Material Safety Data Sheet (MSDS) for Cosmesome-ACE (NE) a Proliposome formulation manufactured by Encapsula NanoSciences that is used specifically in the cosmetic industry. The brand name is Cosmesome-ACE (NE). The Cosmesome-ACE (NE) formulation is composed of saturated phospholipids and it does not contain alcohol. The proliposome formulation forms liposomes that contain vitamins A, C and E upon dilution with water. During the dilution process water soluble active ingredients can be encapsulated inside the liposomes or liposoluble active ingredients can be incorporated into the lipid bilayers.

1. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
1. PRODUCT AND COMPANY IDENTIFICATION
Product name: COSMESOME TM- ACE (NE)
Product Number: COS-1006
Brand: COSMESOME TM
Company Address: ENCAPSULA NANOSCIENCES LLC
6 CADILLAC DRIVE SUITE 245
BRENTWOOD, TN, 37027
Technical Phone: 615-884-4442
Fax: 615-250-8747
Emergency Phone: 615-438-8553
CHEMTREC: 1-800-424-9300
2. COMPOSITION/INFORMATION ON INGREDIENTS
Ingredient Name CAS# Percent
WATER 7732-18-5 >90
GLYCERIN 56-81-5
1, 3 Butanediol 107-88-0
ASCORBYL PALMITATE 137-66-6 <5
TOCOPHERYL ACETATE 58-95-7 <5
RETINYL PALMINTATE 79-81-2
L-α-PHOSPHATIDYLCHOLINE, hydrogenated 97281-48-6 <5
3. HAZARDS IDENTIFCATION
OSHA
No known OSHA hazards
Hazard Statements
Ascorbyl Palmitate: ORAL (LD50)
DERMA (LD50)
Retinyl Palmitate: ORAL (LD50)
HMIS RATING
HEALTH HAZARDS: 1
FLAMMABILITY: 1
CHRONIC HEALTH HAZARDS: *
PHYSICAL HAZARDS: 0

2. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
NFPA RATING
HEALTH HAZARD: 2
FLAMMABILTY: 1
REACTIVITY: 0
POTENTIAL HEALTH EFFECTS
Inhalation May be harmful if inhaled.
Skin May be harmful if absorbed through skin.
Eyes May cause eye irritation.
Ingestion May be harmful if swallowed.
Chronic No existing conditions have been investigated
4. FIRST AID MEASURES
ORAL EXPOSURE
Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with
water. Consult a physician
INHALATION EXPOSURE
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give
oxygen. Consult a physician.
DERMAL EXPOSURE
In case of contact, immediately wash skin with soap and copious amounts of water. Cover skin with
an emollient. Contact a physician.
EYE EXPOSURE
In case of contact, check or remove any contact lenses; immediately flush eyes with copious amounts
of water for at least 15 minutes. Contact a physician.
5. FIRE FIGHTING MEASURES
FLAMMABILITY
Not available
EXTINGUISHING MEDIA
It is suitable to use water spray, alcohol -resistant foam, dry chemical or carbon dioxide.
SPECIAL PROCTECTIVE EQUIPMENT FOR FIRE-FIGHTERS
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and
eyes. Included a positive pressure NIOSH approved self-contained breathing apparatus.

3. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
HAZARDOUS COMBUSTION PRODUCTS
Carbon oxides
SPECIAL REMARKS
N/A
6. ACCIDENTAL RELEASE MEASURES
METHODS FOR CLEANING UP
Soak up inert absorbent material and dispose of as waste. Keep in suitable container for disposal.
Use appropriate tools to put this spilled solid in a convenient waste disposable container and finish
cleaning by spreading water on the contaminated surface and dispose of according to local and
region authority requirements. Allow to evacuate through the sanitary system.
ENVIRONMENTAL PRECAUTIONS
Do not let product enter drains. If safe to do so prevent further leakages or spills.
PERSONAL PRECAUTIONS
Use personal protective equipment. Avoid breathing in vapors, mist or gas. Ensure adequate
ventilation. Prepare evacuation sites.
7. HANDLING AND STORAGE
HANDLING
User Exposure: Do not breathe vapor. Do not get in eyes, on skin, on clothing. Wash hands
thoroughly after handling.
STORAGE
Suitable: Keep tightly container closed. Store in temperature between approximately 2-8 o C. Do not
freeze keep in refrigerator. Keep in a well -ventilated space. Product is sensitive to moisture and
light.
8. EXPOSURE CONTROLS/ PERSONAL PROTECTION
ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory: Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) in accord with 29 CFR 1910.134, use either an atmosphere supply
respirator or air purifying respirator. Also use a full -face respirator with multi -purpose combination
(US) or type ABEK (EN 14387) respirator cartridges as a back up to engineering controls. If the
respirator is the sole means of protection, use a full -face supplied airs respirator. Use respirators
and components tested and approved under appropriate government standers such as NIOSH (US)
or CEN (EU).

4. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
Hand: Compatible chemical -resistant gloves.
Eye: Chemical safety goggles. Safety glasses with side-shields conforming to EN 166 use equipment
for eye protection listed and approved under appropriated government standards such as NIOSH
(US) or EN166 (EU)
Skin and Body: Wear a complete suit protecting against chemicals.
GENERAL HYGIENE MEASURES
Wash hands thoroughly after handling. Wash contaminated clothing before reuse. Prepare all
materials under the fume hood and avoid generating aerosols.
9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
white, viscous liquid
Safety data
N/A
Melting point
N/A
Boiling point
N/A
Flash point
N/A
Ignition Temperature
N/A
Lower explosion limit
N/A
Upper Explosion limit
N/A
Water Solubility
N/A
Density
N/A
10. STABILITY AND REACITIVITY
STORAGE STABILITY
Store under recommended conditions .
MATERIALS TO AVIOD
Excessive heat, light, or air.

5. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
HAZARDOUS DECOMPOSITION PRODUCTS
Not Available
CONDITIONS TO AVOID
Light and exposure to moisture or excessive heat. Strong bases and Strong oxidizing agents.
11. TOXICOLOGICAL INFORMATION
CARCINOGENICITY
This product contains a component that has been reported to be carcinogenic based on its IARC, OHSA, ACGIH,
NTP, or EPA classification.
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by the IARC.
OHSA: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by the OHSA.
ACGIH: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by the ACGIH.
EPA: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by the EPA.
CHRONIC
Retinyl Palmitate: Mutagenic for mammal stomach cells. Teratogenic effects: classified possible
for human. Developmental toxicity: classified reproductive system/ toxin/female, reproductive
system/toxin/male, development toxin (possible). The substance may be toxic to liver,
gastrointestinal tract, skin, CNS. Repeated for prolonged exposure to the substance can produce
target organs damage.
ACUTE TOXICITY
Retinyl Palmitate: Oral LD50- mouse rat-698 mg/kg
Symptoms: Sense organs and special senses (eye-lacrimation; muscle weakness; diarrhea)
Ascorbyl Palmitate: Oral LD50- mouse rat-698 mg/kg
Symptoms: Sense organs and special senses (eye-lacrimation; muscle weakness; diarrhea)
1,3-Butanediol : Oral LD50- mouse rat-698 mg/kg
Symptoms: Sense organs and special senses (eye-lacrimation; muscle weakness; diarrhea)
Dermal LD50- rabbit >20,000 mg/kg
Glycerin: Oral LD50- mouse rat-698 mg/kg
Symptoms: Sense organs and special senses (eye-lacrimation; muscle weakness; diarrhea)
Dermal LD50- rabbit >20,000 mg/kg

6. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
ADDITIONAL INFORMATION
Prolonged or repeated exposure may result in Nausea, Headache, or Vomiting
Kidney- irregularities-based on Human evidence
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation
Skin Absorption: May be harmful if absorbed through the skin
Eye Contact: May Cause eye irritation
Inhalation: Materials may be irritating to mucous membranes and upper respiratory tract.
Ingestion: May be harmful if swallowed
SIGNS AND SYMPTOMS OF EXPOSURE
Symptoms of the GI tract irritation may cause nausea, vomiting, diarrhea, constipation, cramps
and lose of appetite. May also effect behavior/CNS (symptoms may include headache, dizziness,
drowsiness, fatigue, lack on muscular coordination), liver (symptoms may include jaundice, and
elevation of liver enzyme levels), and metabolism. Chronic exposure may also cause adverse
reproductive effects, and birth defects, and may affect genic material.
12. ECOLOGICAL INFORMATION
Elimination information (persistence and degradability)
N/A
Ecotoxicity effects
N/A
Further information on ecology
N/A
13. DISPOSAL CONSIDERATIONS
PRODUCT
Observe all federal, state, and local environment regulations. Contact a licensed professional waste
disposal service to remove this material .
CONTAMINATED PACKAGING
Observe all federal, state, and local environment regulations.
14. TRANSPROT INFORMATION
DOT (US)
Not dangerous goods

7. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
IMDG
Not dangerous goods
IATA
Not dangerous goods
15. REGULATORY INFORMATION
OSHA HAZARDS
OSHA: Hazardous by definition of Hazard Communication Standard (29 SFR 1910.1200). EINECS:
this product is on the European Inventory of Existing Commercial Chemical Substances
SARA 302 COMPONENTS
SARA 302: No chemicals in this material are subject to the reporting requirements of SARA Title
III, Section 302
SARA 313 COMPONENTS
SARA 313: This material does not contain any chemical components with known CAS numbers
that exceed threshold (De Minimis) reporting levels establi shed be SARA Title III, Section 313
SARA 311/312 HAZARDS
Acute health hazards, chronic health hazards
MASSACHUSETTS RIGHT TO KNOW COMPONENTS
Glycerol 56-81-5 2007-03-01
PENNSYVANIA RIGHT TO KNOW COMPONENTS
CAS-No. Revision Date
L-α-PHOSPHATIDYLCHOLINE, hydrogenated 97281-48-6 1989-08-11
Glycerol 56-81-5 2007-03-01
Butane-1,3-diol 107-88-0
Water 7732-18-5
NEW JERSEY RIGHT TO KNOW COMPONENTS
CAS-No. Revision Date
L-α-PHOSPHATIDYLCHOLINE, hydrogenated 97281-48-6 1989-08-11
Glycerol 56-81-5 2007-03-01
Butane-1,3-diol 107-88-0
Water 7732-18-5

8. Material Safety Data Sheet
Version 1.1
Revision Date: 06/05/2014
Print Date: 08/06/2014
CALIFORNIA PROP. 65 COMPONENTS
CAS-No. Revision Date
L-α-PHOSPHATIDYLCHOLINE, hydrogenated 97281-48-6 1989-08-11
WHMIS (Canada)
Not controlled under WHMIS (Canada)
Federal and State Regulation: TSCA 8(b) inventory Ascorbyl Palmintate
TSCA 8(b) inventory Tocopheryl Acetate
TSCA CAS# 7732185 is listed on the TSCA Inventory
California Prop. 65: This product contains the following ingredients for which the state of CA has found to cause
cancer, birth defects, or other reproductive harm, which would require a warring under the statue:
Vitamin A Palmitate, liquid in oil
California prop. 65: This product contains the following ingredients for which the state of CA has found to birth
defects which would require a warring under the statue: Vitamin A Palmitate, Liquid in Oil TSCA 8(b)
inventory: Vitamin A Palmitate, Liquid in Oil
DSCL (EEC): R36-Irritating to eyes. S2- Keep out of reach of children. S46- if swallowed, seek medical advice
immediately and show this container or label.
CANADA
CAS# 7732185 is listed on Canada's DSL List
16. OTHER INFORMATION
Copyright 2013 Encapsula NanoSciences LLC license granted to make unlimited paper copies for internal
use only.
The above information is believed to be correct but does not support to be all inclusive and shall be used
only as a guide. The information in this document is based on the present state of our knowledge and is
applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Encapsula NanoSciences LLC shall not be held liable for any
damage resulting from handling or from contact with the above product.