ALZHEIMER'S DISEASE, ZIKA VIRUS AND PROTEINS

2. LIBLIOGRAPHY
• Michele Vendruscolo, T.
(Thursday 11 August 2016).
Poor protein control key to
Alzheimer's / Dementia.
medicalnews.
• Preidt, R. (THURSDAY, Aug. 11,
2016). 2 Zika Virus Proteins
Linked to Microcephaly ID'd.
HealthDay.
• http://www.merriam-
webster.com/dictionary/protein
The proteins are so much important, are versatile
molecules because can realize diverses functions
and we can use it like: enzymes: can catalysis
chemical reactions
Hormones: the proteins can work with the plataletes
to help to the blood coagulation
Transport of substances
Immunological factor: the antibodies produced with
leukocyte
And the most important characteristic, they are
molecular target so, we can use it to medical
treatment, therapies to the cancer and another
diseases . Also we can use the proteins presence and
characteristic behavior for diagnosis of many
sicknesses

3. are any of various naturally occurring extremely
complex substances that consist of amino-acid
residues joined by peptide bonds, contain the
elements carbon, hydrogen, nitrogen, oxygen,
usually sulfur, and occasionally other elements (as
phosphorus or iron), and include many essential
biological compounds (as enzymes, hormones, or
antibodies)
Poor protein control key to
Alzheimer's progression
New research investigating the pattern of protein
build-up in Alzheimer's brains may open the door to
a deeper understanding.
Previous research has identified that certain areas
of the brain are more sensitive to the aggregation of
proteins. The disease often begins in the entorhinal
region (at the base of the brain) and spreads out to
all of the neocortex (the largest part of the cerebral
cortex)
 How did it?
They analyzed approximately 500 samples of
healthy brain taken from the Allen Brain Atlas In the
healthy tissue, they observed a distinctive joint of
genes important in the control of beta amyloid and
tau protein. They contrasted with Alzheimer`s brains
and discovered a identical pattern in advance of the
sickness throughout the brain.
Student’s observations
I think that it’s very interesting and useful for the
study of specifics cerebral regions and resolve the
likelihood of suffer this sickness and accordingly it’s
importanto to find preventive actions
2 Zika Virus Proteins Linked to
Microcephaly ID'd
First study to examine Zika infection in human
neural stem cells from second-trimester fetuses,
researchers say.
USC researchers have tracked down two Zika
proteins potentially responsible for thousands of
microcephaly cases; taking one small step toward
preventing Zika-infected mothers from birthing
babies with abnormally small heads. Babies with
microcephaly have abnormally small heads and
brains. The Zika virus include 10 proteins, however
only NS4B and NS4A are the responsible, in
accordance with the study published in the journal
Cell Stem Cell. These malicious proteins,
researchers discovered, have two shared life goals:
to handicap fetal brain formation and to mobilize
their malevolent forces.
Student’s observations
I think this discovery is so much useful for
implement measurement prevents to this disease
and have power over about it.

4. Proteins are vital to basic cellular and body functions,
including cellular regeneration and repair, tissue
maintenance and regulation, hormone and enzyme
production, fluid balance, and the provision of
energy.

5. Poor protein control key to
Alzheimer's progression
New research investigating the pattern of protein
build-up in Alzheimer's brains may open the door to
a deeper understanding.
Previous research has identified that certain areas
of the brain are more sensitive to the aggregation of
proteins. The disease often begins in the entorhinal
region (at the base of the brain) and spreads out to
all of the neocortex (the largest part of the cerebral
cortex)
 How did it?
They analyzed approximately 500 samples of
healthy brain taken from the Allen Brain Atlas In the
healthy tissue, they observed a distinctive joint of
genes important in the control of beta amyloid and
tau protein. They contrasted with Alzheimer`s brains
and discovered a identical pattern in advance of the
sickness throughout the brain.
Student’s observations
I think that it’s very interesting and useful for the
study of specifics cerebral regions and resolve the
likelihood of suffer this sickness and accordingly it’s
importanto to find preventive actions
POOR PROTEIN CONTROL KEY TO ALZHEIMER’S
PROGRESSION
By. Prof. Michele Vendruscolo, of the Centre for
Misfolding Diseases at Cambridge's Department of
Chemistry in the United Kingdom.
THURSDAY, Aug. 11, 2016.

6. Alzheimer's disease, is a
chronic neurodegenerative disease that usually
starts slowly and gets worse over
time. Normally appearing around the age of 60.
Although a great deal has been learned about
the disease, there is no cure, and many
questions remain unanswered

7. POOR PROTEIN CONTROL KEY TO
ALZHEIMER’S PROGRESSION
Mapeo de la forma en que se gestiona la proteína en el cerebro da una
nueva perspectiva sobre la enfermedad de Alzheimer.
Crédito de la imagen: J Freer
Amyloid - beta genes and tau
protein, involved in the control
and important factor in this
study to evaluate the pattern in
the Alzheimer brains
compared with healthy brains

8. Previous research has identified that
certain areas of the brain are more
sensitive to the aggregation of proteins.
The disease often begins in the
entorhinal region (at the base of the
brain) and spreads out to all of the
neocortex (the largest part of the
cerebral cortex).

9. Prof. Vendruscolo explains the findings:
"Vulnerability to Alzheimer's disease isn't dictated by
abnormal levels of the aggregation-prone proteins
that form the characteristic deposits in disease, but
rather by the weaker control of these proteins in the
specific brain tissues that first succumb to the
disease."
Co-author Prof. Christopher Dobson says: "Linking the
properties of specific protein molecules to the onset
and spread of neuronal damage is a crucial step in the
quest to find effective drugs to combat this dreadful
neurodegenerative condition."

10. In my opinion the advance in the knowning about
the Alzheimers disease is so much important to the
medicine because actually exist much ignorance
about it and researching, the medicine can to be
near more every day to find any possibility of
resolve this problem with any cure or otherwise
every time improvement in the treatment.
I think that investigations type’s like the previous
are too contributors to the medicine. If it continue
we can reach big steps in medicine.

11. 2 Zika Virus Proteins Linked to
Microcephaly ID'd
Researchers from a team led by University of Southern
California scientists say they've identified two proteins
in the ZIKA VIRUS linked to the severe birth
defect MICROCEPHALY.
THURSDAY, Aug. 11, 2016 (HealthDay News).

12. Zika virus is a mosquito-borne illness that is
spread by the Aedes species of mosquito.
The two known species responsible for Zika
transmission are the Aedes albopictus, known
as the Asian Tiger mosquito, and the Aedes
aegypti species.

13. • Fever
• Eruption
• Arthralgia
• Conjunctivitis
• Myalgia
• Headache
• Vomit
• Ocular pain
Symtomps
• Microcephaly is a medical condition in which
the brain does not develop properly resulting in a
smaller than normal head. Microcephaly may
be present at birth or it may develop in the first few
years of life.
Microcephaly

14. The Zika virus contains 10 proteins, but only two -- called
NS4A and NS4B -- are linked to microcephaly, according
to the researchers.
El descubrimiento podría algún día conducir a una
manera de evitar que el defecto de nacimiento, según los
científicos

15. "We now know the molecular
pathway, so we made the first
big step toward target therapy
for Zika-induced
microcephaly,".
"Dentro de unos años, un
disparo o una serie de
disparos podrían dirigirse a
las proteínas NS4A y NS4B o
sus colaboradores,“
Zhen Zhao author of this study.

16. "It is important to remember that not
every pregnant woman infected with
Zika virus gives birth to a baby with
microcephaly. Nevertheless, we are
trying to develop a cure for that
percentage that does get Zika-related
microcephaly," said study
corresponding co-author Zhen Zhao.

17. My opinion: The zika virus is a disease very
common actually and affect so much person in
the world thanks to discoveries like theses
researches we can advance and go a step
forward and save many person of suffer theses
mishaps

18. The proteins are so much important, are versatile
molecules because can realize diverses functions
and we can use it like: enzymes: can catalysis
chemical reactions
Hormones: the proteins can work with the plataletes
to help to the blood coagulation
Transport of substances
Immunological factor: the antibodies produced with
leukocyte
And the most important characteristic, they are
molecular target so, we can use it to medical
treatment, therapies to the cancer and another
diseases

19. Both researches about
caracteristic proteins in
the human body have a
relation with some disease
and it help to study the
previous diseases
Both researches help to
the medicine to reach
goals like create any
treatment in order to
anticipate theses diseases
and reduce their
frequency

20. • Michele Vendruscolo, T. (Thursday 11 August 2016). Poor protein control key
to Alzheimer's / Dementia. medicalnews.
http://www.medicalnewstoday.com/articles/312243.php
• Preidt, R. (THURSDAY, Aug. 11, 2016). 2 Zika Virus Proteins Linked to
Microcephaly ID'd. HealthDay.
http://www.webmd.com/news/20160811/study-ids-2-zika-virus-proteins-
linked-to-microcephaly
• MARTÍNEZ SÁNCHEZ, Lina María. Biología molecular. Libro de clase. 8
edición. Medellín: UPB. Fac. de Medicina. Pag. 147 .
• Protein. (07 de 09 de 2016). Obtenido de MERRIAM-WEBSTER:
http://www.merriam-webster.com/dictionary/protein
• SMITH, L. (15 de JULIO de 2016). Virus Zika: Síntomas, Datos, Diagnóstico.
Obtenido de http://www.medicalnewstoday.com/articles/305163.php