5. Really Dirty Data
Harmonized data with available dictionaries,
developed systems to resolve combination drugs (i.e. Vicodin = APAP+Hydrocodone)
6. Analyzing Adverse
Reactions
• 3,600,000 different reports
• roughly 3 drugs, 3 reactions per report
Filter
Adverse event
frequency
vectors
Cosine
Similarity
Recommendatio
n
7. Some answers:
Physician
Pharmacist
Other Health
Professional
Lawyer
Consumer/Non-
professional
Reported Adverse Event P(Lawyer|Term)
Polytraumatism 0.57
Neural Tube Defect 0.45
Physical Disability 0.41
Gastrointestinal Injury 0.37
Inflammatory Bowel Disease 0.34
Organ Failure 0.31
Cardiovascular Disorder 0.30
Economic Problem 0.30
Parameter Naïve Database Names Corrected Database
Number of Drugs occurring alone 4018 2082
Number of Reports with only one
Drug
1,565,425 1,596,123
Number of assigned known DDI 430 1453
8. Figure 1. Small molecule evolution by DNA-programmed combinatorial ch
translated into small molecule-DNA conjugates. The covalently attached small molec
Thanks!
Mad Scientist
Ski bum
Editor's Notes
Claritin:
• fast or uneven heart rate;
• feeling like you might pass out;
• jaundice (yellowing of your skin or eyes); or
• seizures (convulsions).
Less serious side effects may include:
• headache;
• nervousness;
• feeling tired or drowsy;
• stomach pain, diarrhea;
• dry mouth, sore throat hoarseness;
• eye redness, blurred vision;
• nosebleed; or
• skin rash.
