Introduction: Organ reinnervation and functional recovery following peripheral nerve injury still remains a major challenge and return of functional recovery to the preinjured level rarely occurs. The aim was to evaluate the effect of locally administered insulin-like growth factor (IGF I) on nerve regeneration. Methods: Eighty male white Wistar rats were divided into four groups (n = 20), randomly: In transected group (TC), left sciatic nerve was transected and stumps were fixed in the adjacent muscle. In treatment group defect was bridged using a silicone conduit (SIL/IGF) and filled with 10 µL IGF I (100 ng/kg). In silicone graft group (SIL), the graft was filled with phosphate-buffered saline alone. In sham-operated group (SHAM), sciatic nerve was exposed and manipulated. Each group was subdivided into three subgroups of five animals each and studied 4, 8 and 12 weeks after surgery.

1. Journal of Surgery and
Surgical Research– ISSN: 2455-2968
Peertechz Journals

2. Research Article
Local Administration of Insulin-like Growth Factor I into Silicon
Rubber Chamber Improves Peripheral Nerve Repair in Rats
 Rahim Mohammadi*, Masoume Masoumi-Verki, Sima Ahsan and Keyvan
Amini
 *Corresponding author: Rahim Mohammadi, Department of Surgery and
Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Nazloo
Road, Urmia, 57153 1177, Iran, Tel: +98 443 2770508; Fax: +98 443 277 1926
 Dates: Received: 06 March, 2015; Accepted: 11 April, 2015; Published: 13
April, 2015
 Citation: Mohammadi R, Masoumi-Verki M, Ahsan S, Amini K (2015) Local
Administration of Insulin-like Growth Factor I into Silicon Rubber Chamber
Improves Peripheral Nerve Repair in Rats. J Surg Surgical Res 1(1): 004-010.
DOI:10.17352/2455-2968.000002

3. Abstract
Introduction: Organ reinnervation and functional recovery following peripheral
nerve injury still remains a major challenge and return of functional recovery to
the preinjured level rarely occurs. The aim was to evaluate the effect of locally
administered insulin-like growth factor (IGF I) on nerve regeneration.
Methods: Eighty male white Wistar rats were divided into four groups (n = 20),
randomly: In transected group (TC), left sciatic nerve was transected and stumps
were fixed in the adjacent muscle. In treatment group defect was bridged using a
silicone conduit (SIL/IGF) and filled with 10 µL IGF I (100 ng/kg). In silicone graft
group (SIL), the graft was filled with phosphate-buffered saline alone. In sham-
operated group (SHAM), sciatic nerve was exposed and manipulated. Each group
was subdivided into three subgroups of five animals each and studied 4, 8 and 12
weeks after surgery.

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