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своевременная диагностика и терапия данного заболевания до сих пор являются нерешенной клинической задачей. По данным на 2011 г., заболе- ваемость раком простаты в России составила 10,7% (40 тыс. первичных случаев) мужского населения, причем в 60% случаев заболевание диа- гностировали на поздней (III–IV) стадии, когда неизбежен процесс активного роста и распространения метастазов. Методы анатомической визуализации при диагностике данного заболевания имеют низкую чувствительность и специфичность. Методы метаболической визуализации, использующие в качестве маркера простатспецифический антиген (ПСА), также малоэффективны. В качестве маркера для диагностики и лечения метастатического рака простаты предлагается рассматривать простатспецифический мембранный антиген (ПСМА). За рубежом проходят клинические испытания наиболее перспективные диагностические радиофармпрепараты на основе малых пептидных молекул, моди- фицированных мочевиной, которые отличаются наибольшим сродством к ПСМА. Отличительной особенностью этих соединений является их благоприятная фармакокинетика, высокое и длительное накопление в опухоли и метастазах, быстрое выведение из организма. Ключевые слова: метастатический рак предстательной железы, простатспецифический мембранный антиген, радиофармпрепараты. (Для цитирования: Власова О.П., Герман К.Э., Крылов В.В., Петриев В.М., Эпштейн Н.Б. Новые радиофармпрепараты для диагности- ки и терапии метастатического рака предстательной железы на основе ингибиторов простатспецифического мембранного антигена. Вестник РАМН. 2015; 70 (3): 360–365. Doi: 10.15690/vramn.v70i3.1334)

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Rule 1 − Check for the blocks connected in series and simplify. Rule 2 − Check for the blocks connected in parallel and simplify. Rule 3 − Check for the blocks connected in feedback loop and simplify. Rule 4 − If there is difficulty with take-off point while simplifying, shift it towards right. Rule 5 − If there is difficulty with summing point while simplifying, shift it towards left. Rule 6 − Repeat the above steps till you get the simplified form, i.e., single block.

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