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Antidiabetic Food Centre – an example of fruitful innovation collaboration
Foodbest Meeting 8 November 2013, Copenhagen

ANTIDIABETIC FOOD CENTRE;
some experiences in research-based innovation

Inger Björck,
Lund University Specialised Centres

Antidiabetic Food Centre at Lund University

। Page 1 I 2013-11-12
ANTIDIABETIC FOOD CENTRE;
A Centre of EXCELLENCE
in RESEARCH and
INNOVATION
at Lund university

Multidisciplinary research
on how to prevent
the metabolic syndrome
(obesity, type 2 diabetes and CVD)
with innovative food
Antidiabetic Food Centre at Lund University

। Page 2 I 2013-11-12
Why antidiabetic food?;
80‐90% cases of type 
2 diabetes and CVD 
can be prevented by 
life style,  where diet 
is the single most 
important factor!

Pharmaceutical treatment
Primary prevention based on dietary strategy
urgently needed and call for;
- joint strategies and close collaboration amongst industry,
health care and academy
- interdisciplinary research strategies within the academy

New antidiabetic food concepts and
new business opportunities
Antidiabetic Food Centre at Lund University

1,5 billion adult, and 170 million children over‐
weight or obese ww
Prognosis by y 2030, 200 million obese in EU
Every fifth pre‐school child in Sweden with 
over‐weight or obesity
366 million with T2D  ww
Prognosis by 2030, 552 million with T2D
Currently more than 30 million EU citizens 
with medication within the MetS
। Page 3 I 2013-11-12
Organisation within the university

AFC
Organised under the Pro Vice-Chancellor for Research
(Lund University Specialised Centres, USV)
Faculty of
Science

Faculty of
Engineering

Faculty of
Medicine

Faculty of
Social
Sciences

About 50 senior AFC researchers cross faculties
Antidiabetic Food Centre at Lund University

। Page 4 I 2013-11-12
The AFC Consortium
A Centre of Excellence in Research and Innovation
Duration 2007-2017
Gross budget 220 MSEK
Current stage 2013-2015, budget 74 MSEK
Partnership;

Antidiabetic Food Centre at Lund University

। Page 5 I 2013-11-12
AFC Research strategy
Preventive food concepts
Avoiding an
inflammatory
gut eco-system
Prebiotics

Avoiding oxidative stress
and inflammation
Antioxidative nutrients
& polyphenols

Enzyme tailoring of

Probiotics

Avoiding
postprandial
dysmetabolism

Specific food
proteins
prebiotics Low glycaemic
impact

Minimal processing/minimizing AGE (Advanced Glycosylation End products)
Encapsulation techniques for targeted delivery (satiety signalling)

anti-inflammatory
eg. adiponectin , IL-4, IL-10

Reduced inflammatory
tonus
& improved appetite
regulation

Antidiabetic Food Centre at Lund University

pro-inflammatory
e.g. CRP, TNF-α, IL-6, IL-18

Page 6 I 2013-11-12
Impaired cognitive functioninga manifestation of the MetS

Antiinflammatory
food concept

Antidiabetic food concepts that reduce
inflammation may also improve
cognitive functioning e.g. working
memory and selective attention

(Adopted from Jang&Johnsson 2010)
Antidiabetic Food Centre at Lund University

। Page 7 I 2013-11-12
AFC Innovation
A mindset of exploring new knowledge on how to prevent the 
metabolic syndrome by new food concepts
A centre agreement regulating
IPR                                                  
(Lund University legal unit)

Invention disclosure proceedure, 
and negotiations of IP                         
(Lund University Innovation System) 

Results notified/alerted and 
communicated to partners & 30d 
delay for publication
Antidiabetic Food Centre at Lund University

An operational plan with a 
project organisation promoting
incentive for innovation 
Integration of the ”Swedish 
intellectual property rights of 
academic staff”  as a resource for 
innovation

। Page 8 I 2013-11-12
Project forms
AFC partners and LU reseacher(s)
joint ownership
100% AFC funding

Centre project
P40
Industry project

Industry partner ownership
40% AFC funding

Antidiabetic Food Centre at Lund University

LU researcher
project

Researcher(s) ownership
AFC partners first-right of refusal
100% AFC funding
। Page 9 I 2013-11-12
AFC Innovation (2007– 2013)
Patents/patent applications 
1.
2.
3.
4.
5.
6.
7.

Protein/Amino acid mix  for facilitated postprandial glycaemic regulation (approved)
Nutrient mix for facilitated postprandial glycaemic regulation (application) 
Pickering emulsions as vehicles for targeted delivery and ileal break (application) 
Rye factor for improved postprandial glucose/insulin (application) 
Glycaemic profiling for improved cognitive function (application)
Gut microbiota modulation for metabolic benefits (application) 
Food for small children (application)

New businesses – licensing/knowhow
1.
2.
3.
4.

Speximo AB        (Pickering emulsion) 
ViscoSence AB   (Viscosity measurement/GI prediction)
InnovaFood AB  (Prot/AA for facilitated glycaemic regulation) 
RyeFactor AB     (Rye factor for improved glycaemic regulation) 

New businesses – production 
1.
2.

DoubleGood AB (Table water for improved glycaemic regulation at meals)
Glucanova AB  (Lassie yoghurt, Indian market)

Swedish national Venture Cup
1.
2.

ViscoSense AB,  3:de placement, 2011 (prediction of GI)
Speximo AB, top‐rated, 2012 (Pickering emulsion for skin care)

Antidiabetic Food Centre at Lund University

। Page 10 I 2013-11-12
Patents/patent applications & trademarks

Innovation out-come in 2012
among 18 Swedish VINN Exc Centres
7

Material Science
Bionano composites (BiMac Innovation)
Surface materials (FUNMAT)
Supramolecular biomaterials (SuMo)
Industry relevant materials (Hero-M)

Life Science
Material science and medical devices
(BIOMATCELL)
Biomedical sensors and
fibre-based packaging (iPack)
Protein technology (Pronova- Alba Nova)

Construction Sciences
CO2 Vehicle Design
Systematic construction (Wingquist Lab.)
Transport/Mobility Sciences
Mobility for learning (HELIX)
Interaction design (MOBILE LIFE)
Market oriented transport (SAMOT)

6

Food Science
Antidiabetic Food Centre (AFC)
5

Telecom/IT/Computer Sciences
Sustainable communication
Signal processing (Chase)
Computer simulation (Faste Lab)
Wireless communication (GigaHertz)
Wireless sensor networks (WISENET)

4

3

2

1

0
1

2

3

4

5

6

7

8

9

10

Antidiabetic Food Centre at Lund University

11

12

13

14

15

16

17

18

VINN Exc Centres
Page 11 I 2013-11-12
Innovative antidiabetic
foods- one example

Table water
with ”nutrient mix”
to lower blood glucose
excursions at composite
meals

Antidiabetic Food Centre at Lund University

। Page 12 I 2013-11-12

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Inger Björck: The Antidiabetic Food Centre

  • 1. Antidiabetic Food Centre – an example of fruitful innovation collaboration Foodbest Meeting 8 November 2013, Copenhagen ANTIDIABETIC FOOD CENTRE; some experiences in research-based innovation Inger Björck, Lund University Specialised Centres Antidiabetic Food Centre at Lund University । Page 1 I 2013-11-12
  • 2. ANTIDIABETIC FOOD CENTRE; A Centre of EXCELLENCE in RESEARCH and INNOVATION at Lund university Multidisciplinary research on how to prevent the metabolic syndrome (obesity, type 2 diabetes and CVD) with innovative food Antidiabetic Food Centre at Lund University । Page 2 I 2013-11-12
  • 3. Why antidiabetic food?; 80‐90% cases of type  2 diabetes and CVD  can be prevented by  life style,  where diet  is the single most  important factor! Pharmaceutical treatment Primary prevention based on dietary strategy urgently needed and call for; - joint strategies and close collaboration amongst industry, health care and academy - interdisciplinary research strategies within the academy New antidiabetic food concepts and new business opportunities Antidiabetic Food Centre at Lund University 1,5 billion adult, and 170 million children over‐ weight or obese ww Prognosis by y 2030, 200 million obese in EU Every fifth pre‐school child in Sweden with  over‐weight or obesity 366 million with T2D  ww Prognosis by 2030, 552 million with T2D Currently more than 30 million EU citizens  with medication within the MetS । Page 3 I 2013-11-12
  • 4. Organisation within the university AFC Organised under the Pro Vice-Chancellor for Research (Lund University Specialised Centres, USV) Faculty of Science Faculty of Engineering Faculty of Medicine Faculty of Social Sciences About 50 senior AFC researchers cross faculties Antidiabetic Food Centre at Lund University । Page 4 I 2013-11-12
  • 5. The AFC Consortium A Centre of Excellence in Research and Innovation Duration 2007-2017 Gross budget 220 MSEK Current stage 2013-2015, budget 74 MSEK Partnership; Antidiabetic Food Centre at Lund University । Page 5 I 2013-11-12
  • 6. AFC Research strategy Preventive food concepts Avoiding an inflammatory gut eco-system Prebiotics Avoiding oxidative stress and inflammation Antioxidative nutrients & polyphenols Enzyme tailoring of Probiotics Avoiding postprandial dysmetabolism Specific food proteins prebiotics Low glycaemic impact Minimal processing/minimizing AGE (Advanced Glycosylation End products) Encapsulation techniques for targeted delivery (satiety signalling) anti-inflammatory eg. adiponectin , IL-4, IL-10 Reduced inflammatory tonus & improved appetite regulation Antidiabetic Food Centre at Lund University pro-inflammatory e.g. CRP, TNF-α, IL-6, IL-18 Page 6 I 2013-11-12
  • 7. Impaired cognitive functioninga manifestation of the MetS Antiinflammatory food concept Antidiabetic food concepts that reduce inflammation may also improve cognitive functioning e.g. working memory and selective attention (Adopted from Jang&Johnsson 2010) Antidiabetic Food Centre at Lund University । Page 7 I 2013-11-12
  • 8. AFC Innovation A mindset of exploring new knowledge on how to prevent the  metabolic syndrome by new food concepts A centre agreement regulating IPR                                                   (Lund University legal unit) Invention disclosure proceedure,  and negotiations of IP                          (Lund University Innovation System)  Results notified/alerted and  communicated to partners & 30d  delay for publication Antidiabetic Food Centre at Lund University An operational plan with a  project organisation promoting incentive for innovation  Integration of the ”Swedish  intellectual property rights of  academic staff”  as a resource for  innovation । Page 8 I 2013-11-12
  • 9. Project forms AFC partners and LU reseacher(s) joint ownership 100% AFC funding Centre project P40 Industry project Industry partner ownership 40% AFC funding Antidiabetic Food Centre at Lund University LU researcher project Researcher(s) ownership AFC partners first-right of refusal 100% AFC funding । Page 9 I 2013-11-12
  • 10. AFC Innovation (2007– 2013) Patents/patent applications  1. 2. 3. 4. 5. 6. 7. Protein/Amino acid mix  for facilitated postprandial glycaemic regulation (approved) Nutrient mix for facilitated postprandial glycaemic regulation (application)  Pickering emulsions as vehicles for targeted delivery and ileal break (application)  Rye factor for improved postprandial glucose/insulin (application)  Glycaemic profiling for improved cognitive function (application) Gut microbiota modulation for metabolic benefits (application)  Food for small children (application) New businesses – licensing/knowhow 1. 2. 3. 4. Speximo AB        (Pickering emulsion)  ViscoSence AB   (Viscosity measurement/GI prediction) InnovaFood AB  (Prot/AA for facilitated glycaemic regulation)  RyeFactor AB     (Rye factor for improved glycaemic regulation)  New businesses – production  1. 2. DoubleGood AB (Table water for improved glycaemic regulation at meals) Glucanova AB  (Lassie yoghurt, Indian market) Swedish national Venture Cup 1. 2. ViscoSense AB,  3:de placement, 2011 (prediction of GI) Speximo AB, top‐rated, 2012 (Pickering emulsion for skin care) Antidiabetic Food Centre at Lund University । Page 10 I 2013-11-12
  • 11. Patents/patent applications & trademarks Innovation out-come in 2012 among 18 Swedish VINN Exc Centres 7 Material Science Bionano composites (BiMac Innovation) Surface materials (FUNMAT) Supramolecular biomaterials (SuMo) Industry relevant materials (Hero-M) Life Science Material science and medical devices (BIOMATCELL) Biomedical sensors and fibre-based packaging (iPack) Protein technology (Pronova- Alba Nova) Construction Sciences CO2 Vehicle Design Systematic construction (Wingquist Lab.) Transport/Mobility Sciences Mobility for learning (HELIX) Interaction design (MOBILE LIFE) Market oriented transport (SAMOT) 6 Food Science Antidiabetic Food Centre (AFC) 5 Telecom/IT/Computer Sciences Sustainable communication Signal processing (Chase) Computer simulation (Faste Lab) Wireless communication (GigaHertz) Wireless sensor networks (WISENET) 4 3 2 1 0 1 2 3 4 5 6 7 8 9 10 Antidiabetic Food Centre at Lund University 11 12 13 14 15 16 17 18 VINN Exc Centres Page 11 I 2013-11-12
  • 12. Innovative antidiabetic foods- one example Table water with ”nutrient mix” to lower blood glucose excursions at composite meals Antidiabetic Food Centre at Lund University । Page 12 I 2013-11-12