1. Novel
Molecular PRODUCT
Technologies
Project title: «Differential Analysis of Oncomutations in Complex DNA Samples (DAOCS) for early non-
invasive molecular profiling of cancer»
Software for
+ NGS-data analysis
and
protocol for sample
processing
Biological sample
Centers for PCR diagnostics NGS-centers
(equipped with thermocyclers) (equipped with NGS machines)
Results of
analysis PCR – polymerase chain reaction
NGS – next generation sequencing

2. Novel
Molecular DAOCS TECHNOLOGY
Technologies
PCR diagnostics DAOCS diagnostics
(PCR) (PCR + NGS)
• detects FOREIGN DNA (bacterial, viral)
in genomic DNA ( sensitivity 1:100 000 and up)
• detects POINT mutations in genomic DNA
• TRANSLOCATIONS in genomic DNA ( proof of concept - sensitivity 1: 10 000;
( sensitivity 1:10 000) no technical limitations for 1:100 000 and up)
• POINT mutations in genomic DNA
( sensitivity 1:100)
1 Test : 1 Gene : 1 Oncomutation 1 Test : 10 (+) Genes : ALL Oncomutations
sensitivity 1:100 sensitivity 1: 10 000
• «broad profiling» of mutational hotspots in cancer tissue
•analysis of «complex» samples (biopsy)
•detection of mutant DNA molecules in biological fluids

3. Novel
Molecular NOMOTECH
Technologies
 fluorescent proteins
( products, licensing, services)
 molecular biology
( products, services)
molecular oncodiagnostics ( services)
NOMOTECH LLC
 mass sequencing ( services)
• innovation and know-how in DAOCS technique • infrastructure and outsourcing of routine technologies
( standard sample preps and mass sequencing)
• DAOCS development to a commercial product •mentors of the DAOCS project
• work in SKOLKOVO format • co-investments