In this presentation, presented as a live webinar on Monday, April 27th, Dr. Louis Cady of the Cady Wellness Institute reviewed practical, common-sense things that can be done to boost your immunity, with documentation from the peer-reviewed medical literature. Dr. Cady also reviews supplements and nutrients that are established in the peer-reviewed medical literature as having antiviral capabilities. These include Vitamins C,D, and E, Zinc, carotenoids and antioxidants, probiotics, the reishi mushroom, elderberry, cannabidiol (CBD - not marijuana or weed!). Points presented are scrupulously documented from the medical literature. This presentation does not guarantee or represent that using ANY of these nutrients will "keep you from getting infected or dying" from COVID 19. They are presented for your thoughtful consideration.

2. COVID 19 – How to Protect Yourself from this
Potentially Deadly Virus by
Boosting Your Immune System
Louis B. Cady, MD, CEO, Founder – Cady Wellness Institute
April 27, 2020 6 PM CST
Presented free of charge to my patients and the general
Evansville and Tri-state community

3. “There are two objects of medical education: to
heal the sick and to advance the science.”
- Dr. Charles H. Mayo, MD
“The glory of medicine is that it is always moving
forward, that there is always more to learn.”
- Dr. William J. Mayo

5. COVID 19 – the Face of a Pandemic
More than 200,000 dead worldwide
(April 25, 2020 per BBC)

6. SARS-C0V-2 (2019-n-CoV) emerging from surface of cells
cultured in the lab. (1/2)

7. SARS-C0V-2 (2019-n-CoV) emerging from surface of cells
cultured in the lab. (2/2)
Both of these two images from: Boretti A, Banik BK. Intravenous Vitamin C for reduction of
cytokines storm in acute respiratory distress syndrome. Pharmanutrition. 2020 Apr 21:100190.

8. Fighting the little beasties…
• Holistic techniques to boost your immune
system (with references).
• A description of supplement strategies.
• This presentation does not constitute
“medical advice” nor the establishment of
treatment relationship with you.
– Do your own due diligence, and talk with your
own health care practitioner.
• DSHEA warning – more later.

9. Step I:
Adequate sleep
Gotta have it.

10. • Study of 56,953 female nurses (37 – 57
yoa) in the Nurses Health Study II.
– Free of hx of cancer, CV disease, diabetes, and asthma.
NO PRIOR HX OF PNEUMONIA.
• Age adjusted relative risk for pneumonia (with
removal of confounding factors) was 1.39 (95%
CI) in those sleeping </= 5 hours per night.
– Also 1.38 RR in those sleeping >/= 9 hours per night.
• Perceived inadequate sleep was also
associated with pneumonia with a relative
risk of 1.50
Patel SR et al. A prospective study of sleep duration and pneumonia risk in
women. Sleep. 2012 Jan;135(1):97-101.

11. Sleep, nutrition, and athletes.
• For sleep to have a restorative effect on the body,
it must be of adequate duration and quality;
particularly for athletes whose physical and mental
recovery needs may be greater due to the high
physiological and psychological demands placed
on them during training and competition.
• Sleep has been shown to have a restorative
effect on the immune system…
Dohert R et al. Sleep and nutrition interactions: implications for athletes.
Nutrients. 2019 Apr 11; 11(4).

12. Doc Cady’s common-sense sleep tips
• Regular, set bedtime and wake up time.
• NO NAPS.
• No big meals within 4 – 6 hours of bedtime.
• No vigorous exercise within 4 – 6 hours of bedtime.
• No caffeine within 6 – 12 hours of bedtime (Cyp 1 A2
variability)
• Hot bath 6 hours before bedtime.
• “Noise perfume.”
• Supplements which can be used:
– Melatonin – instant release or compounded
– GABA, l-theanine, taurine

13. Normalization of cortisol rhythm

14. • Secreted by the pineal gland
• Production decreases with age
• Effectiveness decreases with age
• Circadian rhythm hormone
• Reproductive hormone in lower animals
• Research on PubMed (citations as of 04/25/2020)
– “Melatonin” – 26,090 citations
– “Melatonin sleep” – 4,597 citations
MELATONIN – a full service, non-prescription,
well studied natural body hormone for sleep

15. Prospects of Clinical Utilization of
Melatonin
• Amplifies antitumoral activity of interleukin-1
• Used to treat rhythm disorders (jet lag, shift work,
blindness)
• Improves: Sleep latency, Sleep efficacy, and rising sleep
quality scores in elderly
• Regulates tone of cerebral arteries
• Melatonin receptors in vascular beds regulate body
temperature
• “The major messenger of light-dependent periodicity.”
Bubenik GA et al. Biol Signals Recept. 1998 Jul-Aug;7(4):195-219.

16. 16
Melatonin: Fun Facts
• Secretion increases at night
• Peak @ 40 minutes after light deprivation,
2500-4000 pM/l. Normal levels by AM.
• 0.25 - 0.75 hr. half-life
• 75% by Pineal 25% other
• Levels peak ~ 1 year of age,  thru senescence
•  25-100 fold within minutes of  light
• No toxic dose
• Physiologic dose 0.3mg
Source: Anton Dotson, MD – Cenegenics Module 2: Menopause 2003

17. Melatonin
• Increases natural killer cell activity
– Calvo JR et al. J Pineal Res. 2013 Sep;55(2):103-20.
• Modulates immune function
– Melatonin Miracle by W. Regelson, MD
• Used in network-based drug repurposing for
treatment of 2019-nCoV/SARS CoV-2
• Zhou Y et al. Cell Discov. 2020 Mar 16;6:14.
• May improve night time urination
• Relieves oxidative stress from stress-induced
behavioral and immunological changes in rats.
• Pal R et al. Can J Physiol Pharmacol. 2016 Mar;94(3):296-
301.

18. Melatonin & Respiratory Diseases: A Review
• Receptor dependent AND INDEPENDENT effects
– Antioxidant, anticancer, antitumor, anti-inflammatory,
anti-aging, anti-diabetic, antiviral, & neuroprotective
activities.
• “Numerous scientific reports on the therapeutic
potential of melatonin in treatment of asthma,
respiratory diseases for infections, chronic
obstructive pulmonary disease… vascular
pulmonary disease."
Habtemariam S et al. Curr Top Med Chem. 2017; 17(4):467-
488.

19. Regular “OTC” vs.
Micronized.

20. Contraindication
• 10%: No effect – but still a healthy supplement
• 1%: Adverse effect-stimulation instead of
somnolence
• Minimally effective for those addicted to
sleeping pills
• Use high dose melatonin and taper off of
sleeping pills
Source: clinical experience of Dr. Neal Rouzier, MD and
multiple peer-reviewed studies.

21. Step II: Decrease STRESS

22. Effects of stress
• Suppresses immune system
• Upsets digestive and reproductive systems
• Increases risk of heart attack and stroke.
• Shrinks the hippocampus (via cortisol) = short
term memory problems.
• Common causes:
– Pessimism, inability to accept uncertainty, rigid thinking,
lack of flexibility, negative self talks (“ANTS” – per
Amen), unrealistic expectations, “all or nothing” attitude.
Adapted from Segal, J, Smith M, et al. Help Guide. March 2020.
https://www.helpguide.org/articles/stress/stress-symptoms-signs-and-causes.htm -
accessed 4/26/2020

23. COVID Pandemic selected items in
the “top 10 stressful life events.”
• Imprisonment – (current social distancing
policies probably have milder effects)
• Injury or illness
• Job loss
• Retirement (?)
Adapted from Segal, J, Smith M, et al. Help Guide. March 2020.
https://www.helpguide.org/articles/stress/stress-symptoms-signs-and-causes.htm -
accessed 4/26/2020

24. Stress:
• Aggravates mucosal and immune damage in
mouse model
• Gon Y et al. Exp Ther Med. 2019 Mar;17(3):2341-2348.
• Causes death of leukocytes and their stem cells.
– More severe damage the longer the exposure.
• Sarjan HN et al. Chronic stress induced duration dependent
alterations in immune system and their reversibility in rats.
Immunol Letters. 2018 May;197:31-43
• Disrupts gut microbiota-immune-brain axis. (Post-
weaning social isolation model of rats)
• Dunphy-Dohert F et al. Post-weaning social isolation of rats
leads to long-term disruption of the gut microbiota-immune-brain
axis. Brain Behav Immun. 2018 Feb;68:261-273.
– (Note – men and mouse share 97.5% of their working DNA}

25. More effects of stress
• Alters immune responses during respiratory
infection.
• Griebel P et al. how stress alters immune responses during respiratory
infection. Anim J Health Res Rev. 2014 Dec;15(2):161-5
• Study of TMEV (Theilers’murine encephalomyelitis virus) as a a
mouse model of multiple sclerosis.
– Glucocorticoids implicated in decreased T cell function. “Stress-
induced immunosuppression may provide a mechanism for
enhance viral persistent within the CNS.”
• Steelman AJ et al. Brain Behv Immu. 2009 Aug;23(6):830-43.
• Makes HSV (herpes simplex virus – type 1) infections
worse via increase in glucocorticoids.
• Ashcraft KA et al. Psychoneuroendocrinology. 2008 Aug;33(7):951-63.

26. What to do about it
• Avoid catastrophizing and “fortune telling.”
• REFERENCE: Burns DB, Feeling Good: The New Mood
Therapy. William Morrow © 1999.
• Examples:
– “I just know I’ll have a hard time getting a job.” “I know
I'll lose my job.” “I just know I’m gonna get sick….”
– Antidote:
• “I ______, in my all-knowing, omnipotent, God-like being
know beyond a shadow of a doubt that_____.”
• If you can’t say it with a straight face, you’re committing a
cognitive distortion.

27. Holistic interventions
• Keep a schedule: regular wakeup &
bedtime, scheduled work, homework,
maybe job search.
• Exercise – a great “stress buster.”
• Meditate and practice mindfulness &
meditation (or prayer).

28. Review of meditation apps: 4/26/2020
• #1 – Headspace
– Free trial
– $12.99 per month
– FREE through 2020 for healthcare professionals in US public health
settings.
• Multiple others – similarly priced.
• Free mindfulness apps worth of your attention.
– Insight Timer (iOS/Android)
– Smiling Mind (iOS/Android/web)
– Stop, Breathe & Think (iOS/Android)
– UCLA Mindful (iOS/Android)
– 10% Happier (iOS/Android)
• https://www.mindful.org/free-mindfulness-apps-worthy-of-your-
attention/ accessed 4/26/2020

29. www.youtube.com “Starship Sleeping Quarters” (10 hours!!)

30. Step III:
Eat your fruits and
veggies!!
Boost your antioxidants!
Consider Vitamin C
supplementation.

31. CAN WE MEASURE IT?
WHAT’S THE RELEVANCE?
Levels of
carotenoids and
antioxidants

33. Antioxidant assessment

34. “There was good agreement between a single measure of
skin carotenoids by RRS and multiple measures [6x in 6
months] (K=0.8) The same variables were significantly
associated with carotenoid status based on single or
multiple measures, including a positive association with
intake of total carotenoids….”

35. • “The totality of the evidence supports the use of skin carotenoid status
as an objective biomarker of fruits/vegetable intake…”
• “...skin carotenoids may effectively serve as an integrated biomarker
of health…”

36. TIP: “akbaraly eva” - #5

37. • Study population:
– N=1,389; age range {59-71 yoa}; 9 year study
• Relative risks:
– all cause mortality at 2.94X in men in lowest quintile
(95% CI, P=0.03)
– cancer 1.72X in men (95% CI, P=0.01
• “Total plasma carotenoids levels were
independently associated with mortality
risk in men.”
Epidemiology of Vascular Aging (EVA)

38. Antioxidants and immune function: not
open for debate
• “Antioxidant immune function” 19,633 citations as of
4/25/2020
• Vitamin C supports epithelial barrier function against
pathogens.
• Accumulates in phagocytic cells and can enhance
chemotaxis, phagocytosis, generation of reactive oxygen
species, and ultimately microbial killing.
• Prophylactic prevention of infection requires a minimum of
100 – 200 mg/ day. Treatment of established infection
requires GRAM doses in order to compensate for
increased inflammatory response.
Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017 Nov 3; 9(11).

39. Vitamin C as an antiviral
• Known benefits
– Chemotaxis
– Enhancement of neutrophil phagocytic capacity
& oxidative killing
– Supports lymphocyte (virus killing white blood cells)
proliferation and function
• Leibovitz B, Siegel BV. Ascorbic acid and the immune response. Adv Exp Med
Biol. 1981;135:1–25.
• Carr AC. Vitamin C and Immune Function. Nutrients. 2017;9:1211.
• Dey S, Bishayi B. Killing of S.aureus in murine peritoneal macrophages by
ascorbic acid along with antibiotics chloramphenicol or ofloxacin: correlation with
inflammation. Microb Pathog. 2018;115:239–250.

40. Vitamin C as an antiviral
• Documented antiviral activity against:
– Influenza
– Herpes
– Poliovirus
– Venezuelan equine encephalitis
– HTLVS1 (HIV)
– Parvovirus and rabies.
• Valero N, Mosquera J, Alcocer S, et al. Melatonin, minocycline and ascorbic acid reduce
oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine
encephalitis. Brain Res. 2015;1622:368–376.
• Carr AC. Vitamin C and Immune Function. Nutrients. 2017;9:1211.
• Dey S, Bishayi B. Killing of S.aureus in murine peritoneal macrophages by ascorbic acid
along with antibiotics chloramphenicol or ofloxacin: correlation with inflammation. Microb
Pathog. 2018;115:239–250.
• Harakeh S, Jariwalla RJ, Pauling L. Suppression of human immunodeficiency virus replication by ascorbate
in chronically and acutely infected cells. Proc Natl Acad Sci U S A. 1990;87:7245–7249.

41. Vitamin C as an antiviral
• Inhibits Epstein-Barr virus activation (“mono”)
• Uesato S et al. Inhibitory effects of 6-O-acylated L-ascorbic acids
possessing a straight- or branched-acyl chain on Epstein Barr virus
activation. Cancer Lett. 2001;166:143–146.
• Inhibits cytomegalovirus (CMV) replication
• Cinatl J, Weber B, et al. In vitro inhibition of human cytomegalovirus replication in human
foreskin fibroblasts and endothelial cells by ascorbic acid 2-phosphate. Antiviral
Res. 1995;27:405–418.
• Tightens the endothelial permeability barrier
• May JM, Harrison FE. Role of vitamin C in the function of the vascular
endothelium. Antioxid Redox Signal. 2013;19:2068–2083.
• Essential factor on antiviral response to H3N1 influenza A
• Kim Y, Kim H, Bae S, et al. Vitamin C is an essential factor on the anti-viral
immune response through the production of interferon-alpha/beta at the initial
stage of influenza A virus (H3N2) infection. Immune Netw. 2013;13:70–74.

42. Vitamin C as an anti-inflammatory
• Use of Gulo (-/-) knockout mice – a mouse model of Vitamin C
deficiency.
• Gulo = l-gulono-y-lactone oxidase – something that anthropoid
primates and guinea pigs have lost the ability to synthesize. ((Final
step in synthesizing Vitamin D. Therefore we have to get Vit C in our
diet or supplements).
• Experiments:
– Nasal inoculation of H3N2 influenza was highly lethal in Gulo (-/-) mice
compared to normal mice
• Kim Y, Kim H, Bae S, et al. Vitamin C is an essential factor on the anti-viral immune
response through the production of interferon-alpha/beta at the initial stage of influenza A
virus (H3N2) infection. Immune Netw. 2013;13:70–74.
• Li W, Maeda N, Beck MA. Vitamin C deficiency increases the lung pathology of influenza
virus-infected gulo -/- mice. J Nutr. 2006; 136:2611-2616.
• Used as anti-inflammatory in treatment of sepsis
• Marik PE. Hydrocortisone, ascorbic acid and thiamine (HAT therapy) for the treatment of
sepsis. Focus on ascorbic acid. Nutrients. 2018;10:1762.
• Decreases RSV lung inflammation.
• Castro SM, Guerrero-Plata A, Suarez-Real G, et al. Antioxidant treatment ameliorates respiratory syncytial
virus-induced disease and lung inflammation. Am J Respir Crit Care Med. 2006;174:1361–1369.

43. Vitamin C in sepsis & “Cytokine
storm”
• “Sepsis is associated with an acute deficiency of
Vitamin C. Vitamin C, corticosteroids, and
thiamine may act synergistically to reverse sepsis
induced organ dysfunction.”
• Marik PE. Vitamin C for the treatment of sepsis: the scientific
rationale. Pharmacol Therapeut. 2018;189:63–70.
• Use of intravenous Vitamin C for reduction of
cytokines storm in Acute Respiratory Distress
Syndrome
• Boretti A, Banik BK. PharmaNutrition. 2020 Apr 21:100190.

44. NAC – N-acetylcysteine
• Alleviates Coxsackievirus B-Induced myocarditis
through suppressing viral replication and
inflammatory response.
• Wang Y et al. Antiviral Res. 2019 Dec 26:104699
• Reduced frequency of respiratory influenza-like
episodes, severity, and length of time in bed.
– Study of 262 subjects 78% >/= 65 years.
– Did not prevent the A/H1N1 infection but reduced the
incidence of clinically apparent disease.
• DeFlora S et al. Eur Respire J. 1997 Jul;10(7):1535-41
• Potent antioxidant.

45. Activation of immune system with Vitamin E
[Lee GY, Han SN. The role of vitamin E in immunity. Nutrients. 2018 Nov 1;10(11).

46. Zinc - a Gatekeeper of Immune Function
• Discovered in 1960.
• Involved in intracellular signaling in innate
and adaptive immune cells.
• Can have a pro-inflammatory picture with
Zinc deficiency.
• “The benefits of zinc supplementation for a
malfunctioning immune system become
clear.”
– Caution – take no more than 50 mg per day (Cady)
Wessles I et al. Zinc as a gatekeeper of immune function.
Nutrients. 2017 Nov 25;9(12)

47. Step IV
TAKE
SUPPLEMENTS.

48. Disclaimer: No nutritional
supplement is FDA approved for the
diagnosis, treatment, prevention, or
cure of ANY disease or “medical
condition.”
They ARE appropriate to support the structure
and function of the human body.

52. “Pending strong evidence …from randomized trials, it appears
prudent for all adults to take vitamin supplements.” Fletcher
& Fairfield, JAMA 2002

53. “Once we realize that imperfect
understanding is the human
condition, there is no shame in
being wrong, only in failing to
correct our mistakes.”
-George Soros

55. Use of vitamins by medical professionals
• 64/% of women physicians on MVI/MMS
• Frank, E., Bendich, A., & Denniston, M. (2000). Use of vitamin- mineral supplements by female physicians in the United States.
Am J Clin Nutr, 72(4), 969-975
• 51% of MD’s and 59% of nurses using dietary supplements
(survey of 900 MD’s, 300 nurses)
• Dickinson, A., Boyon, N., & Shao, A. (2009). Physicians and nurses use and recommend dietary supplements: report of a survey.
Nutr J, 8, 29.
• 37% cardiologists 50% orthopedists, and 59%
dermatologists use supplements
• Dickinson, A., Shao, A., & Boyon, N. (2010). Use of dietary supplements by cardiologists, dermatologists and orthopedists: report
of a survey. Paper presented at the Experimental Biology, Anaheim, CA.
• 74% of all dieticians were regular users of nutritional
supplements
• Dickinson, A., Bonci, L., Boyon, N., & Franco, J. C. (2012). Dietitians use and recommend dietary
supplements: report of a survey. Nutr J, 11, 14.

56. Today’s reality
Stats [National Center for Health Statistics April, 2011]:
– 68% of Americans take a dietary supplement
– 55% of people trust their doctor for a
recommendation
–Yet…. Doctors don’t talk about it.
– I now talk about it!

57. A solid “1-2 Punch”: Vitamin D
& Probiotics

58. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821804/

59. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821804/

61. • UCLA scientists – Vitamin D is, in effect, a
potent antibiotic.
• It activates body’s production of
antimicrobial peptides.
• Of these peptides, there are 200 known
peptides which destroy the cell walls of
bacteria, fungi, and viruses including the
influenza virus.
• Gombart AF The vitamin D-antimicrobial
pathways and its role in protection against
infection. Future Microbiol. 2009 Nov;4:1151

62. Vitamin D crucial to activating immune defenses
– University of Copenhagen, May 7, 2010
https://www.eurekalert.org/pub_releases/2010-03/uoc-vdc030410.php

63. • Determination that Vitamin D is crucial to
activating our immune defenses.
• Without it, T cells will not be able to react or
fight off serious infections in the body.
• T cells must be first “triggered” into action and
transform from inactive cells into killer cells
which are “primed to seek out and destroy all
traces of a foreign pathogen.”
• T cells rely on Vitamin D in order to activate.

64. Boosting immunity in munchkins
• 326 children (3-5 yoa) in a double blind, placebo controlled
study. Dosed twice daily for 6 months.
– Placebo (104)
– Lactobacillus acidophilus NCFM (110)
– L. acidophilus NCFM + Bifidobacterium animalis subsp lactis (Bi-
07) (112)
“Daily dietary probiotic supplementation for 6
months was a safe, effective way to reduce
fever, rhinorrhea, cough incidence/duration, and
antibiotic prescription incidence, as well as the
number of missed school days attributable to
illness.”
Leyer GJ et al. Probiotic effects on cold and influenza-like
symptom incidence and duration in children. Pediatrics.
2009 Aug;124(2):e172-9

65. Use of probiotics: medical/emotional
• Lactobacillus helveticus NS8 improved behavior, cognitive,
and biochemical aberrations caused by chronic restraint
stress.
• Lian S et al. Neuroscience 2015 Dec 3;310:561-77.
• Probiotics yielded small but significant effects for
depression and anxiety.
– More difference in clinical/medical population vs. community.
• Liu RT et al. Neurosci Biobehav Res. 2019 Jul;102:13-23
• “The emerging concept of a gut microbiota-brain axis
suggests that the modulation of the gut microbiota may
provide a novel therapeutic target for the treatment and/or
prevention of mood and anxiety disorders.”
– Sypchenko A et a. Gut emotions – mechanisms of action of probiotics as novel
therapeutic targets for depression and anxiety disorders. CNS Neurol Disord Drug
Targets. 2014;13(10):1770-86

66. My recommendations for Vitamin
D/probiotics
• 500 – 1000 IU/ day for children
• 5,000 IU per day for adults (monitor levels)
• {25 – 80 ng/ml or 30 – 100 ng/ml. Optimal is 50 –
80 ng/ml} . Insufficiency is <30; deficiency is <20.
• Must take it with Vitamin K2 (if not
contraindicated)– 180 micrograms/day.
• Probiotics in adults:
– L. acidophilus NCFM + B Lactis Bi-078 – 15
billion per day.

67. More supplements
Lysine &
Plant-based antivirals

68. Lysine
• Decreases replication of feline herpes virus
• Maggs DJ et al. Am. Journal Vet Research December 2000, vol 61, no 12:
1474-1478.
• Lysine suppresses clinical manifestation of herpes virus
infection.
– 45 patients with rec. herpes infections given 312 - 1200 mg of
lysine daily. .
– Recovered faster, and reoccurrence suppressed.
• Griffith RS, et al. A multicentered study of lysine therapy in herpes
simplex infection. Dermatologica 1978;156:257-267.
• Lysine prevented herpes simplex labialis in 26
volunteers
– 12 month, double blind study
• Thein DJ et al. Oral surgery, Oral Medicine, Oral Pathology 1984;58(6)659-666.

69. Antiviral supplement formulation – assigned to VYMEDIC, LLC

70. Plant based antivirals
• Lemon balm – has phenolic compounds
which have potent antiviral activity.
• These phenols neutralize viruses on contact
by attaching to them and preventing their
union with cell receptors.
– Chevallier A. The Encylopedia of Traditional Plants. Lond: Dorling
Kindersley Ltd; 1996.
– Kucera LS et al. Antiviral activity of extracts of the lemon balm plant. Ann
NY Acd Sci 1965;130(1):474-82.

71. Sage – not just for holiday stuffing!
• Contains glycosides – potent antioxidants
and mucosal health support.
• Per German Commission E, sage is anti-
bacterial, fungistatic, virostatic, astringent.
Blumenthal M et al. The Complete German Commission E Monographs:
Therapeutic Guide to Herbal Medicines. Austin Tx: American Botanical Society,
1998.

72. Step V
'shrooms, berries,
and CBD


73. Ganoderma lucidum (“Reishi” or “Ling Chi”)
• Antiviral effects against enterovirus 71 infection
• Zhang W et al. Biochem Biophys Res. Commun. 2014
Jul4:449(3):307-12.
• Effective against HIV proteases and EV 71 (multiplies in
GI tract – can cause mild respiratory symptoms up to
serious, life-threatening complications.)
• Linnakoski R et al. Front Microbiol 2018;9:2325.
• Polysaccharides and triterpenoids are the major antiviral
constituents of Ganoderma species. Mechanisms are
still poorly defined.
» Gao, Yihuai & Zhou, Shufeng & Huang, Min & Xu, Anlong. (2003).
Antibacterial and Antiviral Value of the Genus Ganoderma P. Karst. Species
(Aphyllophoromycetideae): A Review. International Journal of Medicinal
Mushrooms - INT J MED MUSHROOMS. 5. 235-246.
10.1615/InterJMedicMush.v5.i3.20.

74. Sambucus nigra (Elderberry)
• One of the most used medicinal plants
worldwide.
– Antiviral and antimicrobial properties have been demonstrated.
FDA has it categorized as “generally recognized as safe”.
• Porter RS Bode RF. Phytother Res. 2017 Apr;31(4):533-554
• Sambucus nigra, Caesalpinia pulcherrima, and
Hypericum connatum – “hold promising specific antiviral
activities scientifically proven through studies on
experimental animal models.”
- Akram M et al. Antiviral potential of medicinal plants against HIV,
HSV, influenza, hepatitis, and coxsackievirus: a systematic review.
Phytother Re. 2018 May;32(5):881-822

75. Sambucus nigra (Elderberry) – more studies
• Effectively treats upper respiratory symptoms
• Hawkins J et al. Complement Ther Med. 2019 Feb;42:361-365.
• Stimulates immune response and prevents viral
infection (with Human influenza A virus). Showed
“relatively strong defense against IVF infection.”
• Kinoshita E et al. Biosci Biotechnol Biochem. 2012;76(9):1633-8.
• Increases inflammatory cytokines as a function of
stimulating immune system. (IL-1 beat, TNF-alpha,
IL-6, IL-8 increased by 2 – 45 fold)
» Barak V et al. The effect of Smbucol, a black elderberry-based, natural
product, on the production of human cytokines: I. Inflammatory cytokines.
Eur Cytokin Netw. 2001 Apr-Jun;12(2):290-6.

76. CBD; Cannabidiol
• 2 articles on PubMed support use of CBD for the treatment
of Hepatitis C and Kaposi sarcoma
• 1 article reported decrease in neuroinflammation in a virus-
induced animal model of multiple sclerosis.
• “Anecdotal experiences of CBD use retrieved on the
Internet, on the other side, lack any support from sound
scientific evidence…”
• Tagne AM et al. Cannabidiol for viral diseases: hype or hope? Cannabis and
Cannabinoid Research. 15 Jan 2020 https://doi.org/10.1089/can.2019.0060
• CBD exhibited in vitro activity against viral hepatitis C.
• Lowe HI et al. Pharmacognosy Res. 2017 Jan-Mar;9(1):116 – 118.
• CBD & anxiety – 187 citations (4/26/2020) on
www.PubMed.gov

77. Review:
• Step I: Get adequate sleep.
• Step II: Try to lower stress. Meditate.
Schedule.
• Step III: Eat your fruits and veggies.
Supplement with antioxidants. Vitamin
C.& E; NAC.
• Step IV: Take your supplements.
– Vitamin D, Probiotics.
• Step V: “ ’shrooms, berries and CBD”

78. Radical transparency: What I take
• Multivitamin/multimineral/fish oil nutritional system
– one packet twice daily. (with documented high
antioxidant scan scores.)
• Vitamin D 5000 + K2 – 180 ug
• Vitamin C (high quality supplement) 1000 mg
twice daily
• Elderberry – one tablespoon organic syrup daily.
• Immune formula
• Probiotic – daily
• Reishi – twice daily

79. FUTURE VIEW
• UPCOMING WEBINARS:
– “How to Cope with the Psychological Impact of COVID 19, Social Distancing, And All
of the Emotional Stress” – May 4 6 pm
– “Do It Yourself Treatment for Depression Without Leaving Your Home– Not as Crazy
as It Sounds” - - May 13 6 pm.
– “How to Save Money On your Healthcare: How to Pay Reasonable Money for
Excellent Care” – May 20 - 6 pm.
– “Designing Your Future – What’s Coming Next?” - May 27
• RECORDINGS OF OF THESE WEBINARS:
– www.cadywellness.com/hope
– Or – if you forget, go to www.cadywellness.com and click the
“Webinars” button at the top.
– All slide decks at
www.slideshare.net/lcadymd
• Handout goodies: via –email if desired. Make sure we
have yours.

80. “For me, the practice of medicine has
opened the door to the greatest adventure in
life. Medicine is like a hallway lined with
doors, each door opening into a different
room, and each room opening
into another hallway,
again lined with doors.
Medicine is always
wonderful and never will
be finished.”
- Charles H. Mayo, M.D.

81. THANK YOU FOR ATTENDING!