(1) Pathogens are disease-causing microorganisms like bacteria, viruses, parasites, and fungi that live in reservoirs. (2) Reservoirs are places microorganisms can thrive like the human body, animals, and surfaces. Pathogens leave the reservoir through openings like the mouth, nose, or anus and enter a new host through (3) portals of entry. (4) Modes of transmission spread pathogens between hosts through contact, droplets, vectors like mosquitoes, food or water. Pathogens enter through portals of entry and infect susceptible hosts with weak immunity.