The document discusses nano dispersers, which are high-pressure equipment used to disperse and homogenize products, improving stability and performance. Nano dispersers have higher efficiency than other technologies like homomixers and ultrasound. They are widely used in various fields. The document provides examples of how nano dispersers can be used for cell disruption, depolymerization of natural polymers, emulsions, and more. It also includes graphs showing the reduction of particle size and droplet size with increased pressure and number of passes through the nano disperser.

1. FLOW TYPECAVITATIONSHEAR FORCE
IMPACT
Z TYPE Y TYPE
Inlet
Outlet
Shear Zone
Impact Zone
Inlet
Outlet
Shear Zone
Impact
Zone
나노디스퍼져는 초고압을 이용하여 분산, 균질 공정에서 제품의 안정성 및 성능을 높이기 위한 목적으로 적용되는 장비입니다.
기존의 호모믹서, 초음파, 볼밀 등을 이용한 타 기술에 비해 높은 효율을 가지고 있어 다양한 분야에 적용되고 있습니다.
NANO DISPERSER
15
12
9
6
3
0
10
0 Pass
5 Pass
100 1000
Intensity(%)
Particle Size (nm)
Reduction of Droplet Size
Uniform Particle Size
Ref. Electronic Journal of Polish Agricultural Universites. 10(2) (2007) #3.
Cell Disruption by High Energy as shear, cavitation and impact
Viscosity(cP)
Molecularweight(kDa)
The Number of Passes The Number of Passes
180
150
120
90
60
30
0
250
200
150
100
50
0
0 1 2 3 4 5 6 0 1 2 3 4 5 6
500 bar
1000 bar
1500 bar
1500 bar
208
102
50
30
Entalglement and stretch
Shear Force Cavitation & Impact
Smaller Fragment Depolymerization
Ref. Int. J. Pharm. 420 (2011) 93-100.
10
8
6
4
2
0
0.01 0.1 1 10 100 1000 3000
Volume(%)
Particle Size(㎛)
Reduction of Particle Size
Uniform Particle Size
1000 bar, 30 Pass
Ref. Proceed. Int'l. Symp. Control. Rel. Bioact. Mater. 27 (2000) 8141-8142
Droplet
Deformation
Disruption
Increase of Pressure
Drug Particles (Drug - Folic acid)
Food (Milk Droplet ) Cell Disruption (Yeast of Baker) Depolymerization of Nature Polymer (Chitosan)
Drug & Cosmetics (Emulsion, Micelle – Coenzyme Q10
100 bar, 5 Pass 600 bar, 5 Pass 900 bar, 5 Pass
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