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biomarker solutions                                                                                                                     1.1.1




                                                            your projects,
                                                             your needs


                     discovery                              preclinical R&D                           clinical trials
                     target discovery                       animal model validation                   clinical entry selection
                     target validation                      predictive toxicity                       dose selection
                     drug candidate validation              drug efficacy testing                       patient stratification
                     signalling pathways                    clinical candidate selection              patient monitoring
                     drug delivery pathways                 translation to humans                     mode of action




                                                                  biomarker
                                                                  solutions
             protein biomarker expertise                                                                  proof-of-mechanism
             fully customised models & services                                                           drug portfolio management
             consulting & technical support                                                               personalised medicine

                                                                  biomarker
                                                                   services



                             pharmacodynamics                                                           in vitro & ex vivo assays
biomarker selection                                 toxicity, tolerability    cell & tissue imaging                                 project
                             function & efficacy                                                          human & animal models
& assay development                                 & safety testing          image analysis                                        management
                             assessment                                                                 tissues & cell culture




                     organs, systems, cells...                                                        pathologies
                     gastrointestinal tract                                                           cancer
                     cardiovascular system                                                            inflammatory diseases
                     central nervous systems                 service portfolio                        metabolic diseases
                     lungs, skin...                                                                   respiratory diseases
                     membrane, nucleus                                                                cardiovascular diseases
                     endosomes, Golgi...                                                              CNS diseases...




                  IHC, histology      laser confocal        biomarker analysis                  morphometry
specimen                                                                                                                 ELISA        flow
                  cell culture        miscroscopy           detection & expression              & morphology
collection                                                                                                                            cytometry
                  cell biology        videomicroscopy       localisation & quantification        analysis




                                                             your benefits

                                                        better, faster, cheaper
    improved pipeline quality • better R&D portfolios • decreased cycle times • improved cost effectiveness



tel: +33 491 10 60 87 • email: info@biovays.com • biovays.com
biomarker solutions >                                                                                                         1.1.1




                                                             biomarker solutions
                                                             automated protein biomarker analysis
                                                             optimisation of resources & improved cost-effectiveness
                                                             accelerating clinical development
                                                             timely, specific, relevant, high quality data

         cost-cutting                                        drug portfolio management: improved clinical trial success rates
                                                             better R&D portfolios & improved pipeline quality

   solutions for drug                                        protein biomarkers
              success                                        effective & reliable indicators of disease states and drug efficacy
                                                             unique & specific: target/mechanism/disease/outcome-specific
                                                             early indicators of success/failure: earlier than clinical endpoints
                                                             more discriminating tests of product safety & efficacy

          novel strategies & new technologies                effective patient stratification
                                                             effective trial design & early decision-making
           for fast track process development

                       As a biomarker solutions provider,    biomarker services
                 Biovays offers you specialist knowledge,     biomarker expertise & consulting
               innovative approaches and cost-effective
                                                             project management & technical support
                            alternatives for your research
                                                             tailor-made protocols & customised models
                              and development projects.
                   From target discovery through to FDA      biomarker selection & assay development
                approval, biomarker analysis streamlines     pharmacodynamics, function & efficacy testing
                   drug development, reduces costs and       toxicity analysis: safety & tolerability assessment
                      boosts drug approval success rates.    in vitro & ex vivo assays
                                                             microscopic digital biological imaging
                                                             qualitative & quantitative image analysis
                                                             biomarker analysis: detection, localisation, quantification
                                                             morphometric & morphologic analysis


                                                             portfolio of services
                                                             colocalisation analysis
                                                             GPCR internalisation
                                                             protein translocation
                                                             surface protein expression (receptors...)
                                                             protein-protein interaction analysis
                                                             structure analysis (folding)
                                                             analysis of cell functions (migration, differentiation, proliferation...)
                                                             protein & cell growth assays (dynamic growth processes)
                                                             cell tracking & cellular trafficking
                                                             drug delivery pathways
                                                             signalling pathways
                                                             transcription factor activation
                                                             enzyme activity analysis
                                                             ATP quantification
                                                             cell toxicity, proliferation, viability measurement
                                                             quantification of cytokines, nucleic acids...
                                                             apoptosis & cell adhesion assays
                                                             analysis of molecular interactions




tel: +33 491 10 60 87 • email: info@biovays.com • biovays.com

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Ts111 Biomarker Solutions

  • 1. biomarker solutions 1.1.1 your projects, your needs discovery preclinical R&D clinical trials target discovery animal model validation clinical entry selection target validation predictive toxicity dose selection drug candidate validation drug efficacy testing patient stratification signalling pathways clinical candidate selection patient monitoring drug delivery pathways translation to humans mode of action biomarker solutions protein biomarker expertise proof-of-mechanism fully customised models & services drug portfolio management consulting & technical support personalised medicine biomarker services pharmacodynamics in vitro & ex vivo assays biomarker selection toxicity, tolerability cell & tissue imaging project function & efficacy human & animal models & assay development & safety testing image analysis management assessment tissues & cell culture organs, systems, cells... pathologies gastrointestinal tract cancer cardiovascular system inflammatory diseases central nervous systems service portfolio metabolic diseases lungs, skin... respiratory diseases membrane, nucleus cardiovascular diseases endosomes, Golgi... CNS diseases... IHC, histology laser confocal biomarker analysis morphometry specimen ELISA flow cell culture miscroscopy detection & expression & morphology collection cytometry cell biology videomicroscopy localisation & quantification analysis your benefits better, faster, cheaper improved pipeline quality • better R&D portfolios • decreased cycle times • improved cost effectiveness tel: +33 491 10 60 87 • email: info@biovays.com • biovays.com
  • 2. biomarker solutions > 1.1.1 biomarker solutions automated protein biomarker analysis optimisation of resources & improved cost-effectiveness accelerating clinical development timely, specific, relevant, high quality data cost-cutting drug portfolio management: improved clinical trial success rates better R&D portfolios & improved pipeline quality solutions for drug protein biomarkers success effective & reliable indicators of disease states and drug efficacy unique & specific: target/mechanism/disease/outcome-specific early indicators of success/failure: earlier than clinical endpoints more discriminating tests of product safety & efficacy novel strategies & new technologies effective patient stratification effective trial design & early decision-making for fast track process development As a biomarker solutions provider, biomarker services Biovays offers you specialist knowledge, biomarker expertise & consulting innovative approaches and cost-effective project management & technical support alternatives for your research tailor-made protocols & customised models and development projects. From target discovery through to FDA biomarker selection & assay development approval, biomarker analysis streamlines pharmacodynamics, function & efficacy testing drug development, reduces costs and toxicity analysis: safety & tolerability assessment boosts drug approval success rates. in vitro & ex vivo assays microscopic digital biological imaging qualitative & quantitative image analysis biomarker analysis: detection, localisation, quantification morphometric & morphologic analysis portfolio of services colocalisation analysis GPCR internalisation protein translocation surface protein expression (receptors...) protein-protein interaction analysis structure analysis (folding) analysis of cell functions (migration, differentiation, proliferation...) protein & cell growth assays (dynamic growth processes) cell tracking & cellular trafficking drug delivery pathways signalling pathways transcription factor activation enzyme activity analysis ATP quantification cell toxicity, proliferation, viability measurement quantification of cytokines, nucleic acids... apoptosis & cell adhesion assays analysis of molecular interactions tel: +33 491 10 60 87 • email: info@biovays.com • biovays.com