In this video learn about large volume parenterals and its types.Also learn about specialised LVPs

1. Large Volume Parenterals
Dr. Swati Gokul Talele
Sandip Institute of Pharmaceutical Sciences, Nasik

2. LEARNING OBJECTIVES
• Familiarize concept of parenteral with characteristics of LVPs.
• Understand types of LVPs with specialised LVPs.
• Discuss concept of intravenous and nonintravenous LVPs.

3. Definition
 "Parenteral" derived from two Greek words ‘para’ beside
and ‘enteron’ meaning intestine.
Parenteral dosage forms administered directly into body tissues rather
than through the intestine with the help of an injection.
 Active substances are administered using gravity, or force directly into
blood vessels, organs or tissues.
As per USP LVP solutions applies to a single dose injection.
 It is intended for intravenous use.
It is packaged in containers labelled as containing more than 100 ml.

4. Characteristics of Large Volume Parenterals
 It should be sterile, nonpyrogenic, free from particulate matters.
The volume with single units should be more than 100 ml.
 It should not contain any preservative.
 The volume does not exceed 1000ml in IV LVP’S
 Nonintravenous LVP volume may exceed 1000 ml.
(Example: Irrigation and Dialysis solution)
It should be isotonic to minimise damage to blood vessels and blood cells.
Hypertonic solution may be administered efficiently .
Small quantity of hypertonic solution may be administered in a peripheral
vein
Large quantity of hypertonic solution are administered which inserted in a
large central veins as subclavian vein or internal jugular vein.

5. REFLECTION SPOT
What are the various types of large volume parenterals? What are
various specilaised LVPs?

6. Types
of LVPs
Electrolyte
Solutions
Carbohydrate
Solutions
Nutrional
Solutions
Fat Emulsions
Total
Parenteral
Nutrition
Intra Venous
admixtures
Peritoneal
Dialysis Fluid

7. Mulitiple
Electrolyte
Injection
With 5%
w/v
Dextrose
Lacteted
Ringers
Injection
With 5%
w/v
Dextrose
Sodium
Chloride
Mutiple
Electrolyte
Injection
Lactated
Ringers
Injection
ELECROLYTE
SOLUTION

8. 10%
invert
sugar
10%
fructose
injection
5%
dextrose
injection
CARBOHYDRATE
SOLUTION

9. Amino acid
with
electrolytes
Amino
acid
injection
Amino acids
with 25%
dextrose &
electrolytes
Lactated
Ringers
Injection
Nutritional solution

10. Fat emulsion
• Composition
• Soybean oil: 10 gram
• Egg yolk phospholipids: 1.2 gram
• Glycerine: 2.25 gram
• Water for injection: 100 ml
• pH: 8.0
• Osmolarity: 280mOsmol/L

11. Electrolytes
Vitamins
Total
parenteral
Nutrition
Proteins
Energy
Trace
Elements

12. 1
Hyper
alimentati
on
solution
2
Cardiopleg
ia solution
3
Peritoneal
Solution
4
Irrigation
solution
Specialized Large volume Parenterals

13. Hyperalimentation solutions
Dextrose Amino Acids Lipids
VitaminsElectrolytes
Trace
Elements
+ +

14. Calcium
Chloride
Dihydrate
Magnesium
Chloride
Hexahydrate
Water for
Injection
Potassium
Chloride
Sodium
Chloride
Cardioplegia Solution
+ +

15. Peritoneal Dialysis Solution
Water
Glucose Salt
Minerals
+

16. INTRA VENOUS ADMIXTURES
one or more sterile dry products added to an IV fluid.
Additive is SVP added to large volume parenteral
It is used for drugs that intended for continuous infusion.
 Drugs that may cause irritation and toxicity given by direct IV
injection.
 Laminar air flow unit with HEPA filter efficiency 99.97%.(0.3
µm particle)
Personnel handling admixtures should wear gloves and mask.
The process for mixing will deviate.
Totally depend on which IV fluid packaging system utilised by
the hospital.

17. IRRIGATION SOLUTION
 To irrigate, flush and in cleansing body cavities and wounds.
Irrigating solution should not be used parentally .
Irrigating solution must be sterile, pyrogen free.
 Handled with same care as parenteral solution.
 Examples:
Acetic acid irrigation USP
Neomycin and Polymyxin B sulfates solution for irrigation, USP
Ringers Irrigation, USP
Sodium Chloride Irrigation USP
Sterile water for injection USP

19. THANK
YOU