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Writer:  이흐완 히다얏 Advisor:  Prof.  김석영 생체재료실험실
Contents <ul><li>Introduction </li></ul><ul><li>Research Background </li></ul><ul><li>Research Objectives </li></ul><ul><l...
Introduction Nowadays Initially Research & Development Used to improve a patient’s  masticator function Patients desired a...
Research Background <ul><li>The success of an implant depends on the ability of the material to  attach  with the living h...
Research Background <ul><li>Collagen , being the main constituting protein of the hard tissues, has the potential as a coa...
Research Objectives <ul><li>Experimental on  Surface Modifications  to improve Titanium surface activity </li></ul><ul><li...
R&D Flow Chart Substrate:   Titanium Interface: Coupling agent Coating: Collagen (type 1) Dental implants Orthopedic  impl...
Research Methodology Ti discs Polishing Treatment Heat Treatment TFAA treatment & XPS observation 3-APTES grafting SEM/EDS...
Research Progress <ul><li>Blasting treatment with HA and Al2O3 was done to compare the characteristics and to observe the ...
Research Progress <ul><li>The  HA blasted Ti discs  showed the presence of calcium and phosphorous on the surface of Titan...
Research Progress <ul><li>NaOH & H 2 O 2  etching were conducted to obtain OH -  ( hydroxyl groups ) on Ti surface (see ta...
Research Plans <ul><li>Perform heat treatment (after etching treatment) </li></ul><ul><li>Observation on the Ti treated su...
Terima  Kasih Merci Xie xie Syukron Rahmat Danke Arigato Gracias Grazie Mahalo Salamat
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Study of Titanium Surface Modification & Collagen Grafting for dental implants

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My research on Titanium surface modification using blasting, etching, 3-APTES and collagen grafting

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Study of Titanium Surface Modification & Collagen Grafting for dental implants

  1. 1. Writer: 이흐완 히다얏 Advisor: Prof. 김석영 생체재료실험실
  2. 2. Contents <ul><li>Introduction </li></ul><ul><li>Research Background </li></ul><ul><li>Research Objectives </li></ul><ul><li>Research Methodology </li></ul><ul><li>Research Progress </li></ul><ul><li>Research Plans </li></ul>
  3. 3. Introduction Nowadays Initially Research & Development Used to improve a patient’s masticator function Patients desired also the aesthetics , short treatment time and procedural reliability Improving Titanium’s surface activity , osseointegration and fixation Based on the discovery by Swedish Professor Per-Ingvar Brånemark , Titanium can be successfully fused into bone when osteoblasts grow on and into the rough surface of the implanted titanium Dental Implants Why Titanium?
  4. 4. Research Background <ul><li>The success of an implant depends on the ability of the material to attach with the living host tissue. </li></ul><ul><li>Improvement of fixation between implants and hard tissue can be achieved by coating the metal surface with Calcium Phosphates material or Aluminum Oxide. </li></ul><ul><li>Recent studies on a series of protein coatings on Ti have demonstrated their effective roles in the stimulation of cellular responses, such as attachment and proliferation . </li></ul>
  5. 5. Research Background <ul><li>Collagen , being the main constituting protein of the hard tissues, has the potential as a coating moiety on a Ti implant. </li></ul><ul><li>Hydroxyapatite (HA) coating has been particularly well investigated as a preliminary coating for collagen immobilization on titanium surfaces, because human bone is mainly composed of HA and collagen fibers. </li></ul><ul><li>However, the chemical bonding and the composition of HA-collagen is recognized as being difficult, because it involves two dissimilar organic and inorganic nanophases. </li></ul>
  6. 6. Research Objectives <ul><li>Experimental on Surface Modifications to improve Titanium surface activity </li></ul><ul><li>Immobilizing Collagen onto Titanium by using coupling agent </li></ul>
  7. 7. R&D Flow Chart Substrate: Titanium Interface: Coupling agent Coating: Collagen (type 1) Dental implants Orthopedic implant OH radical Surface Processing Collagen coating Cell Attachment/ Proliferation Materials Processing in vitro Tests Applications
  8. 8. Research Methodology Ti discs Polishing Treatment Heat Treatment TFAA treatment & XPS observation 3-APTES grafting SEM/EDS Observation Collagen Coating Cell Culture Blasting Chemical Treatment Surface Roughness Measurement Analysis
  9. 9. Research Progress <ul><li>Blasting treatment with HA and Al2O3 was done to compare the characteristics and to observe the cell growth. </li></ul><ul><li>Etching treatment with H3PO4 and HNO3 was also conducted to find the effect for both blasting materials. </li></ul><ul><li>Surface roughness: </li></ul><ul><ul><li>The surface roughness average for HA blasted discs are lower than Al2O3 blasted discs </li></ul></ul><ul><ul><li>Etching reduced the roughness average as it removed the embedded blasted particles. </li></ul></ul>
  10. 10. Research Progress <ul><li>The HA blasted Ti discs showed the presence of calcium and phosphorous on the surface of Titanium. </li></ul><ul><ul><li>After HNO 3 etching the calcium and phosphorous were all removed from the surface. </li></ul></ul><ul><ul><li>After H 3 PO 4 etching , the calcium was removed from the surface meanwhile the phosphorous remained , it was found that titanium react with phosphorous , confirmed by XRD. </li></ul></ul><ul><li>The Al 2 O 3 blasted Ti discs showed the presence of alumina on the surface and it remain on the surface after acid etching , both with HNO 3 and H 3 PO 4 . it needed stronger acid or longer etching time to remove Al 2 O 3 . </li></ul>Fig. 1 Al 2 O 3 Blasted #200 & H 3 PO 4 Etched Table 1. HA blasted Ti discs Table 2. HA blasted - HNO 3 etching Table 3. HA blasted - H 3 PO 4 etching Element Weight% Atomic% Compd% Formula O K 39.37 65.69 98.29 O2Ti P K 1.71 1.47 0.00 Ti 58.93 32.84 Totals 100.00 Element Weight% Atomic% Compd% Formula O K 40.05 66.67 100.00 O2Ti Ti 59.95 33.33 Totals 100.00 Element Weight% Atomic% O K 30.60 55.38 P K 4.88 4.56 Ca K 9.09 6.56 Ti K 55.43 33.50 Totals 100.00
  11. 11. Research Progress <ul><li>NaOH & H 2 O 2 etching were conducted to obtain OH - ( hydroxyl groups ) on Ti surface (see table). </li></ul><ul><li>The etched Ti surfaces were immersed with 3-APTES , as coupling agent between Titanium and Collagen, with 3 various time : 10 , 30 Minutes , and 1 Hour . </li></ul><ul><li>Surface Morphology of the treated discs were observed, after 3-APTES immersed, there were some difference on the NaOH etched, but not much changes on the H2O2 </li></ul>(a) NaOH etched (b) NaOH + 3-APTES 10 Min (c) H 2 O 2 etched (d) H 2 O 2 + 3-APTES 10 Min Chemical Temperature Concentration Time (Hr) NaOH 70 o C 5 M 24, 12 H 2 O 2 80 o C 35.4 Vol % 48, 24
  12. 12. Research Plans <ul><li>Perform heat treatment (after etching treatment) </li></ul><ul><li>Observation on the Ti treated surface morphology </li></ul><ul><ul><li>Confirmation of what compound are formed on the Ti surface & how many OH - groups formed on the Ti surface </li></ul></ul><ul><ul><li>Tri-fluoro acetic anhydride (TFAA) treatment </li></ul></ul><ul><ul><li>X-Ray Photoelectron Spectroscopy (XPS) observation </li></ul></ul><ul><li>Collagen grafting </li></ul><ul><li>Bone cell test, to compare the cell attachment and cell growth on each treated Ti discs </li></ul>
  13. 13. Terima Kasih Merci Xie xie Syukron Rahmat Danke Arigato Gracias Grazie Mahalo Salamat

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