis of (R) Citronellal-

10. References-
• Han, X., Zhang, J., Huang, J., Wu, X., Yuan, D., Liu, Y., & Cui, Y. (2018). Chiral
induction in covalent organic frameworks. Nature Communications, 9(1).
https://doi.org/10.1038/s41467-018-03689-9
• Pyarasani RD, John A, Santos LS. Recent developments of chiral induction in
the syntheses of biologically important alkaloids. Curr Top Med Chem.
2013;13(17):2184-99. doi: 10.2174/15680266113139990151. PMID:
23978134.
• González, J. M., Vidal, X., Ortuño, M. A., Mascareñas, J. L., & Gulías, M.
(2022). Chiral ligands based on binaphthyl scaffolds for Pd-catalyzed
enantioselective C-H activation/cycloaddition reactions. Journal of the
American Chemical Society, 144(47), 21437–21442.
https://doi.org/10.1021/jacs.2c09479

11. THANK YOU