2. OBJECTIVES:
1. Describe the essentials of diagnosis for the
disorders in this category.
2. Review the signs, symptoms and physical
examination and imaging findings commonly
associated with these disorders.
4. ī¨ Seronegative spondylarthropathy consists of a spectrum
of chronic inflammatory disorders that lack the presence
of rheumatoid factor and are clearly distinct from
rheumatoid arthritis.
ī¨ Where as rheumatoid arthritis involves predominantly
the synovial joints, significant abnormalities in the
cartilaginous joints, entheses, as well as synovial
articulations are seen in spondylarthropathic processes.
5. ī¨ The seronegative spondyloarthropathies are a
group of arthritic diseases that affect multiple
organ systems and are thought to have a
significant genetic component to their origin.
7. ī¨ HLA-B27 is the most important predictor of
AS.
ī§ 90+% of Caucasians with AS are B27+
ī§ Studies suggest B27 antigen accounts for 20-50% of
the risk for AS
ī¨ There are 23 known subtypes of HLA B27 and
not all are associated with disease
īĄ Suggests a structure-function relationship.
ī¨ The absence of HLA-B27 expression in an
individual patient does not exclude the
diagnosis of AS.
9. ī¨ Young adults
īĄ Peak onset ages 20-40
ī¨ overall prevalence is estimated to be as high as
0.2â2%.
ī¨ Males>Females (4:1).
ī¨ More common in Caucasians
11. ī¨ Back pain >3months.
ī¨ Morning stifnness.
ī¨ Tenderness over the SI joints& spinal tenderness 2ry spondyolitis
ī¨ Multiple different maneuvers (all unreliable)
ī¨ Reduced range of motion of the back.
ī¨ Reduced chest expansion owing to costosternal and costovertebral affections.
ī¨ Peripheral joints affection e.g. shoulders and hips.
ī¨ The lower limbs are more frequently involved than the upper limbs.
ī¨ In 20â25% of AS patients, peripheral articular symptoms may precede axial
manifestations.
ī¨ Painful tendinopathy occurs in about 10%
12. ī¨ Evaluation of other joints
īĄ Particular attention to the large joints
ī¨ Lab evaluation
īĄ HLA-B27
ī¨ Imaging for AS
īĄ SI joints, others as clinically indicated
13. ī¨ Clinical Criteria
īĄ Low back pain, > 3
months, improved by
exercise, not relieved
by rest
īĄ Limitation of lumbar
spine motion, sagittal
and frontal planes
īĄ Limitation of chest
expansion relative to
normal values for age
and sex
âĸ Radiologic Criteria
â Sacroiliitis grade âĨ 2
bilaterally or grade 3 â 4
unilaterally
âĸ Grading
â Definite AS if radiologic
criterion present plus at least
one clinical criteria
â Probable AS if:
âĸ Three clinical criterion
âĸ Radiologic criterion
present, but no signs or
symptoms satisfy clinical
criteria
14.
15.
16.
17.
18.
19.
20. ī¨ Sacroiliac Joints and Pelvis
ī§ Sacroiliitis is the hallmark of Ankylosing spondylitis.
ī§ Sacroiliitis is the earliest radiographic sign in 99% of cases of AS
ī§ Although Sacroiliitis alone is a non-specific finding and is not sufficient for the
diagnosis of AS.
ī§ Changes in the sacroiliac joints are considered ubiquitous among patients with AS .
ī§ Both the synovial and ligamentous (superior and posterior) portions of the joint are
involved.
ī§ Classically, the involvement is symmetric and bilateral particularly very early in the
course of the disease.
ī§ unilateral disease may occur.
21.
22. Conventional Radiographic Findings in Ankylosing Spondylitis
ī¨ Small erosions lined up one behind the other at corresponding
sites of the ilium and the sacrum resemble a string of beads or
rosary.
ī¨ The erosions usually develop earlier on the iliac than on the sacral
side of the joint possibly because the cartilage covering the sacrum
is approximately twice as thick as that covering the ilium .
ī¨ Reactive bone proliferation is seen radiographically as sclerosis of
the adjacent cancellous bone with a variable pattern (diffuse, band
shaped,spotty, triangular).
23.
24.
25. ī¨ Abnormalities of the spine can be seen at: The disco vertebral
junctions.
ī¨ Apophyseal joints, costovertebral joints.
ī¨ Posterior ligamentous attachments, and atlantoaxial joints.
ī¨ Classically, changes are initially noted at the thoracolumbar and
lumbosacral junctions.
ī¨ Spinal extension to the midlumbar, as well as the upper thoracic and
cervical vertebrae, occurs with disease progression but may be
arrested at any stage .
26. ī¨ There is a spectrum of:
īĄ Inflammatory and destructive lesions of the spine in
AS.
īĄ This predominantly involves the cartilaginous disco
vertebral junction.
īĄ One of the earliest plain-film findings of spinal
involvement, typically seen at vertebrae T10 through
L2, is the so-called Romanus lesion, also known as
spondylitis anterior
27.
28.
29.
30. ī¨ Marginal osteosclerosis.
ī¨ Along the spectrum of discovertebral diseases are the more destructive lesions, such as
Andersson lesions.
ī¨ Three types are distinguished:
ī¨ Type I shows central focal endplate destruction with intraosseous disc
herniation and associated reactive endplate changes, the nature of which
depends on the age of the lesion. In the relatively acute stage, marrow
edema is identified, with enhancement after intravenous gadolinium
contrast administration
ī¨ Type-II lesions are located more at the periphery of the discovertebral junction.
ī¨ Type-III lesions involving both the central and the peripheral portions may be
difficult to differentiate from infectious spondylodiscitis.
31. ī¨ Diagnostic features:
ī¨ The absence of an anterior paraspinal soft tissue mass .
ī¨ The predominant low signal intensity of the
intervertebral disc on T2-weighted images (with only
possible minor areas of high signal intensity adjacent to
vertebral erosions) indicate a noninfectious Andersson
lesion.
32.
33.
34.
35.
36. ī¨ Vertebral bodies initially erode at
corner, reactive sclerosis occurs
below this leading to squared
appearance
īĄ Eventually anulus fibrosus and
longitudinal ligaments become
ossified (syndesmophytes)
īĄ Discs can become calcified, along
with all ligaments including those
between spinous processes ī
bamboo spine
Dagger sign,
fused spinous
process ligaments
http://uwmsk.org:8080/EvasMSKTF/
40. ī¨ Magnetic resonance imaging :
ī§ Enable early diagnosis of spinal manifestations of AS by an
increased sensitivity for identification of early-stage Sacroiliitis or
vertebral osteitis.
ī§ Is also superior to other imaging techniques for differential
diagnosis of Andersson lesions vs. infectious spondylodiscitis
and in the evaluation of most acute and chronic spinal
complications of AS.
ī§ MRI has been used to assess the effect drugs in the management
of acute inflammatory lesions
46. ī¨ Inflammatory polyarthritis associated with
psoriasis
ī¨ May occur prior to the onset of skin disease
ī¨ Usually seronegative
ī¨ M=F
ī¨ Prevalence rate 0.1%
47. ī¨ Inflammatory DIP disease
ī¨ Asymmetic oligoarthritis with large and small
joints
ī¨ Symmetric polyarthritis
ī¨ Arthritis mutilans
ī¨ Spondyloarthropathy
īĄ Spondylitis and sacroiliitis
52. ī¨ Bilateral, asymmetrical
ī¨ Dramatic joint space loss +/-
ankylosis (arthritis mutilans)
ī¨ Bone proliferation, âmouse earsâ
ī¨ âpencil-in-cupâ deformities
ī¨ Normal mineralization
ī¨ Sausage digits
ī¨ Hands > feet > SI > spine
ī¨ Usually favors DIP and PIP in hand
ī¨ SI involvement usually bilateral,
asymmetrical
ī¨ Large bridging bone formation in
spine, similar to reactive arthritis
http://uwmsk.org:8080/EvasMSKTF/
Sausage
digits
http://uwmsk.org:8080/EvasMSKTF/
http://www.hopkins-arthritis.org/arthritis-
info/psoriatic-arthritis/diagnosis.html
Psoriatic Arthritis
55. ī¨ The appearance of arthritis in patients with inflammatory intestinal disease
(ulcerative colitis, Crohnâs disease, and Whippleâs disease) has been
described since 1950
ī¨ These abnormalities have been designated enteropathic arthritis .
ī¨ Both the peripheral joints and the axial skeleton (spondylarthropathy) may
be involved enteropathic arthritis.
ī¨ The axial skeleton is involved in about 10% of patients.
ī¨ Radiological manifestations of enteropathic spondylarthropathy (sacroiliitis
and spondylitis) are indistinguishable from AS.
ī¨ Axial involvement is poorly correlated with activity of bowel disease,
whereas a close temporal association exists between exacerbations of
intestinal disease and peripheral joint inflammation
58. ī¨ SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis)
ī¨ Is considered as a spondylarthropathy associated with different
types of cutaneous pustules.
ī¨ The term pustulotic arthro-osteitis (PAO) is more appropriate.
59.
60.
61. âĸ Pathology of Rheumatoid Arthritis:
ī RA is the prototype of conditions accompanied by a hyperplastic,
inflammed synovial membrane.
ī In RA and related diseases, the synovial lining becomes
hyperemic and thickened, with extensive overgrowth and
formation of villi.
ī Inflamed synovial lining in RA eventually grows over the
articular surfaces, eroding and destroying cartilage and
underlying bone.
ī The invasive portion of the hyperplastic synovial tissue has been
termed pannus.
62. ī MR manifestations of RA and related diseases are nonspecific
, similar changes can be seen in other inflammatory joint
conditions.
ī Therefore the goal of those using MRI in these conditions is
not to achieve a specific diagnosis, which may be
accomplished using clinical and laboratory parameters, but
to assess the extent of the early soft tissue and bone
manifestations.
66. MRI features Of RA:
ī§ Erosion of the cartilage and bone.
ī§ Tendon or ligamental invasion.
ī§ Synovial pannus :MRI has been used to demonstrate pannus
,and synovial cysts.
Editor's Notes
Clinical Features of AS
Sacroiliitis is the hallmark feature of AS1 and the earliest, most consistent findings are traceable to effects of sacroiliitis and enthesitis. Inflammation of the discovertebral, apophyseal, costovertebral, and costotransverse joints of the spine, and paravertebral ligamentous structures are frequently associated with AS. After many years, chronic inflammation can cause bony ankylosis.2
Â
Chronic low back pain and stiffness, which typically worsens following a period of prolonged inactivity (eg, morning stiffness), are common presentations.1 Over time, lumbar spine mobility becomes restricted in all planes and posture becomes abnormal because of flattening of the lumbar spine and accentuated dorsal spine kyphosis. Radiographic findings in advanced disease include erosions, sclerosis of adjacent bones, pseudo-widening of the sacroiliac joint space, and fibrosis, calcification, interosseous bridging, and ossification of the sacroiliac joints. Extraskeletal manifestations are also frequently part of the clinical picture.2
Khan MA. Spondyloarthropathies. In: Hunder GG, ed. Atlas of Rheumatology. 3rd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2002.
Khan MA. Clinical features of ankylosing spondylitis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. vol 2, 3rd ed, New York, NY: Mosby; 2003:1161-1181.
Modified New York Criteria for the Diagnosis of AS
Three sets of clinical and radiographic criteria have been introduced over the past 40 years. The Modified New York Criteria,1,2 developed in 1984, are now widely used to diagnose AS. Radiographic evidence of sacroiliitis is heavily relied on to diagnose AS because it is the best nonclinical indicator of disease. Diagnosis may be missed early on, though, because routine pelvic radiographs may not clearly demonstrate sacroiliitis in the initial stages of AS.3
Van der Linden S. Ankylosing spondylitis. In: Textbook of Rheumatology 5th ed. Kelly WN, Harris ED, Ruddy S, Sledge CB, eds. Philadelphia, PA: WB Saunders; 1996:969-982.
Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27:361-368.
3. Khan MA. Spondyloarthropathies. In: Hunder GG, ed. Atlas of Rheumatology. 3rd ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2002.
cricoarytenoid
PMNâs in SF â inflammatory fluid WBC>2000
Pannus takes on special invasive properties
Figure 2. Pathogenesis of Rheumatoid Arthritis.
In the normal knee joint, the synovium consists of a synovial membrane (usually one or two cells thick) and underlying loose connective tissue. Synovial-lining cells are designated type A (macrophage-like synoviocytes) or type B (fibroblast-like synoviocytes). In early rheumatoid arthritis, the synovial membrane becomes thickened because of hyperplasia and hypertrophy of the synovial-lining cells. An extensive network of new blood vessels is formed in the synovium. T cells (predominantly CD4 ) and B cells (some of which become plasma cells) infiltrate the synovial membrane. These cells are also found in the synovial fluid, along with large numbers of neutrophils. In the early stages of rheumatoid arthritis, the synovial membrane begins to invade the cartilage. In established rheumatoid arthritis, the synovial membrane becomes transformed into inflammatory tissue, the pannus. This tissue invades and destroys adjacent cartilage and bone. The pannus consists of both type A and type B synoviocytes and plasma cells.