8. 2)
8)
- correspondsto the follicular phase of ovarian cycle in
which development of ovarian follicles and production of
estrogen โก๏ธ cells in basel end of utrine glands proliferate,
migrate to the raw surface and reconstitute the uterine
glands and the epithelial lining of the endometrium
- uterine gland appear straight with narrow empty lumen
- proliferationof C.T cells of lamina propria โก๏ธ growth of
endomertrium as a whole
-spiral artries elongate with lenghening of the functional
group
12. 14)
15)
*Mechanism of action โก๏ธ act on estrogen receptors
Agonist in bone and endometrium
Antagonist in breast
๏ท Clinical use โก๏ธ breat cancer in postmenopousal
patient
๏ท Adverse effect :
1. Venous thromboembolism
2. Hot flushes
3. Nause , vomiting
4. Increase risk of endometrial cancer
...
13. 16)
1) ) indomethacin โก๏ธinhibit production of
prostaglandin
(2) nifedipine โก๏ธ ca channel blockersโก๏ธ inhibit
entery of ca into uterine smooth muscle โก๏ธ its
relaxation
Indications :
1. Inhibit uterine contraction
2. Postpone delivery in case of preterm labor
3. Prolongation of pregnancy from 48 h to a
week
4. Provide time for administration of antenatal
glucocorticoids
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