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Surgeon General’s Perspectives
Public Health Reports / January–
3
FAMILY HEALTH HISTORY:
USING THE PAST TO IMPROVE
FUTURE HEALTH
Boris D. Lushniak, MD, MPH, RADM, USPHS
More than a decade after completion of the Human
Genome Project,1 science has made substantial prog-
ress in the development of genomic tests for disease
diagnosis, prognosis, risk prediction, prevention, and
treatment. Yet, the simplest, most readily available,
and most affordable genomic tool for disease preven-
tion—the family health history—remains underused.
For almost all diseases of public health significance,
people with a family history of the disease have a higher
risk of developing the disease than people without a
family history. Even so, many people do not collect
family health history information and share it with
relatives2 or even with their health-care providers.
The year 2014 marked the 10th anniversary of the
Surgeon General’s Family Health History Initiative,
launched in 2004 by former Surgeon General Dr.
Richard Carmona.3 This initiative is a national cam-
paign to help families learn more about
their family health history. It provides a
free Web-based tool, My Family Health
Portrait, to help people collect, organize,
and record their family health informa-
tion. To highlight the importance of this
initiative, Dr. Carmona and later Surgeons
General have declared Thanksgiving as
Family Health History Day.
The collection of family health history
information is part of routine health-
care interactions and can inform clinical
decision making and preventive services.
Family health history is a part of many
screening and treatment guidelines and,
in some cases, can make a big difference in
the recommended age for screening. For
example, the U.S. Preventive Services Task
Force (USPSTF) strongly recommends
cholesterol screening beginning at age
35 years for men, but recommends early
cholesterol screening beginning at age
20 years for men and women who are at
increased risk of cardiovascular disease.4
A family history of cardiovascular disease
before 50 years of age in male relatives, or before 60
years of age in female relatives, is one of several fac-
tors that are used to define increased risk. Using these
recommendations, about 16% of young adults should
be screened earlier based solely on the estimated
prevalence of family history of early cardiovascular
disease among this age group.5 Likewise, the USPSTF
recommends screening for osteoporosis for women
aged 65 years or older, but earlier screening for women
aged 50–64 years with certain risk factors that include
parental history of fracture.6 Thus, a 55-year-old white
woman whose parent has had a hip fracture should
consider getting screened early because her 10-year
risk for major osteoporotic fracture is at least as great
as a 65-year-old white woman who has no additional
risk factors.
Several other USPSTF recommendations also
include family health history information in determin-
ing who should be screened or treated and when. For
example, the USPSTF recommends that for women
with a family history of breast cancer, clinicians con-
sider further breast cancer risk assessment to inform
shared decision making regarding chemoprevention.7
Likewise, the USPSTF recommends that primary care
Public Health Reports / January–February 2015 / Volume 130
providers screen women who have family members with
breast, ovarian, and other cancers known to be associ-
ated with BRCA (BReast CAncer susceptibility genes)
mutations using one of several family history-based
screening tools to identify those who should receive
genetic counseling and, if indicated after counseling,
BRCA testing.8
National public health initiatives based on guidelines
and recommendations informed by family health
history include Healthy People 2020,9 the Diabetes Pre-
vention Program,10 and the Million Hearts Initiative.11
With more than 70 million additional Americans receiv-
ing preventive services covered under the Affordable
Care Act beginning in 2010, these recommendations
become all the more important.12
Most people have a family health history of at least
one common disease (e.g., cancer, coronary heart
disease, and diabetes) or health condition (e.g., high
blood pressure and hypercholesterolemia). Preventive
services recommendations that incorporate family
health history can improve health outcomes for those
at increased risk. A recent study demonstrated that
systematic collection of family health history increases
the proportion of people identified as having high
cardiovascular risk for the purposes of targeted pre-
vention.13 Similarly, family health history of diabetes
has been shown to have added value for detecting
undiagnosed diabetes in the U.S. population when
combined with other known risk factors.14 But even
in cases where family history does not alter specific
preventive service recommendations (e.g., the USPSTF
recommendations for high blood pressure screening of
adults aged 18 years or older, regardless of risk factors
such as family history),15 providers who know the
patient’s family health history can take this knowledge
into consideration during clinical care.
Recent national efforts can help improve the collec-
tion and use of family health history information. In
2014, the Stage 2 Medicare Meaningful Use measures
for electronic health records (EHRs) took effect, and
they included incentives to collect family health history
information as structured data.16 In 2008, the Family
Health History Multi-Stakeholder Workgroup of the
American Health Information Community (AHIC)
proposed a core dataset for family health history
information and explored approaches to promote the
incorporation of such information in EHRs.17 Clinical
decision support tools that incorporate family health
history information into risk assessment and prevention
plans are becoming available to assist with implement-
ing existing practice guidelines. The Surgeon General’s
My Family Health Portrait has been continually updated
since it was initially developed in 2004, including a
redesign in 2009 to be interoperable with EHRs and
to collect information consistent with the AHIC mini-
mum core dataset. In 2014, My Family Health Portrait
was updated to include new risk assessment tools for
diabetes and colorectal cancer.
With the growing availability of next-generation
genome sequencing, current efforts to develop
predictive tests for common chronic diseases have
moved toward increasing numbers of common and
rare genetic variants. But early studies suggest that
these tests will likely complement rather than replace
family health history.18,19 Family health history gives
information not only about genes, but also about envi-
ronmental and behavioral risk factors shared among
family members. It therefore can provide a more
accurate prediction of disease risk than many genetic
tests can alone. During the next decade, research will
continue to refine the interconnected roles of family
health history and genomic information in screening,
treatment, and prevention. In the meantime, enhanced
training and education of the public health and clini-
cal workforce is needed to realize the health benefits
of these discoveries, and everybody needs to become
more aware and savvy about the potential value of
family health history.
Boris D. Lushniak is the Acting Surgeon General of the United
States.
The author thanks Katherine Kolor, PhD, and Muin J. Khoury,
MD, PhD, of the Office of Public Health Genomics, Centers for
Disease Control and Prevention; and Ridgely Fisk Green, PhD,
of
Carter Consulting Inc., for their contributions to this article.
REFERENCES
1. Guttmacher AE, Collins FS. Welcome to the genomic era. N
Engl
J Med 2003;349:996-8.
2. Awareness of family health history as a risk factor for
disease—United
States, 2004. MMWR Morb Mortal Wkly Rep
2004;53(44):1044-7.
3. Department of Health and Human Services (US). Surgeon
General’s
family health history initiative [cited 2014 Aug 29]. Available
from:
URL: http://www.hhs.gov/familyhistory
4. Preventive Services Task Force (US). Screening for lipid
disor-
ders in adults: recommendation statement. 2008 [cited 2014
Sep 1]. Available from: URL: http://www.uspreventiveservices
taskforce.org/Page/Document/RecommendationStatementFinal
/lipid-disorders-in-adults-cholesterol-dyslipidemia-screening
5. Kuklina EV, Yoon PW, Keenan NL. Prevalence of coronary
heart
disease risk factors and screening for high cholesterol levels
among young adults, United States, 1999–2006. Ann Fam Med
2010;8:327-33.
6. Preventive Services Task Force (US). Screening for osteopo-
rosis: recommendation statement. 2011 [cited 2014 Sep 1].
Available from: URL: http://www.uspreventiveservicestask
force.org/Page/Document/RecommendationStatementFinal
/osteoporosis-screening
7. Preventive Services Task Force (US). Medications for risk
reduc-
tion of primary breast cancer in women: U.S. Preventive
Services
Task Force recommendation statement. 2013 [cited 2014 Sep 1].
Available from: URL: http://www.uspreventiveservicetaskforce
.org/Page/Document/RecommendationStatementFinal/breast-
cancer-medications-for-risk-reduction
Public Health Reports / January–February 2015 / Volume 130
8. Preventive Services Task Force (US). Risk assessment,
genetic counsel-
ing, and genetic testing for BRCA-related cancer in women:
U.S. Pre-
ventive Services Task Force recommendation statement. 2013
[cited
2014 Sep 1]. Available from: URL:
http://www.uspreventiveservices
taskforce.org/Page/Document/RecommendationStatement Final
/brca-related-cancer-risk-assessment-genetic-counseling-and-
genetic-
testing-december-2013
9. Department of Health and Human Services (US). Healthy
People
2020 genomics objective G-1 [cited 2014 Aug 29]. Available
from:
URL: http://www.healthypeople.gov/2020/topicsobjectives2020
/objectiveslist.aspx?topicId=15
10. Albright AL, Gregg EW. Preventing type 2 diabetes in
communities
across the U.S.: the National Diabetes Prevention Program. Am
J
Prev Med 2013;44(4 Suppl 4):S346-51.
11. Frieden TR, Berwick DM. The “Million Hearts” initiative—
prevent-
ing heart attacks and strokes. N Engl J Med 2011;365:e27.
12. Skopec L, Sommers BD. Seventy-one million additional
Americans
are receiving preventive services coverage without cost-sharing
under
the Affordable Care Act. Rockville (MD): Department of Health
and
Human Services (US); 2013. Also available from: URL:
http://aspe
.hhs.gov/health/reports/2013/PreventiveServices/ib_prevention
.cfm [cited 2014 Oct 6].
13. Qureshi N, Armstrong S, Dhiman P, Saukko P, Middlemass
J, Evans
PH, et al. Effect of adding systematic family history enquiry to
car-
diovascular disease risk assessment in primary care: a matched-
pair,
cluster randomized trial. Ann Intern Med 2012;156:253-62.
14. Yang Q, Liu T, Valdez R, Moonesinghe R, Khoury MJ.
Improvements
in ability to detect undiagnosed diabetes by using information
on
family history among adults in the United States. Am J
Epidemiol
2010;171:1079-89.
15. Preventive Services Task Force (US). Screening for high
blood
pressure: reaffirmation recommendation statement. 2007 [cited
2014 Sep 1]. Available from: URL:
http://www.uspreventiveservices
taskforce.org/uspstf07/hbp/hbprs.htm
16. Centers for Medicare & Medicaid Services (US). Stage 2
eligible
professional meaningful use menu set measures: measure 4 of 6
[cited 2014 Aug 29]. Available from: URL: http://www.cms.gov
/Regulations-and-Guidance/Legislation/EHRIncentivePrograms
/downloads/Stage2_EPMenu_4_FamilyHealthHistory.pdf
17. Feero WG, Bigley MB, Brinner KM; the Family Health
History
Multi-Stakeholder Workgroup of the American Health
Information
Community. New standards and enhanced utility for family
health
history information in the electronic health record: an update
from
the American Health Information Community’s Family Health
History Multi-Stakeholder Workgroup. J Am Med Inform Assoc
2008;15:723-8.
18. Park JH, Gail MH, Greene MH, Chatterjee N. Potential
usefulness
of single nucleotide polymorphisms to identify persons at high
cancer risk: an evaluation of seven common cancers. J Clin
Oncol
2012;30:2157-62.
19. Heald B, Edelman E, Eng C. Prospective comparison of
family
medical history with personal genome screening for risk
assessment
of common cancers. Eur J Hum Genet 2012;20:547-51.
Explain of how legal and ethical considerations for group and
family therapy differ from those for individual therapy. Then,
explain how these differences might impact your therapeutic
approaches for clients in group and family therapy. Support
your rationale with evidence-based literature.
American Nurses Association. (2014). Psychiatric-mental health
nursing: Scope and standards of practice (2nd ed.). Washington,
DC: Author.
· Standard 5A “Coordination of Care”
Nichols, M., & Davis, S. D. (2020). The essentials of family
therapy (7th ed.). Boston, MA: Pearson.
Chapter 1, “Introduction Becoming a Family
Therapist”
Chapter 1, “The Evolution of Family Therapy”
Wheeler, K. (Ed.). (2014). Psychotherapy for the advanced
practice psychiatric nurse: A how-to guide for evidence-based
practice. New York, NY: Springer.
Chapter 11, “Group Therapy” (pp. 407–428)

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Surgeon General’s PerspectivesPublic Health Reports Janu.docx

  • 1. Surgeon General’s Perspectives Public Health Reports / January– 3 FAMILY HEALTH HISTORY: USING THE PAST TO IMPROVE FUTURE HEALTH Boris D. Lushniak, MD, MPH, RADM, USPHS More than a decade after completion of the Human Genome Project,1 science has made substantial prog- ress in the development of genomic tests for disease diagnosis, prognosis, risk prediction, prevention, and treatment. Yet, the simplest, most readily available, and most affordable genomic tool for disease preven- tion—the family health history—remains underused. For almost all diseases of public health significance, people with a family history of the disease have a higher risk of developing the disease than people without a family history. Even so, many people do not collect family health history information and share it with relatives2 or even with their health-care providers. The year 2014 marked the 10th anniversary of the Surgeon General’s Family Health History Initiative, launched in 2004 by former Surgeon General Dr. Richard Carmona.3 This initiative is a national cam- paign to help families learn more about their family health history. It provides a free Web-based tool, My Family Health
  • 2. Portrait, to help people collect, organize, and record their family health informa- tion. To highlight the importance of this initiative, Dr. Carmona and later Surgeons General have declared Thanksgiving as Family Health History Day. The collection of family health history information is part of routine health- care interactions and can inform clinical decision making and preventive services. Family health history is a part of many screening and treatment guidelines and, in some cases, can make a big difference in the recommended age for screening. For example, the U.S. Preventive Services Task Force (USPSTF) strongly recommends cholesterol screening beginning at age 35 years for men, but recommends early cholesterol screening beginning at age 20 years for men and women who are at increased risk of cardiovascular disease.4 A family history of cardiovascular disease before 50 years of age in male relatives, or before 60 years of age in female relatives, is one of several fac- tors that are used to define increased risk. Using these recommendations, about 16% of young adults should be screened earlier based solely on the estimated prevalence of family history of early cardiovascular disease among this age group.5 Likewise, the USPSTF recommends screening for osteoporosis for women aged 65 years or older, but earlier screening for women aged 50–64 years with certain risk factors that include parental history of fracture.6 Thus, a 55-year-old white woman whose parent has had a hip fracture should
  • 3. consider getting screened early because her 10-year risk for major osteoporotic fracture is at least as great as a 65-year-old white woman who has no additional risk factors. Several other USPSTF recommendations also include family health history information in determin- ing who should be screened or treated and when. For example, the USPSTF recommends that for women with a family history of breast cancer, clinicians con- sider further breast cancer risk assessment to inform shared decision making regarding chemoprevention.7 Likewise, the USPSTF recommends that primary care Public Health Reports / January–February 2015 / Volume 130 providers screen women who have family members with breast, ovarian, and other cancers known to be associ- ated with BRCA (BReast CAncer susceptibility genes) mutations using one of several family history-based screening tools to identify those who should receive genetic counseling and, if indicated after counseling, BRCA testing.8 National public health initiatives based on guidelines and recommendations informed by family health history include Healthy People 2020,9 the Diabetes Pre- vention Program,10 and the Million Hearts Initiative.11 With more than 70 million additional Americans receiv- ing preventive services covered under the Affordable Care Act beginning in 2010, these recommendations become all the more important.12
  • 4. Most people have a family health history of at least one common disease (e.g., cancer, coronary heart disease, and diabetes) or health condition (e.g., high blood pressure and hypercholesterolemia). Preventive services recommendations that incorporate family health history can improve health outcomes for those at increased risk. A recent study demonstrated that systematic collection of family health history increases the proportion of people identified as having high cardiovascular risk for the purposes of targeted pre- vention.13 Similarly, family health history of diabetes has been shown to have added value for detecting undiagnosed diabetes in the U.S. population when combined with other known risk factors.14 But even in cases where family history does not alter specific preventive service recommendations (e.g., the USPSTF recommendations for high blood pressure screening of adults aged 18 years or older, regardless of risk factors such as family history),15 providers who know the patient’s family health history can take this knowledge into consideration during clinical care. Recent national efforts can help improve the collec- tion and use of family health history information. In 2014, the Stage 2 Medicare Meaningful Use measures for electronic health records (EHRs) took effect, and they included incentives to collect family health history information as structured data.16 In 2008, the Family Health History Multi-Stakeholder Workgroup of the American Health Information Community (AHIC) proposed a core dataset for family health history information and explored approaches to promote the incorporation of such information in EHRs.17 Clinical decision support tools that incorporate family health history information into risk assessment and prevention
  • 5. plans are becoming available to assist with implement- ing existing practice guidelines. The Surgeon General’s My Family Health Portrait has been continually updated since it was initially developed in 2004, including a redesign in 2009 to be interoperable with EHRs and to collect information consistent with the AHIC mini- mum core dataset. In 2014, My Family Health Portrait was updated to include new risk assessment tools for diabetes and colorectal cancer. With the growing availability of next-generation genome sequencing, current efforts to develop predictive tests for common chronic diseases have moved toward increasing numbers of common and rare genetic variants. But early studies suggest that these tests will likely complement rather than replace family health history.18,19 Family health history gives information not only about genes, but also about envi- ronmental and behavioral risk factors shared among family members. It therefore can provide a more accurate prediction of disease risk than many genetic tests can alone. During the next decade, research will continue to refine the interconnected roles of family health history and genomic information in screening, treatment, and prevention. In the meantime, enhanced training and education of the public health and clini- cal workforce is needed to realize the health benefits of these discoveries, and everybody needs to become more aware and savvy about the potential value of family health history. Boris D. Lushniak is the Acting Surgeon General of the United States. The author thanks Katherine Kolor, PhD, and Muin J. Khoury,
  • 6. MD, PhD, of the Office of Public Health Genomics, Centers for Disease Control and Prevention; and Ridgely Fisk Green, PhD, of Carter Consulting Inc., for their contributions to this article. REFERENCES 1. Guttmacher AE, Collins FS. Welcome to the genomic era. N Engl J Med 2003;349:996-8. 2. Awareness of family health history as a risk factor for disease—United States, 2004. MMWR Morb Mortal Wkly Rep 2004;53(44):1044-7. 3. Department of Health and Human Services (US). Surgeon General’s family health history initiative [cited 2014 Aug 29]. Available from: URL: http://www.hhs.gov/familyhistory 4. Preventive Services Task Force (US). Screening for lipid disor- ders in adults: recommendation statement. 2008 [cited 2014 Sep 1]. Available from: URL: http://www.uspreventiveservices taskforce.org/Page/Document/RecommendationStatementFinal /lipid-disorders-in-adults-cholesterol-dyslipidemia-screening 5. Kuklina EV, Yoon PW, Keenan NL. Prevalence of coronary heart disease risk factors and screening for high cholesterol levels among young adults, United States, 1999–2006. Ann Fam Med 2010;8:327-33. 6. Preventive Services Task Force (US). Screening for osteopo-
  • 7. rosis: recommendation statement. 2011 [cited 2014 Sep 1]. Available from: URL: http://www.uspreventiveservicestask force.org/Page/Document/RecommendationStatementFinal /osteoporosis-screening 7. Preventive Services Task Force (US). Medications for risk reduc- tion of primary breast cancer in women: U.S. Preventive Services Task Force recommendation statement. 2013 [cited 2014 Sep 1]. Available from: URL: http://www.uspreventiveservicetaskforce .org/Page/Document/RecommendationStatementFinal/breast- cancer-medications-for-risk-reduction Public Health Reports / January–February 2015 / Volume 130 8. Preventive Services Task Force (US). Risk assessment, genetic counsel- ing, and genetic testing for BRCA-related cancer in women: U.S. Pre- ventive Services Task Force recommendation statement. 2013 [cited 2014 Sep 1]. Available from: URL: http://www.uspreventiveservices taskforce.org/Page/Document/RecommendationStatement Final /brca-related-cancer-risk-assessment-genetic-counseling-and- genetic- testing-december-2013 9. Department of Health and Human Services (US). Healthy People 2020 genomics objective G-1 [cited 2014 Aug 29]. Available
  • 8. from: URL: http://www.healthypeople.gov/2020/topicsobjectives2020 /objectiveslist.aspx?topicId=15 10. Albright AL, Gregg EW. Preventing type 2 diabetes in communities across the U.S.: the National Diabetes Prevention Program. Am J Prev Med 2013;44(4 Suppl 4):S346-51. 11. Frieden TR, Berwick DM. The “Million Hearts” initiative— prevent- ing heart attacks and strokes. N Engl J Med 2011;365:e27. 12. Skopec L, Sommers BD. Seventy-one million additional Americans are receiving preventive services coverage without cost-sharing under the Affordable Care Act. Rockville (MD): Department of Health and Human Services (US); 2013. Also available from: URL: http://aspe .hhs.gov/health/reports/2013/PreventiveServices/ib_prevention .cfm [cited 2014 Oct 6]. 13. Qureshi N, Armstrong S, Dhiman P, Saukko P, Middlemass J, Evans PH, et al. Effect of adding systematic family history enquiry to car- diovascular disease risk assessment in primary care: a matched- pair, cluster randomized trial. Ann Intern Med 2012;156:253-62. 14. Yang Q, Liu T, Valdez R, Moonesinghe R, Khoury MJ. Improvements in ability to detect undiagnosed diabetes by using information
  • 9. on family history among adults in the United States. Am J Epidemiol 2010;171:1079-89. 15. Preventive Services Task Force (US). Screening for high blood pressure: reaffirmation recommendation statement. 2007 [cited 2014 Sep 1]. Available from: URL: http://www.uspreventiveservices taskforce.org/uspstf07/hbp/hbprs.htm 16. Centers for Medicare & Medicaid Services (US). Stage 2 eligible professional meaningful use menu set measures: measure 4 of 6 [cited 2014 Aug 29]. Available from: URL: http://www.cms.gov /Regulations-and-Guidance/Legislation/EHRIncentivePrograms /downloads/Stage2_EPMenu_4_FamilyHealthHistory.pdf 17. Feero WG, Bigley MB, Brinner KM; the Family Health History Multi-Stakeholder Workgroup of the American Health Information Community. New standards and enhanced utility for family health history information in the electronic health record: an update from the American Health Information Community’s Family Health History Multi-Stakeholder Workgroup. J Am Med Inform Assoc 2008;15:723-8. 18. Park JH, Gail MH, Greene MH, Chatterjee N. Potential usefulness of single nucleotide polymorphisms to identify persons at high cancer risk: an evaluation of seven common cancers. J Clin Oncol
  • 10. 2012;30:2157-62. 19. Heald B, Edelman E, Eng C. Prospective comparison of family medical history with personal genome screening for risk assessment of common cancers. Eur J Hum Genet 2012;20:547-51. Explain of how legal and ethical considerations for group and family therapy differ from those for individual therapy. Then, explain how these differences might impact your therapeutic approaches for clients in group and family therapy. Support your rationale with evidence-based literature. American Nurses Association. (2014). Psychiatric-mental health nursing: Scope and standards of practice (2nd ed.). Washington, DC: Author. · Standard 5A “Coordination of Care” Nichols, M., & Davis, S. D. (2020). The essentials of family therapy (7th ed.). Boston, MA: Pearson. Chapter 1, “Introduction Becoming a Family Therapist” Chapter 1, “The Evolution of Family Therapy” Wheeler, K. (Ed.). (2014). Psychotherapy for the advanced practice psychiatric nurse: A how-to guide for evidence-based practice. New York, NY: Springer. Chapter 11, “Group Therapy” (pp. 407–428)