2. Case scenario
A 75 years old, known diabetic(10 yrs) male patient XYZ from
sindhupalchok was brought to emergency department at TUTH and
was admitted in/to cardiology ward bed # 5 with the c/c of:
Single episode of Sudden, rapid onset severe chest pain, lasting more
than 30 min , radiating towards the medial aspect of his left arm
associated with breathlessness , nausea, heavy perspiration,
Lightheadedness, fever, cold clammy skin.
2
3. EXAMINATION REVEALS
Pulse : 48 bpm , regular, normal rhythm
BP= 115/70
Temperature= 99 degree F
RR= 12/MIN
JVP = N
Apex beat non palpable
Heart sounds muffled
3
4. тАв What is your most probable diagnosis ?
тАв What relevant investigation would u do? What complications can
arise if not managed properly?
4
5. Myocardial Infarction
Definition:
MI is defined by the demonstration of myocardial cell necrosis due to significant and
sustained ischaemia.(WHO)
Ischaemia: an inadequate blood supply to an organ or part of the body, especially
the heart muscles.
5
6. Main coronary blood supply
Right coronary artery Left coronary artery
Arises from the aorta behind the right aortic sinus
Supplies
Posterior (inferior) wall of left ventricle
Right ventricle and atrium
SA and AV node
Arises from the aorta behind the left aortic sinus
Supplies
Anterior wall of left ventricle
Anterior two thirds of the inter ventricular septum.
6
7. Etiology
тАв It occurs usually due to formation of occlusive thrombus at a site of
rupture of an atheromatous plaque in a coronary artery.
7
9. The percentages of all deaths caused by heart disease in
2015, listed by ethnicity, race, and sex globally.
тАв Ref: www.cdc.gov, Centres for Disease Control and Prevention,2015.
9
15. Clinical features
Symptoms
Chest pain :-
Site: Central and Retro-sternal
Severity: very severe
Onset: Sudden, usually at rest
Duration: Prolonged
Character: Tight, crushing, heavy constricting
Time: greater then 20 min.(if less than 20 min. then chance of angina)
Radiation: Left shoulder, neck, jaw, left arm, ulnar border of forearm and hand, even to
epigastrium and back
Relief: Not by rest or nitrates, only by strong analgesic like morphine
15
16. Associated symptoms
тАв Breathlessness
тАв Restlessness
тАв Anxiety
тАв Fear of impending death
тАв Nausea and vomiting
тАв Sweating
тАв Collapse or syncopal attack
тАв Features of complication: Heart failure, shock
тАв Silent MI in elderly and diabetic patients.
16
17. Physical signs
тАв Signs of sympathetic activation: pallor, sweating, tachycardia
тАв Signs of vagal activation: vomiting, bradycardia
тАв Signs of impaired myocardial function:
Hypotension (B.P. first rises then decreases), Oliguria, Cold periphery
Narrow pulse pressure
Raised JVP
Prominent S3, quiet S1
GallopтАЩs rhythm (prominent S3 and S4 with tachycardia)
Basal crepitations
тАв Signs of tissue damage: fever
тАв Signs of complications: MR, pericarditis
17
18. CLINICAL CLASSIFICATION OF MYOCARDIAL
INFARCTION
тАв STEMI : infarction due to involvement of obstruction in the branches
of coronary artery
тАв non-ST elevation MI' (NSTEMI) : infarction due to involvement of sub-
endocardial tissue.
18
20. 20
Features Angina MI
Chest pain
onset On exertion At rest
severity Less severe Very severe
Duration Short <20min. Prolonged >20min.
Relief Rest and nitrates morphine
Associated features
Nausea,vomiting Absent Present
Sweating Absent present
Pallor absent present
Anxiety Absent or mild Severe anxiety
Chest finding
Chest auscultation Normal Soft heart sounds
Gallop rhythm
Basal crepitation
Leucocytosis,ESR absent Present
Enzymes Normal Raised
ECG Normal or ST depression, T wave inversion. ST elevation,T wave inversion,Pathological
Q wave.
24. 1) ECG: - ST-elevation (convexity upward)
anterior wall: ST elevation in V1-V6
inferior wall: II,III,aVf ST elevation
Symmetrical T- wave inversion.
Pathological Q- wave
Axis deviation towards opposite site of infarction.
24
25. 2) Plasma enzymes:
тАв Creatinine kinase myocardial Band (CK-MB) - specific for myocardial
injury.
тАв 95% sensitive and specific for MI when measured within 24-36 hours
of chest pain.
тАв Plasma CK-MB begins to elevate at 4-6 hours after the start of pain
and
reaches a peak at 12-24 hours.
25
26. Conditions with raised CK
тАв Myopathy
тАв DC shock (Cardioversion)
тАв Cardiopulmonary resuscitation
тАв Muscle trauma
тАв Intramuscular injections
26
27. Troponin: T And I
тАв Begins to elevate 4-6 hours after start of pain.
тАв Remains elevated for 1-2 weeks:
тАв More specific than CK-MB.
27
28. Lactate dehydrogenase (LDH)
тАв In acute MI, elevations in LDH are detectable at 12 hours after the
onset of chest pain and peak in 24-72 hours.
тАв LDH levels remain elevated for 10-14 days after infarction
тАв An LDH-1 to LDH-2 ratio greater than 1.0 is considered evidence of
MI.
28
31. тАв Echocardiography: To detect regional wall motion abnormalities and
other complication of MI.
тАв Coronary arteriography and ventriculography
31
32. Management of myocardial infarction
1) Early medical management:
тАв Accident and emergency
тАв Thrombolysis
тАв PCI
тАв CABG
32
33. ACCIDENT AND EMERGENCY
тАв Aspirin 150-300 mg+Clopidogrel 300 mg
тАв Sublingual GTN 0.3-1 mg
тАв Oxygen nasal cannula 2-4 l/min
тАв Brief HX
тАв I.V access + blood for markers
тАв Analgesic : morphine
тАв Antiemetics
тАв Beta blocker if no contraindication
тАв Calcium channel blocker
тАв (ACE) inhibitors are administered to patients with anterior wall MI and to patients who
have an MI with heart failure in the absence of significant hypotension.
тАв ACE inhibitors help to prevent ventricular remodeling (dilation) and preserve ejection
fraction
33
34. Thrombolysis
Streptokinase: 1.5 million units in 100 ml 0.9% Normal saline over 1 hour.(is
contraindicated in NSTEMI) administered within 6-12 hours
Or
Altepase (human tissue plasminogen activator or tPA)
Standard regimen is given over 90 minutes.
Bolus dose 15 mg followed by 0.75 mg/kg but not exceeding 50 mg over 30
minutes and then 0.5 mg/kg but not exceeding 35 mg over 60 minutes.
After 12 hours:
Heparin is used as thrombolytic drug
IV bolus of 60 units/kg (max: 4000 units), THEN 12 units/kg/hr (max 1000
units/hr) as continuous IV infusion 34
37. 2) Late management
(a) Risk stratification and further investigation
тАв Left ventricular function: ECG, Echocardiogram and chest X-ray
тАв Ischaemia: exercise tolerance test
(b) Routine drug therapy
Aspirin - 150 mg * PO x daily:
B-blockers: Atenolol 50 mg x PO x daily
Nitrate: Isosorbide mononitrate 10-20 mg x PO daily
ACE inhibitors: Captopril 25 mg x TDS
(c) Risk factor modification
тАв Stop smoking Control weight
тАв Daily exercise
тАв Control lipid by reducing intake of fats and Antilipidaemic drugs
тАв Control of hypertension and diabetes mellitus
37
38. References:
тАв DavidsonтАЩs Principles and Practice of Medicine,23rd edition.
тАв Harrison's Principles of Internal Medicine, 14th Edition.
тАв A Textbook of Clinical Medicine, 2016 edition.
тАв HutchinsonтАЩs Clinical Methods, 24th edition.
тАв Essentials of medical pharmacology, 7th edition.
тАв www.google.com
38
39. рд╣реГрджрдп-рд░реЛрдЧ
рд╣реГ-рд╣рд░рддрд┐- Extracting Aahar (food), Udaka (Water), Prana (Life-oxygen) from external environment.
рдж- рджрджрд╛рддрд┐-Providing Rasa to the whole body
рдп- рдпрддрд┐- in this way Continuing the motion of Rasa, thus maintaining life.
рд╣реГ
рдж рдп
53. Heart diseases described in Ayurveda Comparable heart diseases described in modern medicine
according to symptoms only
рдХ) рд╕рд┐реВрд▓ рд╣реГрджреНрд░реЛрдЧ
рд╣реГрдЪреНрдЫреБрд▓
рд╡рд╛рддрд┐рдХ рд╣реГрджреНрд░реЛрдЧ
рдкреИрддрддреНрддрдХ рд╣реГрджреНрд░реЛрдЧ
рдХрдлрдЬ рд╣реГрджреНрд░реЛрдЧ
рд╕рд╛рддрдиреНрд┐рдкрд╛рддрд┐рдХ рд╣реГрджреНрд░реЛрдЧ
Heart disease with pain:
Severe angina pectoris
DO
Moderate angina pectoris
Mild angina pectoris
Angina pectoris with myocardial infarction
рд┐) рддрд┐рддрдордЬ рдкрд╛рдгреНрдбреБрдЬрдиреНрдп рд╣реГрджреНрд░реЛрдЧ
рддрд┐рддрдордЬ рд╣реГрджреНрд░реЛрдЧ
Heart disease due to worm infestation and anaemia:
Manifestation of anaemia in heart due to ankylostoma duodenale
рдЧ) рд╕реЛрдердпреБрдХреНрдд рд╣реГрджреНрд░реЛрдЧ
рд╡рд╛рддрд┐рдХ рд╕реЛрде
Heart disease with oedema:
Cardiac failure with oedema
рдШ) рд╢реНрд╡рд╛рд╕рдпреБрдХреНрдд рд╣реГрджреНрд░реЛрдЧ
рдХреНрд╖реБрджреНрд░рд╢реНрд╡рд╛рд╕
Heart disease with dyspnea:
Angina pectoris having dyspnea on exertion, mild cardiac
insufficiency.
66. Uro basti/Hridaya basti
Uro basti improves the circulation and breathing functions.
Indication: Coronary heart diseases Angina Bronchiectasis Ischemic heart diseases
Cardiomayopathy Asthma and other respiratory disorders.
The reference of Uro Vasti or Uro Basti has been found quoted and explained in the context (chapter) of Bhaktarodha (aversion
towards food) in Yogamrita text and also in Chikitsamanjari.
69. рдпреЛрдЧ/рдкреНрд░рд╛рдХреГрддрд┐рдХ
тАв рдкреНрд░рд╛рд┐:рдХрд╛рд▓ рд┐рд╛рдВрдЧреЛ рд┐реБрдЯреНрдЯрд╛рд▓реЗ рд╣рд░рд░рдпреЛ рдШрд╛рд╕рдорд╛ рдШреБрдореНрд┐реЗред
тАв рд╕реНрд╡рдЪреНрдЫ рд╣рд╛рд╡рд╛рдорд╛ рдЬреЛрд░-рдЬреЛрд░рд▓реЗ рдЧрддрд╣рд░реЛ рд╕рд╛рдВрд╕ рддрд▓рд┐реЗред
тАв рд╣рд▓реНрдХрд╛ рд╡реНрдпрд╛рдпрд╛рдоред
тАв рдкрджреНрдорд╛рд╕рд┐, рд┐рд╡рд╛рд╕рд┐, рд╕реВрдпрде рд┐рдорд╕реНрдХрд╛рд░ рдЖрддрдж рдпреЛрдЧ рддрд┐рдпрд╛рдХреЛ рдЕрднреНрдпрд╛рд╕ред
тАв рдкреНрд░рд╛рдгрд╛рдпрд╛рдо-рдХреБрдореНрд┐рдХ-рд░реЗрд┐рдХ рдЕрднреНрдпрд╛рд╕
тАв Kundalini Yoga: It energizes the Anahata Chakra seated in the heart and thus gives positive
influence on the heart and mind energizing the whole body. Relieves stress and anxiety.
70. рдЖрддреНрдпрддрдпрдХ рддрд┐рддрдХрддреНрд╕рд╛
тАв A successful story of Rajvaidya Tapan from Pune, he has
thrombolised 250 AMI patient in last 10 years.
тАв Medicine and apparatus required:
тАв Brihat-vata-chintamani ras
тАв jabaarmohara ras
тАв Vasantakusumaakar ras
тАв Vedanantak ras
тАв Hing
тАв Leaf of nagarvel(leaf of betel nut)
тАв Vasti yantra
тАв Khal
тАв Gomutra
71. Remove all clothes from body(this process
is done at the spot before the ambulance
arrives)
Apply hing all over chest region and
around lips
Half tea spoon full vasantakusumaakar ras
and half tea spoon full vedannatak vati are
mix with nagarvel leaf(paan) and made
paste and pasted in floor of mouth.
72. ContinueтАж.
Ready for vasti
Water (luke warm)+til
oil+lavan+dashmul+gomutra
Repeat the vasti process until the
patient becomes conscious
After the patient is conscious and stable
give 250ml of til oil per orally.
73. After patient is stable, he is shifted to hospital and all the diagnostic procedure
are done and he is kept under observation with regular ECG and cardiac injury
marker monitoring.
3 days regimen after stabilization of patient:
1.Brihatvatachintamani ras 3 vati 2 hourly
2.Vedanantak ras 3 vati 2 hourly
3.Arjunarista+ashokarishta 50ml+50ml neat TDS before food.
4.Hemjal (gold preparation) 5 drops 2 hourly
(ras tarangini/swarna tarang adhaya)
After 3 days stop 1. and 2. then start for 7 days :
1.Javahaarmohar ras 2 vati BD
2.Chatu:Shashti Pippali 2 vati BD
3.Dashmoolarishta 30ml BD before food
4.Manjishtaadi kaadaa/rasnaadi kaada 40ml BD
74.
75. Reference : Cyril Tarquinio, A Focus on Adverse Childhood Experiences (ACEs), European Journal of Trauma &
Dissociation, 10.1016/j.ejtd.2020.100181, 4, 4, (100181), (2020).Crossref 75
76. Safety of coffee consumption after myocardial
infarction: A systematic review and meta-analysis
тАв longitudinal studies evaluating the impact of coffee consumption in
patients with previous myocardial infarction
тАв Consumption of coffee was not associated with an increased risk of
all-cause mortality and cardiovascular events in patients with
previous myocardial infarction.
Ribeiro, E. M., Alves, M., Costa, J., Ferreira, J. J., Pinto, F. J., & Caldeira, D. Safety of coffee consumption after myocardial
infarction: A systematic review and meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases. 2020.
doi:10.1016/j.numecd.2020.07.016
76
77. References:
тАв рдкрдВ.рд░рд╛рдЬреЗрд╢реНрд╡рд░рджрддреНрдд рд┐рд╛рд╢реНрд┐реА, рд┐рд░рдХрд╕рдВрддрд╣рд┐рд╛, рд┐реМрд┐рдореНрдмрд╛ рд┐рд╛рд░рд┐реА рдПрдХреЗрдбреЗрдореА,реирежрезрео.
тАв рдЖрд┐рд╛рдпрде рддрд╡рдпрд╛рдзрд░ рд┐реБрдХреНрд▓ ,рд┐рд░рдХрд╕рдВрддрд╣рд┐рд╛, рд┐реМрд┐рдореНрдмрд╛ рд╕рдВрд╕реНрдХреГрд┐ рдкреНрд░рддрд┐рд╖реНрдард╛рд┐,реирежрезрез.
тАв рдбрд╛.рдмреНрд░рд╣реНрдорд╛рд┐рдиреНрдж рддрд┐рдкрд╛рд┐реА ,рдорд╛рдзрд╡рддрд┐рджрд╛рд┐рдореН, рд┐реМрд┐рд╛рдореНрдмрд╛ рд╕реБрд░рд┐рд╛рд░рд┐реА рдкреНрд░рдХрд╛рд┐рд┐,реирежрезрео.
тАв рдбрд╛.рдХрд╛рддрд┐рд┐рд╛рде рд╕рдордЧрдВрдбреА, рд╕реНрд╡рд╕реНрдерд╡реГрддреНрдд рд╕реБрдзрд╛, рдЖрдпреБрд╡реЗрдж рд╕рдВрд╕реНрдХреГрд┐ рддрд╣рддрдиреНрдж рдкреБрд╕реНрд┐рдХ рд┐рдгреНрдбрд╛рд░, реирежрезрен.
тАв рдЖрд┐рд╛рдпрде рддрдкреНрд░рдпрд╡реНрд░рд┐ рд┐рдорд╛рде, рдбрд╛.рдЕрд┐рдиреНрд┐рд░рд╛рдо рд┐рдорд╛рде,рд╕реБрд╢реНрд░реБрд┐рд╕рдВрддрд╣рд┐рд╛, рд┐реМрд┐рд╛рдореНрдмрд╛ рд╕реБрд░рд┐рд╛рд░рд┐реА рдкреНрд░рдХрд╛рд┐рд┐,реирежрезреп.
тАв рдкреНрд░рд╛.рд░рд╛рдорд╣рд╖рде рддрд╕рдВрд╣, рдХрд╛рдпрддрд┐рддрдХрддреНрд╕рд╛, рд┐реМрд┐рдореНрдмрд╛ рд╕рдВрд╕реНрдХреГрд┐ рдкреНрд░рддрд┐рд╖реНрдард╛рд┐,реирежрезрем.
тАв рдкреНрд░рд╛.рдЕрдЬрдп рдХреБрдорд╛рд░ рд┐рдорд╛рде, рдХрд╛рдпрддрд┐рддрдХрддреНрд╕рд╛, рд┐реМрд┐рдореНрдмрд╛ рд╕рдВрд╕реНрдХреГрд┐ рдкреНрд░рддрд┐рд╖реНрдард╛рд┐,реирежрезрем.
тАв Prof. (dr.) S. Suresh Babu, The Principles and practice of kaya chikitsaa , 2016.
тАв Jain, S., Yadav, P.P., Gill, V. et al. Terminalia arjuna a sacred medicinal plant: phytochemical
and pharmacological profile. Phytochem Rev 8, 491тАУ502 (2009). https://doi.org/10.1007/s11101-
009-9134-8
тАв https://www.youtube.com/watch?v=jBOvm2gxbu8
тАв www.google.com