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Jill Werner BScPT
 PT for 13 years

 Focus on neurological disease and
  injury
 Currently own a private home care
  business and work on call at Cedars
Parkinson’s Disease
Common Physical Characteristics:

 Tremors

 Rigidity

 Lack of movement or slowness initiating
  movement

 Flexed or bent forward posture

 Changes in “executive function”
The Science and
          Practice of LSVT BIG
                                    LSVT Global, Inc.
                                   www.lsvtglobal.com

                      Supported, in part by research grants:
         R01 DC01150, R21 RFA-NS-02-006, R21 DC006078, R21 NS043711


Copyright LSVT Global, Inc. 2011
It is a “Stunning Time” to be
           in rehabilitation today
        Basic science evidence for the value of
         exercise in PD (classically drugs, surgery,
         today…)
        Identified key principles of exercise that
         drive activity-dependent neural plasticity
        Demonstrated that exercise can improve
         brain functioning (neural plasticity) and may
         slow disease progression
        Exercise is Medicine!
                                   Kliem & Jones, 2008; Ludlow et al, 2008
Copyright LSVT Global, Inc. 2011
Legitimate Therapeutic Options
To provide symptomatic relief; improve function



             Pharmacological                  Neurosurgical
                 (L-dopa)                      (DBS-STN)




                                   Voice and Body
                                       Exercise

Copyright LSVT Global, Inc. 2011

                                                      Zigmond et al, 2009
LSVT Programs
Administered in an intensive manner to
  to challenge the impaired system.

     Techniques specific to PD-specific
                 deficits!
        bradykinesia/hypokinesia
                   and
          kinesthetic awareness
             (sensory deficit)
 Copyright LSVT Global, Inc. 2011
What are the fundamentals of
                  LSVT BIG?
           Standardized, research-based, specific protocol


      TARGET: Bigness (amplitude)
      MODE: Intensive and High Effort
      CALIBRATION: Generalization
                     Sensory
                     Internal cueing
                     Neuropsychological changes
Copyright LSVT Global, Inc. 2011
MODE
Delivery
  – Certified LSVT BIG Physical/Occupational
     Therapist
     •     1:1 intervention
Time of Practice
  – 4 consecutive days per week for 4 weeks
  – 16 sessions in one month
  – 60 minute sessions
  – Daily carryover assignments (30 days/entire
     month)
  – Daily homework (30 days/entire month)
                     Copyright LSVT Global, Inc. 2011
CALIBRATION
  MISMATCH between
  on-line perception of
  output and how others
  perceive it
    “I had no idea how small my
      world had become”
      “I can’t move like this,
   people will think I am crazy!!”
Imaging Studies with LSVT LOUD
                                   Liotti, Ramig, et al, 2003




Copyright LSVT Global, Inc. 2011
Comparing Exercise in Parkinson’s Disease —
                The Berlin LSVT BIG Study (2010, Movement Disorders)
                 Georg Ebersbach, * Almut Ebersbach, Daniela Edler, Olaf Kaufhold, Matthias Kusch,
                                     1                   1              1               1                1




                                        Andreas Kupsch, and Jo¨rg Wissel
                                                             2


                                                             3




FIG. 2. UPDRS motor score (blinded rating), mean change from baseline (vertical bars 5 standard deviations). Change
between
baseline and follow up at week 16 was superior in BIG (interrupted line) compared to WALK (dotted line) and HOME (solid
line),
Walking Improvements
                                         Faster                                                      Bigger
                                       Preferred Velocity                                            Preferred Stride Length
                          14                                      BIG                           14




                                                                         Absolute Change (cm)
                          12                                      TRAD                          12
             Absolute Change




                          10                                                                    10
 Better
                (cm/sec)




                               8                                                                8

                               6                                                                6

                               4                                                                4

                               2                                                                2

                               0                                                                0

                                   1      T4-T1
                                                            - T12-T1                                    T4-T1           T12-T1




           Improvements occurred in both groups and lasted 3 months.

                         Farley & Koshland, in preparation (Unpublished data)

Copyright LSVT Global, Inc. 2011
Trunk Rotation
                                                                                        BIG
                                                             Trunk Rotation
                                                                                        TRAD
                                                     30                       P < .05
                                                          P < .05



                                   Absolute Change
                                                     25

                                                     20
                       Better

                                                     15

                                                     10

                                                     5

                                                     0
                                                          T4-T1               T12-T1
                                                     -5




                          Only improved for LSVT BIG
                        Farley & Koshland, in preparation (Unpublished data)
Copyright LSVT Global, Inc. 2011
“It is possible to take charge of
your life, even with Parkinson’s.

      It is possible for your will
       to override your brain.

        It is possible to have
      Power Over Parkinson’s”
Sharon Kha, LSVT BIG and LSVT LOUD Graduate
QUESTIONS?

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LSVT Big Presenation

  • 1. Jill Werner BScPT  PT for 13 years  Focus on neurological disease and injury  Currently own a private home care business and work on call at Cedars
  • 2. Parkinson’s Disease Common Physical Characteristics:  Tremors  Rigidity  Lack of movement or slowness initiating movement  Flexed or bent forward posture  Changes in “executive function”
  • 3.
  • 4. The Science and Practice of LSVT BIG LSVT Global, Inc. www.lsvtglobal.com Supported, in part by research grants: R01 DC01150, R21 RFA-NS-02-006, R21 DC006078, R21 NS043711 Copyright LSVT Global, Inc. 2011
  • 5. It is a “Stunning Time” to be in rehabilitation today  Basic science evidence for the value of exercise in PD (classically drugs, surgery, today…)  Identified key principles of exercise that drive activity-dependent neural plasticity  Demonstrated that exercise can improve brain functioning (neural plasticity) and may slow disease progression  Exercise is Medicine! Kliem & Jones, 2008; Ludlow et al, 2008 Copyright LSVT Global, Inc. 2011
  • 6. Legitimate Therapeutic Options To provide symptomatic relief; improve function Pharmacological Neurosurgical (L-dopa) (DBS-STN) Voice and Body Exercise Copyright LSVT Global, Inc. 2011 Zigmond et al, 2009
  • 7. LSVT Programs Administered in an intensive manner to to challenge the impaired system. Techniques specific to PD-specific deficits! bradykinesia/hypokinesia and kinesthetic awareness (sensory deficit) Copyright LSVT Global, Inc. 2011
  • 8. What are the fundamentals of LSVT BIG? Standardized, research-based, specific protocol TARGET: Bigness (amplitude) MODE: Intensive and High Effort CALIBRATION: Generalization Sensory Internal cueing Neuropsychological changes Copyright LSVT Global, Inc. 2011
  • 9. MODE Delivery – Certified LSVT BIG Physical/Occupational Therapist • 1:1 intervention Time of Practice – 4 consecutive days per week for 4 weeks – 16 sessions in one month – 60 minute sessions – Daily carryover assignments (30 days/entire month) – Daily homework (30 days/entire month) Copyright LSVT Global, Inc. 2011
  • 10.
  • 11. CALIBRATION MISMATCH between on-line perception of output and how others perceive it “I had no idea how small my world had become” “I can’t move like this, people will think I am crazy!!”
  • 12. Imaging Studies with LSVT LOUD Liotti, Ramig, et al, 2003 Copyright LSVT Global, Inc. 2011
  • 13. Comparing Exercise in Parkinson’s Disease — The Berlin LSVT BIG Study (2010, Movement Disorders) Georg Ebersbach, * Almut Ebersbach, Daniela Edler, Olaf Kaufhold, Matthias Kusch, 1 1 1 1 1 Andreas Kupsch, and Jo¨rg Wissel 2 3 FIG. 2. UPDRS motor score (blinded rating), mean change from baseline (vertical bars 5 standard deviations). Change between baseline and follow up at week 16 was superior in BIG (interrupted line) compared to WALK (dotted line) and HOME (solid line),
  • 14. Walking Improvements Faster Bigger Preferred Velocity Preferred Stride Length 14 BIG 14 Absolute Change (cm) 12 TRAD 12 Absolute Change 10 10 Better (cm/sec) 8 8 6 6 4 4 2 2 0 0 1 T4-T1 - T12-T1 T4-T1 T12-T1 Improvements occurred in both groups and lasted 3 months. Farley & Koshland, in preparation (Unpublished data) Copyright LSVT Global, Inc. 2011
  • 15. Trunk Rotation BIG Trunk Rotation TRAD 30 P < .05 P < .05 Absolute Change 25 20 Better 15 10 5 0 T4-T1 T12-T1 -5 Only improved for LSVT BIG Farley & Koshland, in preparation (Unpublished data) Copyright LSVT Global, Inc. 2011
  • 16. “It is possible to take charge of your life, even with Parkinson’s. It is possible for your will to override your brain. It is possible to have Power Over Parkinson’s” Sharon Kha, LSVT BIG and LSVT LOUD Graduate
  • 17.