1. Lys4: High Lysine Corn
Product Concept Free Lysine 2004 LY038 Data
§ Transgenic approach to enhance 2000
limiting essential amino acids in feed 1800 S American Hybrid Evaluation 2003/2004
S American Hybrid Evaluation 2003/2004
US Germplasm Evaluation – 5 Locations
US Germplasm Evaluation – 5 Locations
1600
§ Increase free lysine levels 0.1% (1000
Negative Hybrids
Negative Hybrids
1400
Free LYSINE (ppm)
ppm) over current feed corn varieties 1200
1000 Target
Target
Opportunity 800
§ Market value for feed-grade lysine is 600
~ $1 billion annually. (CEH Market Research) 400
200
§ Value shared with Cargill through 0
Commercial Hybrids Derived from
Commercial Hybrids Derived from
50/50 Renessen joint venture Hybrid Variety Commercially Relevant
Hybrid Variety Commercially Relevant
High Oil Inbreds
High Oil Inbreds
§ Available market (acres):
U.S = 4M; Brazil = 1M; Argentina = 4M Lysine Broiler Study (0-42 days)
Benefits Ave. Wt. Gain (kg) Gain:Feed
0.60
2.35
§ Lower cost of animal feed ration 0.55
2.20 a 0.50
a
a
aa
§ Improved amino acid balance 2.05 0.45
Kg Weight Gain
Gain:Feed
0.40
1.90
0.35
§ Increased total energy 1.75 0.30
b b
1.60 0.25
Status b 0.20
1.45
0.15
1.30 0.10
§ S. American commercial germplasm is 1.15 0.05
1.00 + - + - + - (+) (+) 0.00
hitting efficacy target minimum
Reference 3LM(-)
1 2 LM(-) LM(-)xBt LM LMxBt
4 LM(-)xBt LM LMxBt
5678
Reference
§ N. America evaluation: hitting or Treatment
exceeding target
§ US regulatory packages submitted
§ Current Argentina & US efficacy trials
expanded to assess broader targeted
growing areas
§ Excellent performance demonstrated in
feeding trials to date
Discovery Phase 1 Phase 3 Phase 4
Phase 2 Phase 4 Launch
Proof of Early Adv. Pre-Launch
Pre-
Pre- Launch
Concept Development Development