The Future of Back Pain Relief: Stem Cell Therapy | Dr. David Greene Arizona

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The Future of Back Pain Relief: Stem Cell Therapy" explores the innovative approach of using stem cells to alleviate back pain. Join Dr. David Greene Arizona as he delves into this promising treatment, offering hope for a pain-free future and improved spinal health

Healthcare

The Future of
Back Pain Relief:
Stem Cell
Therapy
Dr. David Greene Arizona

Introduction
Chronic low back pain affects
approximately 632 million
people worldwide with
prevalence as high as 68% in
adults older than 60 years of
age

Methods
A comprehensive literature
search was performed
independently by two authors
(AH Barakat, VA Elwell) and the
results were collated and de-
duplicated.

Primary cells
Studies on primary and native
stem cells for DDD have gained
interest over the past decade.
Several studies have confirmed
the presence of NP and AF
progenitor cells in IVD tissues
possessing multipotential
differentiation capabilities

MSC
MSC transplantation has
received considerable attention
due to their versatility, and
potential for stimulating a
healthier host tissue
microenvironment by their
paracrine effects.

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Stem cells (SCs) are important cells for replacement therapy diseases.The interest in the potential of neural stem cells (NSCs) for the treatment of neurodegenerative diseases and brain injuries has substantially promoted research on neural stem cell self-renewal and differentiation.The geneissrybox containing gene 2 (Sox2) has been associated with a SC phenotype that predicts for poor outcomes. Sox2 is a transcription factor that regulates embryonic stem cell pluripotency and drives commitment of airway precursor cells to basal-type and neuroendocrine cells in the developing lung. Sox2gene involved will be investigated in practical pirogue according to the expression patterns.Sox2 has been associated with a SC phenotype that predicts for poor outcomes. Subsequently, information has been compiled on the question how Sox2 in neural differentiation is controlled on the molecular level, and controlled in vivo.

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Eukaryotic cells have their genetic material in the nucleus, in the other side, prokaryotes have it dispersed in the cytoplasm. From this DNA will be synthesized RNA, which will act as an intermediary, carrying genetic information from the nucleus to the ribosomes located in the cytoplasm to carry out protein synthesis. genetic code consists of 64 triplets (codons) of nucleotides, each codon encodes for one of the 20 amino-acids used in the synthesis of proteins. The study of the genetic code, allow s us identify mutations in specific genes, to detect diseases or predispositions to some pathologies such as those proposed by the articles, and with tan information, implement a PREVENTIVE MEDICINE. Knowing the sequence of genes that cause certain genetic diseases, is essential for GENE THERAPY branch. In brief it consist in introduce a correct copy of the defective gene that was visualized into the cells, by some vectors, previously studied. With the knowledge of genetic information, can be provided counseling before and after pregnancy to future parents (Give information about the diseases to which it is susceptible and existing treatments), having always instilled an ethical principle: THE HUMAN LIFE RESPECT. Promote investigation in medicine basic areas, such as cell biology, molecular biology, biochemistry and pharmacology, with the aim of implement humanity solutions .

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The Opposing Viewpoint of Stem Cell Stem cell research explores the nature and growth capabilities of cells essential for ensuring replacement of cells in living organisms (Paddock, 2017). Such cells have an advantage of being manipulated to any type of cells as it is deemed necessary by the scientists based on scarcity or slow rejuvenation process of the natural cells. The general public has largely adopted a reserved approach to stem cell research and therapy despite the positive research and development showcased by leading scientists including; · Jun Takahashi: he explored the safety and applicability of stem cell therapy in primates in relations to the Parkinson’s disease, recording a major success between the interaction of human cells and animals (Sandoiu). Furthermore, no long-term negative effect was established from the treatment that saw full recovery of the primates. · Hai Nguyen, Aileen Anderson and colleagues: carried a similar exercise on injured mice to record tremendous success of the donor cells in a period ranging immediately after the induction process to at most one month (Society for Neuroscience. 2017). · Scientists from the Cedars-Sinai Heart Institute in Los Angeles CA: highlighted the need for stem therapy in replacing aging heart muscles using rats (Paddock, 2017). The induced cells were able to grow and multiply thus repair the heart muscles of the older rats to improve the general body functioning. Despite the breathtaking discoveries as tested and presented by these scientists, ethical concerns have prevailed to the dismay of an excited global scientists’ fraternity. The general public is cautious in its approach to stem cell therapy from various reasons ranging from the potential to cause cancer to how the media overrates the treatment process that still has critical gaps to full implementation (Begley, 2017). There are two major concerns that arise from the Cedars-Sinai Heart Institute research as reported by Paddock. The first concern as perceived by the layman defined as the general public is the fact the findings are based on animals other than human beings. This experiment was purely run on rodent tissue thus raising a legitimate query as to the consistency if replicated in humans. The second concern arises from Paddocks admission that the scientists proposed the need for further research to determine whether the findings are only valid when the donors are young (2017). Since the same article admits the fact modern day medicine has seen prolonged life with a possibility of the elderly to exceed the children population, such a dependency on young donors may endanger the human species in the long run. The excitement surrounding Stem Cell Research is magnified through mainstream media that often cares about moving volumes in sales rather than realistically highlight the caution or reservations pronounced by scientists. However, Sharon Begley is exemplary in her revelation of a high-risk gap in research that li ...

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