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1. Malignant Salivary Glands
Tumors-II
INDIAN DENTAL ACADEMY
Leader in continuing Dental Education
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2. OBJECTIVES
By the end of the lecture student should be able to
•Describe Etiology, clinical features, histopathological features of
• Intraosseous mucoepidermoid carcinoma
•Acinic cell carcinoma
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3. Most common and best recognized intrabony
salivary tumor (central )
Intraosseus Mucoepidermoid
Carcinoma
Malignant Salivary Gland Tumors
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4. Pathogenesis
Ectopic salivary gland tissue developmentally
entrapped within the jaw.
Entrapment of retromolar salivary gland within
the mandible.
Neoplastic transformation of mucous secretary
cells commonly found in epithelial lining of
dentigerous cyst associated with impacted 3rd
molar.
Malignant Salivary Gland Tumors
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5. Clinical Features
Middle aged persons
Female predilection
Three times more common in mandible
Cortical swelling
Pain, trismus, parasthesia is less
Malignant Salivary Gland Tumors
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6. Radiographic features
Unilocular or multilocular radiolucency with well
defined borders
Malignant Salivary Gland Tumors
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7. Acinic Cell Carcinoma
Malignancy of serous acinar cells.
Considered to be a low grade malignancy.
Malignant Salivary Gland Tumors
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8. Malignant Salivary Gland Tumors
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9. Clinical Features
85% in parotid gland as parotid is the largest
gland & is one composed entirely of serous acini
I/O minor gland in buccal mucosa, lip and palate.
2nd to 7th decade of life.
Slow growing mass.
Lesion appears for many months/ years
Asymptomatic
Facial nerve paralysis is infrequent.
Malignant Salivary Gland Tumors
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10. Closely resembles pleomorphic adenoma in
gross appearance, tending to be encapsulated &
lobulated
Malignant Salivary Gland Tumors
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11. Well circumscribed & encapsulated.
Cells of varying degrees of differentiation.
Well differentiated – remarkable resemblance to
normal acinar cells.
Less differentiated – embryonic duct and
immature acinar cells
Histopathology
Malignant Salivary Gland Tumors
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12. Cells with abundant
granular basophilic
cytoplasm and round
darkly stained eccentric
nucleus.
Malignant Salivary Gland Tumors
Serous cell
Eccentric nucleus
Abundant cytoplasmic granuleswww.indiandentalacademy.com

13. Tumor acini cells with basophilic cytoplasm
Malignant Salivary Gland Tumors
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14. Intercalated duct like
cells
Clear vacuolated cells
Malignant Salivary Gland Tumors
Clear vacuolated cells
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15. Superficial lobe – involvement – lobectomy
Deep lobe- total parotidectomy.
Better prognosis.
Treatment & Prognosis
Malignant Salivary Gland Tumors
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16. SUMMARY
Etiology, clinical features, histopathological
features of
• Intraosseous mucoepidermoid carcinoma
•Acinic cell carcinoma
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17. BIBLIOGRAPHY
• Text book of oral pathology Shafer's, 5 & 6th
edition
• Surgical Pathology of Salivary Glands Ellis 1st
Edition
• Color Atlas of Oral Diseases Cawson, R. 2nd
edition
• Oral and Maxillofacial Pathology Neville, Brad
W. 2nd
• Lucas’s Pathology Of Tumor’s of the Oral
Tissues
• Cawson, R. A., Bennie, W. H 5th edition
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