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Discussion: Community-Acquired Pneumonia
Case Study
HH is a 68-yr M who has been admitted to the medical ward
with community-acquired pneumonia for the past three days.
His PMH is
significant for COPD, HTN, hyperlipidemia, and diabetes. He
remains on empiric antibiotics, including ceftriaxone 1 g IV q
day (day 3) and
azithromycin 500 mg IV q day (day 3). Since admission, his
clinical status has improved, with decreased oxygen
requirements. He is not tolerating a
diet at this time, complaining of nausea and vomiting. Ht: 5'8"
Wt: 89 kg Allergies: Penicillin (rash).
Diagnosis: Community-Acquired Pneumonia (CAP)
CAP is the term used to describe an acute infection of the lungs
that develops outside the hospital setting by an immune-
competent
individual who has not been recently hospitalized (Shoar &
Musher, 2020). Adults with CAP typically present with cough,
fever, sputum production or
shortness of breath, oxygen desaturation, confusion,
leukocytosis or leukopenia, and pleuritic chest pain, along with
the presence of an acute
infiltrate on the chest radiograph (Shoar & Musher, 2020).
Antibiotic suggested for CAP's empiric treatment is based on
agents useful against CAP's major treatable bacterial causes.
The bacterial
pathogens responsible for CAP include Streptococcus
pneumoniae, Mycoplasma pneumoniae, Chlamydia pneumoniae,
Haemophilus
influenzae, Staphylococcus aureus, Legionella species, and
Moraxella catarrhalis (Metlay et al., 2019).
The patient is on right treatment, his clinical status has
improved, with decreased oxygen requirement. Recommended
treatment plan for
patients with comorbidities such as alcoholism, COPD, post
influenza, asplenia, diabetes mellitus, lung/liver/renal diseases
include: Combination
of a beta-lactam (ceftriaxone 1 g IV q24h or cefotaxime 1 g IV
q8h or ceftaroline 600 mg IV q12h) plus azithromycin 500 mg
IV q24h (Donovan, 2019).
The therapy duration is a minimum of 5 days. The patient needs
to be afebrile for 48-72 hours, controlled blood pressure,
adequate oral intake, and
room air oxygen saturation of greater than 90% and treatment
duration can be extended if symptoms are not recovered in some
cases (Donovan,
2019).
In this case, the patient symptoms are improving, his
oxygen requirement is decreased, but he is not tolerating a diet
at this time,
complaining of nausea and vomiting. The patient received
antibiotics for three days, so antibiotics need to be continued.
With appropriate antibiotic
therapy, some improvement in the patient's clinical course is
usually seen within 48 to 72 hours (File, 2020).
Health
Needs and Treatment Regimen
The patient is not tolerating diet and complaining of nausea and
vomiting. Gastrointestinal (GI) manifestations such as nausea,
vomiting,
and diarrhea are considered possibly due to adverse drug
(antibiotics) effects (Lin et al., 2009). Changing the antibiotic
can help patients to avoid
these side effects. Levofloxacin 750 mg IV or PO q24h is a
recommended dose to treat CAP patients (Donovan, 2019).
Levofloxacin possesses greater bioavailability and a
longer serum half-life that allows for rapid step-down from
intravenous administration
to oral therapy, minimizing unnecessary hospitalization, which
may decrease costs and improve patient quality of life (Lynch
III et al., 2006). Several
randomized clinical trials to evaluate levofloxacin to treat CAP
demonstrate that levofloxacin is effective and safe for CAP
treatment, displaying
relatively mild adverse effects. Levofloxacin has much to offer
in terms of bacterial eradication (Lynch III et al., 2006). The
other studies also
concluded that monotherapy with oral levofloxacin is as
effective as treatment with Ceftriaxone plus, Azithromycin
combination in patients with CAP
who required hospitalization (Izadi et al., 2019).
Probiotics can be added to the treatment plan.
Probiotics replenish the natural GI flora with nonpathogenic
organisms. Few studies found
probiotics to be useful for preventing and treating antibiotic-
associated diarrhea related to antibiotic treatment (Rodgers et
al., 2013).
An antiemetic medication such as ondansetron can be added. It
is a selective 5-HT3 serotonin-receptor antagonist and acts on
central and
peripheral areas to prevent and treat nausea and vomiting
(Griddine & Bush, 2020).
As the patient is diabetic, his blood sugar needs to monitor
carefully because of sickness, nausea, and vomiting. Sliding
scale insulin (SSI) is
recommended. Both hyperglycemia and hypoglycemia in
hospitalized patients result in adverse outcomes, including
increased infection rates,
longer hospital length of stay, and even death. The use of oral
antidiabetic treatments during hospitalization is generally not
recommended because
of their safety and efficacy and their significant risk of
hypoglycemia and contraindications (Marín-Peñalver et al.,
2016).
Patient Education for
the management of Their Health Needs
The patient needs to be educated and encouraged to use an
incentive spirometer (IS). Incentive spirometry is commonly
used to break up
fluid that builds up in the lungs in people with pneumonia. IS
helps to open the airways and help manage COPD symptoms
(Yetman, 2020).
The patient needs to be educated about importance of the
pneumococcal conjugate vaccine (PCV) and influenza vaccines.
As per International Journal of Chronic Obstructive Pulmonary
Disease study, these vaccines decrease the risk of exacerbations
in patients with
chronic obstructive pulmonary disease (COPD) (Ely, 2018).
Patients over 65 years of age are more susceptible to
community-acquired pneumonia
(CAP), and COPD patients are 20 times more prone to develop
CAP (Ely, 2018). The Community-Acquired Pneumonia
Immunization Trial in Adults
(CAPITA) provided evidence of the benefits of vaccinating with
PCV13, which protects against 13 pneumococcal bacteria types
(Ely, 2018).
At the time of discharge, the patient needs to be
educated to continue his home medications and finish the
prescription of antibiotics if
prescribed, even if he starts to feel better. Taking the entire
course of antibiotics is one way to prevent recurring and more
severe infections and
combat antibiotic resistance (Rosenthal & Burchum, 2020).
Conclusion
Community-acquired pneumonia (CAP) is one of the
most common acute infections requiring hospital admission.
Age is a dominant risk
factor, with CAP's incidence increasing markedly in patients
who are over 65 years of age. Aging increases the mucosal cell
surface protein
expression that bacteria can adhere to, enabling potential
pathogens to avoid normal clearance mechanisms better. There
is evidence that age
directly affects innate and adaptive immunity, a process called
immunosenescence, which weakens lung immunity to invading
microbes (Brown,
2012). Few behavior changes like quitting smoking and alcohol
abuse and administering the vaccine can prevent or decrease
CAP's severity.
References
Brown, J. S. (2012). Community-acquired pneumonia.
Clinical Medicine
,
12
(6), 538–543.
https://doi.org/10.7861/clinmedicine.12-6-538
Donovan, F. M. (2019). Community-acquired pneumonia
empiric therapy: Empiric therapy regimens.
https://emedicine.medscape.com/article/2011819-
overview
Ely, K. (2018). Study Shows the Efficacy of Vaccination in
Patients With COPD.
https://www.ajmc.com/view/study-shows-the-efficacy-of-
vaccination-in-
patients-with-copd
File, T. M. (2020). Treatment of community-acquired
pneumonia in adults who require hospitalization.
UpToDate
.
https://www.uptodate.com/contents/treatment-of-community-
acquired-pneumonia-in-adults-who-require-hospitalization
Griddine, A., & Bush, J. S. (2020).
Ondansetron - statpearls - ncbi bookshelf
.
https://www.ncbi.nlm.nih.gov/books/NBK499839/
Izadi, M., Dadsetan, B., Najafi, Z., Jafari, S., Mazaheri, E.,
Dadras, O., Heidari, H., SeyedAlinaghi, S., & Voltarelli, F.
(2019). Levofloxacin versus
ceftriaxone and azithromycin combination in the
treatment of community acquired pneumonia in hospitalized
patients.
Recent Patents on
Anti-Infective Drug Discovery
,
13
(3), 228–239.
https://doi.org/10.2174/1574891x13666181024154526
Lin, R. Y., Nuruzzaman, F., & Shah, S. N. (2009). Incidence
and impact of adverse effects to antibiotics in hospitalized
adults with pneumonia.
Journal
of Hospital Medicine
,
4
(2), E7–E15.
https://doi.org/10.1002/jhm.414
Lynch III, J. P., File Jr, T. M., & Zhanel, G. G. (2006).
Levofloxacin for the treatment of community-acquired
pneumonia.
Expert Review of Anti-infective
Therapy
,
4
(5), 725–742.
https://doi.org/10.1586/14787210.4.5.725
Marín-Peñalver, J., Martín-Timón, I., & del Cañizo-Gómez, F.
(2016). Management of hospitalized type 2 diabetes mellitus
patients.
Journal of
Translational Internal Medicine
,
4
(4), 155–161.
https://doi.org/10.1515/jtim-2016-0027
Metlay, J. P., Waterer, G. W., Long, A. C., Anzueto, A.,
Brozek, J., Crothers, K., Cooley, L. A., Dean, N. C., Fine, M.
J., Flanders, S. A., Griffin, M. R.,
Metersky, M. L., Musher, D. M., Restrepo, M. I., &
Whitney, C. G. (2019). Diagnosis and treatment of adults with
community-acquired
pneumonia. an official clinical practice guideline of the
american thoracic society and infectious diseases society of
america. American Journal
of Respiratory and Critical Care Medicine, 200(7), e45–
e67.
https://doi.org/10.1164/rccm.201908-1581st
Rodgers, B., Kirley, K., & Mounsey, A. (2013). Prescribing an
antibiotic? pair it with probiotics. PubMed Central (PMC).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601687
Rosenthal, L. D., & Burchum, J. R. (2020). Lehne's
pharmacotherapeutics for advanced practice nurses and
physician assistants (2nd ed.). Saunders.
Shoar, S., & Musher, D. M. (2020). Etiology of community-
acquired pneumonia in adults: A systematic review.
Pneumonia
,
12
(1).
https://doi.org/10.1186/s41479-020-00074-3
Yetman, D. (2020). Incentive spirometer: What it’s for and how
to use it. Healthline.
https://www.healthline.com/health/incentive-spirometer

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  • 1. Respond to this discussion . Add some facts with at least 2 citations APA Format Discussion: Community-Acquired Pneumonia Case Study HH is a 68-yr M who has been admitted to the medical ward with community-acquired pneumonia for the past three days. His PMH is significant for COPD, HTN, hyperlipidemia, and diabetes. He remains on empiric antibiotics, including ceftriaxone 1 g IV q day (day 3) and azithromycin 500 mg IV q day (day 3). Since admission, his clinical status has improved, with decreased oxygen requirements. He is not tolerating a diet at this time, complaining of nausea and vomiting. Ht: 5'8" Wt: 89 kg Allergies: Penicillin (rash). Diagnosis: Community-Acquired Pneumonia (CAP) CAP is the term used to describe an acute infection of the lungs that develops outside the hospital setting by an immune- competent individual who has not been recently hospitalized (Shoar & Musher, 2020). Adults with CAP typically present with cough, fever, sputum production or
  • 2. shortness of breath, oxygen desaturation, confusion, leukocytosis or leukopenia, and pleuritic chest pain, along with the presence of an acute infiltrate on the chest radiograph (Shoar & Musher, 2020). Antibiotic suggested for CAP's empiric treatment is based on agents useful against CAP's major treatable bacterial causes. The bacterial pathogens responsible for CAP include Streptococcus pneumoniae, Mycoplasma pneumoniae, Chlamydia pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Legionella species, and Moraxella catarrhalis (Metlay et al., 2019). The patient is on right treatment, his clinical status has improved, with decreased oxygen requirement. Recommended treatment plan for patients with comorbidities such as alcoholism, COPD, post influenza, asplenia, diabetes mellitus, lung/liver/renal diseases include: Combination of a beta-lactam (ceftriaxone 1 g IV q24h or cefotaxime 1 g IV q8h or ceftaroline 600 mg IV q12h) plus azithromycin 500 mg IV q24h (Donovan, 2019). The therapy duration is a minimum of 5 days. The patient needs to be afebrile for 48-72 hours, controlled blood pressure, adequate oral intake, and room air oxygen saturation of greater than 90% and treatment duration can be extended if symptoms are not recovered in some cases (Donovan,
  • 3. 2019). In this case, the patient symptoms are improving, his oxygen requirement is decreased, but he is not tolerating a diet at this time, complaining of nausea and vomiting. The patient received antibiotics for three days, so antibiotics need to be continued. With appropriate antibiotic therapy, some improvement in the patient's clinical course is usually seen within 48 to 72 hours (File, 2020). Health Needs and Treatment Regimen The patient is not tolerating diet and complaining of nausea and vomiting. Gastrointestinal (GI) manifestations such as nausea, vomiting, and diarrhea are considered possibly due to adverse drug (antibiotics) effects (Lin et al., 2009). Changing the antibiotic can help patients to avoid these side effects. Levofloxacin 750 mg IV or PO q24h is a recommended dose to treat CAP patients (Donovan, 2019). Levofloxacin possesses greater bioavailability and a longer serum half-life that allows for rapid step-down from intravenous administration to oral therapy, minimizing unnecessary hospitalization, which may decrease costs and improve patient quality of life (Lynch III et al., 2006). Several
  • 4. randomized clinical trials to evaluate levofloxacin to treat CAP demonstrate that levofloxacin is effective and safe for CAP treatment, displaying relatively mild adverse effects. Levofloxacin has much to offer in terms of bacterial eradication (Lynch III et al., 2006). The other studies also concluded that monotherapy with oral levofloxacin is as effective as treatment with Ceftriaxone plus, Azithromycin combination in patients with CAP who required hospitalization (Izadi et al., 2019). Probiotics can be added to the treatment plan. Probiotics replenish the natural GI flora with nonpathogenic organisms. Few studies found probiotics to be useful for preventing and treating antibiotic- associated diarrhea related to antibiotic treatment (Rodgers et al., 2013). An antiemetic medication such as ondansetron can be added. It is a selective 5-HT3 serotonin-receptor antagonist and acts on central and peripheral areas to prevent and treat nausea and vomiting (Griddine & Bush, 2020). As the patient is diabetic, his blood sugar needs to monitor carefully because of sickness, nausea, and vomiting. Sliding scale insulin (SSI) is recommended. Both hyperglycemia and hypoglycemia in hospitalized patients result in adverse outcomes, including increased infection rates,
  • 5. longer hospital length of stay, and even death. The use of oral antidiabetic treatments during hospitalization is generally not recommended because of their safety and efficacy and their significant risk of hypoglycemia and contraindications (Marín-Peñalver et al., 2016). Patient Education for the management of Their Health Needs The patient needs to be educated and encouraged to use an incentive spirometer (IS). Incentive spirometry is commonly used to break up fluid that builds up in the lungs in people with pneumonia. IS helps to open the airways and help manage COPD symptoms (Yetman, 2020). The patient needs to be educated about importance of the pneumococcal conjugate vaccine (PCV) and influenza vaccines. As per International Journal of Chronic Obstructive Pulmonary Disease study, these vaccines decrease the risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD) (Ely, 2018). Patients over 65 years of age are more susceptible to community-acquired pneumonia (CAP), and COPD patients are 20 times more prone to develop CAP (Ely, 2018). The Community-Acquired Pneumonia Immunization Trial in Adults (CAPITA) provided evidence of the benefits of vaccinating with
  • 6. PCV13, which protects against 13 pneumococcal bacteria types (Ely, 2018). At the time of discharge, the patient needs to be educated to continue his home medications and finish the prescription of antibiotics if prescribed, even if he starts to feel better. Taking the entire course of antibiotics is one way to prevent recurring and more severe infections and combat antibiotic resistance (Rosenthal & Burchum, 2020). Conclusion Community-acquired pneumonia (CAP) is one of the most common acute infections requiring hospital admission. Age is a dominant risk factor, with CAP's incidence increasing markedly in patients who are over 65 years of age. Aging increases the mucosal cell surface protein expression that bacteria can adhere to, enabling potential pathogens to avoid normal clearance mechanisms better. There is evidence that age directly affects innate and adaptive immunity, a process called immunosenescence, which weakens lung immunity to invading microbes (Brown, 2012). Few behavior changes like quitting smoking and alcohol abuse and administering the vaccine can prevent or decrease CAP's severity.
  • 7. References Brown, J. S. (2012). Community-acquired pneumonia. Clinical Medicine , 12 (6), 538–543. https://doi.org/10.7861/clinmedicine.12-6-538 Donovan, F. M. (2019). Community-acquired pneumonia empiric therapy: Empiric therapy regimens. https://emedicine.medscape.com/article/2011819- overview Ely, K. (2018). Study Shows the Efficacy of Vaccination in Patients With COPD. https://www.ajmc.com/view/study-shows-the-efficacy-of- vaccination-in- patients-with-copd File, T. M. (2020). Treatment of community-acquired pneumonia in adults who require hospitalization. UpToDate . https://www.uptodate.com/contents/treatment-of-community- acquired-pneumonia-in-adults-who-require-hospitalization Griddine, A., & Bush, J. S. (2020). Ondansetron - statpearls - ncbi bookshelf . https://www.ncbi.nlm.nih.gov/books/NBK499839/ Izadi, M., Dadsetan, B., Najafi, Z., Jafari, S., Mazaheri, E.,
  • 8. Dadras, O., Heidari, H., SeyedAlinaghi, S., & Voltarelli, F. (2019). Levofloxacin versus ceftriaxone and azithromycin combination in the treatment of community acquired pneumonia in hospitalized patients. Recent Patents on Anti-Infective Drug Discovery , 13 (3), 228–239. https://doi.org/10.2174/1574891x13666181024154526 Lin, R. Y., Nuruzzaman, F., & Shah, S. N. (2009). Incidence and impact of adverse effects to antibiotics in hospitalized adults with pneumonia. Journal of Hospital Medicine , 4 (2), E7–E15. https://doi.org/10.1002/jhm.414 Lynch III, J. P., File Jr, T. M., & Zhanel, G. G. (2006). Levofloxacin for the treatment of community-acquired pneumonia. Expert Review of Anti-infective Therapy , 4 (5), 725–742. https://doi.org/10.1586/14787210.4.5.725
  • 9. Marín-Peñalver, J., Martín-Timón, I., & del Cañizo-Gómez, F. (2016). Management of hospitalized type 2 diabetes mellitus patients. Journal of Translational Internal Medicine , 4 (4), 155–161. https://doi.org/10.1515/jtim-2016-0027 Metlay, J. P., Waterer, G. W., Long, A. C., Anzueto, A., Brozek, J., Crothers, K., Cooley, L. A., Dean, N. C., Fine, M. J., Flanders, S. A., Griffin, M. R., Metersky, M. L., Musher, D. M., Restrepo, M. I., & Whitney, C. G. (2019). Diagnosis and treatment of adults with community-acquired pneumonia. an official clinical practice guideline of the american thoracic society and infectious diseases society of america. American Journal of Respiratory and Critical Care Medicine, 200(7), e45– e67. https://doi.org/10.1164/rccm.201908-1581st Rodgers, B., Kirley, K., & Mounsey, A. (2013). Prescribing an antibiotic? pair it with probiotics. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601687 Rosenthal, L. D., & Burchum, J. R. (2020). Lehne's pharmacotherapeutics for advanced practice nurses and physician assistants (2nd ed.). Saunders.
  • 10. Shoar, S., & Musher, D. M. (2020). Etiology of community- acquired pneumonia in adults: A systematic review. Pneumonia , 12 (1). https://doi.org/10.1186/s41479-020-00074-3 Yetman, D. (2020). Incentive spirometer: What it’s for and how to use it. Healthline. https://www.healthline.com/health/incentive-spirometer