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Pharmacy-Immunology 19 Primary & Acquired Immunodeficiency Saber Hussein
Objectives ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Features of immunodeficiency diseases ,[object Object],[object Object],Fig12-1 (Extracellular  bacterial infections)
Congenital immunodeficiencies ,[object Object],[object Object],[object Object],[object Object]
Congenital immunodeficiencies caused by defects in lymphocyte maturation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fig12-2:Congenital immunodeficiencies  Fig12-2:Congenital  immunodeficiencies
Features of congenital immunodeficiencies caused by defects in lymphocyte maturation Fig12-3
Features of congenital immunodeficiencies caused by defects in lymphocyte maturation Fig12-3
Congenital immune-deficiencies associated with defects in lymphocyte activation and effector functions ,[object Object],[object Object],[object Object],[object Object],[object Object],Fig12-4  : Sites where immune responses  may be blocked
Congenital immunodeficiencies associated with defects in lymphocyte activation and effector functions Fig12-4:   Features of some of resulting deficiency disorders
Congenital immunodeficiencies caused by defects in innate immunity Fig 12-5
Congenital immunodeficiencies caused by defects in innate immunity Fig 12-5
Acquired (secondary) immunodeficiency diseases Fig 12-6
HIV life cycle Fig 12-8 HIV life cycle
The pathogenesis of HIV-AIDS ,[object Object],[object Object],12-9
The pathogenesis of HIV-AIDS ,[object Object],[object Object],[object Object],12-9
The clinical course of HIV disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The clinical course of HIV disease Fig 12-10

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Pharm immuno19 immunodeficiency

Editor's Notes

  1. Lymphocyte maturation pathways are described in more detail in Chapter 4.
  2. Branchial pouches pharyngeal pouches paired evaginations of embryonic pharyngeal endoderm, between the branchial arches, extending toward the corresponding ectodermally lined branchial grooves; during development they evolve into epithelial tissues and organs, such as thymus and thyroid glands . Syn: branchial pouches, endodermal pouches Hypoplasia (h º” p ½ -pl ³“ zh … , -zh ¶ - … ) n. Incomplete or arrested development of an organ or a part
  3. Examples showing the sites where immune responses may be blocked are illustrated in A, and the features of some of these disorders are summarized in B