1. FRANK E. INSCORE
home - 53 Lufkin Lane, Bristol, CT 06010; cell - 860.899.4943; email - feinscore@gmail.com
SENIOR SCIENTIST
- SPECTROSCOPY / CHEMOMETRICS / ANALYTICS / CHEMISTRY -
Top-performing R&D professional uniquely qualified to deliver leadership excellence in scientific research & support, and
contribute to your business success by driving innovation forward in new technology, applications & products
PhD with chemistry-centric & material science background; wide-ranging experience in multi-disciplinary team /
department management & leadership toward measurement, characterization & analysis, specializing in design of
experiments, vibrational spectroscopy, statistical multivariate chemometrics, analytical techniques, managing labs
Senior level scientist with proven ability to learn quickly, solve complex problems and ability to multitask by paying
attention to detail & using strong organizational skills, who can effectively interact with leaders, collaborate with &
mentor peers as part of a team by combining technical expertise with solid interpersonal & communication skills
PROFESSIONAL QUALIFICATIONS
• Ph.D. in Physical Chemistry & Inorganic Chemistry, (minor Analytical Chemistry) focus spectroscopy, plus
postdoc in Material Science, focus organic / inorganic / organometallic synthesis, purification and characterization
• Demonstrated breadth of knowledge and technical expertise in IR, Raman and NIR vibrational spectroscopy
through strong record of 48 peer reviewed publications, 4 patents and numerous presentations as invited speaker
at national conferences / trade shows - clear evidence possess both strong oral and written communication skills.
e.g. 17 out of 50 projects+14 papers 28 talks 2 patents in pharmaceutical industry supports considerable personal
interest, self-motivation & independent development toward pharmaceutical sciences and clinical applications.
• Extensive hands on experience in preparing samples for spectral measurement; collecting data from solids as
single crystals, crystalline or amorphous powders, tablets, solutions / thin-solid films or glasses, Nujol mineral oil /
PDMS mulls, hardened polymer / PST optical thin films, KBr pellets / disks, AND liquids as neat, solution or glass
• Very conversant with data collection, processing and analysis, including chemometrics principles & multivariate
modeling approaches across various spectroscopic techniques, especially data acquired by portable & bench-top
research-grade FT/dispersive Raman NIR & FT-IR (MIR) spectrometers for field, process & lab applications; good
command of preprocessing spectra - baseline correction, smoothing, scaling & subtraction, and derivatization, in
construction of spectral libraries, calibration & validation test sets and PCA PLS DA SIMCA chemometric models
• Applied Raman spectroscopy as analytical measurement tool for pharma / biotech / petro applications, from
verification of raw materials to process monitoring of production to quality control of products; other technology
developed & tested - near-infrared NIR and for greater sensitivity surface-enhanced Raman spectroscopy SERS
AREAS of EXPERTISE / CORE COMPETENCIES - analytical laboratory management, batch / continuous processing,
process analytical technology PAT, process control / control systems, contract research / contract manufacturing,
active pharmaceutical ingredient API / excipient / drug chemical characterization, pharmaceutical reaction monitoring,
regulatory compliance guidance standards FDA GMP GLP familiarity, product quality, biopharmaceutical industry,
stability and raw material testing, method development / validation, extractables and leachables, pharmaceutical analysis
WORK EXPERIENCE
Analytical R&D / NPD Consulting Scientist, Chemist, Mentor; FI Independent Consultant Hartford CT/US
Engaged as private consultant leveraging transferable career knowledge skills progression for success to build-on
solve new client problems - in medical devices, sensors, biomarker drug metabolite analysis in clinical samples &
combining spectroscopic with organometallic & nanomaterial expertise in new catalytic and sensing applications
- Senior Development Scientist (& Chemistry Consultant) FI IC, January 2014 - present
KEY ACCOMPLISHMENTS
• developed new business relationships via online network by promoting credentials as technical expert & leader
in vibrational spectroscopy - Raman SERS specialist with proven record for strict confidentiality of client / project
details through NDAs, increased contact base from 500 to 2000 in 12 months with 48 new technical consultations
• invited to sit on executive board of new SERS start-up based on materials research and drug library expansion
• continued bioassay work with RTA, DoD & US Army ECBC led to publication & front cover of Analyst 12/21/14
• recognized by peers world wide - accepted editorial board seat of SOJ Biosensors Biomarkers and Diagnostics
• adapted industrial manager leader skills - mentor at STEM science technology engineering mathematics School

2. (feinscore@gmail.com – resume work experience continued pg.2)
- Senior Research / Application Scientist (& Chemistry Consultant) FI IC, Jan 2013 - Jan 2014
KEY CONTRIBUTIONS
• continued comprehensive analysis of real street drug samples, such as bulk / surface / forensic powder cocaine
measured by Raman / SERS, & subsequent measurements of clinical biofluid samples (e.g. saliva) collected from
patients before & after consuming known quantities of bulk (e.g. via nasal inhalation) over 24hr period by SERS
- optimized method development & validated results, by parallel analysis with standard GC-MS HPLC procedures
- discriminated powder samples with respect to purity - nature / number adulterants, by Raman chemometrics
• designed & tested consumables - sampling kits to collect / treat fluid or solid for rapid target release / extraction
Analytical R&D Scientist, Chemist, Leader; Real-Time Analyzers Inc., Middletown CT
“RTA provides FT & dispersive Raman SERS NIR and FT-IR analyzers for complete chemical analysis solutions”
Challenged as a Research & Development applications scientist / engineer toward developing methods and
techniques in field of vibrational spectroscopy, including product development of portable and process analyzers
Challenged to develop optical sensing technology in trace chemical biological detection aimed at commercializing
new sensor platforms based on SERS - novel nanoparticle nanomaterial composites, which can be coupled to
RTA line of Fourier transform (FT) and dispersive CCD Raman analyzers for add-on value and custom solutions
Charged with evaluating competitor products & generating positive recognition of company as an industry leader
- Senior Principle Scientist (& Sr. Development Chemist) RTA, January 2006 - January 2013
Promoted to direct development of new Raman SERS IR research applications products; would report to CEO/VP
in implementation of strategic R&D initiatives as part of a multi-disciplinary team throughout development lifecycle
Used analytical development & validation procedures in new instrument technology; characterization and analysis
tools for developing new methods & analyzers + new nanomaterials & sensors listed below (and addendum pg.4)
- SEM TEM AFM, SPR, SERS SERRS LA-SERS, Raman RR, IR MIR NIR, UV-Vis-NIR, GC LC MS FID HPLC
- FDA figures-of-merit FOM, DoD receiver operating characteristic curve analysis ROC, Six Sigma methods e.g.
statistical design and analysis of experiments DOE, chemometrics RTA in-house with Unscrambler as reference,
spectral analysis processing with RTA RamanVista & Thermo Scientific Grams/AI, RTA spectral match / ChemID
KEY CONTRIBUTIONS
• developed validated Raman chemometrics models - multivariate algorithms (principle component analysis PCA
partial least squares PLS PCR regression, discriminate analysis) and signal preprocessing subroutines generated
with in-house LabView software for spectroscopic analysis, modeling, classification & property prediction of diesel
jet gasoline fuels; benchmarked fuel analyzer, provided logic design & optimal model implementation in analysis
decision-tree, streamlined user interface, validated at SWRI; transferred FT models to dispersive 1064 Raman &
NIR systems and compared; prototypes delivered USMC. success led to 2014 Army contract - hand-held Raman
• demonstrated drug product authentication with portable FT & dispersive-based 1064 Raman systems; identified
number website formulations as counterfeit < 60% API, separating authentic from counterfeit pills tablets by PCA.
success led to 2013 NASA phase1, 2014 phase2 - Raman analyzer of drug stability, expiration / degradation
• achieved real-time saliva analysis for detecting / identifying drugs of abuse (illicit, prescription, OTC) by SERS,
completing goals/milestones of 3yr $1,200,000 project on-time under-budget for UK Home Office that produced &
delivered road-side SERS Saliva Analyzer SSA to ascertain driver impairment in compliance with legal mandates.
success led to 2012 NIH SBIR award as coPI/PM, 2014 phase2 -saliva analyzer diagnosing SRD patient drug use
• launched new commercial products - initiated global market entry of RTA portable Raman/SERS-ID analyzers;
1st SER-active microplates by using polymer-modified sol-gels providing combinatorial high-throughput screening
with capability to couple MP sensor to existing chromatographic tools; 1st SER-active capillaries, allowing flow of
µL to mL volumes to selectively concentrate and detect; 1st SERS libraries constructed for public, with 800 unique
chemicals biochemicals 350 drugs/metabolites/precursors, + compliment 532/633/785/976/1064/1550 Raman libs
• increased RTA public awareness by producing Utube video of surface swab analysis, suitcase handle/finger-tips
promoting new applications for SER vials - airport border port interdiction; viewed 2X more than other RTA videos
• success in drug detection & biofluid analysis led to increased sales / new customers, including collaborations &
numerous subcontracts with DigiLab, Merck, BMS, Novartis, Sanofi, Roche, Sandoz, Barr/Teva, InfraTrac/USPC,
AstraZeneca, GlaxoSmithKline, Miami Yale Harvard Medical Schools, NIH NSF NASA, Colgate, Viagen, Kraft

3. (feinscore@gmail.com – resume work experience continued pg.3)
- Senior Scientist (& Sr. Research Chemist) RTA, January 2003 - January 2006
Recruited to lead research & manage new Raman-SERS technology application product development programs,
targeting biotech chemical med health pharma petro military security environmental food-safety law & art markets
Led preliminary studies to demonstrate Raman capabilities in pharmaceutical petrochemical biotech applications,
incredible analysis achieved by combining chemometrics; improved sensitivity of normal Raman 6-9 fold by SERS
KEY CONTRIBUTIONS
• developed initial models classifying jet diesel fuel & predicting properties by chemometrics with 1064 FT Raman,
based on full spectral & ASTM property analysis via RTAs PCA / PLS software; critical parameters - boiling point
distillation / viscosity / flash freezing cloud pour points / acid number / density / %sulfur / aromatics / cetane index
- performed BTEX calibration and monitored fuel component blending, USMC Navy; olefin analysis for Chevron
- showed synthetic & biofuel blending & fuel contaminant analysis by Raman superior to NIR; US-ONR validated
- measured 2500 fuel/blend/nonfuel samples Library; 400 jet diesel fuels for model references + 400 for validation
- established Raman in monitoring biomass conversions, sugar / ethanol, & process control, reactions / catalyst
• proved Raman feasibility & value in drug synthesis development, drug quality; opening process markets for RTA
- by compositional analysis e.g. identified degradation product p-aminophenol in expired Tylenol tablet; error <1%
- by synthesizing proprietary drug upon patent expiration, developing new multistep reaction pathway using new
precursors / intermediates; could verify raw materials, monitor reactions & characterize products produced and
isolated in each step; identified onset crystallization / polymorphs from product formation by Raman chemometrics
- by process control of esterfication in NeSSI based small batch / microreactor; led to automated continuous flow
sampling interface & reaction platform in collaboration with Parker-Hannifen / Intra-flow system, PAT initiative
• accomplished real-time urine analysis by SERS for diagnosis treatment of osteoporosis & renal-stone formation,
detected muscle bone-loss biomarkers drugs at ppb levels for NASA; expanded nanotechnology to other biofluids
e.g. rapid identification quantification of chemotherapy drugs metabolites in saliva, validated with cancer patient;
success led to future contracts, new prototype deliverables, significant sensor sales - $7,500,000 over next 7yrs
Analytical Postdoctoral Scientist, Chemist, Spectroscopist; University of Arizona, Tucson AZ
- PD Research Associate; Staff Scientist, Synthetic Chemist UAZ, June 2000 - January 2003
Promoted to conduct NIH independent research in design / synthesis / characterization of high-valent transition
metal complexes as geometric & electronic structural analogs of pyranopterin metalloenzyme active-sites;
mentored grad students, advancing research projects within group through spectroscopy / chemistry expertise
Developed advanced synthetic/purification/manipulation methods with Schlenk and inert-atmosphere glove-box
techniques for total water oxygen exclusion that provided ultra-purity & stability necessary for difficult multi-step
synthesis & isolation of over 50 inorganic compounds and complex organic ligands, as small molecule models
Employed wide range analytical, data analysis, characterization and spectroscopic tools for elucidating chemical,
physical, electrochemical geometric electronic properties - CV, NMR, MS, EPR, PES, XAS EXAFS, XRD, IR FTIR
UVvisNIR, Raman RR, MCD; used Gaussian DFT computational methods to evaluate & model experiment results
• provided novel synthetic systems/routes/precursors, active-site mechanisms; producing quality single crystals of
over 20 complexes, a first for 10, including 6 new compounds synthesized - see 6 high-impact journal publications
• showed FTIR & Raman important tools in identifying and discriminating structurally similar series of compounds;
used to monitor integrity and confirm identity of starting materials, progress of reaction and purity of final isolated
product by characteristic frequency, relative intensity, & presence of multiple peaks evident of residual precursor
in reaction workup; Raman probed differences in crystal structure via 50-300cm
-1
lattice modes and complimented
available single crystal results - replacing need for analysis by expensive, time labor intensive powder XRD
- Research Fellow; Bioanalytical Research Scientist, Chemist UAZ, January 2000 - June 2000
Recruited prior to PhD defense as funded postdoc trainee to immediately step-in learn & take control of critical Sr.
biochemist research position vacated; tracked characterized biological samples in cryogenic storage & managed
H2O purification, pH, UV/vis, IR, FPLC HPLC, column chromatography, centrifuge, gel-electrophoresis equipment
• refined QC/QA assays in cold room for isolation purification of Mo/W enzymes - human animal bacterial sources
• characterized by EPR ESR, UV/Vis/NIR Absorption Raman & MCD, and correlated with available EXAFS / XRD
structure, including isotopic substitution analyzing Metal-S vibrations & coupled oxygen atom /e
-
transfer reactions
• achieved success by being a fast-learner, independent confident and agile; flexible - adapts to new situations

4. (feinscore@gmail.com – resume continued, addendum pg.4)
OTHER EXPERIENCE
Research Assistant; Research Chemist, Spectroscopist University of New Mexico, Albuquerque NM
Recruited by new professor to design, outfit & supervise new functional synthetic and optical spectroscopy labs;
trained new students + managed IR, Raman / resonance Raman, cryogenic / UV-vis-NIR absorption / MCD labs
Conducted Ph.D. / M.S. basic research funded by DOE, NSF, Sandia National Laboratory & Petroleum Research
in syntheses and spectroscopic characterization of various small molecule models of metalloprotein active sites
• developed multidisciplinary spectroscopic methodologies to probe small molecule electronic structures that led
to published mechanistic insight how Mo/W enzyme regenerated after catalysis “Oxo-Gate-Hypothesis fold-angle”
• applied Fortran/C knowledge to create normal coordinate analysis program for assigning IR + Raman spectra;
expert in group theory defining symmetry coordinates to construct genuine modes & SALCs; polarization study of
solution Raman used to confirm peak mode symmetries; 77K solid-state resonance Raman RR excitation profiles
350-976nm identified & assigned modes associated with simultaneous Gaussian resolved 4K EA/MCD transitions
• success accomplished by combining multiple analytical theoretical & spectroscopic techniques - novel solutions.
authored SOP standard operating procedures in detail for storing preparing measuring samples and for calibrating
analytical / spectroscopic instrumentation; as an experimental / computational chemist & spectroscopist realized
critical self-need to be able to independently synthesize, isolate and ultra-purify all targeted compounds in future.
ANALYTICAL & TECHNICAL SKILLS
gas liquid chromatography GC LC FPLC HPLC, solid-phase extraction SPE, anionic cationic ion exchange IEX,
size exclusion chromatography SEC, thermogravimetric analysis TGA, differential scanning calorimetry DSC,
melting-point freezing-point, pH, refractive index, dielectric constant / thermal conductivity / resistivity, distillation,
crystallization; microscopy SEM TEM AFM; cyclic voltametry CV, 1H/13C nuclear magnetic resonance NMR,
mass spectroscopy MS ESI FAB TOF, electron spin resonance ESR, electron paramagnetic resonance CW EPR,
photoelectron spectroscopy PES XPS / UPS, atomic absorption AA, elemental analysis, x-ray fluorescence XRF,
x-ray absorption spectroscopy XAS, extended fine structure EXAFS, single crystal powder x-ray diffraction XRD;
infrared IR, Fourier transform infrared FTIR mid-infrared MIR, near-infrared NIR, UVvisNIR, Raman scattering RS,
resonance Raman RR, surface-enhanced Raman laser-ablation SERS SERRS; surface plasmon resonance SPR
VT VH magnetic circular dichroism MCD CD, VT magnetic susceptibility; VT electronic absorption EA; Gaussian
density functional theory DFT, CAMO Unscrambler chemometrics, project management PM, MPM123, Clarizen
new product development NPD stage-gate, Smartdraw CI, Cmap, Tableau informatics; Chemdraw; biochemistry
synthetic chemistry, chemical engineering, analytical chemistry, physical chemistry, inorganic organic chemistry
PROFESSIONAL DEVELOPMENT & EDUCATION
Post Doctorate Materials Science, Bioinorganic Bioorganic chemical engineering, University Arizona, Tucson AZ
Postdoc advanced in synthesis, extraction, separation, purification, characterization, modeling, of new molecules
and materials; Expert in applying a combined multidisciplinary synthetic theoretical spectroscopic approach
Doctor of Philosophy (Ph.D.) in Chemistry / Chemical Biology, University of New Mexico, Albuquerque NM
PhD awarded / MS fulfilled, in both Physical Chemistry & Inorganic Chemistry (analytical chemistry minor)
Bachelor’s degree in Biology / Biological Sciences (organic / biochemistry minor) Austin College, Sherman TX
BA plus BS include strong background in multistep organic / inorganic synthetic chemistry & characterization,
applied mathematics, kinetics / quantum chemistry / spectroscopy & physics, computer science & programming
PROFESSIONAL AWARDS, HONORS & RECOGNITION
NSF + Frost & Sullivan awards for developing & commercializing new nanotechnology in sensors & materials
NASA Innovative Research Award in Medical Technology for SERS lab-on-chip at RTA / Jet Propulsion Labs
Chemistry Dept. Travel awards to ACS & Gordon Conferences and two Recognition awards for PhD Research
Prestigious DOE GANN Fellowship awarded as entering graduate student in chemistry department PhD program
Dean Uhl Award for Excellence in Chemistry & Presidents Honor Roll upon completing B.S. degree requirements
Inducted Kappa Mu Epsilon National Mathematics Honorary & Golden Key National Honor Society for BS
Dean’s List, Biology award, National Merit Scholar, and Academic Scholarships for B.A. degree conferred
PROJECTS, PUBLICATIONS, PATENTS & PRESENTATIONS
15 SBIR proposals authored and awarded as Principle Investigator (PI, principle scientist) and 3 as coPI for RTA
50+ projects programs completed on-time & within budget providing RTA ~$18,000,000 in revenue over 10 years
plus 48 publications, 4 patents (+4 assists) and 50 presentations (with 50+ supported) over career; see appendix