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Ergosterol and Cholesterol: Precursors to Vitamin D Synthesis and Regulation

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Esther Issac
Esther Issac

Vitamin D

Health & Medicine
1 of 11
Chemistry ERGOSTEROL
IN PLANTS IN ANIMALS
7-dehydro cholesterol cholecalciferol 25 ā€“ dihydroxy chole calciferol 1,25 dihydroxy chole calciferol sunlight Calcidiol 2,5 hydroxylase Calcidiol 1- hydroxylase
REGULATION OF SYNTHESIS ā€¢Concentration of calcitriol is regulated by plasma levels of calcium & phosphate ā€¢ Low plasma phosphate increases activity of calcidiol 1- hydroxylase ā€“ DIRECT ā€¢ Low plasma calcium enhances parathyroid hormone production which in turn activates 1-hydroxylase - INDIRECT
RDA Adults: 400 IU in Western countries 200 IU in India Children:400 IU Pregnancy & Lactation:600 IU
Hypervitaminosis ā€¢Among the Vitamins D is most toxic on overdose ā€¢ Demineralization of bone ā€¢ Increased Ca absorption- hypercalcemia ā€¢ Deposition of ca in kidneys & arteries ā€¢ Renal calculi ā€¢ Loss of appetite ā€¢ Nausea ā€¢ Increased thirst ā€¢ Loss of weight

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