[Title]-Stem cell treatment and the positive impact on autoimmune .docx

[Title]-Stem cell treatment and the positive impact on
autoimmune diseases.
Research Question-What positive impact has the use of the stem
cell treatment in patients with autoimmune diseases?
Objectives of the project.
1. To investigate the use of stem cell treatment in autoimmune
diseases.
2. To demonstrate the positive impact of using stem cells to
treat autoimmune diseases.
3. To present through a systematic review of the literature
therapeutic options with stem cells that have the ability to
successfully treat patients with autoimmune diseases.
Theoretical Framework- La teoría de la consecución de
objetivos desarrollada por Imogene King.
My job no needed PICOT question due to be a literature review.
My References-I Needs more references
Ahmed, Z., Imdad, A., Connelly, J. A., & Acra, S. (2019).
Autoimmune Enteropathy: An Updated Review with Special
Focus on Stem Cell Transplant Therapy. Digestive Diseases &
Sciences, 64(3), 643–654. https://doi-org.librarylogin-
cupey.uagm.edu/10.1007/s10620-018-5364-1
Snowden, J. A., Sharrack, B., Akil, M., Kiely, D. G., Lobo, A.,
Kazmi, M., Muraro, P. A., & Lindsay, J. O. (2018). Autologous
haematopoietic stem cell transplantation (aHSCT) for severe
resistant autoimmune and inflammatory diseases -- a guide for
the generalist. Clinical Medicine, 18(4), 329–334. https://doi-
org.librarylogin-cupey.uagm.edu/10.7861/clinmedicine.18-4-
329
Ferreira Zombrilli, A., Leopoldo, V. C., Oliveira, M. C., Cirioli
de Oliveira, M. de F., Ehmke Dolci, M., Merizio Martins Braga,
F. T., & de Campos Pereira Silveira, R. C. (2019). Virtual
learning object in hematopoietic stem cell transplantation for
autoimmune diseases. Revista Brasileira de Enfermagem, 72(4),

994–1000. https://doi-org.librarylogin-
cupey.uagm.edu/10.1590/0034-7167-2018-0669
Balassa, K., Danby, R., & Rocha, V. (2019). Haematopoietic
stem cell transplants: principles and indications. British Journal
of Hospital Medicine (17508460), 80(1), 33–39. https://doi-
org.librarylogin cupey.uagm.edu/10.12968/hmed.2019.80.1.33
Van Laar, J. M., Naraghi, K., & Tyndall, A. (2015).
Haematopoietic stem cell transplantation for poor-prognosis
systemic sclerosis. Rheumatology, 54(12), 2126–2133.
https://doi-org.librarylogin-
cupey.uagm.edu/10.1093/rheumatology/kev117
Atkins, H., Freedman, M., Atkins, H. L., & Freedman, M. S.
(2017). Five Questions Answered: A Review of Autologous
Hematopoietic Stem Cell Transplantation for the Treatment of
Multiple Sclerosis. Neurotherapeutics, 14(4), 888–893.
https://doi-org.librarylogin-cupey.uagm.edu/10.1007/s13311-
017-0564-5
Currò, D., Mancardi, G., & Currò, D. (2016). Autologous
hematopoietic stem cell transplantation in multiple sclerosis: 20
years of experience. Neurological Sciences, 37(6), 857–865.
https://doi-org.librarylogin-cupey.uagm.edu/10.1007/s10072-
016-2564-3
Baharlou, R., Rashidi, N., Ahmadi-Vasmehjani, A., Khoubyari,
M., Sheikh, M., & Erfanian, S. (2019). Immunomodulatory
Effects of Human Adipose Tissue-derived Mesenchymal Stem
Cells on T Cell Subsets in Patients with Rheumatoid Arthritis.
Iranian Journal of Allergy, Asthma & Immunology, 18(1), 114–
119.
Ferreira Zombrilli, A., Leopoldo, V. C., Oliveira, M. C., Cirioli
de Oliveira, M. de F., Ehmke Dolci, M., Merizio Martins Braga,
F. T., & de Campos Pereira Silveira, R. C. (2019). Virtual
learning object in hematopoietic stem cell transplantation for
autoimmune diseases. Revista Brasileira de Enfermagem, 72(4),
994–1000. https://doi-org.librarylogin-
cupey.uagm.edu/10.1590/0034-7167-2018-0669
Snowden, J. A., Sharrack, B., Akil, M., Kiely, D. G., Lobo, A.,

Kazmi, M., Muraro, P. A., & Lindsay, J. O. (2018). Autologous
haematopoietic stem cell transplantation (aHSCT) for severe
resistant autoimmune and inflammatory diseases -- a guide for
the generalist. Clinical Medicine, 18(4), 329–334. https://doi-
org.librarylogin-cupey.uagm.edu/10.7861/clinmedicine.18-4-
329
Ahmed, Z., Imdad, A., Connelly, J. A., & Acra, S. (2019).
Autoimmune Enteropathy: An Updated Review with Special
Focus on Stem Cell Transplant Therapy. Digestive Diseases &
Sciences, 64(3), 643–654. https://doi-org.librarylogin-
cupey.uagm.edu/10.1007/s10620-018-5364-1
APA -Rebeiro, P., & Moore, J. (2016). The role of autologous
haemopoietic stem cell transplantation in the treatment of
autoimmune disorders. Internal medicine journal, 46(1), 17-28
APA- Snowden, J. A., Badoglio, M., Labopin, M., Giebel, S.,
McGrath, E., Marjanovic, Z., ... & Kazmi, M. (2017). Evolution,
trends, outcomes, and economics of hematopoietic stem cell
transplantation in severe autoimmune diseases. Blood advances,
1(27), 2742-2755.
Xiaoxiao Lu, Xilian Wang, Hong Nian, Dan Yang & Ruihua
Wei. Mesenchymal stem cells for treating autoimmune
dacryoadenitis Stem Cell Research & Therapy, volume 8,
Article number: 126 (2017)
How to write a Proposal
1. Literature review
2. Case study (You need a letter of approval from the patient
and/or the provider, describe how you are handling
confidentially of the information)
3. Pre and post-education (You may need to write a consent
form, and you need a letter of approval from your organization)
Components of the Proposal
I. Title
II. Introduction
An introduction should announce your topic. You can start your

introduction with a few sentences, which announce the topic of
your paper and give an indication of the kind of research
questions you will be asking. The first few sentences should act
as an indication of a broader problem, which you will then
focus on more closely in the rest of your introduction, leading
to your specific research questions. The introduction should
include the purpose of the project and the Methods.
III. The Problem
1. Research Question
The research question should be concise and closely focused.
The research question might recall some of the key words
established in the first few sentences and the title of your paper.
You have to write the Question.
2. Objective or Objectives
Objectives must always be set after having formulated a
good research question. After all, they are to explain the way in
which such a question is going to be answered. Objectives are
usually headed by infinitive verbs such as:
·
· To identify
· To establish
· To describe
· To determine
· To estimate
· To develop
· To compare
· To analyze
· To collect
3. You need to explain the contribution of the research to the
topic and to the advanced nursing practice. Use references.
IV. Review of Literature.
The purpose is to offer an overview of the significant literature

published on a topic:
1. identifies areas of prior scholarship
2. Describes the relationship of each source to the others that
you have selected
3. Points the way forward for further research.
The literature review should include the following:
1. Objective of the literature review
2. Overview of the subject under consideration.
3. Particular position, those opposed, and those offering
completely different arguments.
4. Discussion of both the distinctiveness of each source and its
similarities with the others.
No less than 30 references (15 for NURS 502, and 15 for NURS
503).
No older than 2015.
Include a nursing theory or a conceptual model and describe
it.
V. Methodology.
· Describe the design
· Identify the variable
· Describe the reliability and validity of the instrument
· Describe the population and the sample.
· Describe the steps to protect the rights of human according to
IRB criteria.
· Discuss the procedure to complete the study.
VI. Data analysis.
4. Describe the data analysis according to the design and
variables.
Addendum:
1. Copy of the proposal.
2. Copy of instruments.
3. Copy of consents.
4. IRB F01 (or F08).
5. CV
6. CITI training.
7. APA.

NOTE: This is a template and guide. Delete all highlighted
materials.
Note that there is no heading that says Introduction. The
paragraph or two that follows the title on the first page of your
text is assumed to be your introduction. Your introduction
follows the title of your paper (note that the title is not bolded).
You should start your introduction with a powerful statement or
two to stimulate interest. You should identify the purpose of
your paper. Remember that formal papers are in third person, so
no I, me, we except in specified areas. The introduction should
include the purpose of the project and the Methods.
Significance of the Practice Problem
Start this section with identification of the practice problem.
This section should also answer the question “why is this
important?” You should address the significance to the
patient/client (e.g., pain, suffering, quality of life, impact on
income potential, etc.), the family, healthcare system (e.g.,
impact on cost or delivery systems), and society (e.g., cost of
care, need for healthcare policy). Discuss the incidence and/or
prevalence and include the financial impact if possible. You
might discuss the impact on length of stay, readmission, home
health care requirements, disability and/or mortality. Also, you
should address any quality, safety, legal, and ethical
implications. This discussion must be substantiated by citations
from professional literature.
Research Question
This section should include your research question, but also
should include the three objectives that will assist you to
answer your question. This section contains your operational
definitions of the variables in the question. If you use

definitions from the literature, be sure to cite them.
Theoretical Framework
This section should include the theoretical framework that
supports your MSN Project. Describe the theory or model that
served as the foundation for your project. This may be a nursing
theory or a theory from another discipline if pertinent and
applicable.
Synthesis of the Literature
Synthesize at least 30 primary research studies (15 during
NURS 502 & 15 during NURS503) and/or systematic reviews;
do not include summary articles. This section is all about the
scientific evidence rather than someone else’s opinion of the
evidence. Do not use secondary sources; you need to get the
article, read it, and make your own decision about quality and
applicability to your question even if you did find out about the
study in a review of the literature. The studies that you cite in
this section must relate directly to your research question. This
is a synthesis rather than a study-by-study review. Address the
similarities, differences, and controversies in the body of
evidence.
Practice Recommendations
So. . . using available evidence, what is the answer to your
question? This section is for you to summarize the strength of
the body of evidence (quality, quantity, and consistency), make
a summary statement, and based on your conclusions drawn
from the review, give a recommendation for practice change
based on scientific evidence. This would logically be the
intervention of your PICOT question. You might want to design
an algorithm and include it in as a figure. Perhaps you found
substantiation for usual practice, and you recommend
reinforcement and education regarding this best practice.
Project Description

Describe the form that the literature review will carry out, how
many articles, and how many years old. Add the websites that
you will research for the search of articles, keywords that you
will use for your search
Here you should include the impact that your research will
have. It must also include that it will be kept for 5 years in a
locked office of the home of the principal investigator, and that
after that time has elapsed, it will be destroyed.
This section may be in first person.
Project Evaluation Results
This section must include how you will evaluate the planned
change project. Remember that you must have evaluated the
outcome(s) identified in your PICOT question
Here you should mention the tables A and B that you will use
for the evaluation of the results of your literature review.
Describe each of the tables (A & B) that are at the end of the
template. Tables and Figures should follow the References
Discussion and Implications for Nursing and Healthcare
Discuss the conclusions you can make from the project
evaluation results: review and answer your PICOT question.
Examine, interpret, and qualify the results. Discuss internal
validity and limitations of the project evaluation. Take into
account sources of potential bias and other threats to internal
validity, the imprecision of measures, and other limitations and
weaknesses of the evaluation (adapted from APA, 2010, p. 35).
Describe the implications of your project and the project
evaluation on nursing practice and healthcare. Do not overstate
the significance. Identify the impact on the appropriate
microsystem. Include any recommendations you have as a result
of this project and project evaluation. Also, include what you
might recommend with replication of this project and project
evaluation and your potential next steps for this practice
problem.

Plans for Dissemination
This section should include your plan for sharing the results of
your project within the institution and within the professional
community. Discuss who you invited to the presentation of
results at the institution and how you presented the information.
Describe the response of stakeholders to your presentation and
about the potential for sustainability. Also, discuss your plans
for presentation at regional or national meetings and/or
publication. If publication is planned, discuss what journal you
will submit your manuscript to and why. The dissemination
must be among the classmates with a PowerPoint presentation; a
poster with a brief summary of project plan, evaluation, and
results to be exposed in the hall at Ana G Mendez, SFC; and a
hard copy to be left at the library to be reviewed for those
students of facilitators interested in the topic.
Summary and Conclusion
The conclusion should start with a statement regarding the
intent of the paper and your achievement toward that intention.
Remember that the introduction is a preview, and this section
should contain a summary.
When completed your summary and conclusion, do not include a
categorical conclusion, which means, that you should not
mention the results of your literature review, otherwise, this
would give the impression that your project has ended. It must
include the importance of what has been reviewed so far, and
the need to finalize the literature review in order to have a more
conclusive result.
References
Remember that this is a reference list rather than a
bibliography. A bibliography is everything you read to prepare
the paper but a reference list is only what you cited. If there is
not a citation for a reference, it should not be here. PLEASE
make sure that your references here and your citations

throughout the paper are in APA format. Take the time to make
sure that they are correct. We have already formatted the paper
for you with this template.
Figure 1
Figures included here are most likely going to be figures
illustrating your data analysis.
Appendix A
NOTE: Order these appendices in the order in which they were
referred to in the paper.
Summary of Primary Research Evidence (this table may be
single space)
Citation
Question or Hypothesis
Theoretical Foundation
Research Design (include tools) and Sample Size
Key Findings
Recommendations/
Implications
Level of Evidence
Legend:
Level I: systematic reviews or meta-analysis
Level II: well-designed Randomized Controlled Trial (RCT)
Level III: well-designed controlled trials without
randomization, quasi-experimental
Level IV: well-designed case-control and cohort studies
Level V: systematic reviews of descriptive and qualitative
studies

Level VI: single descriptive or qualitative study
Level VII: opinion of authorities and/or reports of expert
committees
Appendix B
Summary of Systematic Reviews (SR) (this table may be single
space)
Citation
Question
Search Strategy
Inclusion/
Exclusion Criteria
Data Extraction and Analysis
Key Findings
Recommendation/
Implications
Level of Evidence

Legend:
Level I: systematic reviews or meta-analysis
Level II: well-designed Randomized Controlled Trial (RCT)
Level III: well-designed controlled trials without
randomization, quasi-experimental
Level IV: well-designed case-control and cohort studies
Level V: systematic reviews of descriptive and qualitative

studies
Level VI: single descriptive or qualitative study
Level VII: opinion of authorities and/or reports of expert
committees
1

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