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HVAC Functions in Pharmaceutical Manufacturing
1. The core functionsof an HVAC system includethe following:
1. Controlling micro-organisms, particles in the air and dust. A working HVAC
system has to primarily control dust, which is eliminated through filtration. Dust
can be a cause of contamination in the manufacturing process if not taken care of.
Airborne particles that are found in the air can also interfere with the
manufacturingprocess and result in contamination. Micro-organisms are also a
potential threat to the successful processing of pharmaceuticalssince the
environment in the plantshould be sterile. All these are eliminated through the
HEPAsystems.
2. Maintainingtheright temperature in the production spaces. Temperatureis very
key in anypharmaceuticalindustry. if the temperature is not well controlled, it
may cause micro bacteria to grow in the spaces or on workers, which may affect
their health adversely.
3. Maintainingtheright pressure in the room. In the pharmaceuticalindustry,
there are areas and surfaces that must be kept cleaner at all times. These areas
must, therefore, be kept at a positive pressurization at all times. The air floor at
these areas should be more at the opening areas. The HVAC system ensures that
positive pressurization is achieved by keeping the air flower into the clear spaces
more than the air that exits at the same time. this ensures that there is no chance or
space for the growth of micro-organisms.
4. Maintainingtheright relative humidity. Controlling the moisture in the
manufacturingspacesis achieved by the installation of desiccant dehumidifiers.
Having the right humiditylevels in the space is key to manufacturingstabledrugs.
The correct relative humidityis usually needed to ensure that tablets are well
2. manufactured.
Conclusion
The main reason why each pharmaceuticalindustrystrives to have a working
HVAC system is to ensure thatthe qualityof the products they manufactureis not
compromised. Also, the manufacturingprocess sometimes includes emission of
harmfulby-products such as gases. This is controlled by these systems through
proper ventilation. With thatin mind, we can say that working HVAC systems are
part of upholding thehealth and safety of operators.