This document discusses the high risk condition of dyspnea, or difficulty breathing. Dyspnea accounts for 2-3% of emergency department visits and requires prompt evaluation to detect life-threatening causes. The evaluation of dyspnea involves taking a thorough history including symptoms and onset, performing a physical exam checking vital signs, lungs, heart and skin, and ordering diagnostic tests like chest x-rays, ECGs, blood tests and echocardiograms. Patients with rapid respiratory distress may require airway management or positioning to improve breathing. Pulmonary embolism is one potential cause that is often difficult to diagnose due to its variable presentation but requires recognition to prevent fatal outcomes.