3. FUROSLIM Irvingia GabonensisTM
• AN EXTRACT OF IRVINGIAAN EXTRACT OF IRVINGIA
GABOGENESIS: AFRICAN MANGOGABOGENESIS: AFRICAN MANGO
• SAFELY AND SIGNIFICANTLY REDUCESSAFELY AND SIGNIFICANTLY REDUCES
BODY WEIGHT ON OVERWEIGHT ANDBODY WEIGHT ON OVERWEIGHT AND
OBESE SUBJECTS AND HAS FAVOURABLEOBESE SUBJECTS AND HAS FAVOURABLE
IMPACT ON VARIETY OF OTHERIMPACT ON VARIETY OF OTHER
METABOLIC PARAMETERS.METABOLIC PARAMETERS.
5. FUROSLIM REVERSES LEPTINFUROSLIM REVERSES LEPTIN RESISTANCERESISTANCE
INHIBIT NYP/AgPP NEURON
REDUCED NYP/AgPP
SECRETION
ACTIVATES POMC NEURON
INCREASES α MSH
EXPRESSION & SECRETION
INCREASED α MSH BINDING &
ACTIVATION OF
MELANOCORTIN RECEPTORS
REDUCED FOOD INTAKE
REDUCES BLOOD C-REACTIVE PROTEIN LEVELS
MORE LEPTIN IS FREELY AVAILABLE THAT CROSSES BLOOD BRAIN BARRIER
6. FUROSLIM INCREASES ADIPONECTIN LEVELSFUROSLIM INCREASES ADIPONECTIN LEVELS
ADIPONECTINS HAVE FOLLOWING
BIOACTIVITIES
•ANTIATHEROGENIC
•ANTI INFLAMMATORY
•ANTI DIABETIC
INCREASES PLASMA ADIPONECTIN LEVELS
INCREASES FATTY ACID CATABOLISM (BREAKDOWN OF FATTY ACIDS)
7. INHIBITS ADIPOGENESIS
FUROSLIM INHIBITS EXPRESSION OF PPARFUROSLIM INHIBITS EXPRESSION OF PPARγγ EXPRESSIONEXPRESSION
FUROSLIM INHIBITS AMYLASE ACTIVITYFUROSLIM INHIBITS AMYLASE ACTIVITY
REDUCES THE AMOUNT OF CARBOHYDRATES THAT WILL BE CONVERTED
AND ABSORBED AS SUGAR.
FUROSLIM INHIBITS ACTIVITY OF GLYCEROL-3-PHOSPHATEFUROSLIM INHIBITS ACTIVITY OF GLYCEROL-3-PHOSPHATE
DEHYDROGENASEDEHYDROGENASE
REDUCES CONVERSION OF GLYCEROL INTO TRIGLYCERIDE
9. Study Report -1
Irvingia Gabonensis a novel seed extract of the West
African plant Irvingia Gabonensis, significantly
reduces body weight and improves metabolic
parameters in overweight humans in a randomized
double-blind placebo controlled investigation
Ngondi JL, Etoundi BC, Nyangono CB, Mbofung
CM, Oben JE.
Source-Laboratory of Nutrition and Nutritional
Biochemistry, Faculty of Science, University of Yaounde
I, Yaounde, Cameroon. jlngondi@yahoo.com
10. • CONCLUSION:
Irvingia gabonensis administered 150 mg twice daily before
meals to overweight and/or obese human volunteers
favorably impacts body weight and a variety of parameters
characteristic of the metabolic syndrome. This is the first
double blind randomized placebo controlled clinical trial
regarding the anti-obesity and lipid profile modulating
effects of an Irvingia gabonensis extract. The positive
clinical results, together with our previously published
mechanisms of gene expression modulation related to key
metabolic pathways in lipid metabolism, provide impetus
for much larger clinical studies. Irvingia gabonensis extract
may prove to be a useful tool in dealing with the emerging
global epidemics of obesity, hyperlipidemia, insulin
resistance, and their co-morbid conditions.
11. Study Report- 2
The effect of Irvingia gabonensis seeds on
body weight and blood lipids of obese
subjects in Cameroon
Judith L Ngondi,1
Julius E Oben,1
and Samuel R
Minka1
Lipids Health Dis. 2005; 4: 12.
PMCID: PMC1168905
Published online 2005 May 25. doi:
10.1186/1476-511X-4-12
12. • Effect on body composition
Irvingia gabonensis induced a decrease in weight
of 2.91 ± 1.48% (p < 0.0001) after two weeks and
5.6 ± 2.7% (p < 0,0001) after one month.
Although the percentage of body fat was not
significantly reduced with both placebo and IG,
the waist circumference (5.07 ± 3.18%; p <
0.0001) and hip circumference (3.42 ± 2.12%; p <
0,0001) were significantly reduced by IG. A
reduction of 1.32 ± 0.41% (p < 0.02) and 2.23 ±
1.05% (p < 0.05) was observed with the placebo
after two and four weeks respectively of
treatment.
13. • Effect on blood lipids components
The plasma total cholesterol
cencentration was reduced by 39.21%,
triglyerides by 44.9% (p < 0,05) and LDL
by 45.58%. This was accompanied by a
significant increase in HDL-cholesterol of
46.852%. The CT/HDL ratio (p < 0.05) and
the blood glucose level were also
reduced (32.36%; p < 0.05). No significant
change was observed in the placebo
group
14. Study report- 3
African mango:- a proprietary seed
extract of Irvingia gabonensis is found to
be effective in reducing body weight and
improving metabolic parameters in
overweight human.
Ross SM.Holist Nurs Pract. 2011 Jul-
Aug;25(4):215-7. No abstract available.
PMID:21697664 [PubMed - indexed for
MEDLINE]
15. • CONCLUSIONS
This preliminary study suggests that ,a proprietary
seed extract of Irvingia gabonensis (150 mg), when
taken twice per day for a 10-week period has the
ability to significantly decrease body fat,body
weight, and waist circumference in overweight
individuals. Furthermore, Irvingia gabonensis has
demonstrated favorable affects on several
metabolic parameters associated with insulin
resistance, a characteristic of metabolic syndrome.
The authors of this study suggest that “Irvingia
gabonensis may be a helpful adjunct in the
management of overweight and/or obesity.”
16. 10 WEEKS Randomize double-blind
placebo controlled study on Irvingia
Gabonensis extract has resulted
• Weight loss : 13%
• Fat loss : 18.4%
• Waist Reduction : 16.2%
• Cholestrol : 26%
• LDL : 27%
• Glucose : 22%
• Leptin : 49%
• CRP :52%
