Solved problems

1. Fast
proton
exchange
Darzens reaction instead of alkylation
of acetone.

2. This is correct
or you may go through
enamine path
Here also
same proton
exchange
will occur
to give Darzen's
Reaction
here proton exchange
will not occur
More acidic
protons
Less acidic protons
And so
We will get desired
product

3. /THF
-78oC
heat
Better go through enamine or
silyl enol ether method.
or use NaH as base instead of LDA.

6. FGI
Not necessary
Not necessary
Because: 1. large number of steps
2. Cost will increase
So avoid protection-deprotection technique and
go through the use of selective
reducing agents likeNaBH4

7. See my study material: Two-group disconnection-
Claisen condensation.
blocked
more reactive
E2
D
E
F
[O]