1. Improvement of PPR quality vaccines for eradication
Dr. Felix Njeumi (FAO) and Dr. Jean-Jacques Soula (OIE)
PPR GEP Secretariat
โExplore options to improve security of vaccine supply against Foot-and-Mouth and other similar
transboundary diseasesโ. FAO HQ, Rome, Italy, 22-23 January 2020
2. Adopted in April 2015
Objectives:
๏ง Eradicate PPR by 2030
๏ง Reinforce Veterinary Services
๏ง Reduce the impact of other major
infectious diseases of small ruminants
โฆ and then contributing to
๏ง Fighting rural poverty
๏ง Ensuring food security and nutrition
๏ง Strengthening resilience and national
economies
โฆ and achieving the SDGs.
PPR Control and Eradication Strategy (PPR GCES)
โImprove security of vaccine supplyโ - Rome, FAO HQ, 22-23 January 2020
3. FAO โ OIE PPR Secretariat
โImprove security of vaccine supplyโ - Rome, FAO HQ, 22-23 January 2020
- Established in January 2016 by FAO and OIE, through a written agreement between the FAO
DG and the DG of the OIE, with ToRs, under GF-TADs umbrella;
- According to the PPR โ GCES and to Membership decisions through formal Resolutions of
FAO (37th FAO Conference) and OIE Governing Bodies;
- Located at FAO HQ, and composed of the FAO Coordinator and OIE Coordinator;
- Mandate: In charge of the implementation of the PPR Global Eradication Programme (PPR
GEP), including Planning, Coordination at global, regional and country levels, Communication,
Human Resources and Finance management, and Scientific Partnerships;
- Governance: Rome Based UN Permanent Representative friend of PPR GEP, PPR Advisory
Committee, PPR Global Research and Expertise Network (PPR GREN);
- The PPR Secretariat is fully committed to work in synergy with other GF-TADs programmes,
provided mutual respect, science โ based approach and fair way of working.
5. Improvement of PPR quality vaccines
Three PPR vaccines producers meetings (Nepal - 2014, Morocco - 2017 and Jordan - 2019) to assess challenges for
quality/quantity, research and delivery of PPR vaccines (next one in India - 2021)
1) Vaccine Quality SWOT (few weaknesses)
๏ญ Most labs do not have trained human resources in QC;
๏ญ QC not established/recognized in many labs;
๏ญ Extraneous agents and contamination (mycoplasma) : no systematic inocuity test;
๏ญ Vaccines supplied most often without diluent;
๏ญ Variable stability / shelf life at +2 to +8C;
๏ญ Characterization of new vaccine strains;
๏ญ Lack of feed back from the field of vaccine effectiveness;
๏ญ Only PANVAC but need QC lab in Asia;
2) In what ways can vaccine producers help to improve vaccine delivery in the field?
3) In what ways can the โfieldโ assist the vaccine producers?
4) What are the research challenges?
5) What are promising areas of research?
6. QUALITY CONTROL OF PPR VACCINES
PPR Vaccines received for Certification: 2015- 2018
Years
Batches
received
Batches Passed
QC
% of Quality
Vaccines
2015 20 20 100%
2016 34 31 91%
2017 55 49 89.1%
2018 55 50 90.1%
AU-PANVAC Mission is โTo promote the use of Good Quality Vaccines and Diagnostic Reagents for the control
and eradication of animal diseases in Africa.โ
7. PPR GEP Second Global Research and Expertise Network meeting (Nairobi, Kenya 13-15 November 2019)
Thermotolerant vaccines
Minimum requirements set for manufacturers to be able to use the term
โthermotolerant vaccineโ.
Storage
Standard cold
chain
Room Field
Temperature 2 โ 8ยฐ C 25ยฐ C 40ยฐ C
Period 2 years 10 days 5 days
-2020: FAO has secured 20 millions doses of PPR vaccines for few countries
Algeria
Phylogenetic analysis indicated a close relationship (99.3%) with the PPRV isolated during the Moroccan outbreak in 2008.
Unlike Morocco, since then, some PPR outbreaks has been continuously confirmed.