8. 2)
8)
- correspondsto the follicular phase of ovarian cycle in
which development of ovarian follicles and production of
estrogen ➡️ cells in basel end of utrine glands proliferate,
migrate to the raw surface and reconstitute the uterine
glands and the epithelial lining of the endometrium
- uterine gland appear straight with narrow empty lumen
- proliferationof C.T cells of lamina propria ➡️ growth of
endomertrium as a whole
-spiral artries elongate with lenghening of the functional
group
12. 14)
15)
*Mechanism of action ➡️ act on estrogen receptors
Agonist in bone and endometrium
Antagonist in breast
Clinical use ➡️ breat cancer in postmenopousal
patient
Adverse effect :
1. Venous thromboembolism
2. Hot flushes
3. Nause , vomiting
4. Increase risk of endometrial cancer
...
13. 16)
1) ) indomethacin ➡️inhibit production of
prostaglandin
(2) nifedipine ➡️ ca channel blockers➡️ inhibit
entery of ca into uterine smooth muscle ➡️ its
relaxation
Indications :
1. Inhibit uterine contraction
2. Postpone delivery in case of preterm labor
3. Prolongation of pregnancy from 48 h to a
week
4. Provide time for administration of antenatal
glucocorticoids
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