SCBC- Bio-Link Conference          Emerging Technologies Panel                      Nanotechnology                       O...
Innovation            “There is nothing more difficult to            plan, more doubtful of success,            more dange...
Where does              Nanotechnology fit in the                 innovation game?(overhead template)                     ...
(overhead template)   4
Nano Dreams….                      A vision of what                      could be possible(overhead template)             ...
Nanotechnology Definition      Nanotechnology is defined by the US        Government as involving:      1) research and de...
But nanoengineering is much           more!An Entirely New Toolbox Of Engineering Capabilities Has Been Opened Up For Us  ...
Nanotechnology: potentially ubiquitous    Medicine          Information   Energy       Materials     Food, Water   Instrum...
Examples of                      Nanotechnology                        in Medicine(overhead template)                    9
Evolution of     Humankind & Disease(overhead template)        10
History of Scientific Medicine(overhead template)                   11
Categories of Nanomedicine(overhead template)               12
Applications - Bioanalysis       High Throughput (HTP) screens, sensors & diagnostic platforms:       •     Multiplexed as...
Applications - Medical Devices       Medical imaging:               – Contrast agents               – Shielding agents    ...
Applications - Therapeutics      Drugs & drug delivery platforms:      Drugs with enhanced bioavailability & specificity  ...
Limitations of Drug Treatment (% Efficacy)   Cancer (all types)       25 %   Alzheimer’s Disease       30%   Incontinence ...
Top 10 Therapeutic      Areas in Drug Development                      R&D Directions Magazine (October 2009 issue) publis...
(overhead template)   18
Nanotechnology is an  Enabler of New Solutions for Cancer  Focus Areas: • Molecular imaging and   early detection • In viv...
Nanotechnology is                      changing the fight                      against cancer(overhead template)          ...
What it takes to make it happen(overhead template)                21
NCI Alliance Therapeutics Spinouts(overhead template)                    22
NCI Alliance Diagnostics Spinouts                      PreDx                          MagArra(overhead template)          ...
Nanotherapeutics in Development   Abraxis Pharmaceuticals      Abraxane                 Albumin-bound paclitaxel     NSC l...
(overhead template)   25
Mission    • To catalyze collaboration and knowledge      exchange in the nanotech field by connecting      people, techno...
NanoTecNexus Brings It All Together              Industry -                        Academia -             Innovative      ...
education     education           education                            education(overhead template)                       28
Challenges and Hurdles                 • Technical/Standards/Financial                 • EH&S                 • Regulatory...
Educational Opportunities                A key challenge for nanotechnology                development is the education an...
Nanotech Job Projections          • It is estimated that about 2 million nanotechnology            workers will be needed ...
Talent Crisis Looming    for Global Companies                      Unemployment remains high, yet                      sen...
Changes to Talent Strategy
Talent Agenda
(overhead template)   35
(overhead template)   36
Title(overhead template)   37
"The question is not whether nanotechnology is                              going to happen but when. … “                 ...
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Presentation13 nanotech vela

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Presentation by Adriana Vela at Southern California Biotechnology Conference

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Presentation13 nanotech vela

  1. 1. SCBC- Bio-Link Conference Emerging Technologies Panel Nanotechnology Opportunities and Challenges Adriana Vela NanoTecNexus Founder & CEO(overhead template)
  2. 2. Innovation “There is nothing more difficult to plan, more doubtful of success, more dangerous to manage than the creation of a new system” – Machiavelli (1469-1527)(overhead template) 2
  3. 3. Where does Nanotechnology fit in the innovation game?(overhead template) 3
  4. 4. (overhead template) 4
  5. 5. Nano Dreams…. A vision of what could be possible(overhead template) 5
  6. 6. Nanotechnology Definition Nanotechnology is defined by the US Government as involving: 1) research and development at the atomic, molecular and sub-molecular levels in the scale of 1-100 nm in scale 2) creating or using structures, devices and systems with novel properties and functions, 3) that are controlled or manipulated at the atomic scale.(overhead template) 6
  7. 7. But nanoengineering is much more!An Entirely New Toolbox Of Engineering Capabilities Has Been Opened Up For Us To Explore, Invent With, Imagine With, And EDUCATE About.
  8. 8. Nanotechnology: potentially ubiquitous Medicine Information Energy Materials Food, Water Instruments and Technology Production Science and the Health / Storage Environment Drug delivery GMR Hard Hydrogen Lightweight Remediation Tunneling Disk Fuel Cells and strong methods microscopy • to serve citizens and satisfy their needs • to support industrial competitiveness • to exploit science and technology advances(overhead template) 8 SOURCE: European Commission
  9. 9. Examples of Nanotechnology in Medicine(overhead template) 9
  10. 10. Evolution of Humankind & Disease(overhead template) 10
  11. 11. History of Scientific Medicine(overhead template) 11
  12. 12. Categories of Nanomedicine(overhead template) 12
  13. 13. Applications - Bioanalysis High Throughput (HTP) screens, sensors & diagnostic platforms: • Multiplexed assays in solution: dots, bars, beads • Arrays by deposition: beads, particles, wires • Nanopore transport (sequencing, ion channels) • Microfluidics to nanofluidics NanoInk • Detection and separation: molecular tags (nanoink) NanoSphere H. Criaghead, Cornell Nanoplex Quantum Dot  Novel detection leads to enhanced sensitivity NanoSys  Higher throughput is nice, but multiplexed format is key(overhead template) 13
  14. 14. Applications - Medical Devices Medical imaging: – Contrast agents – Shielding agents – Tissue-specific image Retinal cortex enhancement Implantable sensors: – Retinal processing BioPhan: MRI compatible coatings – Neural interconnects – Stents with drug delivery and active monitoring Nanoscale Surgery: – Tissue-directed light/heat ablation – Cell-specific gene therapy Atherosclerotic Coronary Disease(overhead template) 14
  15. 15. Applications - Therapeutics Drugs & drug delivery platforms: Drugs with enhanced bioavailability & specificity – Improve drugs with poor solubility – Traverse membranes, possibly blood-brain barrier – Delivery of nanostructured silicon for bone structure APP’s Abraxane Drug delivery systems – Delivery via skin, lungs, GI tract – Encapsulation for “stealth-mode” release – Encapsulation for scavenging/removal – Devices for long-term in vivo delivery Tissue-specific payload deposition – High local dose NanoMed – Lower toxicity & side effects Nanopore drug delivery(overhead template) 15
  16. 16. Limitations of Drug Treatment (% Efficacy) Cancer (all types) 25 % Alzheimer’s Disease 30% Incontinence 40% Hepatitis C 47% Osteoporosis 48% Rheumatoid arthritis 50% Migraine (prophylaxis) 50% Migraine (acute) 52% Diabetes 57% Asthma 60% Cardiac Arrhythmias 60% Schizophrenia 60% Depression 62% TRENDS in Molecular Medicine, Vol. 7, No. 5, 2001. 16
  17. 17. Top 10 Therapeutic Areas in Drug Development R&D Directions Magazine (October 2009 issue) published its 9th annual report profiles for the top 10 areas of research. These areas have the greatest competition for investigator recruiting. # ILS # of Drugs Investigators Oncology 717 1125 CNS 323 1681 Infectious Disease 233 798 Cardio Vascular 182 1386 Diabetes 152 881 Respiratory 142 807 Pain/Inflammation 132 1234 GI 105 1099 Blood 86 834 Dermatology 68 502 Total 2,140 10,347 Source: Investigator Location Services(overhead template) 17
  18. 18. (overhead template) 18
  19. 19. Nanotechnology is an Enabler of New Solutions for Cancer Focus Areas: • Molecular imaging and early detection • In vivo imaging • Reporters of efficacy • Multifunctional therapeutics • Prevention and control • Research enablers Early detection Imaging Therapy(overhead template)
  20. 20. Nanotechnology is changing the fight against cancer(overhead template) 20
  21. 21. What it takes to make it happen(overhead template) 21
  22. 22. NCI Alliance Therapeutics Spinouts(overhead template) 22
  23. 23. NCI Alliance Diagnostics Spinouts PreDx MagArra(overhead template) 23
  24. 24. Nanotherapeutics in Development Abraxis Pharmaceuticals Abraxane Albumin-bound paclitaxel NSC lung cancer, breast, Approved IV others Advanced Magnetics Combidex Iron oxide nanoparticles Tumor imaging NDA filed IV Avidimer Platform, ATI-001 Targeted dendrimers Various cancer Pre-clinical IV BIND Platform technology Targeted PLGA-PEG Prostate cancer, others Pre-clinical IV nanoparticles Calando Targeted siRNA Cyclodextrin polymers- Cancer, others Pre-clinical IV siRNA Carbon Nanotechnology DF1 Dendritic fullerene Chemoprotection Pre-clinical IV Cytimmune Aurimune TNFα-bound colloidal gold Solid tumors Phase I IV Cytimmune Auritol Taxol and TNFα-bound Solid tumors Pre-clinical IV colloidal gold Dendritic Nanotechnologies Dendrimer-Magnevist PAMAM dendrimer MRI imaging agent Pre-clinical IV ImaRx Therapeutics MRX-951 Self-assembling block Cancer Pre-clinical IV copolymer Insert Therapeutics Cyclosert-camptothecin Cyclodextrin nanoparticles Metastatic solid tumors Phase II IV Introgen INGN-401 Liposome Metastatic lung cancer Phase I IV Kereos Platform technology Perfluorocarbon polymers Cancer and cardiovascular Pre-clinical IV Liquidia Technologies Platform technology PRINT™ nanoparticles Cancer, others Pre-clinical IV Nanospectra Biosciences AuroLase Gold nanoshell Head and neck cancer Pre-clinical IV OrthoBiotech Doxil PEGylated liposome Metastatic ovarian cancer Approved IV Triton Biosystems(overhead template) TNT-Anti-Ep-CAM Polymer-coated iron oxide Solid tumors Pre-clinical IV 24
  25. 25. (overhead template) 25
  26. 26. Mission • To catalyze collaboration and knowledge exchange in the nanotech field by connecting people, technology, investment, and industry. The goal is to promote safe and market accepted advances in nanosciences maximizing societal benefits from new product and applications(overhead template)
  27. 27. NanoTecNexus Brings It All Together Industry - Academia - Innovative Leading-edge Companies Research•Industry Events NTN •Grant Support •Education Programs•Consulting Services •Partnership•Collaboration •Collaboration •Outreach Philanthropy - Next Generation Students Business-Education Ecosystem
  28. 28. education education education education(overhead template) 28
  29. 29. Challenges and Hurdles • Technical/Standards/Financial • EH&S • Regulatory – FDA, EPA, etc • Media hype/confusion • Education (lack of) • Future workforce(overhead template) 29
  30. 30. Educational Opportunities A key challenge for nanotechnology development is the education and training of a new generation of skilled workers in the multidisciplinary perspectives necessary for rapid progress of the new technology Source: Mihail C Roco, Senior Advisor for Nanotechnology at the National Science Foundation(overhead template) 30
  31. 31. Nanotech Job Projections • It is estimated that about 2 million nanotechnology workers will be needed worldwide by 2015. • …an approximate distribution of nanotechnology workers needed in various areas by 2015 would be: 0.8-0.9 million in the US, 0.5-0.6 million in Japan, 0.3-0.4 million in Europe, about 0.2 million in the Asia-Pacific region excluding Japan and 0.1 million in other regions. • …nanotechnology has the potential to create 5 million additional related jobs overall by 2015 in the global market. Source: Mihail C Roco, Senior Advisor for Nanotechnology at the National Science Foundation(overhead template) 31
  32. 32. Talent Crisis Looming for Global Companies Unemployment remains high, yet senior execs doubt they can find enough talent to drive growth and successfully pursue global business strategies, according to PwC’s annual survey of global CEOs.(overhead template) 32
  33. 33. Changes to Talent Strategy
  34. 34. Talent Agenda
  35. 35. (overhead template) 35
  36. 36. (overhead template) 36
  37. 37. Title(overhead template) 37
  38. 38. "The question is not whether nanotechnology is going to happen but when. … “ Thank You Contact me: adriana@nanotecnexus.org 858-774-8283 www.nanotecnexus.org(overhead template) 38

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