Lunasin and Epigenetics vs. Conventional Cancer Drugs

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Dr. Alfredo Galvez shows how lunasin the world's first epigenetic superfood affects multiple genes in multiple pathways versus cancer drugs.

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Lunasin and Epigenetics vs. Conventional Cancer Drugs

  1. 1. Lunasin and Nutritional Epigenetics vs. Conventional Cancer Drugs "No other company is advancing the field of epigenetics like Reliv. We are in the middle of a revolution in nutrition, and we are all witnesses." Dr. Alfredo Galvez, the Center of Excellence in Nutritional Genomics at University of California - Davis. Dr. Galvez is working on the development of functional foods and nutraceutical ingredients based on the lunasin peptide, a soy protein component he serendipitously discovered in 1996 as a postdoctoral researcher at UC Berkeley.
  2. 2. What makes lunasin different from cancer drugs? “Cancer drugs, like tamoxifen for example, target a specific gene (ER-estrogen receptor) and a specific physiological pathway (estrogen receptor pathway) in stopping cancer development. Lunasin, as a low potency dietary ingredient, has been shown in a number of publications to affect multiple genes in multiple pathways, albeit in incremental fashion, to help prevent cancer development.” Dr. Galvez View how lunasin affects multiple genes in multiple pathways
  3. 3. Conventional Drug Development From Hanahan and Weinberg, 2000 Cell 100:50-57
  4. 4. Conventional Drug Development From Hanahan and Weinberg, 2000 Cell 100:50-57
  5. 5. PP2 PI3K Conventional Drug Development From Hanahan and Weinberg, 2000 Cell 100:50-57
  6. 6. PP2 PI3K Conventional Drug Development From Hanahan and Weinberg, 2000 Cell 100:50-57
  7. 7. PP2 PI3K chloroquine Conventional Drug Development From Hanahan and Weinberg, 2000 Cell 100:50-57
  8. 8. Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways
  9. 9. Akt Bcl2 Bcl2 Ras Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways α5β3 NF-κB Lunasin inhibits oncogene and carcinogen-induced cell transformation.
  10. 10. p53 Akt Bcl2 Bcl2caspase Bad Ras Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways Rb α5β3 NF-κB p21 Pten Lunasin inhibits oncogene and carcinogen-induced cell transformation. Lunasin increases expression of genes associated with tumor suppression, apoptosis, mitotic control and DNA repair. pp32
  11. 11. p53 Akt Bcl2 Bcl2caspase Bad Ras Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways Rb α5β3 NF-κB p21 Pten Lunasin inhibits oncogene and carcinogen-induced cell transformation. Lunasin increases expression of genes associated with tumor suppression, apoptosis, mitotic control and DNA repair. pp32 Tamoxifen chemopreventive drug inhibits estrogen receptor (ER) ER
  12. 12. 1) Prevents cancer formation induced by chemical carcinogens 2) Prevents cancer formation induced by viral oncogenes 3) Prevents cancer formation caused by inactivation of tumor suppressors. 4) Inhibits inflammation 5) Improves innate immunity or ability to fight infections 6) Enhances anti-oxidant effects in cells 7) Prevents metastasis of colon cancer cells to the liver 8) Has functional and structural similarity to a human tumor suppressor 9) Increases expression of liver enzyme that detoxifies carcinogen that can cause prostate cancer Anti-cancer Properties of Lunasin (published and current research)
  13. 13. Lunasin’s epigenetic mechanism of action Chromosome Chromatin Methyl group DNA methylation HISTONE TAILGENE HISTONEHistones are proteins around which DNA is packaged. Modification of histone tails are important in gene regulation Methyl group can tag DNA at CpG dinucleotide and is associated with gene repression Compacted chromatin – DNA inaccesible – gene inactive Histone tail modifiers (HAT/HDAC) PCAF SirT1 P300/CBP HISTONE ACETYLATION Unwound chromatin – DNA accessible – gene active GENE Gene Expression On
  14. 14. Lunasin’s epigenetic mechanism of action Chromosome Chromatin Methyl group DNA methylation HISTONE TAILGENE HISTONEHistones are proteins around which DNA is packaged. Modification of histone tails are important in gene regulation Methyl group can tag DNA at CpG dinucleotide and is associated with gene repression Compacted chromatin – DNA inaccesible – gene inactive Histone tail modifiers (HAT/HDAC) PCAF SirT1 P300/CBP HISTONE ACETYLATION Unwound chromatin – DNA accessible – gene active GENE Lunasin Gene Expression On
  15. 15. Lunasin’s epigenetic mechanism of action Chromosome Chromatin Methyl group DNA methylation HISTONE TAILGENE HISTONEHistones are proteins around which DNA is packaged. Modification of histone tails are important in gene regulation Methyl group can tag DNA at CpG dinucleotide and is associated with gene repression Compacted chromatin – DNA inaccesible – gene inactive Histone tail modifiers (HAT/HDAC) PCAF SirT1 P300/CBP HISTONE ACETYLATION Unwound chromatin – DNA accessible – gene active GENE Lunasin Gene Expression Off
  16. 16. 0 20 40 60 80 100 120 140 160 180 200 1.00 2.66 6.01 204 FoldIncrease Industry Standard Soy Protein Isolate LunaRich™ Soy Powder LunaRich X™ Lunasin bioactivity of soy protein formulations
  17. 17. LunaRich: Nutrition at a Higher Level What is it? Reliv's exclusive non-GMO LunaRich® delivers five to ten times the amount of lunasin, a naturally occurring peptide that provides many of soy's documented health benefits. Numerous studies demonstrate lunasin’s superior support for cancer-preventive effects, cardiovascular health, significant anti-inflammatory properties, anti-aging, and skin health. LunaRich products are quite simply the most advanced soy formulations on the market today — Take control of your health! Order Today: WealthThruNutrition.com

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