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Birth asphyxia
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Asphyxia
 APGAR score at 1 minute < 7
 Interruption in oxygen delivery to the fetus
• Hypoxia
• Hypercapnia
 Birth asphyxia เเเเเเเเเเเเเเเเเเ
เเเเเเเเเเเเเเเเเเเเเเเเเ
เเเเเเเเเเเเเเเเเเเเเเเเเเ
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Neonatal Evaluation and
Resuscitation
APGAR Scoring
A Appearance
P Pulse
G Grimace
A Activity
R Respirations
APGAR Score
Apgar Score
 Total Score = 10
score 7-10 normal
score 5-6 mild birth asphyxia
score 3-4 moderate birth asphyxia
score 0-2 severe birth asphyxia
Causes of Neonatal Mortality
Infection
32%
Other
5%
Congenital
Anomalies
10%
Birth Asphyxia
29%
Complications
of Prematurity
24%
Source: WHO 2001 estimates (based on data collected around 1999)
Etiology
 Birth asphyxia in undeveloped countries
 10% of newborns suffer mild to moderate birth
asphyxia
 1% of newborns suffer severe birth asphyxia
Risk factors
Antepartum :
Maternal diabetes post-term gestation
Pregnancy induced hypertension multiple gestation
Chronic hypertension size-dates discrepancy
Previous Rh sensitization maternal drug abuse
Previous stillbirth maternal age >35 or<16
Bleeding in second or third trimester no prenatal care
Maternal infection
Polyhydramnios or oligohydramnios
Risk factors
Intrapartum :
Elective or emergency c/s
Precipitous labour, prolonged labour
Prolonged second stage of labour
Premature labour
Abnormal presentation
Rupture of membranes > 24 hours
Foul-smelling amniotic fluid
Non reassuring fetal heart rate patterns
Use of general anesthesia
Prolapsed cord
Assessment
 Fetal heart rate slows
 Electronic fetal monitoring
• persistent late deceleration of any
magnitude
• persistent severe variable deceleration
• prolonged bradycardia
• decreased or absent beat-to-beat variability
 Thick meconium-stained amniotic fluid
 Fetal scalp blood analysis show pH less than 7.2
Effects of Asphyxia
 Central nervous system
• infarction, intracranial hemorrhage,
cerebral edema, seizure, hypoxic-
ischemic encephalopathy
 Cardiovascular
• bradycardia, ventricular hypertrophy,
arrhythmia, hypotension, myocardial
ischemia
Effects of Asphyxia
 Respiratory system
•apnea, respiratory distress syndrome
cyanosis
 KUB
•acute tubular necrosis, bladder paralysis
 Gastrointestinal tract
•necrotizing enterocolitis , stress ulcer
Effects of Asphyxia
 Hematology
•Disseminated intravascular coagulation
 Metabolic
•hypoglycemia, hyperglycemia,
hypocalcemia, hyponatremia
 Integument
• subcutaneous fat necrosis
Neonatal
Resuscitation
Newborn Resuscitation AHA/AAP
Guidelines
 Meconium -stained amniotic fluid: endotracheal
suctioning of the depressed - not the vigorous child
 Hyperthermia should be avoided
 100% oxygen is still recommended, however if
supplemental oxygen is unavailable room air should be
used
 Chest compression: Initiated if heart rate is absent or
remains < 60 bpm despite adequate ventilation for 30
sec
 Medications: Epinephrine 0.01-0.03 mg/kg if heart rate
< 60 bpm in spite of 30 seconds adequate ventilation
and chest compression
 Volume: Isotonic crystalloid solution or 0-neg blood
Prognosis
 Apgar score < 5 at 10 minutes : nearly 50 %
death or disability (Leicester)
 No spontaneous respiration after 20 min : 60
% disability in survivors (USA).
 No spontaneous respiration after 30 minutes :
nearly 100 % disability in survivors (Newcastle).
Facts About Newborn Resuscitation
The most important is to get air into the lungs
Hypoxic-ischemic encephalopathy(HIE)
 Hypoxic-ischemic encephalopathy is an
important cause of permanent damage to
central nervous system cells, which may
result in
- neonatal death
- manifest later as cerebral palsy or
mental deficiency
Essential criteria:
1.Metabolic acidosis on cord blood or very early
(1 hour) neonatal blood (pH 7.0 or base
deficit > 12 mmol/l.)
2.Early onset of severe or moderate neonatal
encephalopathy in infants of > 34 weeks gest
ation.
3.Cerebral palsy of the spastic quadriplegic or
dyskinetic type.
Criteria that together suggest
 A sentinel hypoxic event immediately before
or during labour.
 A sudden, rapid and sustained deterioration
of fetal heart rate.
 Apgar scores of 0-6 for longer than 5
minutes.
 Early evidence of multisystem involvement.
 Early imaging evidence of acute cerebral
abnormality.

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Birth asphyxia

  • 2. Asphyxia  APGAR score at 1 minute < 7  Interruption in oxygen delivery to the fetus • Hypoxia • Hypercapnia  Birth asphyxia เเเเเเเเเเเเเเเเเเ เเเเเเเเเเเเเเเเเเเเเเเเเ เเเเเเเเเเเเเเเเเเเเเเเเเเ เเเเเเเเเเเเเเเเเเเเเเเเ เเเเเ เเเเเเเเเเเเเเเเ เเเเเเ
  • 3. Neonatal Evaluation and Resuscitation APGAR Scoring A Appearance P Pulse G Grimace A Activity R Respirations
  • 5. Apgar Score  Total Score = 10 score 7-10 normal score 5-6 mild birth asphyxia score 3-4 moderate birth asphyxia score 0-2 severe birth asphyxia
  • 6. Causes of Neonatal Mortality Infection 32% Other 5% Congenital Anomalies 10% Birth Asphyxia 29% Complications of Prematurity 24% Source: WHO 2001 estimates (based on data collected around 1999)
  • 7. Etiology  Birth asphyxia in undeveloped countries  10% of newborns suffer mild to moderate birth asphyxia  1% of newborns suffer severe birth asphyxia
  • 8. Risk factors Antepartum : Maternal diabetes post-term gestation Pregnancy induced hypertension multiple gestation Chronic hypertension size-dates discrepancy Previous Rh sensitization maternal drug abuse Previous stillbirth maternal age >35 or<16 Bleeding in second or third trimester no prenatal care Maternal infection Polyhydramnios or oligohydramnios
  • 9. Risk factors Intrapartum : Elective or emergency c/s Precipitous labour, prolonged labour Prolonged second stage of labour Premature labour Abnormal presentation Rupture of membranes > 24 hours Foul-smelling amniotic fluid Non reassuring fetal heart rate patterns Use of general anesthesia Prolapsed cord
  • 10. Assessment  Fetal heart rate slows  Electronic fetal monitoring • persistent late deceleration of any magnitude • persistent severe variable deceleration • prolonged bradycardia • decreased or absent beat-to-beat variability  Thick meconium-stained amniotic fluid  Fetal scalp blood analysis show pH less than 7.2
  • 11. Effects of Asphyxia  Central nervous system • infarction, intracranial hemorrhage, cerebral edema, seizure, hypoxic- ischemic encephalopathy  Cardiovascular • bradycardia, ventricular hypertrophy, arrhythmia, hypotension, myocardial ischemia
  • 12. Effects of Asphyxia  Respiratory system •apnea, respiratory distress syndrome cyanosis  KUB •acute tubular necrosis, bladder paralysis  Gastrointestinal tract •necrotizing enterocolitis , stress ulcer
  • 13. Effects of Asphyxia  Hematology •Disseminated intravascular coagulation  Metabolic •hypoglycemia, hyperglycemia, hypocalcemia, hyponatremia  Integument • subcutaneous fat necrosis
  • 15. Newborn Resuscitation AHA/AAP Guidelines  Meconium -stained amniotic fluid: endotracheal suctioning of the depressed - not the vigorous child  Hyperthermia should be avoided  100% oxygen is still recommended, however if supplemental oxygen is unavailable room air should be used  Chest compression: Initiated if heart rate is absent or remains < 60 bpm despite adequate ventilation for 30 sec  Medications: Epinephrine 0.01-0.03 mg/kg if heart rate < 60 bpm in spite of 30 seconds adequate ventilation and chest compression  Volume: Isotonic crystalloid solution or 0-neg blood
  • 16. Prognosis  Apgar score < 5 at 10 minutes : nearly 50 % death or disability (Leicester)  No spontaneous respiration after 20 min : 60 % disability in survivors (USA).  No spontaneous respiration after 30 minutes : nearly 100 % disability in survivors (Newcastle).
  • 17. Facts About Newborn Resuscitation The most important is to get air into the lungs
  • 18. Hypoxic-ischemic encephalopathy(HIE)  Hypoxic-ischemic encephalopathy is an important cause of permanent damage to central nervous system cells, which may result in - neonatal death - manifest later as cerebral palsy or mental deficiency
  • 19. Essential criteria: 1.Metabolic acidosis on cord blood or very early (1 hour) neonatal blood (pH 7.0 or base deficit > 12 mmol/l.) 2.Early onset of severe or moderate neonatal encephalopathy in infants of > 34 weeks gest ation. 3.Cerebral palsy of the spastic quadriplegic or dyskinetic type.
  • 20. Criteria that together suggest  A sentinel hypoxic event immediately before or during labour.  A sudden, rapid and sustained deterioration of fetal heart rate.  Apgar scores of 0-6 for longer than 5 minutes.  Early evidence of multisystem involvement.  Early imaging evidence of acute cerebral abnormality.

Editor's Notes

  1. Take the APGAR score at one minute and five minutes.
  2. APGAR Score: Appearance The skin of a newborn should be pink. Assess the newborn’s skin color and score as follows: Entire body blue or pale - 0 points Blue hands and feet - 1 point Entire body pink - 2 points APGAR Score: Pulse The pulse of a newborn should be greater than 100 beats per minute. Assess the newborn’s brachial pulse or use a stethoscope and score as follows: Pulse absent - 0 points Pulse less than 100 - 1 point Pulse greater than 100 - 2 points APGAR Score: Activity A newborn should exhibit active flexion and extension of the extremities. Assess the newborn’s activity and score as follows: No extremity movement - 0 points Minimal activity - 1 point Strong activity - 2 points APGAR Score: Respirations A newborn should breathe between 30 and 60 times a minute or exhibit a strong cry. Assess the newborn’s breathing and score as follows: No respiratory effort - 0 points Slow (&amp;lt;30/minute), irregular, or weak cry - 1 point Normal respirations or strong cry - 2 points APGAR Score At the conclusion of the APGAR score, add the numbers together and consider the following: 7-10 points - The newborn should be active and vigorous. Provide routine care. 4-6 points - The newborn is moderately depressed. Provide stimulation and oxygen. 0-3 points - The newborn is severely depressed and requires extensive resuscitation.
  3. Administer blow-by oxygen if the newborn displays: Cyanosis of the skin Spontaneous and adequate breathing Heart rate above 100 beats per minute Ventilation with the Bag Mask Provide ventilations with the bag mask at a rate of 30 to 60 breaths per minute if: The newborn’s breathing is slow or otherwise inadequate. The newborn’s heart rate is less than 100 beats per minute. The newborn’s trunk remains cyanotic despite the administration of blow-by oxygen. Reassess the infant’s color, respiratory effort, and heart rate after 30 seconds of ventilation. Cardiopulmonary Resuscitation Provide CPR if: The newborn’s heart rate is less than 60 beats per minute. Reassess the infant’s color, respiratory effort, and heart rate after 30 seconds of CPR and treat according to findings. Advanced Providers: See protocols for medications/dosages